478
Views
36
CrossRef citations to date
0
Altmetric
Review

Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer

, MD, , , , , , , , , & show all

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Matteo Santoni, Francesca Miccini, Alessia Cimadamore, Francesco Piva, Francesco Massari, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi & Nicola Battelli. (2021) An update on investigational therapies that target STAT3 for the treatment of cancer. Expert Opinion on Investigational Drugs 30:3, pages 245-251.
Read now
Xiaowen Hu, Kandasamy Saravanakumar, Tieyan Jin & Myeong-Hyeon Wang. (2019) Mycosynthesis, characterization, anticancer and antibacterial activity of silver nanoparticles from endophytic fungus Talaromyces purpureogenus. International Journal of Nanomedicine 14, pages 3427-3438.
Read now
Jung-Chen Su, Chuan-Hsun Chang, Szu-Hsien Wu & Chung-Wai Shiau. (2018) Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1248-1255.
Read now
Weiwei Tan, Meihong Pan, Hui Liu, Hequn Tian, Qing Ye & Hongda Liu. (2017) Ergosterol peroxide inhibits ovarian cancer cell growth through multiple pathways. OncoTargets and Therapy 10, pages 3467-3474.
Read now

Articles from other publishers (32)

Zixu Liu, Qingqing Wang, Yupeng Feng, Linxuan Zhao, Nan Dong, Yu Zhang, Tian Yin, Haibing He, Xing Tang, Jingxin Gou & Li Yang. (2023) The self-adjuvant heterocyclic lipid nanoparticles encapsulated with vaccine and STAT3 siRNA boost cancer immunotherapy through DLN-targeted and STING pathway. Chemical Engineering Journal 475, pages 146474.
Crossref
Zijun Geng, Meiqi Chen, Qixuan Yu, Shuoxi Guo, Tianli Chen & Da Liu. (2023) Histone Modification of Colorectal Cancer by Natural Products. Pharmaceuticals 16:8, pages 1095.
Crossref
Zixu Liu, Linxuan Zhao, Yupeng Feng, Qingqing Wang, Nan Dong, Yu Zhang, Tian Yin, Haibing He, Xing Tang, Jingxin Gou & Li Yang. (2023) Dual-responsive PEG–lipid polyester nanoparticles for siRNA and vaccine delivery elicit anti-cancer immune responses by modulating tumor microenvironment. Biomaterials Science.
Crossref
Alessandro Rizzo, Veronica Mollica, Matteo Santoni & Francesco Massari. (2022) Cancer Immunotherapy: Harnessing the Immune System to Fight Cancer. Journal of Clinical Medicine 11:21, pages 6356.
Crossref
Jixiu Wang, Qianhui Sun, Jiaqi Wu, Wanping Tian, Huanling Wang & Hong Liu. (2022) Identification of four STAT3 isoforms and functional investigation of IL-6/JAK2/STAT3 pathway in blunt snout bream (Megalobrama amblycephala). Developmental & Comparative Immunology 135, pages 104484.
Crossref
Yugal Kishore Mohanta, Debasis Nayak, Awdhesh Kumar Mishra, Ishani Chakrabartty, Manjit Kumar Ray, Tapan Kumar Mohanta, Kumananda Tayung, Rajapandian Rajaganesh, Murugan Vasanthakumaran, Saravanan Muthupandian, Kadarkarai Murugan, Gouridutta Sharma, Hans-Uwe Dahms & Jiang-Shiou Hwang. (2022) Green Synthesis of Endolichenic Fungi Functionalized Silver Nanoparticles: The Role in Antimicrobial, Anti-Cancer, and Mosquitocidal Activities. International Journal of Molecular Sciences 23:18, pages 10626.
Crossref
Matteo Santoni, Francesco Massari, Marc R. Matrana, Umberto Basso, Ugo De Giorgi, Gaetano Aurilio, Sebastiano Buti, Lorena Incorvaia, Mimma Rizzo, Angelo Martignetti, Diana Maslov, Karine Tawagi, Ernest Philon, Zoe Blake, Camillo Porta & Nicola Battelli. (2022) Statin use improves the efficacy of nivolumab in patients with advanced renal cell carcinoma. European Journal of Cancer 172, pages 191-198.
Crossref
Donghai Liu, Hong Luo & Chenhui Qiao. (2021) SHP-1/STAT3 Interaction Is Related to Luteolin-Induced Myocardial Ischemia Protection. Inflammation 45:1, pages 88-99.
Crossref
Buyun Kim, Ki Lee & Byoungduck Park. (2022) Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells. Oncology Letters 23:3.
Crossref
Xiaokun Zhou, Liang Lv, Yuan Tan, Zhongyi Zhang, Shuyang Wei & Shaowen Xiao. (2021) Tanshinone IIA sensitizes TRAIL-induced apoptosis in glioblastoma through inducing the expression of death receptors (and suppressing STAT3 activation). Brain Research 1766, pages 147515.
Crossref
Matteo Santoni, Francesco Massari, Giorgio Santoni, Alessia Cimadamore, Rodolfo Montironi & Nicola Battelli. (2021) Re: Human Chimeric Antigen Receptor Macrophages for Cancer Immunotherapy. European Urology 79:6, pages 887-889.
Crossref
Sogand Vahidi & Ali Akbar Samadani. (2021) TERRA Gene Expression in Gastric Cancer: Role of hTERT. Journal of Gastrointestinal Cancer 52:2, pages 431-447.
Crossref
Alessandro Rizzo, Veronica Mollica, Francesca Giunchi, Filippo Gustavo Dall’Olio, Matteo Rosellini, Andrea Marchetti, Tania Franceschini, Riccardo Schiavina, Eugenio Brunocilla, Michelangelo Fiorentino, Andrea Ardizzoni & Francesco Massari. (2021) Impact of HER2 assessment by CISH in urothelial carcinoma: A retrospective single-center experience. Pathology - Research and Practice 220, pages 153410.
Crossref
Anjana K. Vala, Hiral Trivedi, Harengiri Gosai, Haresh Panseriya & Bharti Dave. 2021. Biosynthesized Nanomaterials. Biosynthesized Nanomaterials 547 584 .
Aliaa M. Mohassab, Heba A. Hassan, Dalia Abdelhamid & Mohamed Abdel-Aziz. (2020) STAT3 transcription factor as target for anti-cancer therapy. Pharmacological Reports 72:5, pages 1101-1124.
Crossref
Edward J. Morris, Jordan A. Gillespie, Christopher A. Maxwell & Shoukat Dedhar. (2020) A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance. Cell Reports 30:11, pages 3605-3615.e5.
Crossref
Eun‑Ok Kim, Shi‑Eun Kang, Minji Choi, Ki‑Jong Rhee & Miyong Yun. (2019) CCR4‑NOT transcription complex subunit�2�regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway. International Journal of Molecular Medicine.
Crossref
Esfandiar Heidarian & Mahnaz Keloushadi. (2019) Antiproliferative and anti-invasion effects of carvacrol on PC3 human prostate cancer cells through reducing pSTAT3, pAKT, and pERK1/2 signaling proteins. International Journal of Preventive Medicine 10:1, pages 156.
Crossref
Shuntao Wang, Lili Yu, Wei Shi, Xueqin Li & Lixiu Yu. (2018) Prognostic roles of signal transducers and activators of transcription family in human breast cancer. Bioscience Reports 38:6.
Crossref
Aws Alshamsan. (2018) STAT3-siRNA induced B16.F10 melanoma cell death: more association with VEGF downregulation than p-STAT3 knockdown. Saudi Pharmaceutical Journal 26:8, pages 1083-1088.
Crossref
Loukik Arora, Alan Kumar, Frank Arfuso, Wee Chng & Gautam Sethi. (2018) The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies. Cancers 10:9, pages 327.
Crossref
Qian Gao, Sue Xiang, Kirsty Wilson, Mutsa Madondo, Andrew Stephens & Magdalena Plebanski. (2018) Sperm Protein 17 Expression by Murine Epithelial Ovarian Cancer Cells and Its Impact on Tumor Progression. Cancers 10:8, pages 276.
Crossref
Esfandiar Heidarian, Mahnaz Keloushadi, Keihan Ghatreh-Samani & Effat Jafari-Dehkordi. (2017) Gallic Acid Inhibits Invasion and Reduces IL-6 Gene Expression, pSTAT3, pERK1/2, and pAKT Cellular Signaling Proteins in Human Prostate Cancer DU-145 Cells. International Journal of Cancer Management 10:11.
Crossref
Yan-Ping Li, Wen-Ze Wang, Xue-Qi Chen, Ling-Bo Li, Zhi-Yong Liang, Kun Ru & Jing-Nan Li. (2017) Signal Transducer and Activator of Transcription 3 for the Differentiation of Hepatocellular Carcinoma from Cirrhosis. Chinese Medical Journal 130:22, pages 2686-2690.
Crossref
Hamed Amani, Marjan Ajami, Solmaz Nasseri Maleki, Hamidreza Pazoki-Toroudi, Maria Daglia, Arold Jorel Tsetegho Sokeng, Arianna Di Lorenzo, Seyed Fazel Nabavi, Kasi Pandima Devi & Seyed Mohammad Nabavi. (2017) Targeting signal transducers and activators of transcription (STAT) in human cancer by dietary polyphenolic antioxidants. Biochimie 142, pages 63-79.
Crossref
Jing You, Xiaoyan Shi, Huimin Liang, Juan Ye, Lupeng Wang, Huanxiao Han, Hongyu Fang, Wenyi Kang & Tianxiao Wang. (2017) Cystathionine- γ-lyase promotes process of breast cancer in association with STAT3 signaling pathway. Oncotarget 8:39, pages 65677-65686.
Crossref
Chun-Yu Liu, Kuen-Feng Chen, Tzu-I Chao, Pei-Yi Chu, Chun-Teng Huang, Tzu-Ting Huang, Hsiu-Ping Yang, Wan-Lun Wang, Chia-Han Lee, Ka-Yi Lau, Wen-Chun Tsai, Jung-Chen Su, Chia-Yun Wu, Ming-Huang Chen, Chung-Wai Shiau & Ling-Ming Tseng. (2017) Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells. Journal of Molecular Medicine 95:9, pages 965-975.
Crossref
Azadeh Ranjbari, Esfandiar Heidarian & Keihan Ghatreh-Samani. (2017) Effects of Thymoquinone on IL-6 Gene Expression and Some Cellular Signaling Pathways in Prostate Cancer PC3 Cells. Jundishapur Journal of Natural Pharmaceutical Products 12:3.
Crossref
Chun-Yu Liu, Tzu-Ting Huang, Pei-Yi Chu, Chun-Teng Huang, Chia-Han Lee, Wan-Lun Wang, Ka-Yi Lau, Wen-Chun Tsai, Tzu-I Chao, Jung-Chen Su, Ming-Huang Chen, Chung-Wai Shiau, Ling-Ming Tseng & Kuen-Feng Chen. (2017) The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells. Experimental & Molecular Medicine 49:8, pages e366-e366.
Crossref
Tzu-Ting Huang, Jung-Chen Su, Chun-Yu Liu, Chung-Wai Shiau & Kuen-Feng Chen. (2017) Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy. International Journal of Molecular Sciences 18:6, pages 1234.
Crossref
Esfandiar Heidarian, Mahnaz Keloushadi, Keihan Ghatreh-Samani & Parisa Valipour. (2016) The reduction of IL-6 gene expression, pAKT, pERK1/2, pSTAT3 signaling pathways and invasion activity by gallic acid in prostate cancer PC3 cells. Biomedicine & Pharmacotherapy 84, pages 264-269.
Crossref
Daniella M. Schwartz, Michael Bonelli, Massimo Gadina & John J. O'Shea. (2015) Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nature Reviews Rheumatology 12:1, pages 25-36.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.