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Drug Evaluation

Blinatumomab for the treatment of B-cell lymphoma

, BA & , MD (Professor of Medicine, Koman Chair in Medical Oncology)

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Atsushi Kuwahara, Misae Nazuka, Yuri Kuroki, Kohei Ito, Shunsuke Watanabe, Izumi Kumagai & Ryutaro Asano. (2023) Functional integration of protein A binding ability to antibody fragments for convenient and tag-free purification. Bioengineered 14:1.
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Yining Zhao, Yumei Li, Xiaoqiong Wu, Li Li, Jiayu Liu, Yanlan Wang, Yue Liu, Qing Li & Zhong Wang. (2020) Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies. Cancer Biology & Therapy 21:1, pages 72-80.
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Richard Burt, Dana Warcel & Adele K. Fielding. (2019) Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies. Human Vaccines & Immunotherapeutics 15:3, pages 594-602.
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Kum Ja Lee, Vivian Chow, Ashley Weissman, Sunil Tulpule, Ibrahim Aldoss & Mojtaba Akhtari. (2016) Clinical use of blinatumomab for B-cell acute lymphoblastic leukemia in adults. Therapeutics and Clinical Risk Management 12, pages 1301-1310.
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Articles from other publishers (21)

Jun Fang, Shifa Lai, Haoyang Yu & Lan Ma. (2023) Suppression of MUC1-Overexpressing Tumors by a Novel MUC1/CD3 Bispecific Antibody. Antibodies 12:3, pages 47.
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Sepideh Razi & Nima Rezaei. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 27 .
Yaping Sun & Jian Xu. (2022) Emerging Antibodies in Cancer Therapy. Advanced NanoBiomed Research 3:1.
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Pauline Mocquot, Yasmine Mossazadeh, Léopoldine Lapierre, Fanny Pineau & Fabien Despas. (2022) The pharmacology of blinatumomab: state of the art on pharmacodynamics, pharmacokinetics, adverse drug reactions and evaluation in clinical trials. Journal of Clinical Pharmacy and Therapeutics 47:9, pages 1337-1351.
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Srushti Mahajan, Mayur Aalhate, Santosh Kumar Guru & Pankaj Kumar Singh. (2022) Nanomedicine as a magic bullet for combating lymphoma. Journal of Controlled Release 347, pages 211-236.
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Essam A Tawfik, Norah A Aldrak, Shahad H Albrahim, Dunia A Alzahrani, Haya A Alfassam, Samar M Alkoblan, Abdulaziz M Almalik, Kok-Siong Chen, Rana Abou-Khalil, Khalid Shah & Nada M Zaidan. (2021) Immunotherapy in hematological malignancies: recent advances and open questions. Immunotherapy 13:14, pages 1215-1229.
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Alison Betts, Nahor Haddish-Berhane, Dhaval K. Shah, Piet H. van der Graaf, Frank Barletta, Lindsay King, Tracey Clark, Cris Kamperschroer, Adam Root, Andrea Hooper & Xiaoying Chen. (2019) A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®. The AAPS Journal 21:4.
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Stanton Goldman & Jessica Hochberg. 2019. Non-Hodgkin's Lymphoma in Childhood and Adolescence. Non-Hodgkin's Lymphoma in Childhood and Adolescence 295 304 .
Archana Thakur, Manley Huang & Lawrence G. Lum. (2018) Bispecific antibody based therapeutics: Strengths and challenges. Blood Reviews 32:4, pages 339-347.
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Limin Lin, Li Li, Changhua Zhou, Jing Li, Jiayu Liu, Rui Shu, Bin Dong, Qing Li & Zhong Wang. (2018) A HER2 bispecific antibody can be efficiently expressed in Escherichia�coli with potent cytotoxicity. Oncology Letters.
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Yumei Li, Changhua Zhou, Jing Li, Jiayu Liu, Limin Lin, Li Li, Donglin Cao, Qing Li & Zhong Wang. (2018) Single domain based bispecific antibody, Muc1-Bi-1, and its humanized form, Muc1-Bi-2, induce potent cancer cell killing in muc1 positive tumor cells. PLOS ONE 13:1, pages e0191024.
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Matthew J. Barth, Jessica Hochberg, Nader Kim El-Mallawany & Mitchell S. Cairo. 2018. Immunotherapy for Pediatric Malignancies. Immunotherapy for Pediatric Malignancies 79 116 .
Maureen C. Ryan, Maria Corinna Palanca-Wessels, Brian Schimpf, Kristine A. Gordon, Heather Kostner, Brad Meyer, Changpu Yu, Heather A. Van Epps & Dennis Benjamin. (2017) Therapeutic potential of SGN-CD19B, a PBD-based anti-CD19 drug conjugate, for treatment of B-cell malignancies. Blood 130:18, pages 2018-2026.
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MeiQi May Liau, Valencia Long, Jingxiang Huang & Huma Jaffar. (2017) Blinatumomab-associated vasculitis. JAAD Case Reports 3:5, pages 395-397.
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T. Noelle Lombana & Christoph Spiess. 2017. Analytical Characterization of Biotherapeutics. Analytical Characterization of Biotherapeutics 169 198 .
Matthew Ku, Geoff Chong & Eliza A. Hawkes. (2017) Tumour cell surface antigen targeted therapies in B-cell lymphomas: Beyond rituximab. Blood Reviews 31:1, pages 23-35.
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M Pizzi, M Boi, F Bertoni & G Inghirami. (2016) Emerging therapies provide new opportunities to reshape the multifaceted interactions between the immune system and lymphoma cells. Leukemia 30:9, pages 1805-1815.
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Francesca Ferrari, Stefania Bellone, Jonathan Black, Carlton L. Schwab, Salvatore Lopez, Emiliano Cocco, Elena Bonazzoli, Federica Predolini, Gulden Menderes, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz & Alessandro D. Santin. (2015) Solitomab, an EpCAM/CD3 bispecific antibody construct (BiTE®), is highly active against primary uterine and ovarian carcinosarcoma cell lines in vitro. Journal of Experimental & Clinical Cancer Research 34:1.
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Jingjing Wu, Jiaping Fu, Mingzhi Zhang & Delong Liu. (2015) Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia. Journal of Hematology & Oncology 8:1.
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Yu-Tzu Tai & Kenneth C Anderson. (2015) Targeting B-cell maturation antigen in multiple myeloma. Immunotherapy 7:11, pages 1187-1199.
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Felipe Vences-Catalán, Chiung-Chi Kuo & Shoshana Levy. (2015) Role of an arginine–lysine rich motif in maturation and trafficking of CD19. Biochemical and Biophysical Research Communications 465:3, pages 319-323.
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