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Novel investigational therapies for treating pulmonary arterial hypertension

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Yo Muraki, Takako Naito, Kimio Tohyama, Sachio Shibata, Kanako Kuniyeda, Yasunori Nio, Masatoshi Hazama & Takanori Matsuo. (2019) Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension. Bioscience, Biotechnology, and Biochemistry 83:6, pages 1000-1010.
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Olivier Defert & Sandro Boland. (2017) Rho kinase inhibitors: a patent review (2014 – 2016). Expert Opinion on Therapeutic Patents 27:4, pages 507-515.
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Mayank Sardana, Matthew Moll & Harrison W Farber. (2016) Pharmacokinetic drug evaluation of selexipag for the treatment of pulmonary arterial hypertension. Expert Opinion on Drug Metabolism & Toxicology 12:12, pages 1513-1520.
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Articles from other publishers (7)

Ling Zhu, Ye-li Li, Zhi-qiang Qian, Liang Hua, Yun Yue & Dan-li Yang. (2021) Osthole improves pulmonary artery hypertension by inducing apoptosis in pulmonary artery smooth muscle cells. Journal of Pharmacy and Pharmacology.
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Magdalena Jasińska-Stroschein & Daria Orszulak-Michalak. (2021) Reporting experimental studies on animals – The problems with translating of outcomes to clinical benefits. Methodological and statistical considerations: The example of pulmonary hypertension. European Journal of Pharmacology 897, pages 173952.
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Jin-Ha Yoon, Thi-Thao-Linh Nguyen, Van-An Duong, Kwang-Hoon Chun & Han-Joo Maeng. (2020) Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Pharmacokinetic Application. Molecules 25:6, pages 1369.
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Jahidur Rashid, Eva Nozik-Grayck, Ivan F. McMurtry, Kurt R. Stenmark & Fakhrul Ahsan. (2019) Inhaled combination of sildenafil and rosiglitazone improves pulmonary hemodynamics, cardiac function, and arterial remodeling. American Journal of Physiology-Lung Cellular and Molecular Physiology 316:1, pages L119-L130.
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Katarzyna Sztuka, Daria Orszulak-Michalak & Magdalena Jasińska-Stroschein. (2018) Systematic review and meta-analysis of interventions tested in animal models of pulmonary hypertension. Vascular Pharmacology 110, pages 55-63.
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Yo Muraki, Midori Yamasaki, Hirohisa Takeuchi, Kimio Tohyama, Noriyasu Sano & Takanori Matsuo. (2018) Fluorescent Imaging Analysis for Distribution of Fluorescent Dye Labeled- or Encapsulated-Liposome in Monocrotaline-Induced Pulmonary Hypertension Model Rat. Chemical and Pharmaceutical Bulletin 66:3, pages 270-276.
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Gesheng Cheng, Xingye Wang, Yongxin Li & Lu He. (2017) Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling. Stem Cell Research & Therapy 8:1.
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