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Review

Investigational insulin secretagogues for type 2 diabetes

Pages 405-422 | Received 24 Nov 2015, Accepted 05 Feb 2016, Published online: 27 Feb 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Sachin Sharma, Karan Wadhwa, Manjusha Choudhary & Vikas Budhwar. (2022) Ethnopharmacological perspectives of glucokinase activators in the treatment of diabetes mellitus. Natural Product Research 36:11, pages 2962-2976.
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André J. Scheen, Nicolas Paquot & Pierre J. Lefèbvre. (2017) Investigational glucagon receptor antagonists in Phase I and II clinical trials for diabetes. Expert Opinion on Investigational Drugs 26:12, pages 1373-1389.
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Alexandra Chirila, Mary E Nguyen, Jill Tinmouth & Ilana J Halperin. (2023) Preparing for Colonoscopy in People with Diabetes: A Review with Suggestions for Clinical Practice. Journal of the Canadian Association of Gastroenterology 6:1, pages 26-36.
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Xin Zhao, Lijiao Deng, Lele Ren, Huanhuan Yang, Bin Wang, Xiaochan Zhu, Xiaoli Zhang, Chao Guo, Yi Zhang & Yunfeng Liu. (2023) VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic β cells. Experimental Cell Research 423:2, pages 113471.
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Jun Nagamine. (2023) Pharmacological profile and clinical efficacy of imeglimin hydrochloride (TWYMEEG<sup>®</sup>Tablets), the orally drug for type 2 diabetes mellitus with the first dual mode of action in the world膵作用と膵外作用の2つの血糖降下作用をあわせもつ世界初の経口2型糖尿病治療薬イメグリミン塩酸塩(ツイミーグ<sup>®</sup>錠)の薬理学的特性と臨床効果. Folia Pharmacologica Japonica 158:2, pages 193-202.
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Pierre Theurey, Carole Thang, Valdis Pirags, Andrea Mari, Giovanni Pacini, Sébastien Bolze, Sophie Hallakou‐Bozec & Pascale Fouqueray. (2022) Phase 2 trial with imeglimin in patients with Type 2 diabetes indicates effects on insulin secretion and sensitivity. Endocrinology, Diabetes & Metabolism 5:6.
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Sevgican Demir, Peter P. Nawroth, Stephan Herzig & Bilgen Ekim Üstünel. (2021) Emerging Targets in Type 2 Diabetes and Diabetic Complications. Advanced Science 8:18, pages 2100275.
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Abdul Hameed, Sajda Ashraf, M. Israr Khan, Rahman M. Hafizur & Zaheer Ul-Haq. (2018) Protein kinase A-dependent insulinotropic effect of selected flavonoids. International Journal of Biological Macromolecules 119, pages 149-156.
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Dalong Zhu, Shenglian Gan, Yu Liu, Jianhua Ma, Xiaolin Dong, Weihong Song, Jiao'e Zeng, Guixia Wang, Wenjuan Zhao, Qiu Zhang, Yukun Li, Hui Fang, Xiaofeng Lv, Yongquan Shi, Haoming Tian, Linong Ji, Xin Gao, Lihui Zhang, Yuqian Bao, Minxiang Lei, Ling Li, Longyi Zeng, Xiaoying Li, Xinghua Hou, Yu Zhao, Tianxin Hu, Xiaoyun Ge, Guiyu Zhao, Yongguo Li, Yi Zhang & Li Chen. (2018) Dorzagliatin monotherapy in Chinese patients with type 2 diabetes: a dose-ranging, randomised, double-blind, placebo-controlled, phase 2 study. The Lancet Diabetes & Endocrinology 6:8, pages 627-636.
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Ainhoa NietoVirneliz Fernández-VegaTimothy P. SpicerEmmanuel SturchlerPramisha AdhikariNicole KennedySean MandatPeter ChaseLouis ScampaviaThomas BannisterPeter HodderPatricia H. McDonald. (2018) Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119. ASSAY and Drug Development Technologies 16:5, pages 278-288.
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A.J. Scheen. (2018) Perspectives dans le traitement pharmacologique du diabète de type 2 pour les 10 prochaines années. Médecine des Maladies Métaboliques 12:2, pages 174-181.
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Jin Won Yang, Hyo Seon Kim, Yong‐Won Choi, Young‐Mi Kim & Keon Wook Kang. (2017) Therapeutic application of GPR119 ligands in metabolic disorders . Diabetes, Obesity and Metabolism 20:2, pages 257-269.
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Silvano Piovan, Audrei Pavanello, Giuliana Maria Ledesma Peixoto, Camila Cristina Ianoni Matiusso, Ana Maria Praxedes de Moraes, Isabela Peixoto Martins, Ananda Malta, Kesia Palma-Rigo, Claudinéia Conationi da Silva Franco, Paula Gimenez Milani, Antonio Sérgio Dacome, Silvio Claudio da Costa, Paulo Cezar de Freitas Mathias & Cecília Edna Mareze-Costa. (2018) Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets. International Journal of Endocrinology 2018, pages 1-7.
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Graeme Milligan, Elisa Alvarez-Curto, Brian D. Hudson, Rudi Prihandoko & Andrew B. Tobin. (2017) FFA4/GPR120: Pharmacology and Therapeutic Opportunities. Trends in Pharmacological Sciences 38:9, pages 809-821.
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Jean-Claude Henquin. (2017) Misunderstandings and controversies about the insulin-secreting properties of antidiabetic sulfonylureas. Biochimie.
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Satish K. GargDominique GiordanoTyler GalloViral N. Shah. (2017) New Medications for the Treatment of Diabetes. Diabetes Technology & Therapeutics 19:S1, pages S-128-S-140.
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Kiyomu Fujii, Yi Luo, Rina Fujiwara-Tani, Shingo Kishi, Song He, Shuyun Yang, Takamitsu Sasaki, Hitoshi Ohmori & Hiroki Kuniyasu. (2017) Pro-metastatic intracellular signaling of the elaidic trans fatty acid. International Journal of Oncology 50:1, pages 85-92.
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Cheng Chen, He Li & Ya-Qiu Long. (2016) GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space. Bioorganic & Medicinal Chemistry Letters 26:23, pages 5603-5612.
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