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Drug Evaluation

Glatiramer acetate in the treatment of multiple sclerosis

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Pages 1149-1165 | Published online: 24 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Jane Castelli-Haley, MerriKay A. Oleen-Burkey, Maureen J. Lage & Kenneth Johnson. (2010) Glatiramer acetate and interferon beta-1a for intramuscular administration: a study of outcomes among multiple sclerosis intent-to-treat and persistent-use cohorts. Journal of Medical Economics 13:3, pages 464-471.
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Felix Mor & Alon Monsonego. (2006) Immunization therapy in Alzheimer's disease. Expert Review of Neurotherapeutics 6:5, pages 653-659.
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Jerry S Wolinsky. (2004) Glatiramer acetate for the treatment of multiple sclerosis. Expert Opinion on Pharmacotherapy 5:4, pages 875-891.
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. (2003) Novel peptides for the treatment of multiple sclerosis. Expert Opinion on Therapeutic Patents 13:1, pages 119-123.
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Banu Anlar. (2002) Childhood multiple sclerosis: course and management. Expert Review of Neurotherapeutics 2:3, pages 339-345.
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Rina Aharoni. 2022. Peptide and Peptidomimetic Therapeutics. Peptide and Peptidomimetic Therapeutics 507 520 .
Thomas Prod’homme & Scott S. Zamvil. (2019) The Evolving Mechanisms of Action of Glatiramer Acetate. Cold Spring Harbor Perspectives in Medicine 9:2, pages a029249.
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Iris Grossman, Sarah Kolitz, Arthur Komlosh, Benjamin Zeskind, Vera Weinstein, Daphna Laifenfeld, Adrian Gilbert, Oren Bar-Ilan, Kevin D. Fowler, Tal Hasson, Attila Konya, Kevin Wells-Knecht, Pippa Loupe, Sigal Melamed-Gal, Tatiana Molotsky, Revital Krispin, Galia Papir, Yousif Sahly & Michael R. Hayden. (2017) Compositional differences between Copaxone and Glatopa are reflected in altered immunomodulation ex vivo in a mouse model . Annals of the New York Academy of Sciences 1407:1, pages 75-89.
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Ye-Hyeon Ahn, Sae-Bom Jeon, Chi Young Chang, Eun-Ah Goh, Sang Soo Kim, Ho Jin Kim, Jaewhan Song & Eun Jung Park. (2017) Glatiramer acetate attenuates the activation of CD4+ T cells by modulating STAT1 and −3 signaling in glia. Scientific Reports 7:1.
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Vera Weinstein, Rivka Schwartz, Iris Grossman, Benjamin Zeskind & J. Michael Nicholas. 2015. Non-Biological Complex Drugs. Non-Biological Complex Drugs 107 148 .
Spencer Moore, Anna J. Khalaj, Rhusheet Patel, JaeHee Yoon, Daniel Ichwan, Liat Hayardeny & Seema K. Tiwari‐Woodruff. (2014) Restoration of axon conduction and motor deficits by therapeutic treatment with glatiramer acetate. Journal of Neuroscience Research 92:12, pages 1621-1636.
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Madhan Thamilarasan, Michael Hecker, Robert Hermann Goertsches, Brigitte Katrin Paap, Ina Schröder, Dirk Koczan, Hans-Jürgen Thiesen & Uwe Klaus Zettl. (2013) Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients. Journal of Neuroinflammation 10:1.
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Richard Reynolds & Robert Crichton. 2013. Mechanisms and Metal Involvement in Neurodegenerative Diseases. Mechanisms and Metal Involvement in Neurodegenerative Diseases 163 185 .
Katherine Buzzard, Simon Broadley & Helmut Butzkueven. (2012) What Do Effective Treatments for Multiple Sclerosis Tell Us about the Molecular Mechanisms Involved in Pathogenesis?. International Journal of Molecular Sciences 13:12, pages 12665-12709.
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Yehuda Shoenfeld. (2011) The Future of Autoimmunity. Clinical Reviews in Allergy & Immunology 42:2, pages 113-120.
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Xiaohong Chen, Xiaomeng Ma, Ying Jiang, Rongbiao Pi, Yingying Liu & Lili Ma. (2011) The prospects of minocycline in multiple sclerosis. Journal of Neuroimmunology 235:1-2, pages 1-8.
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Mrinalini Kala, Augusto Miravalle & Timothy Vollmer. (2011) Recent insights into the mechanism of action of glatiramer acetate. Journal of Neuroimmunology 235:1-2, pages 9-17.
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Augusto MiravalleBarry HendinTimothy L. VollmerMrinalini Kala. (2011) Glatiramer Acetate in the Reduction of Relapse Frequency in Multiple Sclerosis. Clinical Medicine Insights: Therapeutics 3, pages CMT.S2057.
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Rakel CarpinteroKarim J. BrandtLyssia GruazNicolas MolnarfiPatrice H. Lalive & Danielle Burger. (2010) Glatiramer acetate triggers PI3Kδ/Akt and MEK/ERK pathways to induce IL-1 receptor antagonist in human monocytes. Proceedings of the National Academy of Sciences 107:41, pages 17692-17697.
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Reza Vosoughi & Mark S. Freedman. (2010) Therapy of MS. Clinical Neurology and Neurosurgery 112:5, pages 365-385.
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Dimitros Karussis, Dvora Teitelbaum, Camille Sicsic & Talma Brenner. (2010) Long-term treatment of multiple sclerosis with glatiramer acetate: Natural history of the subtypes of anti-glatiramer acetate antibodies and their correlation with clinical efficacy. Journal of Neuroimmunology 220:1-2, pages 125-130.
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Chunhua Chen, Xuebin Liu, Bing Wan & Jingwu Z. Zhang. (2009) Regulatory Properties of Copolymer I in Th17 Differentiation by Altering STAT3 Phosphorylation. The Journal of Immunology 183:1, pages 246-253.
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Jane Castelli-Haley, MerriKay A. Oleen-Burkey, Maureen J. Lage & Kenneth P. Johnson. (2009) Glatiramer acetate and interferon beta-1b: a study of outcomes among patients with multiple sclerosis. Advances in Therapy 26:5, pages 552-562.
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Danielle BurgerNicolas MolnarfiMartin S. WeberKarim J. BrandtMahdia Benkhoucha, Lyssia GruazMichel Chofflon, Scott S. ZamvilPatrice H. Lalive. (2009) Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1β in human monocytes and multiple sclerosis. Proceedings of the National Academy of Sciences 106:11, pages 4355-4359.
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L. I. Reikhert, O. A. Kicherova, A. A. Sokolova & Zsh. I. Molchanova. (2009) The basis of membrane stabilized effect of kopaxon in multiple sclerosis. Bulletin of Siberian Medicine 8:1(2), pages 64-68.
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Jane Castelli-Haley, Merry-Kay A. Oleen-Burkey, Maureen J. Lage & Kenneth P. Johnson. (2008) Glatiramer acetate versus interferon beta-1a for subcutaneous administration: Comparison of outcomes among multiple sclerosis patients. Advances in Therapy 25:7, pages 658-673.
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Swati Acharya & C. Garrison Fathman. 2008. Regulatory T Cells and Clinical Application. Regulatory T Cells and Clinical Application 231 252 .
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Ruth Arnon & Rina Aharoni. (2007) Neurogenesis and Neuroprotection in the CNS — Fundamental Elements in the Effect of Glatiramer Acetate on Treatment of Autoimmune Neurological Disorders. Molecular Neurobiology 36:3, pages 245-253.
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Maddalena Ruggieri, Carlo Avolio, Paolo Livrea & Maria Trojano. (2007) Glatiramer Acetate in Multiple Sclerosis: A Review. CNS Drug Reviews 13:2, pages 178-191.
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Michel Chofflon. (2005) Mechanisms of Action for Treatments in??Multiple Sclerosis. BioDrugs 19:5, pages 299-308.
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Michael Sela. (2003) From Proteins and Protein Models to Their Use in Immunology and Immunotherapy. Journal of Biological Chemistry 278:49, pages 48507-48519.
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Man Chen, Reuben Mari Valenzuela & Suhayl Dhib-Jalbut. (2003) Glatiramer acetate-reactive T cells produce brain-derived neurotrophic factor. Journal of the Neurological Sciences 215:1-2, pages 37-44.
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Suhayl Dhib-Jalbut. (2003) Glatiramer acetate (Copaxone®) therapy for multiple sclerosis. Pharmacology & Therapeutics 98:2, pages 245-255.
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