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Drug Evaluations

Cladribine tablets for the treatment of relapsing–remitting multiple sclerosis

, MD, , MD, , PhD, , MD & , MA
Pages 123-136 | Published online: 21 Dec 2012

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Read on this site (4)

Sven G Meuth, Antonios Bayas, Boris Kallmann, Ralf Linker, Peter Rieckmann, Mike P Wattjes, Mathias Mäurer & Christoph Kleinschnitz. (2022) Long-term management of multiple sclerosis patients treated with cladribine tablets beyond year 4. Expert Opinion on Pharmacotherapy 23:13, pages 1503-1510.
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Trygve Holmøy, Øivind Torkildsen & Kjell-Morten Myhr. (2017) An update on cladribine for relapsing-remitting multiple sclerosis. Expert Opinion on Pharmacotherapy 18:15, pages 1627-1635.
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Emanuele D’Amico, Tjalf Ziemssen & Salvatore Cottone. (2017) Induction therapy for the management of early relapsing forms of multiple sclerosis. A critical opinion. Expert Opinion on Pharmacotherapy 18:15, pages 1553-1556.
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Friedemann Paul. (2013) Cladribine in multiple sclerosis: pitfalls in a new treatment landscape. Expert Opinion on Pharmacotherapy 14:1, pages 1-3.
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Articles from other publishers (18)

Robert Hermann, Peter Krajcsi, Markus Fluck, Annick Seithel-Keuth, Afrim Bytyqi, Andrew Galazka & Alain Munafo. (2021) Cladribine as a Potential Object of Nucleoside Transporter-Based Drug Interactions. Clinical Pharmacokinetics 61:2, pages 167-187.
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Robert Hermann, Peter Krajcsi, Markus Fluck, Annick Seithel-Keuth, Afrim Bytyqi, Andrew Galazka & Alain Munafo. (2021) Review of Transporter Substrate, Inhibitor, and Inducer Characteristics of Cladribine. Clinical Pharmacokinetics 60:12, pages 1509-1535.
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Augusto A Miravalle, Joshua Katz, Derrick Robertson, Brooke Hayward, Danielle E Harlow, Lori A Lebson, Jacob A Sloane, Ann D Bass & Edward J Fox. (2021) CLICK-MS and MASTER-2 Phase IV trial design: cladribine tablets in suboptimally controlled relapsing multiple sclerosis. Neurodegenerative Disease Management 11:2, pages 99-111.
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Halina Bartosik-Psujek, Łukasz Kaczyński, Magdalena Górecka, Mirosław Rolka, Rafał Wójcik, Patrycja Zięba & Marcin Kaczor. (2021) Cladribine tablets versus other disease-modifying oral drugs in achieving no evidence of disease activity (NEDA) in multiple sclerosis–A systematic review and network meta-analysis. Multiple Sclerosis and Related Disorders 49, pages 102769.
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Johann Sellner & Paulus S. Rommer. (2020) Immunological consequences of “immune reconstitution therapy” in multiple sclerosis: A systematic review. Autoimmunity Reviews 19:4, pages 102492.
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Robert Hermann, Jeffrey S. Litwin, Lena E. Friberg, Fernando Dangond & Alain Munafo. (2019) Effects of cladribine tablets on heart rate, atrio‐ventricular conduction and cardiac repolarization in patients with relapsing multiple sclerosis. British Journal of Clinical Pharmacology 85:7, pages 1484-1494.
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Giancarlo Comi, Stuart Cook, Gavin Giovannoni, Peter Rieckmann, Per Soelberg Sørensen, Patrick Vermersch, Andrew Galazka, Axel Nolting, Christine Hicking & Fernando Dangond. (2019) Effect of cladribine tablets on lymphocyte reduction and repopulation dynamics in patients with relapsing multiple sclerosis. Multiple Sclerosis and Related Disorders 29, pages 168-174.
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Robert Hermann, Mats O. Karlsson, Ana M. Novakovic, Nadia Terranova, Markus Fluck & Alain Munafo. (2018) The Clinical Pharmacology of Cladribine Tablets for the Treatment of Relapsing Multiple Sclerosis. Clinical Pharmacokinetics 58:3, pages 283-297.
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Chaonan Ye, Kun Han, Jinxiu Lei, Kui Zeng, Su Zeng, Haixing Ju & Lushan Yu. (2018) Inhibition of histone deacetylase 7 reverses concentrative nucleoside transporter 2 repression in colorectal cancer by up-regulating histone acetylation state. British Journal of Pharmacology 175:22, pages 4209-4217.
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A.M. Novakovic, A. Thorsted, E. Schindler, S. Jönsson, A. MunafoM.O. Karlsson. (2018) Pharmacometric Analysis of the Relationship Between Absolute Lymphocyte Count and Expanded Disability Status Scale and Relapse Rate, Efficacy End Points, in Multiple Sclerosis Trials. The Journal of Clinical Pharmacology 58:10, pages 1284-1294.
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Zhifeng Mao, César Álvarez-Gonzalez, Stefania De Trane, Ozlem Yildiz, Christo Albor, Gabriel Doctor, Derek Soon, George Pepper, Benjamin P Turner, Monica Marta, Joela Mathews, Gavin Giovannoni, David Baker & Klaus Schmierer. (2018) Cladribine: Off-label disease modification for people with multiple sclerosis in resource-poor settings?. Multiple Sclerosis Journal - Experimental, Translational and Clinical 4:2, pages 205521731878376.
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R. S. Nicholas, A. Nandoskar, M. Hutchinson & T. Friede. 2018. Progressive Multiple Sclerosis. Progressive Multiple Sclerosis 233 252 .
Mark S Freedman, Thomas P Leist, Giancarlo Comi, Bruce AC Cree, Patricia K Coyle, Hans-Peter Hartung, Patrick Vermersch, Doris Damian & Fernando Dangond. (2017) The efficacy of cladribine tablets in CIS patients retrospectively assigned the diagnosis of MS using modern criteria: Results from the ORACLE-MS study. Multiple Sclerosis Journal - Experimental, Translational and Clinical 3:4, pages 205521731773280.
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A. Nandoskar, J. Raffel, A. S. Scalfari, T. Friede & R. S. Nicholas. (2017) Pharmacological Approaches to the Management of Secondary Progressive Multiple Sclerosis. Drugs 77:8, pages 885-910.
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Karl B. Alstadhaug, Randi Fykse Halstensen & Francis Odeh. (2017) Progressive multifocal leukoencephalopathy in a patient with systemic mastocytosis treated with cladribine. Journal of Clinical Virology 88, pages 17-20.
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Melanie Korsen, Sara Bragado Alonso, Lizzy Peix, Barbara M. Bröker & Alexander Dressel. (2015) Cladribine Exposure Results in a Sustained Modulation of the Cytokine Response in Human Peripheral Blood Mononuclear Cells. PLOS ONE 10:6, pages e0129182.
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Regina Berkovich & Mark A. Agius. (2014) Mechanisms of action of ACTH in the management of relapsing forms of multiple sclerosis. Therapeutic Advances in Neurological Disorders 7:2, pages 83-96.
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Stefan H.P. Kraus, Felix Luessi, Bettina Trinschek, Steffen Lerch, Mario Hubo, Laura Poisa-Beiro, Magdalena Paterka, Helmut Jonuleit, Frauke Zipp & Valérie Jolivel. (2014) Cladribine exerts an immunomodulatory effect on human and murine dendritic cells. International Immunopharmacology 18:2, pages 347-357.
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