2,293
Views
65
CrossRef citations to date
0
Altmetric
Reviews

Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives

, BPharm (Hons) BSc PhD, , DipAppSci (Nuc Med) PhD, , MBBS PhD FRACP & , MBBS PhD FRACP
Pages 1171-1186 | Published online: 11 May 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Gareth J Sanger & Pankaj Jay Pasricha. (2017) Investigational drug therapies for the treatment of gastroparesis. Expert Opinion on Investigational Drugs 26:3, pages 331-342.
Read now
Irene Sarosiek, Mohammad Bashashati & Richard W. McCallum. (2016) Safety of treatment for gastroparesis. Expert Opinion on Drug Safety 15:7, pages 937-945.
Read now

Articles from other publishers (63)

Cheng Li, Yiming Hu, Songnan Li, Xueer Yi, Shuaibo Shao, Wenwen Yu & Enpeng Li. (2023) Biological factors controlling starch digestibility in human digestive system. Food Science and Human Wellness 12:2, pages 351-358.
Crossref
Christopher K. Rayner, Karen L. Jones & Michael Horowitz. 2023. Handbook of Gastrointestinal Motility and Disorders of Gut-Brain Interactions. Handbook of Gastrointestinal Motility and Disorders of Gut-Brain Interactions 331 343 .
Karen L. Jones, Chinmay S. Marathe, Tongzhi Wu, Christopher K. Rayner & Michael Horowitz. 2023. Diabetic Neuropathy. Diabetic Neuropathy 471 490 .
A. E. Babich, N. A. Zubareva & G. G. Ketova. (2022) Priorities in choosing prokinetic for patients with functional dyspepsia: Focus on itopride. Medical alphabet 1:28, pages 28-32.
Crossref
Shin Hwang, Dong-Hwan Jung, Eun-Kyoung Jwa & Yumi Kim. (2022) Preemptive pyloroplasty for iatrogenic vagus nerve injury in intrahepatic cholangiocarcinoma patients undergoing extensive left-sided lymph node dissection: a retrospective observational study. Journal of Yeungnam Medical Science 39:3, pages 235-243.
Crossref
K. O. Kuznetsov, A. J. Mikheeva, A. A. Ishmukhametova, T. A. Tolstykh, A. R. Gallyametdinova, Z. U. Botirova, A. A. Zabirova, A. Sh. Sharipova, A. B. Shaikhlislamova & D. R. Abdrakhmanova. (2022) Diabetic gastroenteropathy: modern methods of diagnosis and treatment. Problems of Endocrinology 68:5, pages 67-78.
Crossref
Sondre Meling, Davide Bertoli, Dag A. Sangnes, Christina Brock, Asbjørn Drewes, Niels Ejskjaer, Georg Dimcevski & Eirik Søfteland. (2022) Diabetic Gastroenteropathy: Soothe the Symptoms or Unravel a Cure?. Current Diabetes Reviews 18:5.
Crossref
Tom D. Y. Reijnders, Hessel Peters-Sengers, Lonneke A. van Vught, Fabrice Uhel, Marc J. M. Bonten, Olaf L. Cremer, Marcus J. Schultz, Martijn M. Stuiver, Tom van der Poll, Friso M. de Beer, Lieuwe D. J. Bos, Gerie J. Glas, Roosmarijn T. M. van Hooijdonk, Janneke Horn, Laura R. A. Schouten, Marleen Straat, Luuk Wieske, Esther Witteveen, Tom D. Y. Reijnders, Alex R. Schuurman, Tjitske S. R. van Engelen, Liza Pereverzeva, Arie J. Hoogendijk, Mischa A. Huson, Maryse A. Wiewel, Peter M. C. Klein Klouwenberg, David S. Y. Ong, Jos F. Frencken, Maria E. Koster-Brouwer, Kirsten van de Groep & Diana M. Verboom. (2022) Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation. Critical Care 26:1.
Crossref
Kristjan Ukegjini & Christian A. Gutschow. (2022) Funktionsstörungen und Lebensqualität nach Ösophagusresektion. Onkologie up2date 04:01, pages 57-75.
Crossref
. 2022. Arzneimitteltherapie in der Palliativmedizin. Arzneimitteltherapie in der Palliativmedizin 109 180 .
Kristjan Ukegjini, Diana Vetter, Rebecca Fehr, Valerian Dirr, Christoph Gubler & Christian A. Gutschow. (2021) Functional syndromes and symptom-orientated aftercare after esophagectomy. Langenbeck's Archives of Surgery 406:7, pages 2249-2261.
Crossref
Fang Dai, Jizheng Guo, Yang Wang, Tian Jiang, Hongbo Chen, Ying Hu, Juan Du, Xianming Xia, Qiu Zhang & Bing Shen. (2021) Enhanced Store-Operated Ca2+ Signal of Small Intestinal Smooth Muscle Cells Accelerates Small Bowel Transit Speed in Type 1 Diabetic Mouse. Frontiers in Physiology 12.
Crossref
Marcio José Concepción Zavaleta, Jhean Gabriel Gonzáles Yovera, Diego Martín Moreno Marreros, Luciana del Pilar Rafael Robles, Kely Roxana Palomino Taype, Karen Nohelly Soto Gálvez, Luis Fernando Arriola Torres, Julia Cristina Coronado Arroyo & Luis Alberto Concepción Urteaga. (2021) Diabetic gastroenteropathy: An underdiagnosed complication. World Journal of Diabetes 12:6, pages 794-809.
Crossref
Kristjan Ukegjini & Christian A. Gutschow. (2021) Funktionsstörungen und Lebensqualität nach Ösophagusresektion. Allgemein- und Viszeralchirurgie up2date 15:01, pages 59-75.
Crossref
Sandy W. Wong & Teresa Fogaren. (2020) Supportive Care for Patients with Systemic Light Chain Amyloidosis. Hematology/Oncology Clinics of North America 34:6, pages 1177-1191.
Crossref
Syed Asim Ali Shah, Muhammad Nadeem, Muzamil Jameel, Rifat Yasmin, Anum Afsar & Faiza Riaz. (2020) Oral Erythromycin Improves the Quality of Endoscopy in Upper Gastrointestinal Bleeding Patients. Cureus.
Crossref
Katherine D. Gray, Timothy M. Ullmann, Adham Elmously, Toni Beninato, Thomas J. FaheyIIIIII, Alfons Pomp, Rasa Zarnegar & Cheguevara Afaneh. (2019) Treatment Utilization and Socioeconomic Disparities in the Surgical Management of Gastroparesis. Journal of Gastrointestinal Surgery 24:8, pages 1795-1801.
Crossref
A. Sullivan, L. Temperley & A. Ruban. (2020) Pathophysiology, Aetiology and Treatment of Gastroparesis. Digestive Diseases and Sciences 65:6, pages 1615-1631.
Crossref
Yumi Suganuma, Tatsunori Shimizu, Takehiro Sato, Tsukasa Morii, Hiroki Fujita, Mariko Harada Sassa & Yuichiro Yamada. (2019) Magnitude of slowing gastric emptying by glucagon‐like peptide‐1 receptor agonists determines the amelioration of postprandial glucose excursion in Japanese patients with type 2 diabetes. Journal of Diabetes Investigation 11:2, pages 389-399.
Crossref
Cheng Li, Wenwen Yu, Peng Wu & Xiao Dong Chen. (2020) Current in vitro digestion systems for understanding food digestion in human upper gastrointestinal tract. Trends in Food Science & Technology 96, pages 114-126.
Crossref
Aleksey Oparin, Anton Kudriavtsev & Anatoliy Oparin. (2020) PECULIARITIES OF STATE OF PROTECTION AND AGGRESSION FACTORS IN PATIENTS WITH DIABETES MELLITUS TYPE II AND GASTROESOPHAGEAL REFLUX DISEASE. EUREKA: Health Sciences 1, pages 27-34.
Crossref
Laura Obici & Ole B. Suhr. (2019) Diagnosis and treatment of gastrointestinal dysfunction in hereditary TTR amyloidosis. Clinical Autonomic Research 29:S1, pages 55-63.
Crossref
Roberta Lupoli, Federica Pisano & Brunella Capaldo. (2019) Postprandial Glucose Control in Type 1 Diabetes: Importance of the Gastric Emptying Rate. Nutrients 11:7, pages 1559.
Crossref
Ibrahim G. Khalifa, Wael L. Tobar, Tarek O. Hegazy, Hany A. Balamoun, Sameh Mikhail, Mohammed Abdalla Salman & Elsayed A. Elsayed. (2019) Food Tolerance After Laparoscopic Sleeve Gastrectomy with Total Antral Resection. Obesity Surgery 29:7, pages 2263-2269.
Crossref
Mengyi Li, Yang Liu, Lan Jin, Wei Wang, Na Zeng, Lixue Wang, Kaixin Zhao, Wei Xu, Zhongtao Zhang & Jigang Yang. (2018) Alterations of Gastric Emptying Features Following Laparoscopic Sleeve Gastrectomy in Chinese Patients with Obesity: a Self-Controlled Observational Study. Obesity Surgery 29:2, pages 617-625.
Crossref
Adam M. Deane, Marianne J. Chapman, Annika Reintam Blaser, Stephen A. McClave & Anton Emmanuel. (2019) Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill. Nutrition in Clinical Practice 34:1, pages 23-36.
Crossref
Jérémie Jacques, Romain Legros, Jacques Monteil, Denis Sautereau & Guillaume Gourcerol. (2019) Outcomes and Future Directions of Per-Oral Endoscopic Pyloromyotomy. Gastrointestinal Endoscopy Clinics of North America 29:1, pages 139-149.
Crossref
Zsuzsanna H. McMahan & Laura K. Hummers. (2018) Gastrointestinal involvement in systemic sclerosis: diagnosis and management. Current Opinion in Rheumatology 30:6, pages 533-540.
Crossref
Bogdan Mircea Mihai, Cătălina Mihai, Cristina Cijevschi-Prelipcean, Elena-Daniela Grigorescu, Mihaela Dranga, Vasile Drug, Ioan Sporea & Cristina Mihaela Lăcătușu. (2018) Bidirectional Relationship between Gastric Emptying and Plasma Glucose Control in Normoglycemic Individuals and Diabetic Patients. Journal of Diabetes Research 2018, pages 1-9.
Crossref
Timothy R. Angeli & Gregory O’Grady. (2018) Challenges in defining, diagnosing, and treating diabetic gastroparesis. Journal of Diabetes and its Complications 32:2, pages 127-128.
Crossref
. 2018. Arzneimitteltherapie in der Palliativmedizin. Arzneimitteltherapie in der Palliativmedizin 83 143 .
Ayah Oglat & Eamonn M. M. Quigley. 2018. Gastrointestinal Complications of Diabetes. Gastrointestinal Complications of Diabetes 91 100 .
Mislav Jelaković & Silvija Čuković-Čavka. 2018. Gastrointestinal Complications of Diabetes. Gastrointestinal Complications of Diabetes 137 142 .
Tzu-Ying Chen, Mario G. Ferruzzi, Qing-Li Wu, James E. Simon, Stephen T. Talcott, Jun Wang, Lap Ho, George Todd, Bruce Cooper, Giulio M. Pasinetti & Elsa M. Janle. (2017) Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Molecular Nutrition & Food Research 61:10, pages 1700111.
Crossref
Gilles Duvoisin & Usha Krishnan. (2017) Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula. Frontiers in Pediatrics 5.
Crossref
A. Prysiazhniuk, T. Dovbynchuk, B. Kopiyak & G. Tolstanova. (2017) The role of central and peripheral D2R receptors in the mechanism of colonic vascular permeability during experimental colitis in rats. Bulletin of Taras Shevchenko National University of Kyiv. Series: Problems of Physiological Functions Regulation 22:1, pages 39-43.
Crossref
Robert E. SteinertChristine Feinle-BissetLori AsarianMichael HorowitzChristoph BeglingerNori Geary. (2017) Ghrelin, CCK, GLP-1, and PYY(3–36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB. Physiological Reviews 97:1, pages 411-463.
Crossref
Roustem N. MiftahofRoustem N. Miftahof. 2017. Biomechanics of the Human Stomach. Biomechanics of the Human Stomach 245 258 .
D. Gallego, O. Ortega, C. Arenas, I. López, E. Mans & P. Clavé. (2016) The effect of levosulpiride on in vitro motor patterns in the human gastric fundus, antrum, and jejunum . Neurogastroenterology & Motility 28:6, pages 879-890.
Crossref
. 2016. Parkinson's Disease. Parkinson's Disease 93 174 .
Hans Gregersen, Donghua Liao, Anne Mohr Drewes, Asbjørn Mohr Drewes & Jingbo Zhao. (2016) Ravages of Diabetes on Gastrointestinal Sensory-Motor Function: Implications for Pathophysiology and Treatment. Current Gastroenterology Reports 18:2.
Crossref
Dag A. Sangnes, Eirik Søfteland, Martin Biermann, Odd Helge Gilja, Hrafnkell Thordarson & Georg Dimcevski. (2016) Gastroparese – årsaker, diagnostikk og behandling. Tidsskrift for Den norske legeforening 136:9, pages 822-826.
Crossref
Jae-Won ChoHae-Won LeeShin Hwang. (2016) Benefit of pyloroplasty to prevent gastric stasis in intrahepatic cholangiocarcinoma patients undergoing extensive left-sided lymph node dissection. Korean Journal of Hepato-Biliary-Pancreatic Surgery 20:1, pages 32.
Crossref
Bei Hu, Heng Ye, Cheng Sun, Yichen Zhang, Zhigang Lao, Fanghong Wu, Zhaohui Liu, Linxi Huang, Changchun Qu, Lewu Xian, Hao Wu, Yingjie Jiao, Junling Liu, Juyu Cai, Weiying Chen, Zhiqiang Nie, Zaiyi Liu & Chunbo Chen. (2015) Metoclopramide or domperidone improves post-pyloric placement of spiral nasojejunal tubes in critically ill patients: a prospective, multicenter, open-label, randomized, controlled clinical trial. Critical Care 19:1.
Crossref
Xiaofeng Zhao & Hiroshi Mashimo. (2015) Current and Emerging Medical Therapies for Gastroparesis. Current Treatment Options in Gastroenterology 13:4, pages 452-472.
Crossref
I. Kostitska. (2015) Efficacy of Itopride in Treatment of Gastroparesis Considering the State of Carbohydrate Metabolism in Patients with Type 2 Diabetes Mellitus. Lviv clinical bulletin 4:12, pages 28-33.
Crossref
Nicole J. Kellow & Melinda T. Coughlan. (2015) Effect of diet-derived advanced glycation end products on inflammation. Nutrition Reviews 73:11, pages 737-759.
Crossref
Stijn Soenen, Chris K. Rayner, Michael Horowitz & Karen L. Jones. (2015) Gastric Emptying in the Elderly. Clinics in Geriatric Medicine 31:3, pages 339-353.
Crossref
Thomas R McCarty & Tarun Rustagi. (2015) Endoscopic treatment of gastroparesis. World Journal of Gastroenterology 21:22, pages 6842-6849.
Crossref
Saleem Islam. (2015) Gastroparesis in children. Current Opinion in Pediatrics 27:3, pages 377-382.
Crossref
Pankaj Jay Pasricha. (2015) Future Directions in the Treatment of Gastroparesis. Gastroenterology Clinics of North America 44:1, pages 185-189.
Crossref
Gianrico Farrugia. (2015) Histologic Changes in Diabetic Gastroparesis. Gastroenterology Clinics of North America 44:1, pages 31-38.
Crossref
Liza K. Phillips, Adam M. Deane, Karen L. Jones, Chris K. Rayner & Michael Horowitz. (2014) Gastric emptying and glycaemia in health and diabetes mellitus. Nature Reviews Endocrinology 11:2, pages 112-128.
Crossref
. 2015. Arzneimitteltherapie in der Palliativmedizin. Arzneimitteltherapie in der Palliativmedizin 65 126 .
Liza K. Phillips, Chris K. Rayner, Karen L. Jones & Michael Horowitz. (2014) Measurement of gastric emptying in diabetes. Journal of Diabetes and its Complications 28:6, pages 894-903.
Crossref
Kfir Ben-David. (2014) Comment on: Gastric bypass surgery as a primary treatment of recalcitrant gastroparesis. Surgery for Obesity and Related Diseases 10:5, pages 799-800.
Crossref
Arja Gerritsen, Thijs de Rooij, Marcel J. van der Poel, Marcel G. W. Dijkgraaf, Willem A. Bemelman, Olivier R. C. Busch, Marc G. H. Besselink & Elisabeth M. H. Mathus-Vliegen. (2014) Endoscopic Versus Bedside Electromagnetic-Guided Placement of Nasoenteral Feeding Tubes in Surgical Patients. Journal of Gastrointestinal Surgery 18:9, pages 1664-1672.
Crossref
O. P. Dhakal, M. Dhakal & D. Bhandari. (2014) Phytobezoar leading to gastric outlet obstruction in a patient with diabetes. Case Reports 2014:jun13 1, pages bcr2013200661-bcr2013200661.
Crossref
M D Poscente, G Wang, D Filip, P Ninova, O Yadid-Pecht, C N Andrews & M P Mintchev. (2014) Real-time gastric motility monitoring using transcutaneous intraluminal impedance measurements (TIIM). Physiological Measurement 35:2, pages 217-229.
Crossref
Fernando Azpiroz, Christine Feinle-Bisset, David Grundy & Jan Tack. (2013) Gastric sensitivity and reflexes: basic mechanisms underlying clinical problems. Journal of Gastroenterology 49:2, pages 206-218.
Crossref
Eirik Søfteland, Christina Brock, Jens B. Frøkjær, Magnus Simrén, Asbjørn M. Drewes & Georg Dimcevski. (2014) Rectal Sensitivity in Diabetes Patients with Symptoms of Gastroparesis. Journal of Diabetes Research 2014, pages 1-8.
Crossref
Gan van Samkar, Wietse J. Eshuis, Marike Lemmers, Dirk J. Gouma, Roel J. Bennink, Markus W. Hollmann, Marcel G. W. Dijkgraaf & Olivier R. C. Busch. (2013) Value of Scintigraphy for Assessing Delayed Gastric Emptying After Pancreatic Surgery. World Journal of Surgery 37:12, pages 2911-2917.
Crossref
J. A. C. M. Burger, B. Liberov, F. Yurd & R. J. L. F. Loffeld. (2013) A Case of Extreme Gastroparesis due to an Occult Small Cell Cancer of the Lung. Case Reports in Gastrointestinal Medicine 2013, pages 1-3.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.