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An update on pharmacological treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors

, MD PhD, , MD, , MD PhD, , MD & , MD PhD
Pages 1333-1344 | Published online: 16 May 2013

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Zachary Melchiode, Tivoli Nguyen, Omar Dawood, Graham A. Bobo & Wayne J.G. Hellstrom. (2023) Phosphodiesterase 5 inhibitors: preclinical and early-phase breakthroughs for impotence treatments. Expert Opinion on Investigational Drugs 32:7, pages 635-642.
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Bassant Elbardisy, Sally Galal, Doaa A. Abdelmonsif & Nabila Boraie. (2019) Intranasal Tadalafil nanoemulsions: formulation, characterization and pharmacodynamic evaluation. Pharmaceutical Development and Technology 24:9, pages 1083-1094.
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Jonathan L. Zurawin, Carrie A. Stewart, James E. Anaissie, Faysal A. Yafi & Wayne J. G. Hellstrom. (2016) Avanafil for the treatment of erectile dysfunction. Expert Review of Clinical Pharmacology 9:9, pages 1163-1170.
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Eric G Katz, Ronny BW Tan, Daniel Rittenberg & Wayne J Hellstrom. (2014) Avanafil for erectile dysfunction in elderly and younger adults: differential pharmacology and clinical utility. Therapeutics and Clinical Risk Management 10, pages 701-711.
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Min Chul Cho & Jae-Seung Paick. (2014) Udenafil for the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management 10, pages 341-354.
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Ahmed K. ElHady, Dalia S. El-Gamil, Mohammad Abdel-Halim & Ashraf H. Abadi. (2023) Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives. Pharmaceuticals 16:9, pages 1266.
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Lei Xu, Lilei Sun, Peng Su, Teng Ma, Yingcong Yu, Haibin Liu & Xianfeng Huang. (2023) Identification of Potential Inhibitors of PDE5 based on Structure-based Virtual Screening Approaches. Current Computer-Aided Drug Design 19:3, pages 234-242.
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Kawthar K. Abla, Amina T. Mneimneh, Ahmed N. Allam & Mohammed M. Mehanna. (2023) Application of Box-Behnken Design in the Preparation, Optimization, and In-Vivo Pharmacokinetic Evaluation of Oral Tadalafil-Loaded Niosomal Film. Pharmaceutics 15:1, pages 173.
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Iman Shamohammadi, Seyedmohammad Kazemeyni, Mohammadali Sadighi, Tara Hasanzadeh & Alireza Dizavi. (2022) Efficacy of tadalafil on improvement of men with erectile dysfunction caused by COVID-19: A randomized placebo-controlled trial. Asian Journal of Urology.
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J. O. Aiyekomogbon, D. U. Itanyi, T. Atim & J. B. Igashi. (2021) Evaluation of erectile dysfunction in the ageing men using colour Doppler sonography. African Journal of Urology 27:1.
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Bernhard Kutscher. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry 1 69 .
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Osama A.A. Ahmed & Shaimaa M. Badr-Eldin. (2019) Development of an optimized avanafil-loaded invasomal transdermal film: Ex vivo skin permeation and in vivo evaluation. International Journal of Pharmaceutics 570, pages 118657.
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S. I. Gamidov, T. V. Shatylko, N. G. Gasanov & N. A. Naumov. (2018) The use of tadalafil on demand in specific categories of patients. Andrology and Genital Surgery 19:4, pages 15-20.
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M. Abu El‐Hamd. (2018) Efficacy and safety of daily use of tadalafil in treatment of patients with premature ejaculation: A randomised placebo‐controlled clinical trial. Andrologia 50:5.
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Vanessa D. G. Silva, Angélica S. Reis, Mikaela P. Pinz, Caren A. R. da Fonseca, Luis Fernando B. Duarte, Juliano A. Roehrs, Diego Alves, Cristiane Luchese & Ethel A. Wilhelm. (2017) Further analysis of acute antinociceptive and anti-inflammatory actions of 4-phenylselenyl-7-chloroquinoline in mice. Fundamental & Clinical Pharmacology 31:5, pages 513-525.
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Sabrina Noel, Nadtha Panin, Mathilde Beka, Barbara Dhooghe, François Huaux & Teresinha Leal. (2017) Vardenafil reduces macrophage pro-inflammatory overresponses in cystic fibrosis through PDE5- and CFTR-dependent mechanisms. Clinical Science 131:11, pages 1107-1121.
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Richard Berges, Dieter Schremmer & Roger Limberg. (2017) Avanafil zur Therapie der erektilen Dysfunktion in der PraxisAvanafil for the treatment of erectile dysfunction in practice. Non-interventional study AVANTI. MMW - Fortschritte der Medizin 159:S5, pages 16-21.
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Crossref
Tom MunyerJennifer Elliott. 2017. PharmacotherapyFirst: A Multimedia Learning Resource. PharmacotherapyFirst: A Multimedia Learning Resource.
D. Francomano, A. Ilacqua, A. Cortese, G. Tartaglia, A. Lenzi, M. Inghilleri & A. Aversa. (2016) Effects of daily tadalafil on lower urinary tract symptoms in young men with multiple sclerosis and erectile dysfunction: a pilot study. Journal of Endocrinological Investigation 40:3, pages 275-279.
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Kwang-Youl KimMoonsuk NamHyun-Jung KwonKwang-Hyeon KimSeung-Hyun KangSang-Il KimCheol-Woo KimSang-Heon Cho. (2017) Validated UPLC-MS/MS method for the determination of tadalafil in human plasma and its application to a pharmacokinetic study. Translational and Clinical Pharmacology 25:1, pages 21.
Crossref
Muhammad Atif, Muhammad Rehan Sarwar & Shane Scahill. (2016) The relationship between epilepsy and sexual dysfunction: a review of the literature. SpringerPlus 5:1.
Crossref
Giovanni Corona, Mario Maggi & Emmanuele A. Jannini. (2016) Avanafil: The Second-Generation Treatment of Erectile Dysfunction. European Medical Journal, pages 61-69.
Crossref
Veronika K. Jaeger & Ulrich A. Walker. (2016) Erectile Dysfunction in Systemic Sclerosis. Current Rheumatology Reports 18:8.
Crossref
Rachel S. Rubin & Irwin Goldstein. (2016) Medical Management of Sexual Dysfunction in the Aging Male. Topics in Geriatric Rehabilitation 32:3, pages 167-173.
Crossref
Taymour Mostafa. (2016) Useful Implications of Low-dose Long-term Use of PDE-5 Inhibitors. Sexual Medicine Reviews 4:3, pages 270-284.
Crossref
Min Chul Cho & Jae-Seung Paick. (2016) A review of the efficacy and safety of mirodenafil in the management of erectile dysfunction. Therapeutic Advances in Urology 8:2, pages 100-117.
Crossref
Konstantinos Hatzimouratidis, Andrea Salonia, Ganesan Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Andrew McCullough, Luiz Otavio Torres & Mohit Khera. (2016) Pharmacotherapy for Erectile Dysfunction: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015). The Journal of Sexual Medicine 13:4, pages 465-488.
Crossref
A. Aversa, S. Fittipaldi, V. M. Bimonte, F. Wannenes, V. Papa, D. Francomano, E. A. Greco, A. Lenzi & S. Migliaccio. (2015) Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model. Journal of Endocrinological Investigation 39:2, pages 199-205.
Crossref
C. Corinaldesi, L. Di Luigi, A. Lenzi & C. Crescioli. (2015) Phosphodiesterase type 5 inhibitors: back and forward from cardiac indications. Journal of Endocrinological Investigation 39:2, pages 143-151.
Crossref
R. Pofi, D. Gianfrilli, R. Badagliacca, C. Di Dato, M. A. Venneri & E. Giannetta. (2015) Everything you ever wanted to know about phosphodiesterase 5 inhibitors and the heart (but never dared ask): How do they work?. Journal of Endocrinological Investigation 39:2, pages 131-142.
Crossref
Genichiro Tsuji & Herman O. Sintim. (2016) Cyclic dinucleotide detection with riboswitch–G-quadruplex hybrid. Molecular BioSystems 12:3, pages 773-777.
Crossref
Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 783 800 .
Zhi-wei Gao, Yun-ting Zhu, Ming-ming Yu, Bin Zan, Jia Liu, Yi-fan Zhang, Xiao-yan Chen, Xue-ning Li & Da-fang Zhong. (2015) Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model. Acta Pharmacologica Sinica 36:12, pages 1528-1536.
Crossref
C. Bruni, J. Raja, C.P. Denton & M. Matucci-Cerinic. (2015) The clinical relevance of sexual dysfunction in systemic sclerosis. Autoimmunity Reviews 14:12, pages 1111-1115.
Crossref
A Burri & H Porst. (2015) Results from an online survey investigating ED patients' insights and treatment expectations. International Journal of Impotence Research 27:5, pages 191-196.
Crossref
Giovanni Ribaudo, Mario Angelo Pagano, Valeria Pavan, Marco Redaelli, Maira Zorzan, Raffaele Pezzani, Carla Mucignat-Caretta, Tiziano Vendrame, Sergio Bova & Giuseppe Zagotto. (2015) Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors. Fitoterapia 105, pages 132-138.
Crossref
Giuseppe Defeudis, Daniele Gianfrilli, Chiara Di Emidio, Riccardo Pofi, Dario Tuccinardi, Andrea Palermo, Andrea Lenzi & Paolo Pozzilli. (2015) Erectile dysfunction and its management in patients with diabetes mellitus. Reviews in Endocrine and Metabolic Disorders 16:3, pages 213-231.
Crossref
Valeria Pavan, Carla Mucignat-Caretta, Marco Redaelli, Giovanni Ribaudo & Giuseppe Zagotto. (2015) The Old Made New: Natural Compounds against Erectile Dysfunction. Archiv der Pharmazie 348:9, pages 607-614.
Crossref
J. Chen, Z. Hu, L. Zhuan, H. Xiao, Y. Zhang & J. Yang. (2015) Intracellular calcium concentration of corpus cavernosum smooth muscle cells is decreased by the overexpression of PnNOS gene in adipose tissue-derived stem cells. Andrologia 47:6, pages 711-719.
Crossref
Wayne J.G. Hellstrom, Jed Kaminetsky, Laurence H. Belkoff, Irwin Goldstein, James P. Tursi, Jonathan Uy, Craig A. Peterson, Charles H. Bowden & Wesley W. Day. (2015) Efficacy of Avanafil 15 Minutes after Dosing in Men with Erectile Dysfunction: A Randomized, Double-Blind, Placebo Controlled Study. Journal of Urology 194:2, pages 485-492.
Crossref
Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Seyedmehrad Tavallai, Timothy Webb, Peter Samuel, Adam Conley, Brittany Binion, Harold F. Young, Andrew Poklepovic, Sarah Spiegel & Paul Dent. (2015) PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types. Journal of Cellular Physiology 230:5, pages 1115-1127.
Crossref
Roland Seifert, Erich H. Schneider & Heike Bähre. (2015) From canonical to non-canonical cyclic nucleotides as second messengers: Pharmacological implications. Pharmacology & Therapeutics 148, pages 154-184.
Crossref
Ajay K. Singh, Anas Raed & Jameela Kari. 2015. Chronic Renal Disease. Chronic Renal Disease 310 319 .
Juan Ignacio Martínez-Salamanca, Javier González, Patricia Ramírez & Javier Angulo. 2015. PanVascular Medicine. PanVascular Medicine 3887 3915 .
Toshiaki Sakamoto, Yuichi Koga, Masataka Hikota, Kenji Matsuki, Michino Murakami, Kohei Kikkawa, Kotomi Fujishige, Jun Kotera, Kenji Omori, Hiroshi Morimoto & Koichiro Yamada. (2014) The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor. Bioorganic & Medicinal Chemistry Letters 24:23, pages 5460-5465.
Crossref
Ghazwan Butrous. (2014) The role of phosphodiesterase inhibitors in the management of pulmonary vascular diseases. Global Cardiology Science and Practice 2014:3, pages 42.
Crossref
Nina Schlueter, Anita de Sterke, Diana M. Willmes, Joachim Spranger, Jens Jordan & Andreas L. Birkenfeld. (2014) Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome. Pharmacology & Therapeutics 144:1, pages 12-27.
Crossref
Ibrahim A. Abdel-Hamid, Mohamed A. Abo-Aly & Moustafa A. Elsaied. (2014) Nonresponse to PDE5 inhibitors in erectile dysfunction. Part 2. Human Andrology 4:3, pages 45-53.
Crossref
Ibrahim A. Abdel-Hamid, Mohamed A. Abo-Aly & Moustafa A. Elsaied. (2014) Nonresponse to phosphodiesterase 5 inhibitors in erectile dysfunction. Part 1. Human Andrology 4:2, pages 23-29.
Crossref
Michael D. Berry & Philip D. Berry. (2014) Integrative Approaches to the Treatment of Erectile Dysfunction. Current Sexual Health Reports 6:2, pages 114-123.
Crossref
Pietro Gareri, Alberto Castagna, Davide Francomano, Gregorio Cerminara & Pasquale De Fazio. (2014) Erectile Dysfunction in the Elderly: An Old Widespread Issue with Novel Treatment Perspectives. International Journal of Endocrinology 2014, pages 1-15.
Crossref
Juan Ignacio Martínez-Salamanca, Javier González, Patricia Ramírez & Javier Angulo. 2013. PanVascular Medicine. PanVascular Medicine 1 39 .

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