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Original Research

Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism

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Pages 1723-1736 | Published online: 23 Jul 2013

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Read on this site (5)

Emmanuel Ejiofor, Sunday Oyedemi, Chima Egedigwe-Ekeleme, Chiemeziem Obike, Chinedu Aguwamba, Paul Nweje-Anyalowu, Maureen Ejiofor & Oluchi Okwuonu. (2023) Essential oil components with antidiabetic and anti-obesity properties: a review of mechanisms of action and toxicity. Journal of Essential Oil Research 35:4, pages 335-371.
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Christian Rafael Quijia & Marlus Chorilli. (2020) Characteristics, Biological Properties and Analytical Methods of Piperine: A Review. Critical Reviews in Analytical Chemistry 50:1, pages 62-77.
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Kevin Ita. (2017) Insights into the percutaneous penetration of antidiabetic agents. Journal of Drug Targeting 25:2, pages 102-111.
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BrahmaNaidu Parim, Nemani Harishankar, Meriga Balaji, Sailaja Pothana & Ramgopal Rao Sajjalaguddam. (2015) Effects of Piper nigrum extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague–Dawley rats. Pharmaceutical Biology 53:9, pages 1318-1328.
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Articles from other publishers (30)

Yujie WangShan XuLidan TangJinhong GongDan SuHao Yang. (2023) Piperine as a Potential Nutraceutical Agent for Managing Diabetes and Its Complications: A Literature Review. Journal of Medicinal Food 26:10, pages 693-704.
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Tan Khanh Nguyen, Linh Thuy Thi Tran, Duc Ho Viet, Pham Hong Thai, Tran Phuong Ha, Pham Viet Ty, Le Phu Duc, Dat Ton That Huu & Le Canh Viet Cuong. (2023) Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot: In vitro and in silico studies. Heliyon 9:8, pages e19148.
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Sohail Hussain, Mohammad Ashafaq, Saeed Alshahrani, Rahimullah Siddiqui, Mohammad Intakhab Alam, Manal Mohammed, Yosif Almoshari & Saad S Alqahtani. (2023) Cardioprotective Effects of Nano-Piperine Against Cypermethrin Toxicity Through Oxidative Stress, Histopathological and Immunohistochemical Studies in Male Wistar Rats. Natural Product Communications 18:3, pages 1934578X2311540.
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Quentin Haguet, Florian Le Joubioux, Vivien Chavanelle, Hugo Groult, Nathan Schoonjans, Cédric Langhi, Arnaud Michaux, Yolanda F. Otero, Nathalie Boisseau, Sébastien L. Peltier, Pascal Sirvent & Thierry Maugard. (2023) Inhibitory Potential of α-Amylase, α-Glucosidase, and Pancreatic Lipase by a Formulation of Five Plant Extracts: TOTUM-63. International Journal of Molecular Sciences 24:4, pages 3652.
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Qichao Hu, Lan Jiang, Qi Yan, Jinhao Zeng, Xiao Ma & Yanling Zhao. (2023) A natural products solution to diabetic nephropathy therapy. Pharmacology & Therapeutics 241, pages 108314.
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Guang‐Hui Gou, Liu Liu, Sardorbek Abdubakiev, Xue‐Lei Xin, Haji Akber Aisa & Jun Li. (2022) Anti‐Diabetic Effects and Molecular Mechanisms of Amide Alkaloids from Piper longum Based on Network Pharmacology Integrated with Cellular Assays . Chemistry & Biodiversity 20:1.
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Protha Biswas, Mimosa Ghorai, Tulika Mishra, Abilash Valsala Gopalakrishnan, Debleena Roy, Abhijit Bhagwan Mane, Avinash Mundhra, Neela Das, Vikas Moreshwar Mohture, Manoj Tukaram Patil, Md. Habibur Rahman, Niraj Kumar Jha, Gaber El‐Saber Batiha, Suchismita Chatterjee Saha, Mahipal S Shekhawat, Radha, Manoj Kumar, Devendra Kumar Pandey & Abhijit Dey. (2022) Piper longum L.: A comprehensive review on traditional uses, phytochemistry, pharmacology, and health‐promoting activities . Phytotherapy Research 36:12, pages 4425-4476.
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Apichaya Niyomchan, Wasapon Chatgat, Bodin Chatawatee, Thaweeporn Keereekoch, Patcharawalai Jaisamut, Sasitorn Chusri & Nongluk Kunworarath. (2022) Supplementation with the Traditional Thai Polyherbal Medicine NawaTab Ameliorates Lipid Profiles in High-Fat Diet-Induced Hyperlipidemic Rats. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-11.
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Juliet A. Prieto-Rodríguez, Kevin P. Lévuok-Mena, Juan C. Cardozo-Muñoz, Jorge E. Parra-Amin, Fabián Lopez-Vallejo, Luis E. Cuca-Suárez & Oscar J. Patiño-Ladino. (2022) In Vitro and In Silico Study of the α-Glucosidase and Lipase Inhibitory Activities of Chemical Constituents from Piper cumanense (Piperaceae) and Synthetic Analogs. Plants 11:17, pages 2188.
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Chitra S. M.Anbu N.Uma K. S.. (2022) Antihypertensive activity of Polyherbal Siddha Formulation Veppampoo Mathirai – A Review. Research Journal of Pharmacy and Technology, pages 1365-1370.
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Ameeduzzafar Zafar, Nabil K. Alruwaili, Syed Sarim Imam, Omar Awad Alsaidan, Khalid Saad Alharbi, Mohd Yasir, Mohammed Elmowafy, Elshaer F. Mohammed & Ziad H. Al-Oanzi. (2021) Formulation of Chitosan-Coated Piperine NLCs: Optimization, In Vitro Characterization, and In Vivo Preclinical Assessment. AAPS PharmSciTech 22:7.
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Kunle Okaiyeto, Raphael I. Adeoye & Oluwafemi O. Oguntibeju. (2021) Some common West African spices with antidiabetic potential: A review. Journal of King Saud University - Science 33:6, pages 101548.
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Xingming Hou, Congxiao Zhang, Limei Wang & KeWei Wang. (2021) Natural Piperine Improves Lipid Metabolic Profile of High-Fat Diet-Fed Mice by Upregulating SR-B1 and ABCG8 Transporters. Journal of Natural Products 84:2, pages 373-381.
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Iahtisham‐Ul Haq, Muhammad Imran, Muhammad Nadeem, Tabussam Tufail, Tanweer A. Gondal & Mohammad S. Mubarak. (2020) Piperine: A review of its biological effects. Phytotherapy Research 35:2, pages 680-700.
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Vijaya Padma Viswanadha, Velumani Dhivya, Narasimha Murthy Beeraka, Chih-Yang Huang, Liliya V. Gavryushova, Nina N. Minyaeva, Vladimir N. Chubarev, Liudmila M. Mikhaleva, Vadim V. Tarasov & Gjumrakch Aliev. (2020) The protective effect of piperine against isoproterenol-induced inflammation in experimental models of myocardial toxicity. European Journal of Pharmacology 885, pages 173524.
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Jansy Isabella Rani Antony Rathinasamy, Veera Venkata Sathibabu Uddandrao, Nivedha Raveendran & Vadivukkarasi Sasikumar. (2020) Antiobesity Effect of Biochanin-A: Effect on Trace Element Metabolism in High Fat Diet-Induced Obesity in Rats. Cardiovascular & Hematological Agents in Medicinal Chemistry 18:1, pages 21-30.
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Vaishali Yadav, Anuja Krishnan & Divya Vohora. (2020) A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research. Journal of Ethnopharmacology 247, pages 112255.
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Maria Bastaki, Michel Aubanel, Mark Bauter, Thierry Cachet, Jan Demyttenaere, Maodo Malick Diop, Christie L. Harman, Shim-mo Hayashi, Gerhard Krammer, Xiaodong Li, Craig Llewellyn, Odete Mendes, Kevin J. Renskers, Jürgen Schnabel, Benjamin P.C. Smith & Sean V. Taylor. (2018) Absence of adverse effects following administration of piperine in the diet of Sprague-Dawley rats for 90 days. Food and Chemical Toxicology 120, pages 213-221.
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Aminu Mohammed & Md. Shahidul Islam. (2018) Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus. Frontiers in Pharmacology 9.
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Paravazhi Radhakrishanan, Varanasi Subose & Guru C Bhuyan. (2018) Evaluation of Vyoshadi Guggulu and Haritaki Churna in the Management of Dyslipidemia: A Multicenter Prospective Clinical Study . Journal of Research in Ayurvedic Sciences 2:1, pages 12-19.
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Makoto Takahashi, Makiko Ohshiro, Suguru Ohno, Kaoru Yonamine, Mika Arakaki & Koji Wada. (2017) Effects of solar‐ and oven‐drying on physicochemical and antioxidant characteristics of hihatsumodoki ( Piper retrofractum Vahl) fruit . Journal of Food Processing and Preservation 42:2, pages e13469.
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Sunil T. Pai. 2018. Integrative Medicine. Integrative Medicine 120 132.e8 .
Ramachandran Vinayagam, Jianbo Xiao & Baojun Xu. (2017) An insight into anti-diabetic properties of dietary phytochemicals. Phytochemistry Reviews 16:3, pages 535-553.
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Velumani Dhivya, Lohanathan Bharathi Priya, Hilda T Chirayil, Swamiappan Sathiskumar, Chih-Yang Huang & Viswanadha Vijaya Padma. (2017) Piperine modulates isoproterenol induced myocardial ischemia through antioxidant and anti-dyslipidemic effect in male Wistar rats. Biomedicine & Pharmacotherapy 87, pages 705-713.
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Ginpreet Kaur, Mihir Invally & Meena Chintamaneni. (2016) Influence of piperine and quercetin on antidiabetic potential of curcumin. Journal of Complementary and Integrative Medicine 13:3, pages 247-255.
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Vikas Kumar, Ajit Kumar Thakur, Suruchi Verma, Vaishali Yadav & Shyam Sunder Chatterjee. (2015) Potential of some traditionally used edible plants for prevention and cure of diabesity associated comorbidities. TANG [HUMANITAS MEDICINE] 5:2, pages 8.1-8.22.
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Koichi Takao, Takaki Miyashiro & Yoshiaki Sugita. (2015) Synthesis and Biological Evaluation of Piperic Acid Amides as Free Radical Scavengers and α-Glucosidase Inhibitors. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 63:5, pages 326-333.
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Heon-Myung Lee, Hong-Kun Rim, Jong-Hwan Seo, Yoon-Bum Kook, Sung-Kew Kim, Chang-Hyun Oh, Kyung Ho Yoo, Jong-Sik Jin & Hyo-Jin An. (2014) HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice. BMC Complementary and Alternative Medicine 14:1.
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Palanisamy Arulselvan, Hasfar Amynurliyana Abdul Ghofar, Govindarajan Karthivashan, Mohd Firdaus Abdul Halim, Muhammad Syafiq Abdul Ghafar & Sharida Fakurazi. (2014) Antidiabetic therapeutics from natural source: A systematic review. Biomedicine & Preventive Nutrition 4:4, pages 607-617.
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Parim BrahmaNaidu, Harishankar Nemani, Balaji Meriga, Santosh Kumar Mehar, Sailaja Potana & Sajjalaguddam Ramgopalrao. (2014) Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats. Chemico-Biological Interactions 221, pages 42-51.
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