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Original Research

Efficacy and safety of canagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled with diet and exercise: a 24-week, randomized, double-blind, placebo-controlled, Phase III study

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Mitsuyoshi Takahara, Toshihiko Shiraiwa, Taka-aki Matsuoka, Kaoru Yamamoto, Yoshifumi Maeno, Yuka Shiraiwa, Yoko Yoshida, Naoto Katakami, Hiroaki Iijima, Hideyuki Katsumata, Kenji Arakawa, Toshio Hashimoto & Iichiro Shimomura. (2020) Investigation of the Effect of Canagliflozin on the Disposition Index, a Marker of Pancreatic Beta Cell Function, in Patients with Type 2 Diabetes. Diabetes, Metabolic Syndrome and Obesity 13, pages 4457-4468.
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Nobuya Inagaki, Shin-ichi Harashima & Hiroaki Iijima. (2018) Canagliflozin for the treatment of type 2 diabetes: a comparison between Japanese and non-Japanese patients. Expert Opinion on Pharmacotherapy 19:8, pages 895-908.
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Takahiro Takase, Akinobu Nakamura, Chiho Yamamoto, Tatsuya Atsumi & Hideaki Miyoshi. (2018) Improvement in the proinsulin/C-peptide ratio during treatment with ipragliflozin in Japanese patients with type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 19:7, pages 631-632.
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Maki Goda, Tomoko Yamakura, Kazuyo Sasaki, Takumi Tajima & Makoto Ueno. (2018) Safety and efficacy of canagliflozin in elderly patients with type 2 diabetes mellitus: a 1-year post-marketing surveillance in Japan. Current Medical Research and Opinion 34:2, pages 319-327.
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Joseph A Messana, Stanley S Schwartz & Raymond R Townsend. (2017) An evidence-based practice-oriented review focusing on canagliflozin in the management of type 2 diabetes. Vascular Health and Risk Management 13, pages 43-54.
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Konstantinos P. Imprialos, Konstantinos Stavropoulos, Michael Doumas, Asterios Karagiannis & Vasilios G. Athyros. (2017) The effect of SGLT2 inhibitors on cardiovascular events and renal function. Expert Review of Clinical Pharmacology 10:11, pages 1251-1261.
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Yaowen Wang, Xueting Hu, Xueying Liu & Zengqi Wang. (2016) An overview of the effect of sodium glucose cotransporter 2 inhibitor monotherapy on glycemic and other clinical laboratory parameters in type 2 diabetes patients. Therapeutics and Clinical Risk Management 12, pages 1113-1131.
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Hiroyuki Ito, Masahiro Shinozaki, Shinya Nishio & Mariko Abe. (2016) SGLT2 inhibitors in the pipeline for the treatment of diabetes mellitus in Japan. Expert Opinion on Pharmacotherapy 17:15, pages 2073-2084.
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Stanley S. Schwartz & Intekhab Ahmed. (2016) Sodium–glucose cotransporter 2 inhibitors: an evidence-based practice approach to their use in the natural history of type 2 diabetes. Current Medical Research and Opinion 32:5, pages 907-919.
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Tamer Yacoub. (2016) Dapagliflozin combination therapy in type 2 diabetes mellitus. Postgraduate Medicine 128:1, pages 124-136.
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Nobuya Inagaki, Maki Goda, Shoko Yokota, Nobuko Maruyama & Hiroaki Iijima. (2015) Safety and efficacy of canagliflozin in Japanese patients with type 2 diabetes mellitus: post hoc subgroup analyses according to body mass index in a 52-week open-label study. Expert Opinion on Pharmacotherapy 16:11, pages 1577-1591.
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Xi Rong, Xinran Li, Qiling Gou, Kai Liu & Xiaoping Chen. (2020) Risk of orthostatic hypotension associated with sodium-glucose cotransporter-2 inhibitor treatment: A meta-analysis of randomized controlled trials. Diabetes and Vascular Disease Research 17:5, pages 147916412095362.
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