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Drug Evaluation

Apremilast: a PDE4 inhibitor for the treatment of psoriatic arthritis

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Marco Barbieri, F. Loconsole, A. Migliore & S. Capri. (2020) A cost-effectiveness and budget impact analysis of apremilast in patients with psoriasis in the Italian setting. Journal of Medical Economics 23:4, pages 362-370.
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Hunar Abdulrahim, Hisham Sharlala & Adewale O. Adebajo. (2019) An evaluation of tofacitinib for the treatment of psoriatic arthritis. Expert Opinion on Pharmacotherapy 20:16, pages 1953-1960.
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Katelyn R. Glines, Katherine M. Stiff, Megan Freeze, Abigail Cline, Lindsay C. Strowd & Steven R. Feldman. (2019) An update on the topical and oral therapy options for treating pediatric atopic dermatitis. Expert Opinion on Pharmacotherapy 20:5, pages 621-629.
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Luca Bianchi, Ester Del Duca, Marco Romanelli, Rosita Saraceno, Sergio Chimenti & Andrea Chiricozzi. (2016) Pharmacodynamic assessment of apremilast for the treatment of moderate-to-severe plaque psoriasis. Expert Opinion on Drug Metabolism & Toxicology 12:9, pages 1121-1128.
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Andrea Chiricozzi, Dante Caposiena, Virginia Garofalo, Maria Vittoria Cannizzaro, Sergio Chimenti & Rosita Saraceno. (2016) A new therapeutic for the treatment of moderate-to-severe plaque psoriasis: apremilast. Expert Review of Clinical Immunology 12:3, pages 237-249.
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Articles from other publishers (29)

Dhritiman Roy, Shivaramakrishnan Balasubramanian, Praveen Thaggikuppe Krishnamurthy, Piyong Sola & Emdormi Rymbai. (2023) Phosphodiesterase-4 Inhibition in Parkinson’s Disease: Molecular Insights and Therapeutic Potential. Cellular and Molecular Neurobiology 43:6, pages 2713-2741.
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Neelam PatelSunita ChaudharyAnkit Chaudhary. (2023) Formulation Development and Evaluation of Apremilast Nanoemulsion. Research Journal of Pharmacy and Technology, pages 2859-2866.
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Annika Mohr, Manuela Besser, Sonja Broichhausen, Maximiliane Winter, Alexander D. Bungert, Benjamin Strücker, Mazen A. Juratli, Andreas Pascher & Felix Becker. (2023) The Influence of Apremilast-Induced Macrophage Polarization on Intestinal Wound Healing. Journal of Clinical Medicine 12:10, pages 3359.
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Neelam Patel, Sunita Chaudhary & Ankit Chaudhary. (2023) Formulation Development and Evaluation of Apremilast Nanoemulgel for Enhancing Permeability. Current Drug Therapy 18:2, pages 132-150.
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Kentaro Nakamura, Yukiyasu Arakawa, Koji Masuda, Takahiro Arita, Norito Katoh & Jun Asai. (2022) Exacerbation of psoriatic arthritis due to topical imiquimod therapy. International Journal of Dermatology 62:3.
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Yinsi Lin, Jianhui Su, Mingqiang Wang, Yanzhen Li, Zhongxiang Zhao & Zhanghua Sun. (2022) Hypericum sampsonii attenuates inflammation in mice with ulcerative colitis via regulation of PDE4/PKA/CREB signaling pathway. Journal of Ethnopharmacology 296, pages 115447.
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Ingrid Allart-Simon, Aurélie Moniot, Nicolo Bisi, Miguel Ponce-Vargas, Sandra Audonnet, Marie Laronze-Cochard, Janos Sapi, Eric Hénon, Frédéric Velard & Stéphane Gérard. (2021) Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors. RSC Medicinal Chemistry 12:4, pages 584-592.
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Paulo Sarango-Granda, Marcelle Silva-Abreu, Ana Calpena, Lyda Halbaut, María-José Fábrega, María Rodríguez-Lagunas, Natalia Díaz-Garrido, Josefa Badia & Lupe Espinoza. (2020) Apremilast Microemulsion as Topical Therapy for Local Inflammation: Design, Characterization and Efficacy Evaluation. Pharmaceuticals 13:12, pages 484.
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Maurizio Cutolo, Stefano Soldano, Paola Montagna, Giulia Martinelli, Samuele Tardito, Claudio Corallo, Nicola Giordano, Pierpaolo Tavilla, Emanuele Cozzani, Aurora Parodi, Alberto Sulli, Carmen Pizzorni, Massimo Patane, Vanessa Smith & Sabrina Paolino. (2020) Apremilast interferes with the TGFβ1-induced transition of human skin fibroblasts into profibrotic myofibroblasts: in vitro study . Rheumatology 59:12, pages 3927-3938.
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Cervantes-Durán Claudia, Velázquez-Hernández María-Elena, Valentín-Escalera Josué, Bartolomé-Camacho María-Carmen, Rodríguez-Orozco Alain-Raimundo & García-Pérez Martha-Estrella. (2020) Small molecules under development for psoriasis: on the road to the individualized therapies. Archives of Dermatological Research 312:9, pages 611-627.
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Christopher Ma, Robert Battat, Parambir S. Dulai, Claire E. Parker, William J. Sandborn, Brian G. Feagan & Vipul Jairath. (2019) Innovations in Oral Therapies for Inflammatory Bowel Disease. Drugs 79:12, pages 1321-1335.
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Heng Li, Chen Fan, Chunlan Feng, Yanwei Wu, Huimin Lu, Peilan He, Xiaoqian Yang, Fenghua Zhu, Qing Qi, Yuanzhuo Gao, Jianping Zuo & Wei Tang. (2019) Inhibition of phosphodiesterase‐4 attenuates murine ulcerative colitis through interference with mucosal immunity. British Journal of Pharmacology.
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Chang Huang, Qiu‐Ping Zhong, Lv Tang, Hai‐Tao Wang, Jiang‐Ping Xu & Zhong‐Zhen Zhou. (2018) Discovery of 2‐(3,4‐dialkoxyphenyl)‐2‐(substituted pyridazin‐3‐yl)acetonitriles as phosphodiesterase 4 inhibitors with anti‐neuroinflammation potential based on three‐dimensional quantitative structure–activity relationship study. Chemical Biology & Drug Design 93:4, pages 484-502.
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Heng Li, Jianping Zuo & Wei Tang. (2018) Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases. Frontiers in Pharmacology 9.
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E. Yu. Loginova & T. V. Korotaeva. (2018) Clinical experience with apremilast for psoriatic arthritis. Modern Rheumatology Journal 12:3, pages 103-108.
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Xuemei Liu, Rui Chen, Guanghuai Zeng, Ying Gao, Xiuping Liu, Donglei Zhang, Pei Hu, Hongyun Wang & Ji Jiang. (2018) Determination of a PDE4 inhibitor Hemay005 in human plasma and urine by UPLC–MS/MS and its application to a PK study. Bioanalysis 10:11, pages 863-875.
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Chantal Barberot, Aurélie Moniot, Ingrid Allart-Simon, Laurette Malleret, Tatiana Yegorova, Marie Laronze-Cochard, Abderrazzaq Bentaher, Maurice Médebielle, Jean-Philippe Bouillon, Eric Hénon, Janos Sapi, Frédéric Velard & Stéphane Gérard. (2018) Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents. European Journal of Medicinal Chemistry 146, pages 139-146.
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Gaopeng Song, Xiang Zhu, Junhua Li, Dekun Hu, Dongsheng Zhao, Yixian Liao, Juntong Lin, Lian-Hui Zhang & Zi-Ning Cui. (2017) Rational design of conformationally constrained oxazolidinone-fused 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorganic & Medicinal Chemistry 25:20, pages 5709-5717.
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Daniel Wendling & Clément Prati. (2017) Targeted synthetic disease-modifying antirheumatic drugs in spondyloarthritis. Immunotherapy 9:3, pages 221-223.
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Zhong-Zhen Zhou, Yu-Fang Cheng, Zheng-Qiang Zou, Bing-Chen Ge, Hui Yu, Cang Huang, Hai-Tao Wang, Xue-Mei Yang & Jiang-Ping Xu. (2016) Discovery of N -Alkyl Catecholamides as Selective Phosphodiesterase-4 Inhibitors with Anti-neuroinflammation Potential Exhibiting Antidepressant-like Effects at Non-emetic Doses . ACS Chemical Neuroscience 8:1, pages 135-146.
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Shashikant B. Landge, Sunil B. Dahale, Sanjay A. Jadhav, Pavankumar V. Solanki, Saroj R. Bembalkar & Vijayavitthal T. Mathad. (2017) Development and Validation of Stability Indicating Rapid RP-LC Method for Determination of Process and Degradation Related Impurities of Apremilast, an Anti-Inflammatory Drug. American Journal of Analytical Chemistry 08:06, pages 380-394.
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Zhong-Zhen Zhou, Bing-Chen Ge, Qiu-Ping Zhong, Chang Huang, Yu-Fang Cheng, Xue-Mei Yang, Hai-Tao Wang & Jiang-Ping Xu. (2016) Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. European Journal of Medicinal Chemistry 124, pages 372-379.
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Rachael C. Saporito & David J. Cohen. (2016) Apremilast Use for Moderate-to-Severe Atopic Dermatitis in Pediatric Patients. Case Reports in Dermatology 8:2, pages 179-184.
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Peter H. Schafer, Francesca Truzzi, Anastasia Parton, Lei Wu, Jolanta Kosek, Ling-Hua Zhang, Gerald Horan, Annalisa Saltari, Marika Quadri, Roberta Lotti, Alessandra Marconi & Carlo Pincelli. (2016) Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex. Cellular Signalling 28:7, pages 753-763.
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Kaihe Xiong, Xingling Ma, Na Cao, Lei Liu, Lili Sun, Qiaogen Zou & Ping Wei. (2016) Identification, characterization and HPLC quantification of impurities in apremilast. Analytical Methods 8:8, pages 1889-1897.
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Amit Om, Dane Hill & Steven R. Feldman. 2016. Therapy for Severe Psoriasis. Therapy for Severe Psoriasis 75 82 .
Garry G. Graham & Kevin D. Pile. 2016. Compendium of Inflammatory Diseases. Compendium of Inflammatory Diseases 1079 1084 .
Fabiola Atzeni, Ignazio F Masala, Laura Boccassini & Piercarlo Sarzi-Puttini. (2015) Early psoriatic arthritis: should we treat it in the same way as we treat rheumatoid arthritis?. International Journal of Clinical Rheumatology 10:6, pages 399-408.
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Silvia Martina Ferrari, Ilaria Ruffilli, Michele Colaci, Alessandro Antonelli, Clodoveo Ferri & Poupak Fallahi. (2015) CXCL10 in psoriasis. Advances in Medical Sciences 60:2, pages 349-354.
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