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HIV integrase inhibitors: a new era in the treatment of HIV

, MD PhD, , MD, , MD PhD & , MD PhD

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Fengting Yu, Qun Li, Linghang Wang, Hongxin Zhao, Hao Wu, Siyuan Yang, Yunxia Tang, Jiang Xiao & Fujie Zhang. (2022) Drug Resistance to HIV-1 Integrase Inhibitors Among Treatment-Naive Patients in Beijing, China. Pharmacogenomics and Personalized Medicine 15, pages 195-203.
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Elisabeth Olliges, Bernhard Bührlen, Franz Fischer, Christoph Boesecke, Tim Kümmerle, Jochen Schneider, Simon Weidlich, Christiane Cordes, Hans Heiken, Hans-Jürgen Stellbrink, Ivanka Krznaric, Stefan Scholten, Björn Erik-Ole Jensen, Eva Wolf, Joram Ronel, Christoph D. Spinner & on behalf of the DUALIS STUDY GROUP. (2022) Health-related quality-of-life in people living with HIV after switching to dual therapy with ritonavir-boosted darunavir + dolutegravir: a DUALIS sub-study. AIDS Care 34:6, pages 698-707.
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Arturo Ciccullo, Gianmaria Baldin, Alberto Borghetti & Simona Di Giambenedetto. (2020) Dolutegravir plus lamivudine for the treatment of HIV-1 infection. Expert Review of Anti-infective Therapy 18:4, pages 279-292.
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Vincenzo Spagnuolo, Caterina Uberti-Foppa & Antonella Castagna. (2019) Pharmacotherapeutic management of HIV in transplant patients. Expert Opinion on Pharmacotherapy 20:10, pages 1235-1250.
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Crossref
A Inciarte, L Leal, E González, A León, C Lucero, J Mallolas, B Torres, M Laguno, J Rojas, M Martínez-Rebollar, A González-Cordón, A Cruceta, J A Arnaiz, J M Gatell, F García, Eva González, Lorna Leal, Agathe León, Berta Torres, Alexy Inciarte, Constanza Lucero, José L Blanco, Esteban Martínez, Josep Mallolas, Josep M Miró, Monserrat Laguno, Jhon Rojas, María Martínez-Rebollar, Ana González-Cordón, Christian Manzardo, Cristina de la Calle, Gerard Espinosa, Joan Albert Arnaiz, Jose M Gatell, Felipe García, Juan Manuel Pericas, David Nicolás, Marta Bodro, Ana del Río & Celia Cardozo. (2017) Tenofovir disoproxil fumarate/emtricitabine plus ritonavir-boosted lopinavir or cobicistat-boosted elvitegravir as a single-tablet regimen for HIV post-exposure prophylaxis. Journal of Antimicrobial Chemotherapy 72:10, pages 2857-2861.
Crossref
Biswajit G Roy. (2017) Potential of small-molecule fungal metabolites in antiviral chemotherapy. Antiviral Chemistry and Chemotherapy 25:2, pages 20-52.
Crossref
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Crossref
Anna Fettiplace, Chris Stainsby, Alan Winston, Naomi Givens, Sarah Puccini, Vani Vannappagari, Ricky Hsu, Jennifer Fusco, Romina Quercia, Michael Aboud & Lloyd Curtis. (2017) Psychiatric Symptoms in Patients Receiving Dolutegravir. JAIDS Journal of Acquired Immune Deficiency Syndromes 74:4, pages 423-431.
Crossref
Eugenia Negredo, David Back, José-Ramón Blanco, Julià Blanco, Kristine M. Erlandson, Maite Garolera, Giovanni Guaraldi, Patrick Mallon, José Moltó, José Antonio Serra & Bonaventura Clotet. (2017) Aging in HIV-Infected Subjects: A New Scenario and a New View. BioMed Research International 2017, pages 1-9.
Crossref
Ying-Shan Han, Thibault Mesplède & Mark A. Wainberg. 2017. Antimicrobial Drug Resistance. Antimicrobial Drug Resistance 559 564 .
Adam Trickey, Margaret T. May, Janne Vehreschild, Niels Obel, Michael John Gill, Heidi Crane, Christoph Boesecke, Hasina Samji, Sophie Grabar, Charles Cazanave, Matthias Cavassini, Leah Shepherd, Antonella d’Arminio Monforte, Colette Smit, Michael Saag, Fiona Lampe, Vicky Hernando, Marta Montero, Robert Zangerle, Amy C. Justice, Timothy Sterling, Jose Miro, Suzanne Ingle & Jonathan A. C. Sterne. (2016) Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy. PLOS ONE 11:8, pages e0160460.
Crossref
Ricardo Moure, Pere Domingo, José M. Gallego-Escuredo, Joan Villarroya, Maria del Mar Gutierrez, Maria G. Mateo, Joan C. Domingo, Marta Giralt & Francesc Villarroya. (2016) Impact of elvitegravir on human adipocytes: Alterations in differentiation, gene expression and release of adipokines and cytokines. Antiviral Research 132, pages 59-65.
Crossref
Winston Yan Wang, Jack Ho Wong, Denis Tsz Ming Ip, David Chi Cheong Wan, Randy Chifai Cheung & Tzi Bun Ng. (2016) Bovine Lactoferrampin, Human Lactoferricin, and Lactoferrin 1-11 Inhibit Nuclear Translocation of HIV Integrase. Applied Biochemistry and Biotechnology 179:7, pages 1202-1212.
Crossref
Emilie Elliot, Alieu Amara, Akil Jackson, Graeme Moyle, Laura Else, Saye Khoo, David Back, Andrew Owen & Marta Boffito. (2016) Dolutegravir and elvitegravir plasma concentrations following cessation of drug intake. Journal of Antimicrobial Chemotherapy 71:4, pages 1031-1036.
Crossref
Narasimha M. Midde, Mohammad A. Rahman, Chetan Rathi, Junhao Li, Bernd Meibohm, Weihua Li & Santosh Kumar. (2016) Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method. PLOS ONE 11:2, pages e0149225.
Crossref
Takashi Masaoka, Haiyan Zhao, Danielle R. Hirsch, Michael P. D’Erasmo, Christine Meck, Brittany Varnado, Ankit Gupta, Marvin J. Meyers, Joel Baines, John A. Beutler, Ryan P. Murelli, Liang Tang & Stuart F. J. Le Grice. (2016) Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors. Biochemistry 55:5, pages 809-819.
Crossref
Yonghou Jiang, Shijie Cao, Danielle K. Bright, Alaina M. Bever, Anna K. Blakney, Ian T. Suydam & Kim A. Woodrow. (2015) Nanoparticle-Based ARV Drug Combinations for Synergistic Inhibition of Cell-Free and Cell–Cell HIV Transmission. Molecular Pharmaceutics 12:12, pages 4363-4374.
Crossref
Thibault Mesplède & Mark Wainberg. (2015) Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence. Viruses 7:7, pages 3703-3718.
Crossref

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