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Drug Evaluations

Peramivir: an intravenous neuraminidase inhibitor

, PharmD MSc, , BS & , MD MS

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Read on this site (4)

Jin Seo Lee, Mi Suk Lee, Yoonseon Park, Jacob Lee, Eun-Jeong Joo & Joong Sik Eom. (2020) Clinical Effectiveness of Intravenous Peramivir versus Oseltamivir for the Treatment of Influenza in Hospitalized Patients. Infection and Drug Resistance 13, pages 1479-1484.
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Matteo Bassetti, Nadia Castaldo & Alessia Carnelutti. (2019) Neuraminidase inhibitors as a strategy for influenza treatment: pros, cons and future perspectives. Expert Opinion on Pharmacotherapy 20:14, pages 1711-1718.
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Mazhar Hussain, Henry D Galvin, Tatt Y Haw, Ashley N Nutsford & Matloob Husain. (2017) Drug resistance in influenza A virus: the epidemiology and management. Infection and Drug Resistance 10, pages 121-134.
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Ashley Wester & Avinash K Shetty. (2016) Peramivir injection in the treatment of acute influenza: a review of the literature. Infection and Drug Resistance 9, pages 201-214.
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Andrey Bogoyavlenskiy, Irina Zaitseva, Pavel Alexyuk, Madina Alexyuk, Elmira Omirtaeva, Adolat Manakbayeva, Yergali Moldakhanov, Elmira Anarkulova, Anar Imangazy, Vladimir Berezin, Dmitry Korulkin, Aso Hameed Hasan, Mahmoud Noamaan & Joazaizulfazli Jamalis. (2023) Naturally Occurring Isorhamnetin Glycosides as Potential Agents Against Influenza Viruses: Antiviral and Molecular Docking Studies. ACS Omega.
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Dagmara Bialy, Samuel Richardson, Klaudia Chrzastek, Sushant Bhat, Noemi Polo, Graham Freimanis, Munir Iqbal & Holly Shelton. (2023) Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo. Virology, pages 109954.
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Sihan Wang, Tian-hao Zhang, Menglong Hu, Kejun Tang, Li Sheng, Mengying Hong, Dongdong Chen, Liubo Chen, Yuan Shi, Jun Feng, Jing Qian, Lifeng Sun, Kefeng Ding, Ren Sun & Yushen Du. (2023) Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations in vivo . mSystems 8:5.
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Vanessa Escuret & Olivier Terrier. (2023) Co-infection of the respiratory epithelium, scene of complex functional interactions between viral, bacterial, and human neuraminidases. Frontiers in Microbiology 14.
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Jinna Wang, Hongdou Chen, Lie Zhuo, Ying Guo, Xu Wang, Lina Chen & Fangfang Zheng. (2023) Effectiveness of intravenous peramivir for the treatment of influenza A/H3N2 and influenza B/Victoria in hospitalized children. Journal of Infection and Chemotherapy.
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Guo-Qiang Zhang, Hao Chang, Zhiyuan Gao, Yang-ping Deng, Sheng Zeng, Luqing Shang, Dan Ding & Qian Liu. (2023) Neuraminidase-Activatable NIR Fluorescent Probe for Influenza Virus Ratiometric Imaging in Living Cells and Colorimetric Detection on Cotton Swabs. ACS Materials Letters 5:3, pages 722-729.
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Jeremy C. Jones, Hui-Ling Yen, Peter Adams, Kimberly Armstrong & Elena A. Govorkova. (2023) Influenza antivirals and their role in pandemic preparedness. Antiviral Research 210, pages 105499.
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Pobitra Borah, Sangeeta Hazarika, Mohamed A. Morsy, Manoj Goyal, Ashna Chettri, Katharigatta N. Venugopala, Viresh Mohanlall, Pratap Chandra Acharya, Pran Kishore Deb & Raghu Prasad Mailavaram. 2023. Medicinal Chemistry of Chemotherapeutic Agents. Medicinal Chemistry of Chemotherapeutic Agents 319 359 .
Walid F. Elkhatib, Shereen S. Abdelkareem, Wafaa S. Khalaf, Mona I. Shahin, Dounia Elfadil, Alaa Alhazmi, Ahmed I. El-Batal & Gharieb S. El-Sayyad. (2022) Narrative review on century of respiratory pandemics from Spanish flu to COVID-19 and impact of nanotechnology on COVID-19 diagnosis and immune system boosting. Virology Journal 19:1.
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Edita Sarukhanyan, Tipack Ayothyapattanam Shanmugam & Thomas Dandekar. (2022) In Silico Studies Reveal Peramivir and Zanamivir as an Optimal Drug Treatment Even If H7N9 Avian Type Influenza Virus Acquires Further Resistance. Molecules 27:18, pages 5920.
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Han Ju, Lingxin Hou, Fabao Zhao, Ying Zhang, Ruifang Jia, Laura Guizzo, Anna Bonomini, Jiwei Zhang, Zhen Gao, Ruipeng Liang, Chiara Bertagnin, Xiujie Kong, Xiuli Ma, Dongwei Kang, Arianna Loregian, Bing Huang, Xinyong Liu & Peng Zhan. (2022) Iterative Optimization and Structure–Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity . Journal of Medicinal Chemistry 65:17, pages 11550-11573.
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Hao Chang, Yu Mei, Yidan Li & Luqing Shang. (2022) An AIE and ESIPT based neuraminidase fluorescent probe for influenza virus detection and imaging. Talanta 247, pages 123583.
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Chanakan Winyakul, Weerachai Phutdhawong, Poomipat Tamdee, Jitnapa Sirirak, Thongchai Taechowisan & Waya S. Phutdhawong. (2022) 2,5-Diketopiperazine Derivatives as Potential Anti-Influenza (H5N2) Agents: Synthesis, Biological Evaluation, and Molecular Docking Study. Molecules 27:13, pages 4200.
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Magdalena Świerczyńska, Dagmara M. Mirowska-Guzel & Edyta Pindelska. (2022) Antiviral Drugs in Influenza. International Journal of Environmental Research and Public Health 19:5, pages 3018.
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Sphamandla E. Mtambo, Samuel C. Ugbaja & Hezekiel M. Kumalo. (2022) Impact of the R292K Mutation on Influenza A (H7N9) Virus Resistance towards Peramivir: A Molecular Dynamics Perspective. Molecules 27:5, pages 1645.
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Helga Rübsamen‐Schaeff & Helmut BuschmannOliver Planz. 2022. New Drug Development for Known and Emerging Viruses. New Drug Development for Known and Emerging Viruses 59 96 .
Hongfei Jiang, Xiaofei Qin, Qi Wang, Qi Xu, Jie Wang, Yudong Wu, Wujun Chen, Chao Wang, Tingting Zhang, Dongming Xing & Renshuai Zhang. (2021) Application of carbohydrates in approved small molecule drugs: A review. European Journal of Medicinal Chemistry 223, pages 113633.
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Indrapal Singh Aidhen & Naveenkumar Thoti. (2021) Natural Products & Bioactivity Inspired Synthetic Pursuits Interfacing with Carbohydrates: Ongoing Journey with C ‐Glycosides . The Chemical Record 21:11, pages 3131-3177.
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Rueshandra Roosenhoff, Martin Schutten, Vaughan Reed, Barry Clinch, Anne van der Linden, Ron A.M. Fouchier & Pieter L.A. Fraaij. (2021) Secondary substitutions in the hemagglutinin and neuraminidase genes associated with neuraminidase inhibitor resistance are rare in the Influenza Resistance Information Study (IRIS). Antiviral Research 189, pages 105060.
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Dharma Rao Tompa, Aruldoss Immanuel, Srimari Srikanth & Saraboji Kadhirvel. (2021) Trends and strategies to combat viral infections: A review on FDA approved antiviral drugs. International Journal of Biological Macromolecules 172, pages 524-541.
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Sphamadla E. Mtambo, Daniel G. Amoako, Anou M. Somboro, Clement Agoni, Monsurat M. Lawal, Nelisiwe S. Gumede, Rene B. Khan & Hezekiel M. Kumalo. (2021) Influenza Viruses: Harnessing the Crucial Role of the M2 Ion-Channel and Neuraminidase toward Inhibitor Design. Molecules 26:4, pages 880.
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Hong-Dou Chen, Xu Wang, Shu-Le Yu, Yue-Hui Ding, Meng-Lei Wang & Jin-Na Wang. (2021) Clinical Effectiveness of Intravenous Peramivir Compared With Oseltamivir in Patients With Severe Influenza A With Primary Viral Pneumonia: A Randomized Controlled Study. Open Forum Infectious Diseases 8:1.
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Yashwant Kumar Ratre, Naveen Kumar Vishvakarma, L. V. K. S. Bhaskar & Henu Kumar Verma. (2020) Dynamic Propagation and Impact of Pandemic Influenza A (2009 H1N1) in Children: A Detailed Review. Current Microbiology 77:12, pages 3809-3820.
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Jui-Yi Chen, Shih-Kai Wei, Chih-Cheng Lai, Teng-Song Weng & Hsin-Hua Wang. (2020) A Meta-Analysis Comparing the Efficacy and Safety of Peramivir with Other Neuraminidase Inhibitors for Influenza Treatment. Medicina 56:2, pages 63.
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Samir Chtita, Adnane Aouidate, Assia Belhassan, Abdellah Ousaa, Abdelali Idrissi Taourati, Bouhya Elidrissi, Mounir Ghamali, Mohammed Bouachrine & Tahar Lakhlifi. (2020) QSAR study of N -substituted oseltamivir derivatives as potent avian influenza virus H5N1 inhibitors using quantum chemical descriptors and statistical methods . New Journal of Chemistry 44:5, pages 1747-1760.
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Yaping Hu, Binfeng Chen, Zaiqiang Lei, Hongqian Zhao, Hongxi Zhu, Peng Quan & Yongshou Tian. (2019) Synthesis and Biological Evaluation of NH2-Sulfonyl Oseltamivir Analogues as Influenza Neuraminidase Inhibitors. Molecules 24:11, pages 2176.
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Nelson Lee & Michael G Ison. (2019) Inhibiting Viral Polymerase and Neuraminidase in Treating Influenza. The Journal of Infectious Diseases 219:7, pages 1013-1015.
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Lesley J. Scott. (2018) Peramivir: A Review in Uncomplicated Influenza. Drugs 78:13, pages 1363-1370.
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Ya-Jun Yang, Xi-Wang Liu, Xiao-Jun Kong, Zhe Qin, Zeng-Hua Jiao, Shi-Hong Li & Jian-Yong Li. (2018) Preparation and Evaluation of Oseltamivir Molecularly Imprinted Polymer Silica Gel as Liquid Chromatography Stationary Phase. Molecules 23:8, pages 1881.
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Monika Fijak, Adrian Pilatz, Mark P Hedger, Nour Nicolas, Sudhanshu Bhushan, Vera Michel, Kenneth S K Tung, Hans-Christian Schuppe & Andreas Meinhardt. (2018) Infectious, inflammatory and ‘autoimmune’ male factor infertility: how do rodent models inform clinical practice?. Human Reproduction Update 24:4, pages 416-441.
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Ying Li, Zhiyuan Wang, Xin Li, Wei Gong, Xiangyang Xie, Yang Yang, Wu Zhong & Aiping Zheng. (2016) In Vitro Evaluation of Absorption Characteristics of Peramivir for Oral Delivery. European Journal of Drug Metabolism and Pharmacokinetics 42:5, pages 757-765.
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