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Drug Evaluation

Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease

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Pages 1827-1835 | Published online: 25 Feb 2005

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Saadoun Bin-Hasan & Felix Ratjen. (2015) Tiotropium bromide for cystic fibrosis. Expert Opinion on Orphan Drugs 3:8, pages 957-966.
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Dramane I Lainé. (2010) Long-acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease. Expert Review of Clinical Pharmacology 3:1, pages 43-53.
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David A Lipson. (2006) Tiotropium bromide. International Journal of Chronic Obstructive Pulmonary Disease 1:2, pages 107-114.
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Yaopeng Zhao, Jixia Wang, Tao Hou, Yancheng Yu, Han Zhou, Yang Han, Junxiang Cheng, Yanfang Liu, Chaoran Wang, Long Chen & Xinmiao Liang. (2023) Design and synthesis of 2-(2,2-diarylethyl)-cyclamine derivatives as M3 receptor antagonists and functional evaluation on COPD. Bioorganic Chemistry 131, pages 106308.
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O M Kurbacheva, S A Polner & D S Smirnov. (2014) BRONCHOLITIC THERAPY IN BRONCHIAL ASTHMA: PROPER CHOICE. Russian Journal of Allergy 11:5, pages 28-35.
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Heung-Woo Park. (2012) The role of tiotropium in the management of asthma. Asia Pacific Allergy 2:2, pages 109.
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Antonio Mete, Keith Bowers, Eric Chevalier, David K. Donald, Helen Edwards, Katherine J. Escott, Rhonan Ford, Ken Grime, Ian Millichip, Barry Teobald & Vince Russell. (2011) The discovery of AZD9164, a novel muscarinic M3 antagonist. Bioorganic & Medicinal Chemistry Letters 21:24, pages 7440-7446.
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Jakob Busch-PetersenDramane I Lainé. (2011) Inhaled long-acting muscarinic antagonists in chronic obstructive pulmonary disease. Future Medicinal Chemistry 3:13, pages 1623-1634.
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Michael J. Stocks, Lilian Alcaraz, Andrew Bailey, Keith Bowers, David Donald, Helen Edwards, Fraser Hunt, Nicholas Kindon, Garry Pairaudeau, Jill Theaker & Daniel J. Warner. (2010) The discovery of new spirocyclic muscarinic M3 antagonists. Bioorganic & Medicinal Chemistry Letters 20:24, pages 7458-7461.
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Dramane I. Lainé, Zehong Wan, Hongxing Yan, Chongjie Zhu, Haibo Xie, Wei Fu, Jakob Busch-Petersen, Christopher Neipp, Roderick Davis, Katherine L. Widdowson, Frank E. Blaney, James Foley, Alicia M. Bacon, Edward F. Webb, Mark A. Luttmann, Miriam Burman, Henry M. Sarau, Michael Salmon, Michael R. Palovich & Kristen Belmonte. (2009) Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists. Journal of Medicinal Chemistry 52:16, pages 5241-5252.
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Dramane I. Lainé, Brent McCleland, Sonia Thomas, Christopher Neipp, Brian Underwood, Jeremy Dufour, Katherine L. Widdowson, Michael R. Palovich, Frank E. Blaney, James J. Foley, Edward F. Webb, Mark A. Luttmann, Miriam Burman, Kristen Belmonte & Michael Salmon. (2009) Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists. Journal of Medicinal Chemistry 52:8, pages 2493-2505.
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Kazuomi Kario, Hideyuki Uno & Kazuyuki Shimada. (2008) Sleep-Predominant Lowering of Ambulatory Blood Pressure by Bedtime Inhalation of a Novel Muscarinic M3 Receptor Antagonist: A New “Bronchoantihypertensive” Strategy Targeting the Lung in Hypertension with Chronic Obstructive Pulmonary Disease. Hypertension Research 31:4, pages 817-821.
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J. Ancochea Bermúdez, R.M. Girón Moreno & M.A. Ruiz Cobos. (2005) Tiotropio: análisis crítico. Archivos de Bronconeumología 41, pages 39-47.
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