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Drug Evaluation

The role of decitabine in the treatment of myelodysplastic syndromes

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Pages 65-73 | Published online: 13 Dec 2006

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Fang Zhao, Jie Wang, Liu Yao, Yu-ting Qin, Niluopaer Tuerxun, Huan Wang, Ming Jiang & Jian-ping Hao. (2021) Synergistic inhibitory effect of Smo inhibitor jervine and its combination with decitabine can target Hedgehog signaling pathway to inhibit myelodysplastic syndrome cell line. Hematology 26:1, pages 518-528.
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Yuan-yuan Ma, Min Zhao, Yi Liu, De-feng Zhao, Li-xin Wang, Xiao-ping Chen & Li Li. (2019) Use of decitabine for patients with refractory or relapsed acute myeloid leukemia: a systematic review and meta-analysis. Hematology 24:1, pages 507-515.
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Xinwei Shi, Ping Chen, Hao Liu, Fuyuan Qiao, Haiyi Liu, Xun Gong, Yuqi Li, Hui Du, Wanlu Liu, Guiju Tang, Jing Cao & Yuanyuan Wu. (2015) Decitabine Improves the Clinical Manifestations of Rats With l-NAME-Induced Pre-eclampsia: A Potential Approach to Studying Pre-eclampsia. Hypertension in Pregnancy 34:4, pages 464-473.
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Jeffrey Bryan, Hagop Kantarjian, Guillermo Garcia-Manero & Elias Jabbour. (2011) Pharmacokinetic evaluation of decitabine for the treatment of leukemia. Expert Opinion on Drug Metabolism & Toxicology 7:5, pages 661-672.
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Alvin Gomez & Magnus Ingelman-Sundberg. (2009) Pharmacoepigenetic aspects of gene polymorphism on drug therapies: effects of DNA methylation on drug response. Expert Review of Clinical Pharmacology 2:1, pages 55-65.
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Tapan M Kadia & Guillermo Garcia-Manero. (2008) Role of epigenetic therapy in myelodysplastic syndrome. Expert Review of Hematology 1:2, pages 161-174.
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Haodong Ding, Yuwei Li, Maoxin Fang, Jiaojiao Chen, Lipin Liu, Zhigang Lu, Jia Hou & Min Luo. (2023) Epigenetic activation of the TUSC3 gene as a potential therapy for XMEN disease. Journal of Allergy and Clinical Immunology 151:6, pages 1622-1633.e10.
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Sung-Eun Lee, Feng Wang, Maison Grefe, Abel Trujillo-Ocampo, Wilfredo Ruiz-Vasquez, Koichi Takahashi, Hussein A. Abbas, Pamella Borges, Dinler Amaral Antunes, Gheath Al-Atrash, Naval Daver, Jeffrey J. Molldrem, Andrew Futreal, Guillermo Garcia-Manero & Jin S. Im. (2023) Immunologic Predictors for Clinical Responses during Immune Checkpoint Blockade in Patients with Myelodysplastic Syndromes. Clinical Cancer Research 29:10, pages 1938-1951.
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Côme Thieulent, Erika S. Hue, Gabrielle Sutton, Christine Fortier, Patrick Dallemagne, Stephan Zientara, Hélène Munier-Lehmann, Aymeric Hans, Romain Paillot, Pierre-Olivier Vidalain & Stéphane Pronost. (2020) Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: Efficacy of decitabine and valganciclovir alone or in combination. Antiviral Research 183, pages 104931.
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Hemant Gujar, Daniel Weisenberger & Gangning Liang. (2019) The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome. Genes 10:2, pages 172.
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Chao Niu, Min Li, Shan Zhu, Yongchong Chen, Lei Zhou, Dongsheng Xu, Wei Li, Jiuwei Cui, Yongjun Liu & Jingtao Chen. (2018) Decitabine Inhibits Gamma Delta T Cell Cytotoxicity by Promoting KIR2DL2/3 Expression. Frontiers in Immunology 9.
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Tatjana Maria Swerev, Thomas Wirth & Alexey Ushmorov. (2017) Activation of oncogenic pathways in classical Hodgkin lymphoma by decitabine: A rationale for combination with small molecular weight inhibitors. International Journal of Oncology 50:2, pages 555-566.
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Metin Karahoca & Richard L Momparler. (2013) Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy. Clinical Epigenetics 5:1.
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Hanfeng Guan, Linka Xie, Kay Klapproth, Clarissa D Weitzer, Thomas Wirth & Alexey Ushmorov. (2013) Decitabine represses translocated MYC oncogene in Burkitt lymphoma . The Journal of Pathology 229:5, pages 775-783.
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Mengyong Yan, Nourredine Himoudi, B. Piku Basu, Rebecca Wallace, Edmund Poon, Stuart Adams, Fyeza Hasan, Shao-An Xue, Natalie Wilson, Angus Dalgleish, Owen Williams & John Anderson. (2011) Increased PRAME antigen-specific killing of malignant cell lines by low avidity CTL clones, following treatment with 5-Aza-2′-Deoxycytidine. Cancer Immunology, Immunotherapy 60:9, pages 1243-1255.
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Jeffrey Bryan, Elias Jabbour, Hillary Prescott, Guillermo Garcia-Manero, Jean-Pierre Issa & Hagop Kantarjian. (2010) Current and Future Management Options for Myelodysplastic Syndromes. Drugs 70:11, pages 1381-1394.
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Chie Nishioka, Takayuki Ikezoe, Jing Yang, Naoki Komatsu, H. Phillip Koeffler & Akihito Yokoyama. (2009) Blockade of MEK signaling potentiates 5-Aza-2′-deoxycytidine-induced apoptosis and upregulation of p21waf1 in acute myelogenous leukemia cells. International Journal of Cancer 125:5, pages 1168-1176.
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A. A. Evdokimov, V. V. Zinoviev, V. V. Kuznetsov, N. A. Netesova & E. G. Malygin. (2009) Design of oligonucleotide inhibitors for human DNA methyltransferase 1. Molecular Biology 43:3, pages 418-425.
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Ina Patties, Jutta Jahns, Guido Hildebrandt, Rolf-Dieter Kortmann & Annegret Glasow. (2009) Additive Effects of 5-Aza-2’-deoxycytidine and Irradiation on Clonogenic Survival of Human Medulloblastoma Cell LinesAdditive Effekte von 5-Aza-2’-deoxycytidin und Bestrahlung auf das klonogene Überleben von humanen Medulloblastomzelllinien. Strahlentherapie und Onkologie 185:5, pages 331-338.
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Shan Gao, Aaron Mobley, Claudia Miller, Jessica Boklan & Joya Chandra. (2008) Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells. Leukemia Research 32:5, pages 771-780.
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Vladimir Beljanski. 2008. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 5 .
Bruce A. Feinberg, James Gilmore, Wendy Hawke Lenz, Carlos M. Franco, Tom Gondesen & Mansoor N. Saleh. (2007) Changing Treatment Paradigms for Myelodysplastic Syndromes in a Community Oncology Practice: Georgia Cancer Specialists' Experience. Clinical Leukemia 1:6, pages 345-352.
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