Advanced search
Publication Cover
Expert Opinion on Pharmacotherapy Volume 8, 2007 - Issue 2
Submit an article Journal homepage
330
Views
46
CrossRef citations to date
0
Altmetric
Drug Evaluation

Memantine in the treatment of mild-to-moderate Alzheimer’s disease

Kelly M Cosman University of Rochester School of Medicine, Alzheimer’s Disease Care Research and Education Program (AD-CARE), Monroe Community Hospital, 435 East Henrietta Road, Rochester, NY 14620, USA. [email protected]
,
Lisa L Boyle University of Rochester School of Medicine, Psychiatry Department, 300 Crittenden Boulevard, Rochester, NY 14642, USA. [email protected]
&
Anton P Porsteinsson University of Rochester School of Medicine, Alzheimer’s Disease Care Research and Education Programme (AD-CARE), Monroe Community Hospital, 435 East Henrietta Road, Rochester, NY 14620, USA. [email protected]
Pages 203-214 | Published online: 26 Jan 2007

Citations (46)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Cesare Mancuso, Raffaella Siciliano, Eugenio Barone, David Allan Butterfield & Paolo Preziosi. (2011) Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before. Expert Opinion on Investigational Drugs 20:9, pages 1243-1261.
Read now
J D Best & Wendy K Alderton. (2008) Zebrafish: An in vivo model for the study of neurological diseases. Neuropsychiatric Disease and Treatment 4:3, pages 567-576.
Read now
David B Hogan. (2007) Progress update: Pharmacological treatment of Alzheimer’s disease. Neuropsychiatric Disease and Treatment 3:5, pages 569-578.
Read now

Articles from other publishers (43)

Fawaz Alasmari, Farraj M. Alotaibi, Wedad Saeed Al-Qahtani, Abdullah F. AlAsmari & Faleh Alqahtani. (2023) Therapeutic Effects of Thymoquinone on Alzheimer’s Disease through Modulating Amyloid-beta Neurotoxicity and Neuro-inflammatory Cytokine Levels. CNS & Neurological Disorders - Drug Targets 22:5, pages 736-744.
Crossref
Júlia Companys-Alemany, Andreea L. Turcu, Santiago Vázquez, Mercè Pallàs & Christian Griñán-Ferré. (2022) Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist. Scientific Reports 12:1.
Crossref
Wen-Hui Ma, Ai-Fang Chen, Xiao-Yang Xie & Yun-Sheng Huang. (2021) Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease. Neuropharmacology 190, pages 108342.
Crossref
Roberta Andrejew, Ágatha Oliveira-Giacomelli, Deidiane Elisa Ribeiro, Talita Glaser, Vanessa Fernandes Arnaud-Sampaio, Claudiana Lameu & Henning Ulrich. (2020) The P2X7 Receptor: Central Hub of Brain Diseases. Frontiers in Molecular Neuroscience 13.
Crossref
Simonetta Pazzaglia, Giovanni Briganti, Mariateresa Mancuso & Anna Saran. (2020) Neurocognitive Decline Following Radiotherapy: Mechanisms and Therapeutic Implications. Cancers 12:1, pages 146.
Crossref
N. M. Zalutskaya, I. A. Beltceva & N. G. Neznanov. (2018) Tolerability of antidementive therapy: results of observational research. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY:2, pages 117-124.
Crossref
Ana Marta de Matos, Maria Paula de Macedo & Amélia Pilar Rauter. (2018) Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential. Medicinal Research Reviews 38:1, pages 261-324.
Crossref
Emanuela Mhillaj, Vincenzo Cuomo & Cesare Mancuso. (2017) The contribution of transgenic and nontransgenic animal models in Alzheimer’s disease drug research and development. Behavioural Pharmacology 28:2 and 3, pages 95-111.
Crossref
N. V. Titova. (2017) Memantine: from the original brand to generics. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 117:10, pages 136.
Crossref
Jingfen Zhu, Rong Shi, Su Chen, Lihua Dai, Tian Shen, Yi Feng, Pingping Gu, Mina Shariff, Tuong Nguyen, Yeats Ye, Jianyu Rao & Guoqiang Xing. (2016) The Relieving Effects of BrainPower Advanced, a Dietary Supplement, in Older Adults with Subjective Memory Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine 2016, pages 1-16.
Crossref
Andreas Soejitno, Anastasia Tjan & Thomas Eko Purwata. (2015) Alzheimer’s Disease: Lessons Learned from Amyloidocentric Clinical Trials. CNS Drugs 29:6, pages 487-502.
Crossref
Mathias Hallberg. (2015) Neuropeptides: Metabolism to Bioactive Fragments and the Pharmacology of Their Receptors. Medicinal Research Reviews 35:3, pages 464-519.
Crossref
Xiaofeng Xiong & Kristian Strømgaard. 2015. Polyamines. Polyamines 201 214 .
Zhenglin Gu, Jia Cheng, Ping Zhong, Luye Qin, Wenhua Liu & Zhen Yan. (2014) Aβ Selectively Impairs mGluR7 Modulation of NMDA Signaling in Basal Forebrain Cholinergic Neurons: Implication in Alzheimer's Disease. The Journal of Neuroscience 34:41, pages 13614-13628.
Crossref
Umer Rashid & Farzana L. Ansari. 2014. Drug Design and Discovery in Alzheimer's Disease. Drug Design and Discovery in Alzheimer's Disease 40 141 .
Hilmar Bading. (2013) Nuclear calcium signalling in the regulation of brain function. Nature Reviews Neuroscience 14:9, pages 593-608.
Crossref
Mary Pipan, Paul P. Wang & Rebecca Thompson Penna. 2013. Pediatric Drug Development. Pediatric Drug Development 355 382 .
Simon Lucas, Mette H. Poulsen, Niels G. Nørager, Anne F. Barslund, Tinna B. Bach, Anders S. Kristensen & Kristian Strømgaard. (2012) General Synthesis of β-Alanine-Containing Spider Polyamine Toxins and Discovery of Nephila Polyamine Toxins 1 and 8 as Highly Potent Inhibitors of Ionotropic Glutamate Receptors . Journal of Medicinal Chemistry 55:22, pages 10297-10301.
Crossref
H. Nashawi, T. Bartl, P. Bartl, L. Novotny, M.A. Oriowo & S.B. Kombian. (2012) TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro. Neuroscience 220, pages 70-84.
Crossref
Michiko Konno. (2012) Treatment of Dementias: Current Approaches and Disease Modifying Drugs. Journal of Nihon University Medical Association 71:6, pages 379-384.
Crossref
Hanna Andersson & Mathias Hallberg. (2012) Discovery of Inhibitors of Insulin-Regulated Aminopeptidase as Cognitive Enhancers. International Journal of Hypertension 2012, pages 1-18.
Crossref
Christian A. Olsen, Anders S. Kristensen & Kristian Strømgaard. (2011) Small Molecules from Spiders Used as Chemical Probes. Angewandte Chemie International Edition 50:48, pages 11296-11311.
Crossref
Christian A. Olsen, Anders S. Kristensen & Kristian Strømgaard. (2011) Niedermolekulare Verbindungen aus Spinnen als chemische Sensoren. Angewandte Chemie 123:48, pages 11492-11508.
Crossref
Hanna Andersson, Heidi Demaegdt, Anders Johnsson, Georges Vauquelin, Gunnar Lindeberg, Mathias Hallberg, Máté Erdélyi, Anders Karlén & Anders Hallberg. (2011) Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis. Journal of Medicinal Chemistry 54:11, pages 3779-3792.
Crossref
Mohammed Filali, Robert Lalonde & Serge Rivest. (2011) Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer’s disease. Neuropharmacology 60:6, pages 930-936.
Crossref
Anne F. Barslund, Mette H. Poulsen, Tinna B. Bach, Simon Lucas, Anders S. Kristensen & Kristian Strømgaard. (2010) Solid-Phase Synthesis and Biological Evaluation of Joro Spider Toxin-4 from Nephila clavata . Journal of Natural Products 74:3, pages 483-486.
Crossref
Hanna Andersson, Heidi Demaegdt, Georges Vauquelin, Gunnar Lindeberg, Anders Karlén, Mathias Hallberg, Máté Erdélyi & Anders Hallberg. (2010) Disulfide Cyclized Tripeptide Analogues of Angiotensin IV as Potent and Selective Inhibitors of Insulin-Regulated Aminopeptidase (IRAP). Journal of Medicinal Chemistry 53:22, pages 8059-8071.
Crossref
D. Kabogo, G. Rauw, A. Amritraj, G. Baker & S. Kar. (2010) β-Amyloid-related peptides potentiate K+-evoked glutamate release from adult rat hippocampal slices. Neurobiology of Aging 31:7, pages 1164-1172.
Crossref
Jin Hwan LeeSun Mi WonJaehong SuhSun Joo SonGyeong Joon MoonUi-Jin ParkByoung Joo Gwag. (2010) Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice. Experimental and Molecular Medicine 42:5, pages 386.
Crossref
Jin-Tai Yu, Raymond Chuen-Chung Chang & Lan Tan. (2009) Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities. Progress in Neurobiology 89:3, pages 240-255.
Crossref
Miou Zhou, Wei Xu, Guanghong Liao, Xiaoning Bi & Michel Baudry. (2009) Neuroprotection against neonatal hypoxia/ischemia-induced cerebral cell death by prevention of calpain-mediated mGluR1α truncation. Experimental Neurology 218:1, pages 75-82.
Crossref
Jared K. Nelson, Sidsel U. Frølund, Dennis B. Tikhonov, Anders S. Kristensen & Kristian Strømgaard. (2009) Synthesis and Biological Activity of Argiotoxin 636 and Analogues: Selective Antagonists for Ionotropic Glutamate Receptors. Angewandte Chemie International Edition 48:17, pages 3087-3091.
Crossref
Jared K. Nelson, Sidsel U. Frølund, Dennis B. Tikhonov, Anders S. Kristensen & Kristian Strømgaard. (2009) Synthesis and Biological Activity of Argiotoxin 636 and Analogues: Selective Antagonists for Ionotropic Glutamate Receptors. Angewandte Chemie 121:17, pages 3133-3137.
Crossref
João QuevedoClarissa M Comim & Elaine C Gavioli. (2009) Ketamine induces rapid onset of antidepressant action: neurophysiological biomarkers as predictors of effect. Biomarkers in Medicine 3:1, pages 5-8.
Crossref
Emily O. Dumas & Gary M. Pollack. (2008) Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective. The AAPS Journal 10:4.
Crossref
Siew Yeen Chai, Holly R Yeatman, Michael W Parker, David B Ascher, Philip E Thompson, Hayley T Mulvey & Anthony L Albiston. (2008) Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase. BMC Neuroscience 9:S2.
Crossref
Lêda S. Garcia, Clarissa M. Comim, Samira S. Valvassori, Gislaine Z. Réus, Ana Cristina Andreazza, Laura Stertz, Gabriel R. Fries, Elaine Cristina Gavioli, Flavio Kapczinski & João Quevedo. (2008) Chronic Administration of Ketamine Elicits Antidepressant-Like Effects in Rats without Affecting Hippocampal Brain-Derived Neurotrophic Factor Protein Levels. Basic & Clinical Pharmacology & Toxicology 103:6, pages 502-506.
Crossref
Kethireddy V.V. Ananthalakshmi, Tomáš Bartl, Mohammed H. Aziza, Ladislav Novotný, Radek Marek, Luděk Beneš & Samuel B. Kombian. (2008) Synthesis and structure–activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro. Bioorganic & Medicinal Chemistry 16:17, pages 8142-8150.
Crossref
Andrea Pinto, Paola Conti, Marco De Amici, Lucia Tamborini, Ulf Madsen, Birgitte Nielsen, Thomas Christesen, Hans Bräuner-Osborne & Carlo De Micheli. (2008) Synthesis and Pharmacological Characterization at Glutamate Receptors of the Four Enantiopure Isomers of Tricholomic Acid. Journal of Medicinal Chemistry 51:7, pages 2311-2315.
Crossref
D. Jantas, M. Pytel, J.W. Mozrzymas, M. Leskiewicz, M. Regulska, L. Antkiewicz-Michaluk & W. Lason. (2008) The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neurochemistry International 52:4-5, pages 864-877.
Crossref
Scott M. Whitcup. 2008. Glaucoma: An Open Window to Neurodegeneration and Neuroprotection. Glaucoma: An Open Window to Neurodegeneration and Neuroprotection 323 335 .
V A Campbell & A Gowran. (2007) Alzheimer's disease; taking the edge off with cannabinoids?. British Journal of Pharmacology 152:5, pages 655-662.
Crossref
. (2007) Current awareness in geriatric psychiatry. International Journal of Geriatric Psychiatry 22:10, pages 1055-1062.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.