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Treating human cancers with heat shock protein-peptide complexes: the road ahead

, PhD MD, , MD PhD & , MD
Pages 179-186 | Published online: 16 Jan 2009

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Maxim A Shevtsov, Alexander V Kim, Konstantin A Samochernych, Irina V Romanova, Boris A Margulis, Irina V Guzhova, Igor V Yakovenko, Alexander M Ischenko & William A Khachatryan. (2014) Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children. OncoTargets and Therapy 7, pages 1071-1081.
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Xiaofei Yu, John R Subjeck & Xiang-Yang Wang. (2013) Integrating a ‘danger’ signal into molecular chaperoning to improve vaccination against cancer. Expert Review of Vaccines 12:6, pages 581-583.
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Benjamin Frey, Eva-Maria Weiss, Yvonne Rubner, Roland Wunderlich, Oliver J. Ott, Rolf Sauer, Rainer Fietkau & Udo S. Gaipl. (2012) Old and new facts about hyperthermia-induced modulations of the immune system. International Journal of Hyperthermia 28:6, pages 528-542.
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Ayesha Murshid, Jianlin Gong, Mary Ann Stevenson & Stuart K Calderwood. (2011) Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come. Expert Review of Vaccines 10:11, pages 1553-1568.
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Daniel R. Ciocca, Mariel A. Fanelli, Fernando D. Cuello-Carrion & Gisela N. Castro. (2010) Heat shock proteins in prostate cancer: from tumorigenesis to the clinic. International Journal of Hyperthermia 26:8, pages 737-747.
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Carrie E. Andrews, Jenny Zilberberg, Raul Perez-Olle, Mark A. Exley & David W. Andrews. (2023) Targeted immunotherapy for glioblastoma involving whole tumor-derived autologous cells in the upfront setting after craniotomy. Journal of Neuro-Oncology.
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Tianrui Yang, Yixin Shi, Tingyu Liang, Hao Xing, Wenbin Ma, Yan Michael Li & Yu Wang. (2022) Peptide vaccine against glioblastoma: from bench to bedside. Holistic Integrative Oncology 1:1.
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Robert J. Binder. (2019) Immunosurveillance of cancer and the heat shock protein-CD91 pathway. Cellular Immunology 343, pages 103814.
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Yan Gu, Yanfang Liu, Li Fu, Lili Zhai, Jie Zhu, Yanmei Han, Yingming Jiang, Yi Zhang, Peng Zhang, Zhengping Jiang, Xiang Zhang & Xuetao Cao. (2019) Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG. Nature Medicine 25:2, pages 312-322.
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Lan B. Hoang-Minh & Duane A. Mitchell. (2018) Immunotherapy for Brain Tumors. Current Treatment Options in Oncology 19:11.
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Julia R Schneider, Kay O Kulason, Muhammad Babar Khan, Timothy G White, Kevin Kwan, Lukas Faltings, Andrew J Kobets, Shamik Chakraborty, Jason A Ellis, Rafael A Ortiz, Christopher G Filippi, David J Langer & John A Boockvar. (2018) Commentary: Advances in Glioblastoma Therapies: A Collaborative Effort Between Physicians and the Biotechnology Industry. Neurosurgery 83:4, pages E162-E168.
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Robert J. Binder. 2018. Heat Shock Proteins in the Immune System. Heat Shock Proteins in the Immune System 63 73 .
Orin Bloch, Michael Lim, Michael E. Sughrue, Ricardo J. Komotar, John M. Abrahams, Donald M. O'Rourke, Anthony D'Ambrosio, Jeffrey N. Bruce & Andrew T. Parsa. (2017) Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy. Clinical Cancer Research 23:14, pages 3575-3584.
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Kartik Baruah, Parisa Norouzitallab & Peter Bossier. 2017. Heat Shock Proteins in Veterinary Medicine and Sciences. Heat Shock Proteins in Veterinary Medicine and Sciences 197 213 .
Willem van Eden & Ruurd van der Zee. 2016. Compendium of Inflammatory Diseases. Compendium of Inflammatory Diseases 569 575 .
Maxim A. Shevtsov, Boris P. Nikolaev, Liudmila Y. Yakovleva, Marina A. Parr, Yaroslav Y. Marchenko, Igor Eliseev, Anna Yudenko, Anatolii V. Dobrodumov, Olga Zlobina, Alexander Zhakhov, Alexander M. Ischenko, Emil Pitkin & Gabriele Multhoff. (2015) 70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma. Journal of Controlled Release 220, pages 329-340.
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Nabiha Yusuf, Tahseen H. Nasti, Israr Ahmad, Sanim Chowdhury, Hasan Mohiuddin, Hui Xu, Mohammad Athar, Laura Timares & Craig A. Elmets. (2015) In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical. The Journal of Immunology 194:10, pages 4796-4803.
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Hongxia Wang, Abdul Mohammad Pezeshki, Xiaofei Yu, Chunqing Guo, John R. Subjeck & Xiang-Yang Wang. (2015) The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics. Frontiers in Oncology 4.
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Orin Bloch. 2015. Current Understanding and Treatment of Gliomas. Current Understanding and Treatment of Gliomas 143 158 .
Orin Bloch, Courtney A. Crane, Yelena Fuks, Rajwant Kaur, Manish K. Aghi, Mitchel S. Berger, Nicholas A. Butowski, Susan M. Chang, Jennifer L. Clarke, Michael W. McDermott, Michael D. Prados, Andrew E. Sloan, Jeffrey N. Bruce & Andrew T. Parsa. (2014) Heat-shock protein peptide complex?96 vaccination for recurrent glioblastoma: a phase II, single-arm trial. Neuro-Oncology 16:2, pages 274-279.
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Maxim A. Shevtsov, Ludmila Y. Yakovleva, Boris P. Nikolaev, Yaroslav Y. Marchenko, Anatolii V. Dobrodumov, Kirill V. Onokhin, Yana S. Onokhina, Sergey A. Selkov, Anastasiia L. Mikhrina, Irina V. Guzhova, Marina G. Martynova, Olga A. Bystrova, Alexander M. Ischenko & Boris A. Margulis. (2014) Tumor targeting using magnetic nanoparticle Hsp70 conjugate in a model of C6 glioma. Neuro-Oncology 16:1, pages 38-49.
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Willem van Eden & Ruurd van der Zee. 2015. Encyclopedia of Inflammatory Diseases. Encyclopedia of Inflammatory Diseases 1 8 .
Zhenzhen Ding, Rongying Ou, Bing Ni, Jun Tang & Yunsheng Xu. (2013) Cytolytic Activity of the Human Papillomavirus Type 16 E7 11-20 Epitope-Specific Cytotoxic T Lymphocyte Is Enhanced by Heat Shock Protein 110 in HLA-A*0201 Transgenic Mice . Clinical and Vaccine Immunology 20:7, pages 1027-1033.
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Tatiana Blanchard, Pramod K. Srivastava & Fei Duan. (2013) Vaccines against advanced melanoma. Clinics in Dermatology 31:2, pages 179-190.
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Sudesh Pawaria, Laura E. Kropp & Robert J. Binder. (2012) Immunotherapy of Tumors with α2-Macroglobulin-Antigen Complexes Pre-Formed In Vivo. PLoS ONE 7:11, pages e50365.
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Marco Randazzo, Peter Terness, Gerhard Opelz & Christian Kleist. (2012) Active‐specific immunotherapy of human cancers with the heat shock protein Gp96—revisited. International Journal of Cancer 130:10, pages 2219-2231.
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Giampaolo Buriani, Camillo Mancini, Eugenio Benvenuto & Selene Baschieri. (2012) Heat‐shock protein 70 from plant biofactories of recombinant antigens activate multiepitope‐targeted immune responses. Plant Biotechnology Journal 10:3, pages 363-371.
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Christina Siebke, Tharappel C. James, Robert Cummins, Tony O’Grady, Elaine Kay & Ursula Bond. (2011) Phage display biopanning identifies the translation initiation and elongation factors (IF1α-3 and eIF-3) as components of Hsp70–peptide complexes in breast tumour cells. Cell Stress and Chaperones 17:2, pages 145-156.
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Scott Fisher, Steve Broomfield, Robbert van Der Most, Richard Lake, Bruce Robinson & Andrew Currie. (2012) Heat-Shocking of Murine Malignant Mesothelioma Cells Enhances Their Effectiveness as an Autologous Anti-Tumour Vaccine. Journal of Cancer Therapy 03:01, pages 47-56.
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Sabine Tischer, Megan Basila, Britta Maecker-Kolhoff, Stephan Immenschuh, Mathias Oelke, Rainer Blasczyk & Britta Eiz-Vesper. (2011) Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies. Journal of Translational Medicine 9:1.
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Luigi Buonaguro, Annacarmen Petrizzo, Maria Lina Tornesello & Franco M. Buonaguro. (2011) Translating Tumor Antigens into Cancer Vaccines. Clinical and Vaccine Immunology 18:1, pages 23-34.
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G. Multhoff & U. Gaipl. (2010) Molekulare und immunologische Effekte der Hyperthermie auf Tumorprogression und MetastasierungMolecular and immunological effects of hyperthermia on tumor progression and metastasis. Der Onkologe 16:11, pages 1043-1051.
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