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Immunoregulatory T cells in cancer immunotherapy

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Pages 827-834 | Published online: 23 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

AnYuan Zhong, Xue Pan & MinHua Shi. (2015) Expression of PD-1 by CD4+CD25+CD127low Treg cells in the peripheral blood of lung cancer patients. OncoTargets and Therapy 8, pages 1831-1833.
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Dominique Cathelin, Alexandra Nicolas, André Bouchot, Jennifer Fraszczak, Jérôme Labbé & Bernard Bonnotte. (2011) Dendritic cell–tumor cell hybrids and immunotherapy: what's next?. Cytotherapy 13:7, pages 774-785.
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Ravi A Madan, Jeanny B Aragon-Ching, James L Gulley & William L Dahut. (2011) From clinical trials to clinical practice: therapeutic cancer vaccines for the treatment of prostate cancer. Expert Review of Vaccines 10:6, pages 743-753.
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Ravi A Madan, Mahsa Mohebtash, Jeffrey Schlom & James L Gulley. (2010) Therapeutic vaccines in metastatic castration-resistant prostate cancer: principles in clinical trial design. Expert Opinion on Biological Therapy 10:1, pages 19-28.
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Evangelia M Fatourou & John S Koskinas. (2009) Adaptive immunity in hepatocellular carcinoma: prognostic and therapeutic implications. Expert Review of Anticancer Therapy 9:10, pages 1499-1510.
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Ravi A Madan, Philip M Arlen, Mahsa Mohebtash, James W Hodge & James L Gulley. (2009) Prostvac-VF: a vector-based vaccine targeting PSA in prostate cancer. Expert Opinion on Investigational Drugs 18:7, pages 1001-1011.
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Articles from other publishers (34)

Sara Abdelal Mohammed, Helal F. Hetta, Asmaa M. Zahran, Mohammed E. M. Tolba, Rasha A. H. Attia, Hosny M. Behnsawy, Abdelazeem M. Algammal, Gaber El-Saber Batiha, Ahmed Qasem Mohammed & Alzahraa Abdelraouf Ahmad. (2023) T cell subsets, regulatory T, regulatory B cells and proinflammatory cytokine profile in Schistosoma haematobium associated bladder cancer: First report from Upper Egypt. PLOS Neglected Tropical Diseases 17:4, pages e0011258.
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Hsin-Yu Liu, Christophe Pedros, Kok-Fai Kong, Ann J Canonigo-Balancio, Wen Xue & Amnon Altman. (2021) Leveraging the Treg-intrinsic CTLA4–PKCη signaling pathway for cancer immunotherapy. Journal for ImmunoTherapy of Cancer 9:9, pages e002792.
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Furong Qin, Fan Xia, Hongli Chen, Bomiao Cui, Yun Feng, Ping Zhang, Jiao Chen & Min Luo. (2021) A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications. Frontiers in Cell and Developmental Biology 9.
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Minsig Choi & Archana Thakur. (2014) Identifying Appropriate Colorectal Cancer-Associated Antigens for the Clinical Trials. Current Colorectal Cancer Reports 11:1, pages 29-36.
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Muzammal Hussain, Aqeel Javeed, Muhammad Ashraf, Nuha Al-Zaubai, Alastair Stewart & Muhammad Mahmood Mukhtar. (2012) Non-steroidal anti-inflammatory drugs, tumour immunity and immunotherapy. Pharmacological Research 66:1, pages 7-18.
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S M Ansell, H Tang, P J Kurtin, P A Koenig, G S Nowakowski, D A Nikcevich, G D Nelson, Z Yang, D M Grote, S C Ziesmer, P T Silberstein, C Erlichman & T E Witzig. (2011) Denileukin diftitox in combination with rituximab for previously untreated follicular B-cell non-Hodgkin's lymphoma. Leukemia 26:5, pages 1046-1052.
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Peter T ScardinoCinzia Remondo & James L Gulley. 2011. Targeted Therapies for Castration-Resistant Prostate Cancer. Targeted Therapies for Castration-Resistant Prostate Cancer 54 65 .
Wen‐Chun Chang, Chao‐Hsu Li, Su‐Cheng Huang, Daw‐Yuan Chang, Li‐Yun Chou & Bor‐Ching Sheu. (2010) Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma. Cancer 116:24, pages 5777-5788.
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Ravi A. Madan & James L. Gulley. (2010) The Current and Emerging Role of Immunotherapy in Prostate Cancer. Clinical Genitourinary Cancer 8:1, pages 10-16.
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Ravi A. Madan, James L. Gulley, Jackie Celestin, Philip M. Arlen & Jeffrey Schlom. 2010. Drug Management of Prostate Cancer. Drug Management of Prostate Cancer 305 319 .
Fan He, Zhishui Chen, Shengyuan Xu, Ming Cai, Min Wu, Hongzhou Li & Xiaoping Chen. (2009) Increased CD4+CD25+Foxp3+ regulatory T cells in tolerance induced by portal venous injection. Surgery 145:6, pages 663-674.
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Bin Xiong, Gansheng Feng, Shihua Luo, Huimin Liang, Lingyun Qiu, Chuansheng Zheng, Xi Liu & Guofeng Zhou. (2008) Changes of CD4+ CD25+ regulatory T cells in peripheral blood in patients with hepatocellular carcinoma before and after TACE. Journal of Huazhong University of Science and Technology [Medical Sciences] 28:6, pages 645-648.
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Zhao Yang, JingBo Zhang, Li Wang, YuZhang Wu & Shuguang Wang. (2008) Expression of PD-1 is up-regulated in CD4+CD25+ FoxP3+ regulatory T cell of non-responders after hepatitis B surface antigen vaccine immunization. Clinical Immunology 129:1, pages 176-177.
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Siegfried Schulz, Ulrich Häussler, Robert Mandic, Johannes T. Heverhagen, Andreas Neubauer, Anja A. Dünne, Jochen A. Werner, Eberhard Weihe & Michael Bette. (2008) Treatment with ozone/oxygen‐pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas. International Journal of Cancer 122:10, pages 2360-2367.
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S Audia, A Nicolas, D Cathelin, N Larmonier, C Ferrand, P Foucher, A Fanton, E Bergoin, M Maynadie, L Arnould, A Bateman, B Lorcerie, E Solary, B Chauffert & B Bonnotte. (2007) Increase of CD4+CD25+ regulatory T cells in the peripheral blood of patients with metastatic carcinoma: a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4+CD25+ T lymphocytes. Clinical and Experimental Immunology 150:3, pages 523-530.
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Robyn S. AriasMeg L. FlanaganKeith D. MillerYu-Chih NienPeisheng HuDixon GrayLeslie A. KhawliAlan L. Epstein. (2007) RA8, A Human Anti-CD25 Antibody Against Human Treg Cells. Hybridoma 26:3, pages 119-130.
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W Kimryn Rathmell, Caroline A Martz & Brian I Rini. (2007) Renal cell carcinoma. Current Opinion in Oncology 19:3, pages 234-240.
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Xiu Hua Yang, Satoshi Yamagiwa, Takafumi Ichida, Yasunobu Matsuda, Satoshi Sugahara, Hisami Watanabe, Yoshinobu Sato, Toru Abo, David A. Horwitz & Yutaka Aoyagi. (2006) Increase of CD4+CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma. Journal of Hepatology 45:2, pages 254-262.
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H. Roddie, M. Klammer, C. Thomas, R. Thomson, A. Atkinson, A. Sproul, M. Waterfall, K. Samuel, J. Yin, P. Johnson & M. Turner. (2006) Phase I/II study of vaccination with dendritic-like leukaemia cells for the immunotherapy of acute myeloid leukaemia. British Journal of Haematology 133:2, pages 152-157.
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Clare Baecher-Allan & David E. Anderson. (2006) Regulatory cells and human cancer. Seminars in Cancer Biology 16:2, pages 98-105.
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Guliang Xia, Robert L. Truitt & Bryon D. Johnson. (2006) Graft-versus-Leukemia and Graft-versus-Host Reactions after Donor Lymphocyte Infusion Are Initiated by Host-Type Antigen-Presenting Cells and Regulated by Regulatory T Cells in Early and Long-Term Chimeras. Biology of Blood and Marrow Transplantation 12:4, pages 397-407.
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Aihong Liu, Peisheng Hu, Leslie A. Khawli & Alan L. Epstein. (2005) Combination B7-Fc Fusion Protein Treatment and Treg Cell Depletion Therapy. Clinical Cancer Research 11:23, pages 8492-8502.
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Dan A. Laheru, Drew M. Pardoll & Elizabeth M. Jaffee. (2005) Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology. Molecular Cancer Therapeutics 4:11, pages 1645-1652.
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Chie Kudo-Saito, Jeffrey Schlom, Kevin Camphausen, C. Norman Coleman & James W. Hodge. (2005) The Requirement of Multimodal Therapy (Vaccine, Local Tumor Radiation, and Reduction of Suppressor Cells) to Eliminate Established Tumors. Clinical Cancer Research 11:12, pages 4533-4544.
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Cécile Badoual, Benoît Vingert, Nour Agueznay, Olivier Adotevi, Nacilla Haicheur, Thierry Molina, Patrick Bruneval, Wolf H Fridman & Eric Tartour. (2005) Phénotypes et fonctions des lymphocytes T en pathologie tumorale. Annales de Pathologie 25:3, pages 211-219.
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Lars A. Ormandy, Tina Hillemann, Heiner Wedemeyer, Michael P. Manns, Tim F. Greten & Firouzeh Korangy. (2005) Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma. Cancer Research 65:6, pages 2457-2464.
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Jong Myun Park, Masaki Terabe, Leon T. van den Broeke, Debra D. Donaldson & Jay A. Berzofsky. (2005) Unmasking immunosurveillance against a syngeneic colon cancer by elimination of CD4+ NKT regulatory cells and IL-13. International Journal of Cancer 114:1, pages 80-87.
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Milcho Mincheff, Serguei Zoubak, Iskra Altankova, Stoyan Tchakarov, Petro Pogribnyy, Yevgen Makogonenko, Chavdar Botev & Harold T Meryman. (2004) Depletion of CD25+ cells from human T-cell enriched fraction eliminates immunodominance during priming with dendritic cells genetically modified to express a secreted protein. Cancer Gene Therapy 12:2, pages 185-197.
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G�rald J. Prud'homme. (2005) DNA vaccination against tumors. The Journal of Gene Medicine 7:1, pages 3-17.
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Andreas O. Eggert, Mads H. Andersen, Heike Voigt, David Schrama, Eckhardt Kämpgen, Per thor Straten & Jürgen C. Becker. (2004) Characterization of mouse MAGE-derived H-2K b -restricted CTL epitopes . European Journal of Immunology 34:11, pages 3285-3290.
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Graham Pawelec. (2004) Immunotherapy and immunoselection - tumour escape as the final hurdle. FEBS Letters 567:1, pages 63-66.
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Michael A. Morse, Timothy M. Clay & H. Kim Lyerly. 2004. Handbook of Cancer Vaccines. Handbook of Cancer Vaccines 3 10 .
Eddy C Hsueh & Donald L Morton. (2003) Antigen-based immunotherapy of melanoma: Canvaxin therapeutic polyvalent cancer vaccine. Seminars in Cancer Biology 13:6, pages 401-407.
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Ludmila Müller & Graham Pawelec. (2016) Cytokines and Antitumor Immunity. Technology in Cancer Research & Treatment 2:3, pages 183-194.
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