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Katherine E. Lewis, Mark J. Selby, Gregg Masters, Jose Valle, Gennaro Dito, Wendy R. Curtis, Richard Garcia, Kathy A. Mink, Kimberly S. Waggie, Matthew S. Holdren, Joseph F. Grosso, Alan J. Korman, Maria Jure-Kunkel & Stacey R. Dillon. (2018) Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models. OncoImmunology 7:1.
Read now
Read now
Shruti Bhatt, Kristopher A. Sarosiek & Izidore S. Lossos. (2017) Interleukin 21 – its potential role in the therapy of B-cell lymphomas. Leukemia & Lymphoma 58:1, pages 17-29.
Read now
Read now
Sandeep Nayar, Prokar Dasgupta & Christine Galustian. (2015) Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies–A review. OncoImmunology 4:4.
Read now
Read now
Trang Nguyen, Julie Urban & Pawel Kalinski. (2014) Therapeutic cancer vaccines and combination immunotherapies involving vaccination. ImmunoTargets and Therapy 3, pages 135-150.
Read now
Read now
Brianne Wood, Soma Sikdar, Suk Jin Choi, Shakeel Virk, Abdulmohsen Alhejaily, Tara Baetz & David P. LeBrun. (2013) Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease. Leukemia & Lymphoma 54:6, pages 1212-1220.
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Arseniy E. Yuzhalin & Anton G. Kutikhin. (2012) Interleukin-12: Clinical usage and molecular markers of cancer susceptibility. Growth Factors 30:3, pages 176-191.
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Articles from other publishers (58)
Tanjilur Rahman, Ayan Das, Mehedy Hasan Abir, Iqbal Hossain Nafiz, Aar Rafi Mahmud, Md. Rifat Sarker, Talha Bin Emran & Mohammad Mahmudul Hassan. (2023) Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts. Cytokine 169, pages 156268.
Crossref
Crossref
Yangyihua Zhou, Guiqi Quan, Yujun Liu, Zhihong Wang, Ning Shi, Yahui Wu, Qiuju Liu, Xiang Gao, Ran Zhang & Longlong Luo. (2023) Anti-Claudin18.2-IL-21 fusion protein bifunctional molecule has more powerful anti-tumor effect and better safety. International Immunopharmacology 115, pages 109634.
Crossref
Crossref
Marshall V. Williams, Irene Mena-Palomo, Brandon Cox & Maria Eugenia Ariza. (2023) EBV dUTPase: A Novel Modulator of Inflammation and the Tumor Microenvironment in EBV-Associated Malignancies. Cancers 15:3, pages 855.
Crossref
Crossref
Nathan E. Welty & Saar I. Gill. (2022) Cancer Immunotherapy Beyond Checkpoint Blockade. JACC: CardioOncology 4:5, pages 563-578.
Crossref
Crossref
Cesare Di Nitto, Dario Neri, Tobias Weiss, Michael Weller & Roberto De Luca. (2022) Design and Characterization of Novel Antibody-Cytokine Fusion Proteins Based on Interleukin-21. Antibodies 11:1, pages 19.
Crossref
Crossref
Hongchuan Liu, Rui Wang, Duopeng An, Hui Liu, Fan Ye, Baoxian Li, Jing Zhang, Peixiang Liu, Xuyao Zhang, Sheng Yao, Ziyang Zhong, Hui Feng & Meiqing Feng. (2021) An engineered IL-21 with half-life extension enhances anti-tumor immunity as a monotherapy or in combination with PD-1 or TIGIT blockade. International Immunopharmacology 101, pages 108307.
Crossref
Crossref
Zhengyang Hu, Guoshu Bi, Qihai Sui, Yunyi Bian, Yajing Du, Jiaqi Liang, Ming Li, Cheng Zhan, Zongwu Lin & Qun Wang. (2020) Analyses of multi-omics differences between patients with high and low PD1/PDL1 expression in lung squamous cell carcinoma. International Immunopharmacology 88, pages 106910.
Crossref
Crossref
Raki Sudan. 2020. Systems and Synthetic Immunology. Systems and Synthetic Immunology
255
269
.
Fang Gong, Ting Zheng & Pengcheng Zhou. (2019) T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma. Frontiers in Immunology 10.
Crossref
Crossref
P. M. Gershovich, A. V. Karabelskii, A. B. Ulitin & R. A. Ivanov. (2019) The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells. Biochemistry (Moscow) 84:7, pages 695-710.
Crossref
Crossref
Josh Poorbaugh, Tanushree Samanta, Stuart W. Bright, Sean E. Sissons, Ching-Yun Chang, Pankaj Oberoi, Angus J. MacDonald, Andrea P. Martin, Karen L. Cox & Robert J. Benschop. (2019) Measurement of IL-21 in human serum and plasma using ultrasensitive MSD S-PLEX® and Quanterix SiMoA methodologies. Journal of Immunological Methods 466, pages 9-16.
Crossref
Crossref
Huilin Yang, Rakeeb Kureshi & Jamie B. Spangler. 2019. Structural Immunology. Structural Immunology
1
19
.
Pei-Yi Su & Chiaho Shih. 2019. Viral Hepatitis in Children. Viral Hepatitis in Children
211
227
.
Y Huang, D Li, D-Y Qin, H-F Gou, W Wei, Y-S Wang, Y-Q Wei & W Wang. (2017) Interleukin-armed chimeric antigen receptor-modified T cells for cancer immunotherapy. Gene Therapy 25:3, pages 192-197.
Crossref
Crossref
Dixon H. Xu, Ziwen Zhu, Huaping Xiao, Mark R. Wakefield, Qian Bai, Michael B. Nicholl, Vivi A. Ding & Yujiang Fang. (2017) Unveil the mysterious mask of cytokine-based immunotherapy for melanoma. Cancer Letters 394, pages 43-51.
Crossref
Crossref
Rosanne Spolski & Warren J. Leonard. 2017. Cancer Therapeutic Targets. Cancer Therapeutic Targets
369
374
.
Haley Ward, Lydia Tang, Bhawna Poonia & Shyam Kottilil. (2016) Treatment of hepatitis B virus: an update. Future Microbiology 11:12, pages 1581-1597.
Crossref
Crossref
Zhi-xiang Yuan, Jingxin Mo, Guixian Zhao, Gang Shu, Hua-lin Fu & Wei Zhao. (2016) Targeting Strategies for Renal Cell Carcinoma: From Renal Cancer Cells to Renal Cancer Stem Cells. Frontiers in Pharmacology 7.
Crossref
Crossref
Jiyu Ju, Lina Wang, Dalin Di, Weiling Xiao, Meiyu Peng, Yishuai Liu, Xiaoyan Fu, Chunling Zhao & Xuebin Qin. (2016) Adenovirus-mediated interleukin 21 gene transfer enhances antitumor immunity and reduces tumorigenicity of Hepa1–6 in mice. Oncology Letters 12:5, pages 3749-3754.
Crossref
Crossref
Chiaho Shih, Shu-Fan Chou, Ching-Chun Yang, Jyun-Yuan Huang, Gansukh Choijilsuren & Ren-Shiang Jhou. (2016) Control and Eradication Strategies of Hepatitis B Virus. Trends in Microbiology 24:9, pages 739-749.
Crossref
Crossref
Tiphaine Parrot, Mathilde Allard, Romain Oger, Houssem Benlalam, Diane Raingeard de la Blétière, Anne Coutolleau, Laurence Preisser, Juliette Desfrançois, Amir Khammari, Brigitte Dréno, Nathalie Labarrière, Yves Delneste, Philippe Guardiola & Nadine Gervois. (2016)
IL-9 promotes the survival and function of human melanoma-infiltrating CD4
+
CD8
+
double-positive T cells
. European Journal of Immunology 46:7, pages 1770-1782.
Crossref
Crossref
Bin Ju, Dan Li, Xiaolin Ji, Jiandong Liu, Hong Peng, Shuo Wang, Ying Liu, Yanling Hao, Cassian Yee, Hua Liang & Yiming Shao. (2016) Interleukin-21 administration leads to enhanced antigen-specific T cell responses and natural killer cells in HIV-1 vaccinated mice. Cellular Immunology 303, pages 55-65.
Crossref
Crossref
Russell Pachynski & Holbrook Kohrt. 2016. Novel Immunotherapeutic Approaches to the Treatment of Cancer. Novel Immunotherapeutic Approaches to the Treatment of Cancer
79
108
.
Rosanne Spolski & Warren J. Leonard. 2016. Cancer Therapeutic Targets. Cancer Therapeutic Targets
1
6
.
Nayoun KimYoung-Sun NamKeon-Il ImJung-Yeon LimEun-Sol LeeYoung-Woo JeonSeok-Goo Cho. (2015) IL-21-Expressing Mesenchymal Stem Cells Prevent Lethal B-Cell Lymphoma Through Efficient Delivery of IL-21, Which Redirects the Immune System to Target the Tumor. Stem Cells and Development 24:23, pages 2808-2821.
Crossref
Crossref
Luca Micci, Emily S. Ryan, Rémi Fromentin, Steven E. Bosinger, Justin L. Harper, Tianyu He, Sara Paganini, Kirk A. Easley, Ann Chahroudi, Clarisse Benne, Sanjeev Gumber, Colleen S. McGary, Kenneth A. Rogers, Claire Deleage, Carissa Lucero, Siddappa N. Byrareddy, Cristian Apetrei, Jacob D. Estes, Jeffrey D. Lifson, Michael PiatakJr.Jr., Nicolas Chomont, Francois Villinger, Guido Silvestri, Jason M. Brenchley & Mirko Paiardini. (2015) Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. Journal of Clinical Investigation 125:12, pages 4497-4513.
Crossref
Crossref
Shruti BhattJulie MatthewsSalma ParvinKristopher A. SarosiekDekuang ZhaoXiaoyu JiangElif Isik, Anthony Letai & Izidore S. Lossos. (2015) Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma. Blood 126:13, pages 1555-1564.
Crossref
Crossref
P Siupka, O T Hamming, L Kang, H H Gad & R Hartmann. (2015) A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane. Genes & Immunity 16:6, pages 405-413.
Crossref
Crossref
Tao WangAlexis CunninghamAyotunde O. DokunSurovi HazarikaKevin HoustonLingdan ChenR. John LyeRosanne SpolskiWarren J. LeonardBrian H. Annex. (2015) Loss of Interleukin-21 Receptor Activation in Hypoxic Endothelial Cells Impairs Perfusion Recovery After Hindlimb Ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology 35:5, pages 1218-1225.
Crossref
Crossref
Matthew R. Davis, Ziwen Zhu, Dwayne M. Hansen, Qian Bai & Yujiang Fang. (2015) The role of IL-21 in immunity and cancer. Cancer Letters 358:2, pages 107-114.
Crossref
Crossref
Chansavath Phetsouphanh, Yin Xu & John Zaunders. (2015) CD4 T Cells Mediate Both Positive and Negative Regulation of the Immune Response to HIV Infection: Complex Role of T Follicular Helper Cells and Regulatory T Cells in Pathogenesis. Frontiers in Immunology 5.
Crossref
Crossref
Suhendan Ekmekcioglu, Razelle Kurzrock & Elizabeth A. Grimm. 2015. The Molecular Basis of Cancer. The Molecular Basis of Cancer
789
808.e4
.
Brianna Oliver, Erica Jackson & Hatem Soliman. 2015. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies
411
431
.
Scott J. Antonia, James Larkin & Paolo A. Ascierto. (2014) Immuno-oncology Combinations: A Review of Clinical Experience and Future Prospects. Clinical Cancer Research 20:24, pages 6258-6268.
Crossref
Crossref
Rama Kapoor & Shyam Kottilil. (2014) Strategies to eliminate HBV infection. Future Virology 9:6, pages 565-585.
Crossref
Crossref
Elisabeth Salzer, Aydan Kansu, Heiko Sic, Peter Májek, Aydan Ikincioğullari, Figen E. Dogu, Nina Kathrin Prengemann, Elisangela Santos-Valente, Winfried F. Pickl, Ivan Bilic, Sol A Ban, Zarife Kuloğlu, Arzu Meltem Demir, Arzu Ensari, Jacques Colinge, Marta Rizzi, Hermann Eibel & Kaan Boztug. (2014) Early-onset inflammatory bowel disease and common variable immunodeficiency–like disease caused by IL-21 deficiency. Journal of Allergy and Clinical Immunology 133:6, pages 1651-1659.e12.
Crossref
Crossref
HONG-MEI CHEN, HONG-LI LIU, YU-CONG YANG, XIAO-LI CHENG, YUE-FEI WANG, FAN-FAN XING & YING-REN ZHAO. (2014) Serum IL-21 levels associated with chronic hepatitis B and hepatitis B-related liver failure. Experimental and Therapeutic Medicine 7:4, pages 1013-1019.
Crossref
Crossref
Suresh Pallikkuth & Savita Pahwa. (2013) Interleukin-21 and T follicular helper cells in HIV infection: research focus and future perspectives. Immunologic Research 57:1-3, pages 279-291.
Crossref
Crossref
Liang Wu, Barbro Ehlin‐Henriksson, Hong Zhu, Ingemar Ernberg & George Klein. (2013) EBV counteracts IL‐21‐induced apoptosis in an EBV‐positive diffuse large B‐cell lymphoma cell line. International Journal of Cancer 133:3, pages 766-770.
Crossref
Crossref
Suresh Pallikkuth, Luca Micci, Zachary S. Ende, Robin I. Iriele, Barbara Cervasi, Benton Lawson, Colleen S. McGary, Kenneth A. Rogers, James G. Else, Guido Silvestri, Kirk Easley, Jacob D. Estes, Francois Villinger, Savita Pahwa & Mirko Paiardini. (2013) Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21. PLoS Pathogens 9:7, pages e1003471.
Crossref
Crossref
Zhian Chen, Yanfang Cui, Yew Ann Leong, Travis Beddoe & Di Yu. (2013) Efficient production of recombinant IL-21 proteins for pre-clinical studies by a two-step dilution refolding method. International Immunopharmacology 16:3, pages 376-381.
Crossref
Crossref
Massimiliano Sarra, Francesco Pallone & Giovanni Monteleone. (2013) Interleukin-21 in chronic inflammatory diseases. BioFactors 39:4, pages 368-373.
Crossref
Crossref
Cecile M. Krejsa, Rick D. Holly, Mark Heipel, Ken M. Bannink, Rebecca Johnson, Richard Roque, Jane Heffernan, Julie Hill, Lay Chin, Felecia Wagener, Faith Shiota, Katherine Henderson, Pallavur V. Sivakumar, Hong-Ping Ren, Fariba Barahmand-pour, Don Foster, Chris Clegg, Wayne Kindsvogel, Rafael Ponce, Steven D. Hughes & Kim Waggie. (2013) Interleukin-21 Enhances Rituximab Activity in a Cynomolgus Monkey Model of B Cell Depletion and in Mouse B Cell Lymphoma Models. PLoS ONE 8:6, pages e67256.
Crossref
Crossref
Aysefa Doganci, Julia Birkholz, Stephan Gehring, Alexander G. Puhl, Fred Zepp & Claudius U. Meyer. (2013)
In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing T
h
1 but not T
h
17 or T
h
2 cells.
. International Immunology 25:3, pages 157-169.
Crossref
Crossref
XIU-CHENG PAN, LI LI, JUAN-JUAN MAO, WEI YAO, JUN-NIAN ZHENG, MEI LIU & JUAN-JUAN FU. (2013) Synergistic effects of soluble PD-1 and IL-21 on antitumor immunity against H22 murine hepatocellular carcinoma. Oncology Letters 5:1, pages 90-96.
Crossref
Crossref
Luca MicciBarbara CervasiZachary S. EndeRobin I. IrieleElane Reyes-AvilesCarol VintonJames ElseGuido SilvestriAftab A. AnsariFrancois VillingerSavita Pahwa, Jacob D. Estes, Jason M. BrenchleyMirko Paiardini. (2012) Paucity of IL-21–producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques. Blood 120:19, pages 3925-3935.
Crossref
Crossref
Teresa M. PetrellaRichard TozerKarl BelangerKerry J. SavageRalph WongMichael SmylieSuzanne Kamel-ReidVictor TronBingshu E. ChenNaomi N. HunderLinda HagermanWendy WalshElizabeth A. Eisenhauer. (2012) Interleukin-21 Has Activity in Patients With Metastatic Melanoma: A Phase II Study. Journal of Clinical Oncology 30:27, pages 3396-3401.
Crossref
Crossref
Suresh Pallikkuth, Anita Parmigiani & Savita Pahwa. (2012) The role of interleukin-21 in HIV infection. Cytokine & Growth Factor Reviews 23:4-5, pages 173-180.
Crossref
Crossref
Ole J. Hamming, Lishan Kang, Anders Svensson, Jesper L. Karlsen, Henrik Rahbek-Nielsen, Søren R. Paludan, Siv A. Hjorth, Kent Bondensgaard & Rune Hartmann. (2012) Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R. Journal of Biological Chemistry 287:12, pages 9454-9460.
Crossref
Crossref
Christopher R. Zito & Harriet M. Kluger. (2012) Immunotherapy for metastatic melanoma. Journal of Cellular Biochemistry 113:3, pages 725-734.
Crossref
Crossref
Michael Campoli, Scott Freeman, David G. Brodland & John Zitelli. 2012. Mohs Micrographic Surgery. Mohs Micrographic Surgery
211
223
.
Yongju Tian, Cunzhong Yuan, Daoxin Ma, Yan Zhang, Yi Liu, Wenjing Zhang, Fei Hou & Baoxia Cui. (2011)
IL-21 and IL-12 Inhibit Differentiation of Treg and T
H
17 Cells and Enhance Cytotoxicity of Peripheral Blood Mononuclear Cells in Patients With Cervical Cancer
. International Journal of Gynecologic Cancer 21:9, pages 1672-1678.
Crossref
Crossref
Moran Elishmereni, Yuri Kheifetz, Henrik Søndergaard, Rune Viig Overgaard & Zvia Agur. (2011) An Integrated Disease/Pharmacokinetic/Pharmacodynamic Model Suggests Improved Interleukin-21 Regimens Validated Prospectively for Mouse Solid Cancers. PLoS Computational Biology 7:9, pages e1002206.
Crossref
Crossref
. (2011) Current World Literature. Current Opinion in Supportive & Palliative Care 5:3, pages 297-305.
Crossref
Crossref
Harjeet Singh, Matthew J. Figliola, Margaret J. Dawson, Helen Huls, Simon Olivares, Kirsten Switzer, Tiejuan Mi, Sourindra Maiti, Partow Kebriaei, Dean A. Lee, Richard E. Champlin & Laurence J.N. Cooper. (2011) Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies. Cancer Research 71:10, pages 3516-3527.
Crossref
Crossref
Courtney Nicholas & Gregory B Lesinski. (2011) Immunomodulatory cytokines as therapeutic agents for melanoma. Immunotherapy 3:5, pages 673-690.
Crossref
Crossref
Sofie C Van Huffel, Jill M Tham, XiaoQian Zhang, KohPang Lim, ChunXuan Yang, YikLoo Tan, Felicia Ong, Ian Lee & WanJin Hong. (2011) Systematic analysis of secreted proteins reveals synergism between IL6 and other proteins in soft agar growth of MCF10A cells. Cell & Bioscience 1:1.
Crossref
Crossref
Antonio Costanzo, Maria Sole Chimenti, Elisabetta Botti, Roberta Caruso, Massimiliano Sarra & Giovanni Monteleone. (2010) IL-21 in the pathogenesis and treatment of skin diseases. Journal of Dermatological Science 60:2, pages 61-66.
Crossref
Crossref