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Targeting methionine auxotrophy in cancer: discovery & exploration

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Pages 53-61 | Published online: 05 Nov 2011

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Isabelle R. Miousse, Kristy R. Kutanzi & Igor Koturbash. (2017) Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications. International Journal of Radiation Biology 93:5, pages 457-469.
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Rindert Missiaen, Nicole M. Anderson, Laura C. Kim, Bailey Nance, Michelle Burrows, Nicolas Skuli, Madeleine Carens, Romain Riscal, An Steensels, Fuming Li & M. Celeste Simon. (2022) GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment. Cell Metabolism 34:8, pages 1151-1167.e7.
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Andrey A. Parkhitko, Lin Wang, Elizabeth FilinePatrick JouandinDmitry LeshchinerRichard BinariJohn M. Asara, Joshua D. RabinowitzNorbert Perrimon. (2021) A genetic model of methionine restriction extends Drosophila health- and lifespan . Proceedings of the National Academy of Sciences 118:40.
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Robert Fried, Richard M. Carlton & Dennis A. Fried. 2021. Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression. Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression 25 111 .
Nisreen Wahwah, Debanjan Dhar, Hui Chen, Shunhui Zhuang, Adriano Chan, Darren E. Casteel, Hema Kalyanaraman, Renate B. Pilz & Gerry R. Boss. (2020) Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity. Scientific Reports 10:1.
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Nai-Yun Sun & Muh-Hwa Yang. (2020) Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy. Frontiers in Oncology 10.
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David A. Bader & Sean E. McGuire. (2020) Tumour metabolism and its unique properties in prostate adenocarcinoma. Nature Reviews Urology 17:4, pages 214-231.
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Andrey A. Parkhitko, Patrick Jouandin, Stephanie E. Mohr & Norbert Perrimon. (2019) Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species. Aging Cell 18:6.
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Sydney M. Sanderson, Xia Gao, Ziwei Dai & Jason W. Locasale. (2019) Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nature Reviews Cancer 19:11, pages 625-637.
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Songyun Zou, Xiangmei Wang, Po Liu, Changneng Ke & Shi Xu. (2019) Arginine metabolism and deprivation in cancer therapy. Biomedicine & Pharmacotherapy 118, pages 109210.
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Mahdis Zolfaghar, Mohammad Ali Amoozegar, Khosro Khajeh, Hamid Babavalian & Hamid Tebyanian. (2019) Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran. Molecular Biology Reports 46:3, pages 3275-3286.
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Isabelle R Miousse, Julia Tobacyk, Charles M Quick, Azemat Jamshidi-Parsian, Charles M Skinner, Rajshekhar Kore, Stepan B Melnyk, Kristy R Kutanzi, Fen Xia, Robert J Griffin & Igor Koturbash. (2018) Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors. Carcinogenesis 39:9, pages 1117-1126.
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Isabelle R. Miousse, Julia Tobacyk, Stepan Melnyk, S. Jill James, Amrita K. Cheema, Marjan Boerma, Martin Hauer-Jensen & Igor Koturbash. (2017) One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomolecular Concepts 8:2, pages 83-92.
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Friederike Manig, Konstantin Kuhne, Cläre von Neubeck, Uwe Schwarzenbolz, Zhanru Yu, Benedikt M. Kessler, Jens Pietzsch & Leoni A. Kunz-Schughart. (2017) The why and how of amino acid analytics in cancer diagnostics and therapy. Journal of Biotechnology 242, pages 30-54.
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M D Patil, J Bhaumik, S Babykutty, U C Banerjee & D Fukumura. (2016) Arginine dependence of tumor cells: targeting a chink in cancer’s armor. Oncogene 35:38, pages 4957-4972.
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Yaroslav Bobak, Yuliya Kurlishchuk, Bozhena Vynnytska-Myronovska, Olesia Grydzuk, Galyna Shuvayeva, Maria J. Redowicz, Leoni A. Kunz-Schughart & Oleh Stasyk. (2016) Arginine deprivation induces endoplasmic reticulum stress in human solid cancer cells. The International Journal of Biochemistry & Cell Biology 70, pages 29-38.
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C von Neubeck, A Seidlitz, H H Kitzler, B Beuthien-Baumann & M Krause. (2015) Glioblastoma multiforme: emerging treatments and stratification markers beyond new drugs. The British Journal of Radiology 88:1053, pages 20150354.
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Paul A. Dutchak, Sunil Laxman, Sandi Jo Estill, Chensu Wang, Yun Wang, Yiguang Wang, Gamze B. Bulut, Jinming Gao, Lily J. Huang & Benjamin P. Tu. (2015) Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Reports 12:3, pages 371-379.
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Iuliia Pavlyk, Yuriy Rzhepetskyy, Adam K. Jagielski, Jakub Drozak, Anna Wasik, Galyna Pereverzieva, Marta Olchowik, Leoni A. Kunz-Schugart, Oleh Stasyk & Maria Jolanta Redowicz. (2014) Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of ?-actin arginylation. Amino Acids 47:1, pages 199-212.
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Isolde Summerer, Maximilian Niyazi, Kristian Unger, Adriana Pitea, Verena Zangen, Julia Hess, Michael J Atkinson, Claus Belka, Simone Moertl & Horst Zitzelsberger. (2013) Changes in circulating microRNAs after radiochemotherapy in head and neck cancer patients. Radiation Oncology 8:1.
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Bozhena Vynnytska-Myronovska, Yuliya Kurlishchuk, Yaroslav Bobak, Claudia Dittfeld, Leoni A. Kunz-Schughart & Oleh Stasyk. (2013) Three-dimensional environment renders cancer cells profoundly less susceptible to a single amino acid starvation. Amino Acids 45:5, pages 1221-1230.
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L.A. Kunz-Schughart, W. Mueller-Klieser & P. Vaupel. (2012) TumorpathophysiologieTumor pathophysiology. Strahlentherapie und Onkologie 188:S3, pages 299-303.
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