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Targeting methionine auxotrophy in cancer: discovery & exploration

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Pages 53-61 | Published online: 05 Nov 2011

Bibliography

  • Kroemer G, Pouyssegur J. Tumor cell metabolism: Cancer's Achilles' Heel. Cancer Cell 2008;13:472-82
  • Deberardinis RJ, Sayed N, Ditsworth D, Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 2008;18:54-61
  • Dinndorf PA, Gootenberg J, Cohen MH, FDA drug approval summary: Pegaspargase (Oncaspar) for the first-line treatment of children with acute lymphoblastic leukemia (ALL). Oncologist 2007;12:991-8
  • Taylor CW, Dorr RT, Fanta P, A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumor. Cancer Chemother Pharmacol 2001;47:83-8
  • Glazer ES, Piccirillo M, Albino V, Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma. J Clin Oncol 2010;28:2220-6
  • Thivat E, Farges MC, Bacin F, Phase II trial of the association of a methionine-free diet with cystemustine therapy in melanoma and glioma. Anticancer Res 2009;29:5235-40
  • Halpern BC, Clark BR, Hardy DN, The effect of replacement of methionine by homocysteine on survival of malignant and normal adult mammalian cells in culture. PNAS 1974;71:1133-6
  • Wilson MJ, Poirier LA. An increased requirement for methionine by transformed rat liver epithelial cells in vitro. Exp Cell Res 1978;11:397-400
  • Kreis W, Goodenow M. Methionine requirement and replacement by homocysteine in tissue cultures of selected rodent and human malignant and normal cells. Cancer Res 1978;38:2259-62
  • Hoffman RM, Erbe RW. High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotropic for methionine. PNAS 1976;73:1523-7
  • Tautt JW, Anuszewska EL, Koziorowska JH. Methionine regulation of N-5-methyltetrahydrfolate: homocysteine methyltransferase and its influence on the growth and protein synthesis in normal, neoplastic, and transformed cells in culture. JNCI 1982;69:9-14
  • Ashe H, Clark BR, Chu F, N5-Methyltetrahydrofolate: homocysteine methyltransferase activity in extracts from normal, malignant and embryonic tissue culture cells. Biochem Biophys Res Commun 1974;57:417-25
  • Jacobsen SJ, North JA, Rao NA, 5-Methyltetradrofolate: synthesis and utilization in normal and SV40-transformed BHK-21 cells. Biochem Biophys Res Commun 1977;76:46-52
  • Kamely D, Littlefield JW, Erbe RW. Regulation of 5-methytetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells. PNAS 1973;70:2585-9
  • Mecham JO, Rowitch D, Wallace D, The metabolic defect of methionine dependence occurs frequently in human tumor cell lines. Biochem Biophys Res Commun 1983;117:429-34
  • Hoffman RM, Jacobsen SJ, Erbe RW. Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation. PNAS 1979;76:1313-17
  • Hoffman RM, Jacobsen SJ, Erbe RW. Reversion to methionine independence by malignant rat and SV40-transformed human fibroblasts. Biochem Biophys Res Commun 1978;82:228-34
  • Fiskerstrand T, Christensen B, Tysnes OB, Development and reversion of methionione dependency in a human glioma cell line: Relation to homocysteine remethylation and cobalamin status. Cancer Res 1994;54:4899-906
  • Tang B, Mustafa A, Gupta S, Methionine deficient diet induces post-transcriptional downregulation of cystathionine beta-synthase. Nutrition 2010;26:1170-5
  • Pena MM, Melo SP, Xing YY, The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway. J Bio Chem 2009;284:597-607
  • Joseph B, Jeschke G, Goetz BA, Transmembrane gate movements in the type 2 ABC importer BTUCD-F during nucloetide cycle. JBC 2011; published online 27 September 2011; doi: 10.1074/jbc.M111.269472
  • Breillout F, Hadida F, Echinard-Garin P, Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet. Anticancer Res 1987;7(4B):861-7
  • Goseki N, Endo M, Onodera T, Influence of l-methionine-deprived total parenteral nutrition on the tumor tissue and plasma amino acids fraction and the host metabolism: experimental study with sato lung carcinoma-brearing rats. J Exp Med 1989;157:251-60
  • Epner DE, Morrow S, Wilcox M, Nutrition intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction. Nutr Cancer 2002;42:158-66
  • Stern PH, Hoffman RM. Enhanced in vitro selective toxicity of chemotherapeutic agents for human cancer cells based on a metabolic defect. J Natl Cancer Inst 1986;76:629-39
  • Hoshiya Y, Kubota T, Matsuzaki SW, Methionine starvation modulates the efficacy of cisplatin on human breast cancer in nude mice. Anticancer Res 1996;16(6B):3515-18
  • Goseki N, Yamazaki S, Shimojyu K, Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial. Jpn J Cancer Res 1995;86:484-9
  • Durando X, Thivat E, Farges MC, Optimal Methionine-free diet duration for nutrourea treatment: a phase I clinical trial. Nutr Cancer 2011;60:23-30
  • Thivat E, Durando X, Demidem A, A methionine-free diet associated with nitrosourea treatment down-regulates methylguanine-DNA methyl transferase activity in patients with metastatic cancer. Anticancer Res 2007;27(4C):2779-84
  • Tan Y, Xu M, Tan X, Overexpression and large-scale production of recombinant l-methionine-a-deamino-y-mercaptomethane-lyase for novel anticancer therapy. Protein Expr Purif 1997;9:233-45
  • Tan Y, Xu M, Hoffman RM. Broad selective efficacy of rMetase and PEG-rMetase on cancer cells in vitro. Anticancer Res 2010;30:793-8
  • Hu J, Cheung NKV. Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs. Int J Cancer 2010;124:1700-6
  • Alfano RW, Leppla SH, Liu S, Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formatin during in vitro morphogenesis. Mol Cancer Res 2009;7:452-61
  • Tan Y, Xinghua S, Mingxu X, Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice. Clin Cancer Res 1999;5:2157-63
  • Yang Z, Wang J, Yoskioka T, Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates. Clin Cancer Res 2004;10:2131-8
  • Tan Y, Zavala J, Han Q, Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high stage cancer patients. Anticancer Res 1997;17(5B):3857-60
  • Tan Y, Zavala J, Xu M, Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients. Anticancer Res 1996;16(6C):3937-42
  • Tan Y, Xinghua S, Mingxu X, Polyethylene glycol conjugation of recombinant methioninase for cancer therapy. Protein Expr Purif 1998;12:45-52
  • Yang Z, Wang J, Quan L, PEGylation confers greately extended half-life and attenuated immunogenicity to recombinant methioninase in primates. Cancer Res 2004;64(18):6673-8
  • Cantor JR, Yoo TH, Dixit A, Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. PNAS 2011;108:1272-7
  • Alpar HO, Lewis DA. Therapeutic efficacy of asparaginase encapsulated in intact erythrocytes. Biochem Pharmacol 1985;34:257-61
  • Ataullakhanov FI, Vitvitskii VM, Zhabotinskii AM, Permeability of human erythrocytes to asparagine. Biokhimiia 1986;50:1733-7
  • Agrawal V, Woo JH, Borthakur G, Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia. Protein Pept Lett 2011; In press
  • Domenech C, Thomas X, Chabaud S, L-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial. Br J Haematol 2011;153:58-65
  • Borek E, Srinivasan PR. The methylation of nucleic acids. Annu Rev Biochem 1966;35:275-98
  • Graham ML. Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev 2003;55:1293-302
  • Glazer ES, Piccirillo M, Albino V, Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma. J Clin Oncol 2010;28:2220-6
  • Ensor CM, Holtsberg FW, Bomalaski JS, Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Cancer Res 2007;62:5443-50
  • Rytting M. Peg-asparaginase for acute lymphoblastic leukemia. Expert Opin Biol Ther 2010;10:833-9
  • Capizzi RL, Bertino JR, Skeel RT, L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. Ann Intern Med 1971;74:893-901
  • Clarkson B, Krakoff I, Burchenal J, Clinical results of treatment with E. coli l-asparaginase in adults with leukemia, lymphoma, and solid tumors. Cancer 1969;25:279-301
  • Ascierto PA, Scala S, Castello G, Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies. J Clin Oncol 2005;23:7660-8

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