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Drug Evaluations

Benralizumab – a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity – a novel approach for the treatment of asthma

, MD, , MD & , MD
Pages 113-118 | Published online: 05 Dec 2011

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Tommy Tsang Cheung, Tu H Mai, Yen Lin Chia, Desmond YH Yap, Chi-Ho Lee, Cecil Chi-Keung Chen, Ying Huang, Yuwen Jin, James Johnston, Viktoria Werkström, Yuhui Yao, Xiaoyun Ge & Wenying Zheng. (2023) Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants. Drug Design, Development and Therapy 17, pages 209-218.
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Justin C Morse, Craig Miller & Brent Senior. (2021) Management of Chronic Rhinosinusitis with Nasal Polyposis in the Era of Biologics. Journal of Asthma and Allergy 14, pages 873-882.
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Nora Drick, Katrin Milger, Benjamin Seeliger, Jan Fuge, Stephanie Korn, Roland Buhl, Maren Schuhmann, Felix Herth, Benjamin Kendziora, Juergen Behr, Nikolaus Kneidinger, Karl-Christian Bergmann, Christian Taube, Tobias Welte & Hendrik Suhling. (2020) Switch from IL-5 to IL-5-Receptor α Antibody Treatment in Severe Eosinophilic Asthma. Journal of Asthma and Allergy 13, pages 605-614.
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Amelia Licari, Riccardo Castagnoli, Maria De Filippo, Thomas Foiadelli, Maria Angela Tosca, Gian Luigi Marseglia & Giorgio Ciprandi. (2020) Current and emerging biologic therapies for allergic rhinitis and chronic rhinosinusitis. Expert Opinion on Biological Therapy 20:6, pages 609-619.
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Marco Caminati, Diego Bagnasco, Rachele Vaia & Gianenrico Senna. (2019) New horizons for the treatment of severe, eosinophilic asthma: benralizumab, a novel precision biologic. Biologics: Targets and Therapy 13, pages 89-95.
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Francesco Menzella, Manuela Latorre, Patrizia Ruggiero, Diego Bagnasco & Enrico Heffler. (2019) Reduction of oral corticosteroids in patients with severe eosinophilic asthma treated with Benralizumab: could it represent a marker of treatment efficacy?. Expert Opinion on Biological Therapy 19:7, pages 601-606.
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Diego Bagnasco, Enrico Heffler, Elisa Testino, Giovanni Passalacqua & Giorgio Walter Canonica. (2019) Pharmacokinetics and pharmacodynamics of monoclonal antibodies for asthma treatment. Expert Opinion on Drug Metabolism & Toxicology 15:2, pages 113-120.
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Corrado Pelaia, Alessandro Vatrella, Andrea Bruni, Rosa Terracciano & Girolamo Pelaia. (2018) Benralizumab in the treatment of severe asthma: design, development and potential place in therapy. Drug Design, Development and Therapy 12, pages 619-628.
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Garry M. Walsh. (2018) Recent developments in the use of biologics targeting IL-5, IL-4, or IL-13 in severe refractory asthma. Expert Review of Respiratory Medicine 12:11, pages 957-963.
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Bao-ping Tian, Gen-sheng Zhang, Jian Lou, Hong-bin Zhou & Wei Cui. (2018) Efficacy and safety of benralizumab for eosinophilic asthma: A systematic review and meta-analysis of randomized controlled trials. Journal of Asthma 55:9, pages 956-965.
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Daniel Colodenco, Oscar Palomares, Carlos Celis, Alan Kaplan & Christian Domingo. (2018) Moving toward consensus on diagnosis and management of severe asthma in adults. Current Medical Research and Opinion 34:3, pages 387-399.
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Francesco Menzella, Carla Galeone, Francesca Bertolini, Claudia Castagnetti & Nicola Facciolongo. (2017) Innovative treatments for severe refractory asthma: how to choose the right option for the right patient?. Journal of Asthma and Allergy 10, pages 237-247.
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Maria Gabriella Matera, Luigino Calzetta, Barbara Rinaldi & Mario Cazzola. (2017) Pharmacokinetic/pharmacodynamic drug evaluation of benralizumab for the treatment of asthma. Expert Opinion on Drug Metabolism & Toxicology 13:9, pages 1007-1013.
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Sabina Antonela Antoniu. (2017) Benralizumab as a potential treatment of asthma. Expert Opinion on Biological Therapy 17:7, pages 895-900.
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Tara Vinyette Saco, Amber N. Pepper & Richard F. Lockey. (2017) Benralizumab for the treatment of asthma. Expert Review of Clinical Immunology 13:5, pages 405-413.
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Garry M. Walsh. (2017) Biologics targeting IL-5, IL-4 or IL-13 for the treatment of asthma – an update. Expert Review of Clinical Immunology 13:2, pages 143-149.
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Francesco Menzella, Mirco Lusuardi, Gloria Montanari, Carla Galeone, Nicola Facciolongo & Luigi Zucchi. (2016) Clinical usefulness of mepolizumab in severe eosinophilic asthma. Therapeutics and Clinical Risk Management 12, pages 907-916.
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Laren D Tan, Jennifer M Bratt, Dorottya Godor, Samuel Louie & Nicholas J Kenyon. (2016) Benralizumab: a unique IL-5 inhibitor for severe asthma. Journal of Asthma and Allergy 9, pages 71-81.
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Con Panousis, Urmi Dhagat, Kirsten M. Edwards, Veronika Rayzman, Matthew P. Hardy, Hal Braley, Gail M. Gauvreau, Timothy R. Hercus, Steven Smith, Roma Sehmi, Laura McMillan, Mara Dottore, Barbara J. McClure, Louis J. Fabri, Gino Vairo, Angel F Lopez, Michael W. Parker, Andrew D. Nash, Nicholas J. Wilson, Michael J. Wilson & Catherine M. Owczarek. (2016) CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors. mAbs 8:3, pages 436-453.
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Megan F Patterson, Larry Borish & Joshua L Kennedy. (2015) The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review. Journal of Asthma and Allergy 8, pages 125-134.
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Juan Carlos Cardet & Elliot Israel. (2015) Update on reslizumab for eosinophilic asthma. Expert Opinion on Biological Therapy 15:10, pages 1531-1539.
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Philip M Hansbro, Grace V Scott, Ama-Tawiah Essilfie, Richard Y Kim, Malcolm R Starkey, Duc H Nguyen, Paul D Allen, Gerard E Kaiko, Ming Yang, Jay C Horvat & Paul S Foster. (2013) Th2 cytokine antagonists: potential treatments for severe asthma. Expert Opinion on Investigational Drugs 22:1, pages 49-69.
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Nestor A Molfino. (2012) Targeting of eosinophils in asthma. Expert Opinion on Biological Therapy 12:7, pages 807-809.
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