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Proliferative human cell sources applied as biocomponent in bioartificial livers: a review

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Pages 905-921 | Published online: 31 May 2012

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Jian Jiang, Jarno EJ Wolters, Simone G van Breda, Jos C Kleinjans & Theo M de Kok. (2015) Development of novel tools for the in vitro investigation of drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 11:10, pages 1523-1537.
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Martien van Wenum, Robert AFM Chamuleau, Thomas M van Gulik, Adriaan Siliakus, Jurgen Seppen & Ruurdtje Hoekstra. (2014) Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications. Expert Opinion on Biological Therapy 14:12, pages 1745-1760.
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Yuichiro Higuchi, Kenji Kawai, Hiroshi Yamazaki, Masato Nakamura, Françoise Bree, Christiane Guguen-Guillouzo & Hiroshi Suemizu. (2014) The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice. Xenobiotica 44:2, pages 146-153.
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Articles from other publishers (31)

Melissa Anne Tutty, Dania Movia & Adriele Prina-Mello. (2022) Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials. Drug Delivery and Translational Research 12:9, pages 2048-2074.
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Kahaer Tuerxun, Jianyu He, Irxat Ibrahim, Zainuer Yusupu, Abudoukeyimu Yasheng, Qilin Xu, Ronghua Tang, Aizemati Aikebaier, Yuanquan Wu, Maimaitituerxun Tuerdi, Mayidili Nijiati, Xiaoguang Zou & Tao Xu. (2022) Bioartificial livers: a review of their design and manufacture. Biofabrication 14:3, pages 032003.
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Matheus Felipe da Silva, Luan Vitor Alves de Lima, Thalita Alves Zanetti, Ingrid Felicidade, Phelipe Oliveira Favaron, Sandra Regina Lepri, Débora Berbel Lirio Rondina & Mário Sérgio Mantovani. (2022) Diosgenin increases BBC3 expression in HepG2/C3A cells and alters cell communication in a 3D spheroid model. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 879-880, pages 503512.
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Megan J. Reiniers, Lianne R. de Haan, Laurens F. Reeskamp, Mans Broekgaarden, Ruurdtje Hoekstra, Rowan F. van Golen & Michal Heger. 2022. Photodynamic Therapy. Photodynamic Therapy 721 747 .
Krzysztof Dariusz Pluta, Malgorzata Ciezkowska, Monika Wisniewska, Agnieszka Wencel & Dorota Genowefa Pijanowska. (2021) Cell-based clinical and experimental methods for assisting the function of impaired livers – Present and future of liver support systems. Biocybernetics and Biomedical Engineering 41:4, pages 1322-1346.
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Eléanor Luce, Antonietta Messina, Jean‐Charles Duclos‐Vallée & Anne Dubart‐Kupperschmitt. (2021) Advanced Techniques and Awaited Clinical Applications for Human Pluripotent Stem Cell Differentiation into Hepatocytes. Hepatology 74:2, pages 1101-1116.
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Megan J. Reiniers, Lianne R. de Haan, Laurens F. Reeskamp, Mans Broekgaarden, Rowan F. van Golen & Michal Heger. (2021) Analysis and Optimization of Conditions for the Use of 2′,7′-Dichlorofluorescein Diacetate in Cultured Hepatocytes. Antioxidants 10:5, pages 674.
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Martina Štampar, Helle Sedighi Frandsen, Adelina Rogowska-Wrzesinska, Krzysztof Wrzesinski, Metka Filipič & Bojana Žegura. (2021) Hepatocellular carcinoma (HepG2/C3A) cell-based 3D model for genotoxicity testing of chemicals. Science of The Total Environment 755, pages 143255.
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Vincent A. van der Mark, Aziza A.A. Adam, Jung-Chin Chang, Ronald P. Oude Elferink, Robert A.F.M. Chamuleau & Ruurdtje Hoekstra. (2020) Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells. Toxicology and Applied Pharmacology 399, pages 115055.
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Zu-Hong Li, Zhong-Yang Xie, Xiao-Xi Ouyang, Kai-Zhou Huang, Xiao-Peng Yu, Ya-Lei Zhao, Yan-Hong Zhang, Dan-Hua Zhu, Jiong Yu & Lan-Juan Li. (2020) Assessment of biological functions for C3A cells interacting with adverse environments of liver failure plasma. Hepatobiliary & Pancreatic Diseases International 19:2, pages 129-137.
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Charlotte J. Green, Siôn A. Parry, Pippa J. Gunn, Carlo D.L. Ceresa, Fredrik Rosqvist, Marie-Eve Piché & Leanne Hodson. (2020) Studying non-alcoholic fatty liver disease: the ins and outs of in vivo, ex vivo and in vitro human models. Hormone Molecular Biology and Clinical Investigation 41:1.
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Badr Ibrahim, Jan Stange, Adrian Dominik, Martin Sauer, Sandra Doss & Martin Eggert. (2020) Albumin promotes proliferation of G1 arrested serum starved hepatocellular carcinoma cells. PeerJ 8, pages e8568.
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Krzysztof Dariusz Pluta, Anna Samluk, Agnieszka Wencel, Karolina Ewa Zakrzewska, Monika Gora, Beata Burzynska, Malgorzata Ciezkowska, Joanna Motyl & Dorota Genowefa Pijanowska. (2020) Genetically modified C3A cells with restored urea cycle for improved bioartificial liver. Biocybernetics and Biomedical Engineering 40:1, pages 378-387.
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Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene & Beatriz Martínez-Delgado. (2019) Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease. Hepatology International 14:1, pages 127-137.
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Muhammad Nadeem Ashraf, Muhammad Waheed Asghar, Yan Rong, Michael R. Doschak & Tony K. L. Kiang. (2018) Advanced In Vitro HepaRG Culture Systems for Xenobiotic Metabolism and Toxicity Characterization. European Journal of Drug Metabolism and Pharmacokinetics 44:4, pages 437-458.
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Thomas Hiller, Johanna Berg, Laura Elomaa, Viola Röhrs, Imran Ullah, Katrin Schaar, Ann-Christin Dietrich, Munir Al-Zeer, Andreas Kurtz, Andreas Hocke, Stefan Hippenstiel, Henry Fechner, Marie Weinhart & Jens Kurreck. (2018) Generation of a 3D Liver Model Comprising Human Extracellular Matrix in an Alginate/Gelatin-Based Bioink by Extrusion Bioprinting for Infection and Transduction Studies. International Journal of Molecular Sciences 19:10, pages 3129.
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Shu‑Yu Fang, Chao‑Qun Hu, Meng‑Nan Liu, Li Tao, Yi Wang, Meng‑Jia Gong, Yun He, Tong‑Chuan He & Yang Bi. (2018) Reversibly immortalized hepatic progenitor cell line containing double suicide genes. International Journal of Molecular Medicine.
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Viktoriia Starokozhko, Mette Hemmingsen, Layla Larsen, Soumyaranjan Mohanty, Marjolijn Merema, Rodrigo C. Pimentel, Anders Wolff, Jenny Emnéus, Anders Aspegren, Geny Groothuis & Martin Dufva. (2018) Differentiation of human-induced pluripotent stem cell under flow conditions to mature hepatocytes for liver tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 12:5, pages 1273-1284.
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Aziza A. A. Adam, Vincent A. van der Mark, Joanne M. Donkers, Manon E. Wildenberg, Ronald P. J. Oude Elferink, Robert A. F. M. Chamuleau & Ruurdtje Hoekstra. (2018) A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines. PLOS ONE 13:4, pages e0193664.
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Aziza A.A. Adam, Martien van Wenum, Vincent A. van der Mark, Aldo Jongejan, Perry D. Moerland, Riekelt H. Houtkooper, Ronald J.A. Wanders, Ronald P. Oude Elferink, Robert A.F.M. Chamuleau & Ruurdtje Hoekstra. (2018) AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration. Mitochondrion 39, pages 30-42.
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Viktoriia Starokozhko & Geny M.M. Groothuis. (2018) Challenges on the road to a multicellular bioartificial liver. Journal of Tissue Engineering and Regenerative Medicine 12:1, pages e227-e236.
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Christopher J. Hindley, Lucía Cordero-Espinoza & Meritxell Huch. (2016) Organoids from adult liver and pancreas: Stem cell biology and biomedical utility. Developmental Biology 420:2, pages 251-261.
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Zara Hannoun, Clara Steichen, Noushin Dianat, Anne Weber & Anne Dubart-Kupperschmitt. (2016) The potential of induced pluripotent stem cell derived hepatocytes. Journal of Hepatology 65:1, pages 182-199.
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Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams & Steven D. Webb. (2016) Characterization of a functional C3A liver spheroid model. Toxicology Research 5:4, pages 1053-1065.
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Takashi Hoshiba, Takayuki Otaki, Eri Nemoto, Hiroka Maruyama & Masaru Tanaka. (2015) Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development. ACS Applied Materials & Interfaces 7:32, pages 18096-18103.
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Charlotte J. Green, Camilla Pramfalk, Karl J. Morten & Leanne Hodson. (2015) From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations. American Journal of Physiology-Endocrinology and Metabolism 308:1, pages E1-E20.
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Angeles Baquerizo, Rafael Bañares & Faouzi Saliba. 2015. Transplantation of the Liver. Transplantation of the Liver 1463 1487 .
Eva Ramboer, Bram De Craene, Joery De Kock, Tamara Vanhaecke, Geert Berx, Vera Rogiers & Mathieu Vinken. (2014) Strategies for immortalization of primary hepatocytes. Journal of Hepatology 61:4, pages 925-943.
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Dominic P Williams. (2014) Modeling hepatic drug metabolism and toxicity: where are we heading?. Future Medicinal Chemistry 6:7, pages 725-727.
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Clare Selden, Catherine Wendy Spearman, Delawir Kahn, Malcolm Miller, Anthony Figaji, Eloy Erro, James Bundy, Isobel Massie, Sherri-Ann Chalmers, Hiram Arendse, Aude Gautier, Peter Sharratt, Barry Fuller & Humphrey Hodgson. (2013) Evaluation of Encapsulated Liver Cell Spheroids in a Fluidised-Bed Bioartificial Liver for Treatment of Ischaemic Acute Liver Failure in Pigs in a Translational Setting. PLoS ONE 8:12, pages e82312.
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