2,134
Views
368
CrossRef citations to date
0
Altmetric
Reviews

Advances in the formation, use and understanding of multi-cellular spheroids

, BS, & , PhD
Pages 1347-1360 | Published online: 12 Jul 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Seda İpek, Aylin Üstündağ & Benay Can Eke. (2023) Three-dimensional (3D) cell culture studies: a review of the field of toxicology. Drug and Chemical Toxicology 46:3, pages 523-533.
Read now
Rahul S Rathore, Senthil R Ayyannan & Sanjeev K Mahto. (2022) Emerging three-dimensional neuronal culture assays for neurotherapeutics drug discovery. Expert Opinion on Drug Discovery 17:6, pages 619-628.
Read now
Blaise Calpe & Werner J. Kovacs. (2020) High-throughput screening in multicellular spheroids for target discovery in the tumor microenvironment. Expert Opinion on Drug Discovery 15:8, pages 955-967.
Read now
Yusaku Inubushi, Yoshiki Sakaguchi & Akira Tachibana. (2020) Uniform straw-like cell architecture for three-dimensional cell–cell communication assay. Bioscience, Biotechnology, and Biochemistry 84:8, pages 1681-1684.
Read now
Regina-Veronicka Kalaydina, Hedi Zhou, Elena Markvicheva, Sergey V Burov, Farhana Zulkernine & Myron R Szewczuk. (2019) Impact of Fucosylation on Self-Assembly of Prostate and Breast Tumor Spheroids by Using Cyclo-RGDfK(TPP) Peptide and Image Object Detection. OncoTargets and Therapy 12, pages 11153-11173.
Read now
Hongli Chen, Xiangjuan Wei, Hongyang Chen, Hongliang Wei, Yongxue Wang, Wenbin Nan, Qiqing Zhang & Xuejun Wen. (2019) The study of establishment of an in vivo tumor model by three-dimensional cells culture systems methods and evaluation of antitumor effect of biotin-conjugated pullulan acetate nanoparticles. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 123-131.
Read now
Carlemi Calitz, Josias H. Hamman, Stephen J. Fey, Krzysztof Wrzesinski & Chrisna Gouws. (2018) Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective. Toxicology Mechanisms and Methods 28:5, pages 369-385.
Read now
Timothy. R. Olsen, Brandon. Mattix, Megan. Casco, Austin. Herbst, Colby. Williams, Anna. Tarasidis, Grace. Evans, Linda. Jenkins, Chad. L. McMahan, Dan. Simionescu, Richard. P. Visconti & Frank. Alexis. (2014) Processing cellular spheroids for histological examination. Journal of Histotechnology 37:4, pages 138-142.
Read now
Lora Dyakova, Daniela-Cristina Culita, Gabriela Marinescu, Marin Alexandrov, Reni Kalfin, Luminita Patron & Radostina Alexandrova. (2014) Metal Zn(II), Cu(II), Ni (II) complexes of ursodeoxycholic acid as putative anticancer agents. Biotechnology & Biotechnological Equipment 28:3, pages 543-551.
Read now

Articles from other publishers (359)

Ricardo Martins-Santos, Gabriela S. Kronemberger, Leandra Santos Baptista, Russell S. Taichman, José Mauro Granjeiro & Maria Eugenia Leite Duarte. 2024. Resident Stem Cells and Regenerative Therapy. Resident Stem Cells and Regenerative Therapy 251 283 .
Leandra Santos Baptista. 2024. Resident Stem Cells and Regenerative Therapy. Resident Stem Cells and Regenerative Therapy 339 355 .
Leandra Santos BaptistaVladimir MironovElizaveta KoudanÉrica Almeida AmorimTathiana Proença PampolhaVladimir KasyanovAlexey KovalevFedor SenatovJosé Mauro Granjeiro. (2023) Bioprinting using organ building blocks: spheroids, organoids, and assembloids. Tissue Engineering Part A.
Crossref
Nathalia de Carvalho Indolfo, Melissa Dibbernn Ganzerla, Tábata Renée Doratioto, Thayná Mendonça Avelino, Larissa Bueno Tofani, Luis Antonio Peroni, Renata Santos Rabelo, Kelen Fabiola Arroteia & Ana Carolina Migliorini Figueira. (2023) Combining a microphysiological system of three organ equivalents and transcriptomics to assess toxicological endpoints for cosmetic ingredients. Lab on a Chip 23:24, pages 5092-5106.
Crossref
Diamante Boscaro & Pawel Sikorski. (2023) Spheroids as a 3D in vitro model to study bone and bone mineralization. Biomaterials Advances, pages 213727.
Crossref
Gabriela S. Kronemberger, Thiago Nunes Palhares, Alexandre Malta Rossi, Brunno R. F. Verçosa, Suelen C. Sartoretto, Rodrigo Resende, Marcelo J. Uzeda, Adriana T. N. N. Alves, Gutemberg G. Alves, Mônica D. Calasans-Maia, José Mauro Granjeiro & Leandra Santos Baptista. (2023) A Synergic Strategy: Adipose-Derived Stem Cell Spheroids Seeded on 3D-Printed PLA/CHA Scaffolds Implanted in a Bone Critical-Size Defect Model. Journal of Functional Biomaterials 14:12, pages 555.
Crossref
Negar Abbasi Aval, Ekeram Lahchaichi, Oana Tudoran, Farzaneh Fayazbakhsh, Rainer Heuchel, Matthias Löhr, Torbjörn Pettersson & Aman Russom. (2023) Assessing the Layer-by-Layer Assembly of Cellulose Nanofibrils and Polyelectrolytes in Pancreatic Tumor Spheroid Formation. Biomedicines 11:11, pages 3061.
Crossref
Ross Burdis, Xavier Barceló Gallostra & Daniel J. Kelly. (2023) Temporal Enzymatic Treatment to Enhance the Remodeling of Multiple Cartilage Microtissues into a Structurally Organized Tissue. Advanced Healthcare Materials.
Crossref
Michelle B. Chen, Yousef Javanmardi, Somayeh Shahreza, Bianca Serwinski, Amir Aref, Boris Djordjevic & Emad Moeendarbary. (2023) Mechanobiology in oncology: basic concepts and clinical prospects. Frontiers in Cell and Developmental Biology 11.
Crossref
Nattarika Niwetbowornchai, Thanawat Chaisirirat, Sira Sriswasdi, Supichcha Saithong, Grace Filbertine, Helen L. Wright, Steven W. Edwards, Sita Virakul & Direkrit Chiewchengchol. (2023) Regulation of dermal fibroblasts by human neutrophil peptides. Scientific Reports 13:1.
Crossref
Anna Senrung, Sakshi Lalwani, Divya Janjua, Tanya Tripathi, Jasleen Kaur, Netra Ghuratia, Nikita Aggarwal, Arun Chhokar, Joni Yadav, Apoorva Chaudhary, Udit Joshi & Alok Chandra Bharti. (2023) 3D tumor spheroids: morphological alterations a yardstick to anti-cancer drug response. In vitro models.
Crossref
Sayoni Maitra Roy, Purvi Kishore, Disha Saha, Priyanka Ghosh, Rishav Kar, Sourav Barman, Vishal Agrawal, Abhishek Roy, Ratnadip Deb, Shrestha Sherry Chakraborty, Pousali Bag, Partha Sona Maji, Arnab Basu, Tapas Ghatak, Rupam Mukherjee & Amit Ranjan Maity. (2023) 3D multicellular tumor spheroids used for in vitro preclinical therapeutic screening. Journal of Drug Delivery Science and Technology 86, pages 104636.
Crossref
Cristina Quílez, Leticia Valencia, Jorge González‐Rico, Leticia Suárez‐Cabrera, Lidia Amigo‐Morán, José Luis Jorcano & Diego Velasco. (2023) In vitro induction of hair follicle signatures using human dermal papilla cells encapsulated in fibrin microgels. Cell Proliferation.
Crossref
Alandi van Niekerk, Krzysztof Wrzesinski, Dewald Steyn & Chrisna Gouws. (2023) A Novel NCI-H69AR Drug-Resistant Small-Cell Lung Cancer Mini-Tumor Model for Anti-Cancer Treatment Screening. Cells 12:15, pages 1980.
Crossref
Ornella Urzì, Roberta Gasparro, Elisa Costanzo, Angela De Luca, Gianluca Giavaresi, Simona Fontana & Riccardo Alessandro. (2023) Three-Dimensional Cell Cultures: The Bridge between In Vitro and In Vivo Models. International Journal of Molecular Sciences 24:15, pages 12046.
Crossref
Diogo M. Engrácia, Catarina I. G. Pinto & Filipa Mendes. (2023) Cancer 3D Models for Metallodrug Preclinical Testing. International Journal of Molecular Sciences 24:15, pages 11915.
Crossref
Hongmei Liu, Ruili Wang, Yuxin Zhao, Hongyan Chen, Junjun Wang, Junhua Xiao, Xuefen Wang, Xiang Fei & Meifang Zhu. (2023) Interfacial-Crystallization-Constructed Fractal Nanofiber-Based Bio-Platforms Enable Highly Effective Culture of Three-Dimensional Stem Cell Spheroids. ACS Applied Materials & Interfaces 15:28, pages 33480-33490.
Crossref
Yunus Celik, Kadir Alptekin, S. Furkan Demirden & Suphi S. Oncel. (2023) A novel low shear horizontal bioreactor design for the production of animal cells: Effect of bioreactor dynamics on the 3D spheroid formation of HepG2. Biochemical Engineering Journal 196, pages 108952.
Crossref
Leandra S. Baptista, Karina R. Silva, Lara Jobeili, Lucile Guillot & Dominique Sigaudo-Roussel. (2023) Unraveling White Adipose Tissue Heterogeneity and Obesity by Adipose Stem/Stromal Cell Biology and 3D Culture Models. Cells 12:12, pages 1583.
Crossref
Eva Pasquier, Jennifer Rosendahl, Amalie Solberg, Anders Ståhlberg, Joakim Håkansson & Gary Chinga-Carrasco. (2023) Polysaccharides and Structural Proteins as Components in Three-Dimensional Scaffolds for Breast Cancer Tissue Models: A Review. Bioengineering 10:6, pages 682.
Crossref
Ola Habanjar, Anne-Catherine Maurin, Cyrielle Vituret, Caroline Vachias, Lucie Longechamp, Cécile Garnier, Caroline Decombat, Céline Bourgne, Mona Diab-Assaf, Florence Caldefie-Chezet & Laetitia Delort. (2023) A bicellular fluorescent ductal carcinoma in situ (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization . Biomaterials Science 11:9, pages 3308-3320.
Crossref
Toka A. Ahmed, Bassant Eldaly, Shadwa Eldosuky, Hoda Elkhenany, Azza M. El-Derby, Muhamed F. Elshazly & Nagwa El-Badri. (2023) The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy. Stem Cell Research & Therapy 14:1.
Crossref
Ivana Kutle, Robert Polten, Jens Hachenberg, Rüdiger Klapdor, Michael Morgan & Axel Schambach. (2023) Tumor Organoid and Spheroid Models for Cervical Cancer. Cancers 15:9, pages 2518.
Crossref
Fermín Robledo, Lila González-Hodar, Pablo Tapia, Ana-María Figueroa, Fernando Ezquer & Víctor Cortés. (2023) Spheroids derived from the stromal vascular fraction of adipose tissue self-organize in complex adipose organoids and secrete leptin. Stem Cell Research & Therapy 14:1.
Crossref
Ridhima Goel, Deepak Gulwani, Priyanka Upadhyay, Vijaya Sarangthem & Thoudam Debraj Singh. (2023) Unsung versatility of elastin-like polypeptide inspired spheroid fabrication: A review. International Journal of Biological Macromolecules 234, pages 123664.
Crossref
Suchitra Maheswari Ajjarapu, Apoorv Tiwari & Sundip Kumar. (2023) Applications and Utility of Three-Dimensional In Vitro Cell Culture for Therapeutics. Future Pharmacology 3:1, pages 213-228.
Crossref
Atakan Tevlek, Seren Kecili, Ozge S. Ozcelik, Haluk Kulah & H. Cumhur Tekin. (2023) Spheroid Engineering in Microfluidic Devices. ACS Omega 8:4, pages 3630-3649.
Crossref
Ana Carolina Batista Brochado, Daniela Costa Silva, Joice Correa da Silva, Adam Lowenstein, Vinicius Schott Gameiro, Elena Mavropoulos, Carlos F. Mourão & Gutemberg Gomes Alves. (2023) Characterization and Applicability of a Bone Spheroid Model for the Evaluation of Cytocompatibility of Bone Substitutes. Applied Sciences 13:3, pages 1602.
Crossref
Savneet Kaur, Srivatsan Kidambi, Martí Ortega-Ribera, Le Thi Thanh Thuy, Natalia Nieto, Victoria C. Cogger, Wei-Fen Xie, Frank Tacke & Jordi Gracia-Sancho. (2023) In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations. Cellular and Molecular Gastroenterology and Hepatology 15:3, pages 559-571.
Crossref
Sadra Mohaghegh & Hanieh Nokhbatolfoghahaei. 2023. Emerging Technologies in Oral and Maxillofacial Surgery. Emerging Technologies in Oral and Maxillofacial Surgery 345 354 .
Melissa Anne Tutty & Adriele Prina-Mello. 2023. Cancer Cell Culture. Cancer Cell Culture 65 103 .
Ryotaro Kazama, Satoshi Fujita & Shinji Sakai. (2022) Cell Dome as an Evaluation Platform for Organized HepG2 Cells. Cells 12:1, pages 69.
Crossref
Yingjuan Liu, Honglin Xu, Sabu Abraham, Xin Wang & Bernard D. Keavney. (2022) Progress of 3D Organoid Technology for Preclinical Investigations: Towards Human In Vitro Models. International Journal of Drug Discovery and Pharmacology, pages 9.
Crossref
Priyanka Pulugu, Neha Arya, Prasoon Kumar & Akshay Srivastava. (2022) Polystyrene-Based Slippery Surfaces Enable the Generation and Easy Retrieval of Tumor Spheroids. ACS Applied Bio Materials 5:12, pages 5582-5594.
Crossref
Mari Tsujimura, Kosuke Kusamori, Kodai Takamura, Temmei Ito, Takatoshi Kaya, Kazunori Shimizu, Satoshi Konishi & Makiya Nishikawa. (2022) Quality evaluation of cell spheroids for transplantation by monitoring oxygen consumption using an on-chip electrochemical device. Biotechnology Reports 36, pages e00766.
Crossref
Robert A. Gutierrez, Vera C. Fonseca & Eric M. Darling. (2022) Chondrogenesis of Adipose-Derived Stem Cells Using an Arrayed Spheroid Format. Cellular and Molecular Bioengineering 15:6, pages 587-597.
Crossref
Jinsheng Zhang & Shih-Mo Yang. (2022) Construction of 3D Asthma Model Based on Microfluidic Technology. Construction of 3D Asthma Model Based on Microfluidic Technology.
Ayman A. Abdelrahim, Sera Hong & Joon Myong Song. (2022) Integrative In Situ Photodynamic Therapy-Induced Cell Death Measurement of 3D-Bioprinted MCF-7 Tumor Spheroids . Analytical Chemistry 94:40, pages 13936-13943.
Crossref
Anowar H. Khan, Sophia P. Zhou, Margaret Moe, Braulio A. Ortega Quesada, Khashayar R. Bajgiran, Haley R. Lassiter, James A. Dorman, Elizabeth C. Martin, John A. Pojman & Adam T. Melvin. (2022) Generation of 3D Spheroids Using a Thiol–Acrylate Hydrogel Scaffold to Study Endocrine Response in ER + Breast Cancer . ACS Biomaterials Science & Engineering 8:9, pages 3977-3985.
Crossref
Cristina Quílez, Enrique Cerdeira, Jorge González-Rico, Gonzalo de Aranda, Maria Luisa López-Donaire, José Luis Jorcano & Diego Velasco. (2022) Evaluation of different methodologies for primary human dermal fibroblast spheroid formation: automation through 3D bioprinting technology. Biomedical Materials 17:5, pages 055002.
Crossref
Melissa Anne Tutty, Dania Movia & Adriele Prina-Mello. (2022) Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials. Drug Delivery and Translational Research 12:9, pages 2048-2074.
Crossref
Jianyu He, Chang Zhou, Xiaolei Xu, Zhenzhen Zhou, Mathieu Danoy, Marie Shinohara, Wenjin Xiao, Dong Zhu, Xiuying Zhao, Xiaobin Feng, Yilei Mao, Wei Sun, Yasuyuki Sakai, Huayu Yang & Yuan Pang. (2022) Scalable Formation of Highly Viable and Functional Hepatocellular Carcinoma Spheroids in an Oxygen‐Permeable Microwell Device for Anti‐Tumor Drug Evaluation. Advanced Healthcare Materials 11:18, pages 2200863.
Crossref
Paloma Fuentes, María José Torres, Rodrigo Arancibia, Francisco Aulestia, Mauricio Vergara, Flavio Carrión, Nelson Osses & Claudia Altamirano. (2022) Dynamic Culture of Mesenchymal Stromal/Stem Cell Spheroids and Secretion of Paracrine Factors. Frontiers in Bioengineering and Biotechnology 10.
Crossref
Reham M. Balahmar, Bhuvaneshwari Ranganathan, Vernon Ebegboni, Jumanah Alamir, Augustine Rajakumar, Venkataraman Deepak & Shiva Sivasubramaniam. (2022) Analyses of selected tumour-associated factors expression in normotensive and preeclamptic placenta. Pregnancy Hypertension 29, pages 36-45.
Crossref
Rafaella B.L. Henrique, Rennan R.M. Lima, Camila A.P. Monteiro, Weslley F. Oliveira, Goreti Pereira, Paulo E. Cabral Filho & Adriana Fontes. (2022) Advances in the study of spheroids as versatile models to evaluate biological interactions of inorganic nanoparticles. Life Sciences 302, pages 120657.
Crossref
Ali Hazrati, Kosar Malekpour, Sara Soudi & Seyed Mahmoud Hashemi. (2022) Mesenchymal stromal/stem cells spheroid culture effect on the therapeutic efficacy of these cells and their exosomes: A new strategy to overcome cell therapy limitations. Biomedicine & Pharmacotherapy 152, pages 113211.
Crossref
Sheng-Meng Yuan, Xue-Ting Yang, Si-Yuan Zhang, Wei-Dong Tian & Bo Yang. (2022) Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications. World Journal of Stem Cells 14:7, pages 435-452.
Crossref
Leena Arora, Moyna Kalia, Suman Dasgupta, Navneet Singh, Anita K. Verma & Durba Pal. (2022) Development of a Multicellular 3D Tumor Model to Study Cellular Heterogeneity and Plasticity in NSCLC Tumor Microenvironment. Frontiers in Oncology 12.
Crossref
Masanobu Horie, Noriko Yamano-Adachi, Yoshinori Kawabe, Hidenori Kaneoka, Hideaki Fujita, Eiji Nagamori, Ryosuke Iwai, Yasushi Sato, Kei Kanie, Seiichi Ohta, Masaharu Somiya & Kosuke Ino. (2022) Recent advances in animal cell technologies for industrial and medical applications. Journal of Bioscience and Bioengineering 133:6, pages 509-514.
Crossref
Yu. D. Vasilets, K. V. Dergilev, Z. I. Tsokolaeva & E. V. Parfenova. (2022) Culturing of Cardiac Cells in 3D Spheroids Modulates Their Expression Profile and Increases Secretion of Proangiogenic Growth Factors. Bulletin of Experimental Biology and Medicine 173:2, pages 235-239.
Crossref
Linna Guo, Ziang Zou, Marcus Freytag, Reinhard E. Friedrich, Philip Hartjen, Martin Gosau, Ralf Smeets & Lan Kluwe. (2022) Human Dental Pulp Cells form Spheroids in the Presence of Serum When Seeded on a Low-Attachment Cultural Surface. Processes 10:5, pages 1021.
Crossref
Paola De Stefano, Elena Bianchi & Gabriele Dubini. (2022) The impact of microfluidics in high-throughput drug-screening applications. Biomicrofluidics 16:3.
Crossref
Monize Caiado Decarli, Amanda Mizukami, Rafael Abboud Azoubel, Paulo Inforçatti Neto, Carlos Mota, Ângela Maria Moraes, Jorge Vicente L. Silva & Lorenzo Moroni. (2022) Static systems to obtain 3D spheroid cell models: a cost analysis comparing the implementation of four types of microwell array inserts. Biochemical Engineering Journal 182, pages 108414.
Crossref
Florian Petry & Denise Salzig. (2022) Large-Scale Production of Size-Adjusted β-Cell Spheroids in a Fully Controlled Stirred-Tank Reactor. Processes 10:5, pages 861.
Crossref
Katja Stange, Amir Keric, Andreas Friese & Monika Röntgen. (2022) Preparation of Spheroids from Primary Pig Cells in a Mid-Scale Bioreactor Retaining Their Myogenic Potential. Cells 11:9, pages 1453.
Crossref
Monize Caiado Decarli, Mateus Vidigal de Castro, Júlia Adami Nogueira, Mariana Harue T. Nagahara, Cecília Buzatto Westin, Alexandre Leite R. de Oliveira, Jorge Vicente L. da Silva, Lorenzo Moroni, Carlos Mota & Ângela Maria Moraes. (2022) Development of a device useful to reproducibly produce large quantities of viable and uniform stem cell spheroids with controlled diameters. Biomaterials Advances 135, pages 112685.
Crossref
Salvatore Di Stefano, Alessandro Giammarini, Chiara Giverso & Alfio Grillo. (2022) An elasto-plastic biphasic model of the compression of multicellular aggregates: the influence of fluid on stress and deformation. Zeitschrift für angewandte Mathematik und Physik 73:2.
Crossref
Prachi Bangde, Tejal Pant, Ganesh Gaikwad, Ratnesh Jain & Prajakta Dandekar. (2022) Trimethyl chitosan coated palladium nanoparticles as a photothermal agent and its in vitro evaluation in 2D and 3D model of breast cancer cells. Colloids and Surfaces B: Biointerfaces 211, pages 112287.
Crossref
Madalina Andreea Badea, Mihaela Balas & Anca Dinischiotu. (2021) Biological properties and development of hypoxia in a breast cancer 3D model generated by hanging drop technique. Cell Biochemistry and Biophysics 80:1, pages 63-73.
Crossref
Ramesh Pai Roopesh, Senthilkumar Muthusamy, Shiny Velayudhan, Arumugham Sabareeswaran & Pallickaveedu RajanAsari Anil Kumar. (2022) High‐throughput production of liver parenchymal microtissues and enrichment of organ‐specific functions in gelatin methacrylamide microenvironment. Biotechnology and Bioengineering 119:3, pages 1018-1032.
Crossref
Jesil Kasamkattil, Anna Gryadunova, Ivan Martin, Andrea Barbero, Stefan Schären, Olga Krupkova & Arne Mehrkens. (2022) Spheroid-Based Tissue Engineering Strategies for Regeneration of the Intervertebral Disc. International Journal of Molecular Sciences 23:5, pages 2530.
Crossref
Elaheh Dalir Abdolahinia, Ghasem Barati, Zahra Ranjbar-Navazi, Jamileh Kadkhoda, Maryam Islami, Nastaran Hashemzadeh, Solmaz Maleki Dizaj & Simin Sharifi. (2022) Application of nanogels as drug delivery systems in multicellular spheroid tumor model. Journal of Drug Delivery Science and Technology 68, pages 103109.
Crossref
Yong He, Qing Gao & Yifei Jin. 2022. Cell Assembly with 3D Bioprinting. Cell Assembly with 3D Bioprinting 11 45 .
Yusuke Tsuruwaka & Eriko Shimada. (2022) Reprocessing seafood waste: challenge to develop aquatic clean meat from fish cells. npj Science of Food 6:1.
Crossref
Atsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Hironori Kitajima, Takashi Takaki, Terutsugu Koya, Ikuhiro Tanida, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa & Norio Kawahara. (2022) Evaluation of the Usefulness of Human Adipose-Derived Stem Cell Spheroids Formed Using SphereRing® and the Lethal Damage Sensitivity to Synovial Fluid In Vitro. Cells 11:3, pages 337.
Crossref
Amna M. I. Rabie, Ahmed S. M. Ali, Munir A. Al-Zeer, Ahmed Barhoum, Salwa EL-Hallouty, Wafaa G. Shousha, Johanna Berg, Jens Kurreck & Ahmed S. G. Khalil. (2022) Spontaneous Formation of 3D Breast Cancer Tissues on Electrospun Chitosan/Poly(ethylene oxide) Nanofibrous Scaffolds. ACS Omega 7:2, pages 2114-2126.
Crossref
Simeon Kofman, Neha Mohan, Xiaohuan Sun, Larisa Ibric, Emanuela Piermarini & Liang Qiang. (2022) Human mini brains and spinal cords in a dish: Modeling strategies, current challenges, and prospective advances. Journal of Tissue Engineering 13, pages 204173142211133.
Crossref
Mahboobeh Rezaeeyazdi, Thibault Colombani, Loek J. Eggermont & Sidi A. Bencherif. (2022) Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction. Materials Today Bio 13, pages 100207.
Crossref
M.G. Rea, T. John, Y-W. Chen & A.L. Ryan. 2022. 3D Lung Models for Regenerating Lung Tissue. 3D Lung Models for Regenerating Lung Tissue 73 89 .
Kanwaljit Chopra, Sandip V. Pawar, Manju Maurya, Tavish Gupta & Jatinder Dhaliwal. 2022. Biomedical Translational Research. Biomedical Translational Research 215 237 .
Lynn M. Sidor & Anne S. Meyer. 2022. Engineered Living Materials. Engineered Living Materials 149 185 .
A. I. Moisieiev, I. F. Kovalenko, G. A. Bozhok & O. I. Gordiyenko. (2021) Theoretical approaches to determination of optimal cryopreservation regimens for cell spheroids of different cultivation terms. Biophysical Bulletin:46, pages 7-22.
Crossref
Anton Moisieiev, Igor Kovalenko, Svitlana Kovalenko, Galyna Bozhok & Olga Gordienko. (2021) Dynamics of Dimethyl Sulfoxide Penetration Into L929 Cells and L929-Based Spheroids. Problems of Cryobiology and Cryomedicine 31:4, pages 316-325.
Crossref
Rizwan Ali, Sarah Huwaizi, Alshaimaa Alhallaj, Arwa Al Subait, Tlili Barhoumi, Hajar Al Zahrani, Abdullah Al Anazi, Abdul Latif Khan & Mohamed Boudjelal. (2021) New Born Calf Serum Can Induce Spheroid Formation in Breast Cancer KAIMRC1 Cell Line. Frontiers in Molecular Biosciences 8.
Crossref
Sayoni Maitra Roy, Vrinda Garg, Sourav Barman, Chitrita Ghosh, Amit Ranjan Maity & Surya K. Ghosh. (2021) Kinetics of Nanomedicine in Tumor Spheroid as an In Vitro Model System for Efficient Tumor-Targeted Drug Delivery With Insights From Mathematical Models. Frontiers in Bioengineering and Biotechnology 9.
Crossref
Jinkyu Lee, Sangmin Lee, Sung Min Kim & Heungsoo Shin. (2021) Size-controlled human adipose-derived stem cell spheroids hybridized with single-segmented nanofibers and their effect on viability and stem cell differentiation. Biomaterials Research 25:1.
Crossref
Irmak Ayvaz, Dilara Sunay, Ece Sariyar, Esra Erdal & Zeynep Firtina Karagonlar. (2021) Three-Dimensional Cell Culture Models of Hepatocellular Carcinoma — a Review. Journal of Gastrointestinal Cancer 52:4, pages 1294-1308.
Crossref
Guya Diletta Marconi, Cristina Porcheri, Oriana Trubiani & Thimios A. Mitsiadis. (2021) Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease. International Journal of Molecular Sciences 22:22, pages 12473.
Crossref
Ola Habanjar, Mona Diab-Assaf, Florence Caldefie-Chezet & Laetitia Delort. (2021) 3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages. International Journal of Molecular Sciences 22:22, pages 12200.
Crossref
Stephen J. Winter, Hunter A. Miller & Jill M. Steinbach-Rankins. (2021) Multicellular Ovarian Cancer Model for Evaluation of Nanovector Delivery in Ascites and Metastatic Environments. Pharmaceutics 13:11, pages 1891.
Crossref
Hidetaka Togo, Kento Yoshikawa-Terada, Yudai Hirose, Hideo Nakagawa, Hiroki Takeuchi & Masanobu Kusunoki. (2021) Development of a Simple Spheroid Production Method Using Fluoropolymers with Reduced Chemical and Physical Damage. Applied Sciences 11:21, pages 10495.
Crossref
Giulia Morello, Alessandra Quarta, Antonio Gaballo, Lorenzo Moroni, Giuseppe Gigli, Alessandro Polini & Francesca Gervaso. (2021) A thermo-sensitive chitosan/pectin hydrogel for long-term tumor spheroid culture. Carbohydrate Polymers 274, pages 118633.
Crossref
Lu Tian, Jinghui Gao, Irving M. Garcia, Huanhuan Joyce Chen, Alessandra Castaldi & Ya‐Wen Chen. (2020) Human pluripotent stem cell‐derived lung organoids: Potential applications in development and disease modeling. WIREs Developmental Biology 10:6.
Crossref
Xiaowen Wu, Junxiang Su, Jizhen Wei, Nan Jiang & Xuejun Ge. (2021) Recent Advances in Three-Dimensional Stem Cell Culture Systems and Applications. Stem Cells International 2021, pages 1-13.
Crossref
Jimpi Langthasa, Purba Sarkar, Shruthi Narayanan, Rahul Bhagat, Annapurna Vadaparty & Ramray Bhat. (2021) Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids. Life Science Alliance 4:10, pages e202000942.
Crossref
Gabriela S. Kronemberger, Anderson Beatrici, Gisele M. L. Dalmônico, André L. Rossi, Guilherme A. S. C. Miranda, Leonardo C. Boldrini, José Mauro Granjeiro & Leandra Santos Baptista. (2021) The hypertrophic cartilage induction influences the building‐block capacity of human adipose stem/stromal cell spheroids for biofabrication. Artificial Organs 45:10, pages 1208-1218.
Crossref
Yejin Park, Seung Taek Ji, Uijung Yong, Sanskrita Das, Woong Bi Jang, Geunseon Ahn, Sang-Mo Kwon & Jinah Jang. (2021) 3D bioprinted tissue-specific spheroidal multicellular microarchitectures for advanced cell therapy. Biofabrication 13:4, pages 045017.
Crossref
Rie Utoh, Sakiko Enomoto, Masumi Yamada, Keigo Yamanaka, Yuya Yajima, Kazuya Furusawa & Minoru Seki. (2021) Polyanion-induced, microfluidic engineering of fragmented collagen microfibers for reconstituting extracellular environments of 3D hepatocyte culture. Materials Science and Engineering: C 129, pages 112417.
Crossref
Ekaterina Naumenko, Elena Zakirova, Ivan Guryanov, Farida Akhatova, Mikhail Sergeev, Anastasia Valeeva & Rawil Fakhrullin. (2021) COMPOSITE BIODEGRADABLE POLYMERIC MATRIX DOPED WITH HALLOYSITE NANOTUBES FOR THE REPAIR OF BONE DEFECTS IN DOGS. Clays and Clay Minerals 69:5, pages 522-532.
Crossref
Angello Huerta Gomez, Sanika Joshi, Yong Yang, Johnathan D. Tune, Ming-Tao Zhao & Huaxiao Yang. (2021) Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration. Journal of Cardiovascular Development and Disease 8:10, pages 125.
Crossref
Priyakshi Kalita-de Croft, Shayna Sharma, Nihar Godbole, Gregory E. Rice & Carlos Salomon. (2021) Ovarian-Cancer-Associated Extracellular Vesicles: Microenvironmental Regulation and Potential Clinical Applications. Cells 10:9, pages 2272.
Crossref
Della S. Shin & Kristi S. Anseth. (2021) Recent advances in 3D models of tumor invasion. Current Opinion in Biomedical Engineering 19, pages 100310.
Crossref
Zaki Abou-Mrad, Jolie Bou Gharios, Maya M Moubarak, Ahmad Chalhoub, Charbel Moussalem, Hisham F Bahmad & Wassim Abou-Kheir. (2021) Central nervous system tumors and three-dimensional cell biology: Current and future perspectives in modeling. World Journal of Stem Cells 13:8, pages 1112-1126.
Crossref
Karl Olofsson, Valentina Carannante, Madoka Takai, Björn Önfelt & Martin Wiklund. (2021) Single cell organization and cell cycle characterization of DNA stained multicellular tumor spheroids. Scientific Reports 11:1.
Crossref
Sunil Shrestha, Vinod Kumar Reddy Lekkala, Prabha Acharya, Darshita Siddhpura & Moo-Yeal Lee. (2021) Recent advances in microarray 3D bioprinting for high-throughput spheroid and tissue culture and analysis. Essays in Biochemistry 65:3, pages 481-489.
Crossref
Sabina Pozzi, Anna Scomparin, Sahar Israeli Dangoor, Daniel Rodriguez Ajamil, Paula Ofek, Lena Neufeld, Adva Krivitsky, Daniella Vaskovich-Koubi, Ron Kleiner, Pradip Dey, Shani Koshrovski-Michael, Noa Reisman & Ronit Satchi-Fainaro. (2021) Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?. Advanced Drug Delivery Reviews 175, pages 113760.
Crossref
Wolfgang Metzger, Barbara Rösch, Daniela Sossong, Monika Bubel & Tim Pohlemann. (2021) Flow cytometric quantification of apoptotic and proliferating cells applying an improved method for dissociation of spheroids. Cell Biology International 45:8, pages 1633-1643.
Crossref
Monize Caiado Decarli, Robson Amaral, Diogo Peres dos Santos, Larissa Bueno Tofani, Eric Katayama, Rodrigo Alvarenga Rezende, Jorge Vicente Lopes da Silva, Kamilla Swiech, Claudio Alberto Torres Suazo, Carlos Mota, Lorenzo Moroni & Ângela Maria Moraes. (2021) Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications. Biofabrication 13:3, pages 032002.
Crossref
Daniel T O Carvalho, Tália Feijão, Mariana I Neves, Ricardo M P da Silva & Cristina C Barrias. (2021) Directed self-assembly of spheroids into modular vascular beds for engineering large tissue constructs. Biofabrication 13:3, pages 035008.
Crossref
Eda Acikgoz, Burak Cem Soner, Berrin Ozdil & Mustafa Guven. (2021) CD133+/CD44+ prostate cancer stem cells exhibit embryo-like behavior patterns. Acta Histochemica 123:5, pages 151743.
Crossref
Moritz Pfeiffenberger, Alexandra Damerau, Annemarie Lang, Frank Buttgereit, Paula Hoff & Timo Gaber. (2021) Fracture Healing Research—Shift towards In Vitro Modeling?. Biomedicines 9:7, pages 748.
Crossref
Xiaoli Liu, Huichao Lin, Jiaao Song, Taiyi Zhang, Xiaoying Wang, Xiaowen Huang & Chengyun Zheng. (2021) A Novel SimpleDrop Chip for 3D Spheroid Formation and Anti-Cancer Drug Assay. Micromachines 12:6, pages 681.
Crossref
Reza Bayat Mokhtari, Bessi Qorri, Manpreet Sambi, Narges Baluch, Sushil Kumar, Bikul Das, Myron R. Szewczuk, Herman Yeger & Hai-Ling Margaret Cheng. (2021) 3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model. Cancers 13:11, pages 2784.
Crossref
Gabriela S. Kronemberger, Fabiana A. Carneiro, Danielle F. Rezende & Leandra S. Baptista. (2021) Spheroids and organoids as humanized 3D scaffold‐free engineered tissues for SARS‐CoV‐2 viral infection and drug screening. Artificial Organs 45:6, pages 548-558.
Crossref
Ji‐Yun Ko, Jeong‐Won Park, Juyoung Kim & Gun‐Il Im. (2020) Characterization of adipose‐derived stromal/stem cell spheroids versus single‐cell suspension in cell survival and arrest of osteoarthritis progression. Journal of Biomedical Materials Research Part A 109:6, pages 869-878.
Crossref
Ian C. Berg, Erfan Mohagheghian, Krista Habing, Ning Wang & Gregory H. Underhill. (2021) Microtissue Geometry and Cell‐Generated Forces Drive Patterning of Liver Progenitor Cell Differentiation in 3D. Advanced Healthcare Materials 10:12, pages 2100223.
Crossref
Seokyoung Bang, Songhyun Lee, Nakwon Choi & Hong Nam Kim. (2021) Emerging Brain‐Pathophysiology‐Mimetic Platforms for Studying Neurodegenerative Diseases: Brain Organoids and Brains‐on‐a‐Chip. Advanced Healthcare Materials 10:12, pages 2002119.
Crossref
Guadalupe Tonantzin de Dios-Figueroa, Janette del Rocío Aguilera-Marquez, Tanya A. Camacho-Villegas & Pavel H. Lugo-Fabres. (2021) 3D Cell Culture Models in COVID-19 Times: A Review of 3D Technologies to Understand and Accelerate Therapeutic Drug Discovery. Biomedicines 9:6, pages 602.
Crossref
Fuyang Qu, Shirui Zhao, Guangyao Cheng, Habibur Rahman, Qinru Xiao, Renee Wan Yi Chan & Yi-Ping Ho. (2021) Double emulsion-pretreated microwell culture for the in vitro production of multicellular spheroids and their in situ analysis. Microsystems & Nanoengineering 7:1.
Crossref
Cheng-Tai Lee, Elisabeth L Gill, Wenyu Wang, Magda Gerigk, Eugene M Terentjev & Yan Yan Shery Huang. (2021) Guided assembly of cancer ellipsoid on suspended hydrogel microfibers estimates multi-cellular traction force. Physical Biology 18:3, pages 036001.
Crossref
Ary Marsee, Floris J.M. Roos, Monique M.A. Verstegen, Helmuth Gehart, Eelco de Koning, Frédéric Lemaigre, Stuart J. Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc J.W. van der Laan, Bart Spee, Ary Marsee, Floris Roos, Monique Verstegen, Hans Clevers, Ludovic Vallier, Takanori Takebe, Meritxell Huch, Weng Chuan Peng, Stuart Forbes, Frédéric Lemaigre, Eelco de Koning, Helmuth Gehart, Luc van der Laan, Bart Spee, Sylvia Boj, Pedro Baptista, Kerstin Schneeberger, Carol Soroka, Markus Heim, Sandro Nuciforo, Kenneth Zaret, Yoshimasa Saito, Matthias Lutolf, Vincenzo Cardinale, Ben Simons, Sven van IJzendoorn, Akihide Kamiya, Hiromi Chikada, Shuyong Wang, Seon Ju Mun, Myung Jin Son, Tamer Tevfik Onder, James Boyer, Toshiro Sato, Nikitas Georgakopoulos, Andre Meneses, Laura Broutier, Luke Boulter, Dominic Grün, Jan IJzermans, Benedetta Artegiani, Ruben van Boxtel, Ewart Kuijk, Guido Carpino, Gary Peltz, Jesus Banales, Nancy Man, Luigi Aloia, Nicholas LaRusso, Gregory George, Casey Rimland, George Yeoh, Anne Grappin-Botton, Daniel Stange, Nicole Prior, Janina E.E. Tirnitz-Parker, Emma Andersson, Chiara Braconi, Nicholas Hannan, Wei-Yu Lu, Stephen Strom, Pau Sancho-Bru, Shinichiro Ogawa, Vincenzo Corbo, Madeline Lancaster, Huili Hu, Sabine Fuchs & Delilah Hendriks. (2021) Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. Cell Stem Cell 28:5, pages 816-832.
Crossref
Ross Burdis & Daniel J. Kelly. (2021) Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues. Acta Biomaterialia 126, pages 1-14.
Crossref
Ariana E. Shannon, Claire E. Boos & Amanda B. Hummon. (2021) Co‐culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques. PROTEOMICS 21:9.
Crossref
Marna Eliana Sakalem, Maria Teresa De Sibio, Felipe Allan da Silva da Costa & Miriane de Oliveira. (2021) Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine. Biotechnology Journal 16:5, pages 2000463.
Crossref
Miao Sun, An Liu, Xiaofu Yang, Jiaxing Gong, Mengfei Yu, Xinhua Yao, Huiming Wang & Yong He. (2021) 3D Cell Culture—Can It Be As Popular as 2D Cell Culture?. Advanced NanoBiomed Research 1:5, pages 2000066.
Crossref
Alex Markoski, Ian Y. Wong & Jeffrey T. Borenstein. (2021) 3D Printed Monolithic Device for the Microfluidic Capture, Perfusion, and Analysis of Multicellular Spheroids. Frontiers in Medical Technology 3.
Crossref
Kanishka Fernando, Leng Gek Kwang, Joanne Tze Chin Lim & Eliza Li Shan Fong. (2021) Hydrogels to engineer tumor microenvironments in vitro . Biomaterials Science 9:7, pages 2362-2383.
Crossref
Tiantian Liu, Shuting Yi, Gang Liu, Xin Hao, Ting Du, Jialin Chen, Tao Meng, Ping Li & Yaolei Wang. (2021) Aqueous two-phase emulsions-templated tailorable porous alginate beads for 3D cell culture. Carbohydrate Polymers 258, pages 117702.
Crossref
Fabien Gava, Carla Faria, Pauline Gravelle, Juan G. Valero, Cèlia Dobaño-López, Renaud Morin, Marine Norlund, Aurélie Gomes, Jean-Michel Lagarde, Cédric Rossi, Julie Bordenave, Laetitia Pieruccioni, Jacques Rouquette, Alba Matas-Céspedes, Jean-Jacques Fournié, Loïc Ysebaert, Camille Laurent, Patricia Pérez-Galán & Christine Bezombes. (2021) 3D Model Characterization by 2D and 3D Imaging in t(14;18)-Positive B-NHL: Perspectives for In Vitro Drug Screens in Follicular Lymphoma. Cancers 13:7, pages 1490.
Crossref
Hallie Thorp, Kyungsook Kim, Makoto Kondo, Travis Maak, David W. Grainger & Teruo Okano. (2021) Trends in Articular Cartilage Tissue Engineering: 3D Mesenchymal Stem Cell Sheets as Candidates for Engineered Hyaline-Like Cartilage. Cells 10:3, pages 643.
Crossref
David Sánchez-Porras, Daniel Durand-Herrera, Ana B. Paes, Jesús Chato-Astrain, Rik Verplancke, Jan Vanfleteren, José Darío Sánchez-López, Óscar Darío García-García, Fernando Campos & Víctor Carriel. (2021) Ex Vivo Generation and Characterization of Human Hyaline and Elastic Cartilaginous Microtissues for Tissue Engineering Applications. Biomedicines 9:3, pages 292.
Crossref
Giovana Bicudo Gomes, Claudia Stutz Zubieta, Simone Schneider Weber, Dênis Pires de Lima, Thatikonda Narendar Reddy, Ana Tereza Gomes Guerrero, Maria de Fatima Cepa Matos, Eduardo Benedetti Parisotto & Renata Trentin Perdomo. (2020) Thiopyrimidine derivatives induce cytotoxicity, cell cycle arrest and oxidative stress in breast cancer 3D-spheroids. Chemical Papers 75:3, pages 1211-1220.
Crossref
Oyku Sarigil, Muge Anil‐Inevi, Burcu Firatligil‐Yildirir, Yagmur Ceren Unal, Ozden Yalcin‐Ozuysal, Gulistan Mese, H. Cumhur Tekin & Engin Ozcivici. (2020) Scaffold‐free biofabrication of adipocyte structures with magnetic levitation. Biotechnology and Bioengineering 118:3, pages 1127-1140.
Crossref
Sreenivasulu Gunti, Austin T.K. Hoke, Kenny P. Vu & Nyall R. LondonJr.Jr.. (2021) Organoid and Spheroid Tumor Models: Techniques and Applications. Cancers 13:4, pages 874.
Crossref
Pauline Maury, Erika Porcel, Adrien Mau, François Lux, Olivier Tillement, Pierre Mahou, Marie-Claire Schanne-Klein & Sandrine Lacombe. (2021) Rapid Evaluation of Novel Therapeutic Strategies Using a 3D Collagen-Based Tissue-Like Model. Frontiers in Bioengineering and Biotechnology 9.
Crossref
Raja Vadivelu, Navid Kashaninejad, Mohammad Reza Nikmaneshi, Rubina Rahaman Khadim, Seyedeh Sarah Salehi, Naveen Chintala Ramulu, Yasuyuki Sakai, Masaki Nishikawa, Bahar Firoozabadi & Nam‐Trung Nguyen. (2021) Sessile Liquid Marbles with Embedded Hydrogels as Bioreactors for Three‐Dimensional Cell Culture. Advanced Biology 5:2, pages 2000108.
Crossref
M. M. Bobrova, L. A. Safonova, A. E. Efimov, O. I. Agapova & I. I. Agapov. (2021) Natural silk fiber microcarriers for cell culture. Russian Journal of Transplantology and Artificial Organs 22:4, pages 98-104.
Crossref
Kalaivani Muniandy, Zuhaida Asra Ahmad, Sylvia Annabel Dass, Shaharum Shamsuddin, Nethia Mohana Kumaran & Venugopal Balakrishnan. (2021) Growth and Invasion of 3D Spheroid Tumor of HeLa and CasKi Cervical Cancer Cells. Oncologie 23:2, pages 279-291.
Crossref
Vaibhav Sharma, Alagiri Srinivasan, Fredrik Nikolajeff & Saroj Kumar. (2021) Biomineralization process in hard tissues: The interaction complexity within protein and inorganic counterparts. Acta Biomaterialia 120, pages 20-37.
Crossref
Sanyog Jain, Kaisar Raza, Ashish Kumar Agrawal & Ankur Vaidya. 2021. Nanotechnology Applications for Cancer Chemotherapy. Nanotechnology Applications for Cancer Chemotherapy 599 609 .
Remya Komeri, H. P. Syama, G. U. Preethi, B. S. Unnikrishnan, R. Shiji, M. G. Archana, Deepa Mohan, Anuj Tripathi & T. T. Sreelekha. 2021. Immobilization Strategies. Immobilization Strategies 165 193 .
Munther Alomari. 2021. Advances in Application of Stem Cells: From Bench to Clinics. Advances in Application of Stem Cells: From Bench to Clinics 123 154 .
Tomás Bauleth-Ramos & Bruno Sarmento. 2021. Bio-Nanomedicine for Cancer Therapy. Bio-Nanomedicine for Cancer Therapy 223 242 .
Christabella Adine & João Ferreira. 2021. Organ Tissue Engineering. Organ Tissue Engineering 173 194 .
Sung‐Min Kang, Daehan Kim, Ji‐Hoon Lee, Shuichi Takayama & Joong Yull Park. (2020) Engineered Microsystems for Spheroid and Organoid Studies. Advanced Healthcare Materials 10:2, pages 2001284.
Crossref
Giada Bassi, Silvia Panseri, Samuele Maria Dozio, Monica Sandri, Elisabetta Campodoni, Massimiliano Dapporto, Simone Sprio, Anna Tampieri & Monica Montesi. (2020) Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche. Scientific Reports 10:1.
Crossref
Junha Park, Goeun Choe, Seulgi Oh & Jae Young Lee. (2020) In Situ Formation of Proangiogenic Mesenchymal Stem Cell Spheroids in Hyaluronic Acid/Alginate Core–Shell Microcapsules . ACS Biomaterials Science & Engineering 6:12, pages 6938-6948.
Crossref
Heshu Sulaiman Rahman, Bee Ling Tan, Hemn Hassan Othman, Max Stanley Chartrand, Yashwant Pathak, Syam Mohan, Rasedee Abdullah & Noorjahan Banu Alitheen. (2020) An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies. BioMed Research International 2020, pages 1-14.
Crossref
Anheng Wang, Leigh A. Madden & Vesselin N. Paunov. (2020) Advanced biomedical applications based on emerging 3D cell culturing platforms. Journal of Materials Chemistry B 8:46, pages 10487-10501.
Crossref
Bárbara Pinto, Ana C. Henriques, Patrícia M. A. Silva & Hassan Bousbaa. (2020) Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research. Pharmaceutics 12:12, pages 1186.
Crossref
Tong Wang, Lin Wang, Guan Wang & Yingping Zhuang. (2020) Leveraging and manufacturing in vitro multicellular spheroid-based tumor cell model as a preclinical tool for translating dysregulated tumor metabolism into clinical targets and biomarkers. Bioresources and Bioprocessing 7:1.
Crossref
Charles‐Henri Wassmer, Fanny Lebreton, Kevin Bellofatto, Domenico Bosco, Thierry Berney & Ekaterine Berishvili. (2020) Generation of insulin‐secreting organoids: a step toward engineering and transplanting the bioartificial pancreas. Transplant International 33:12, pages 1577-1588.
Crossref
Se‐jeong Kim, Eun Mi Kim, Masaya Yamamoto, Hansoo Park & Heungsoo Shin. (2020) Engineering Multi‐Cellular Spheroids for Tissue Engineering and Regenerative Medicine. Advanced Healthcare Materials 9:23, pages 2000608.
Crossref
Md. Hafiz Uddin, Boyun Kim, Untack Cho, Asfar S. Azmi & Yong Sang Song. (2020) Association of ALDH1A1-NEK-2 axis in cisplatin resistance in ovarian cancer cells. Heliyon 6:11, pages e05442.
Crossref
Abdolkhaleg Deezagi & Naser Safari. (2020) Rosuvastatin inhibit spheroid formation and epithelial–mesenchymal transition (EMT) in prostate cancer PC-3 cell line. Molecular Biology Reports 47:11, pages 8727-8737.
Crossref
Advika Kamatar, Gokhan Gunay & Handan Acar. (2020) Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids. Polymers 12:11, pages 2506.
Crossref
Gizem Damla Yalcin, Nurseda Danisik, Rana Can Baygin & Ahmet Acar. (2020) Systems Biology and Experimental Model Systems of Cancer. Journal of Personalized Medicine 10:4, pages 180.
Crossref
Mohamed Zakaria Nassef, Daniela Melnik, Sascha Kopp, Jayashree Sahana, Manfred Infanger, Ronald Lützenberg, Borna Relja, Markus Wehland, Daniela Grimm & Marcus Krüger. (2020) Breast Cancer Cells in Microgravity: New Aspects for Cancer Research. International Journal of Molecular Sciences 21:19, pages 7345.
Crossref
Yongjun Jang, Yongdoo Park & Jongseong Kim. (2020) Engineering Biomaterials to Guide Heart Cells for Matured Cardiac Tissue. Coatings 10:10, pages 925.
Crossref
Albert Li & Pei-Ming Yang. (2020) Overexpression of miR-21-5p in colorectal cancer cells promotes self-assembly of E-cadherin-dependent multicellular tumor spheroids. Tissue and Cell 65, pages 101365.
Crossref
Vignesh R. A., Shalini Kumari, Puja Poddar, Dibakar Dhara & Souvik Maiti. (2020) Poly( N ‐isopropylacrylamide)‐Based Polymers as Additive for Rapid Generation of Spheroid via Hanging Drop Method . Macromolecular Bioscience 20:8, pages 2000180.
Crossref
Nastasia V. Kosheleva, Yuri M. Efremov, Boris S. Shavkuta, Irina M. Zurina, Deying Zhang, Yuanyuan Zhang, Nikita V. Minaev, Anastasiya A. Gorkun, Shicheng Wei, Anastasia I. Shpichka, Irina N. Saburina & Peter S. Timashev. (2020) Cell spheroid fusion: beyond liquid drops model. Scientific Reports 10:1.
Crossref
Lei Dong, Paolo S. Ravaynia, Qing-An Huang, Andreas Hierlemann & Mario M. Modena. (2020) Parallelized Wireless Sensing System for Continuous Monitoring of Microtissue Spheroids. ACS Sensors 5:7, pages 2036-2043.
Crossref
Aleksandra Jauković, Desislava Abadjieva, Drenka Trivanović, Elena Stoyanova, Milena Kostadinova, Shina Pashova, Snejana Kestendjieva, Tamara Kukolj, Michal Jeseta, Elena Kistanova & Milena Mourdjeva. (2020) Specificity of 3D MSC Spheroids Microenvironment: Impact on MSC Behavior and Properties. Stem Cell Reviews and Reports.
Crossref
Tamaghna Gupta, Srivatsa Aithal, Sarah Mishriki, Rakesh P. Sahu, Fei Geng & Ishwar K. Puri. (2020) Label-Free Magnetic-Field-Assisted Assembly of Layer-on-Layer Cellular Structures. ACS Biomaterials Science & Engineering 6:7, pages 4294-4303.
Crossref
Gabriela S. Kronemberger, Gisele M. L. Dalmônico, André L. Rossi, Paulo Emílio Correa Leite, Antonio M. Saraiva, Anderson Beatrici, Karina Ribeiro Silva, José Mauro Granjeiro & Leandra Santos Baptista. (2020) Scaffold‐ and serum‐free hypertrophic cartilage tissue engineering as an alternative approach for bone repair. Artificial Organs 44:7.
Crossref
Hongwei Cai, Zhuhao Wu, Zheng Ao, Asael Nunez, Bin Chen, Lei Jiang, Maria Bondesson & Feng Guo. (2020) Trapping cell spheroids and organoids using digital acoustofluidics. Biofabrication 12:3, pages 035025.
Crossref
Tomas Gonzalez-FernandezAlejandro J. TenorioJ. Kent Leach. (2020) Three-Dimensional Printed Stamps for the Fabrication of Patterned Microwells and High-Throughput Production of Homogeneous Cell Spheroids. 3D Printing and Additive Manufacturing 7:3, pages 139-147.
Crossref
Ana Katrina Mapanao & Valerio Voliani. (2020) Three-dimensional tumor models: Promoting breakthroughs in nanotheranostics translational research. Applied Materials Today 19, pages 100552.
Crossref
Lise De Moor, Sélina Fernandez, Chris Vercruysse, Liesbeth Tytgat, Mahtab Asadian, Nathalie De Geyter, Sandra Van Vlierberghe, Peter Dubruel & Heidi Declercq. (2020) Hybrid Bioprinting of Chondrogenically Induced Human Mesenchymal Stem Cell Spheroids. Frontiers in Bioengineering and Biotechnology 8.
Crossref
Chin-Yi Cho, Tzu-Hsiang Chiang, Li-Hung Hsieh, Wen-Yu Yang, Hsiang-Hao Hsu, Chih-Kuang Yeh, Chieh-Cheng Huang & Jen-Huang Huang. (2020) Development of a Novel Hanging Drop Platform for Engineering Controllable 3D Microenvironments. Frontiers in Cell and Developmental Biology 8.
Crossref
Reiko Minamikawa-Tachino, Kiyoshi Ogura, Ayane Ito & Katsuya Nagayama. (2020) Time-lapse imaging of HeLa spheroids in soft agar culture provides virtual inner proliferative activity. PLOS ONE 15:4, pages e0231774.
Crossref
Ching‐Fen Jiang, Shan‐hui Hsu, Yu‐Man Sun & Ming‐Hong Tsai. (2020) Quantitative Bioimage Analysis of Passaging Effect on the Migratory Behavior of Human Mesenchymal Stem Cells During Spheroid Formation. Cytometry Part A 97:4, pages 394-406.
Crossref
Yu Tan, Allister Suarez, Matthew Garza, Aadil A. Khan, Jennifer Elisseeff & Devin Coon. (2020) Human fibroblast-macrophage tissue spheroids demonstrate ratio-dependent fibrotic activity for in vitro fibrogenesis model development . Biomaterials Science 8:7, pages 1951-1960.
Crossref
Lixia Huang, Ahmed M.E. Abdalla, Lin Xiao & Guang Yang. (2020) Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation. International Journal of Molecular Sciences 21:5, pages 1895.
Crossref
Thi Phuong Thuy Nguyen, Nguyen Xuan Thanh Le & Nae Yoon Lee. (2019) Microfluidic Approach to Generate a Tadpole-Egg-Shaped Alginate Fiber and Its Application in Tissue Engineering. ACS Biomaterials Science & Engineering 6:3, pages 1663-1670.
Crossref
Cheol‐Hwi Kim, Intan Rosalina Suhito, Novi Angeline, Yoojoong Han, Hyungbin Son, Zhengtang Luo & Tae‐Hyung Kim. (2020) Vertically Coated Graphene Oxide Micro‐Well Arrays for Highly Efficient Cancer Spheroid Formation and Drug Screening. Advanced Healthcare Materials, pages 1901751.
Crossref
Yong He, Boxin Huang, Elrade Rofaani, Jie Hu, Yuanhui Liu, Gabriele Pitingolo, Li Wang, Jian Shi, Carole Aimé & Yong Chen. (2020) Fabrication of micro-cages and caged tumor spheroids for microfluidic chip-based assays. Microelectronic Engineering 225, pages 111256.
Crossref
Gabriela S Kronemberger, Renata Akemi Morais Matsui, Guilherme Almeida Santos Castro Miranda, José Mauro Granjeiro & Leandra Santos Baptista. (2020) Cartilage and bone tissue engineering using adipose stromal/stem cells spheroids as building blocks. World Journal of Stem Cells 12:2, pages 110-122.
Crossref
A. Rodríguez-Pena, J. Uranga-Solchaga, C. Ortiz-de-Solórzano & I. Cortés-Domínguez. (2020) Spheroscope: A custom-made miniaturized microscope for tracking tumour spheroids in microfluidic devices. Scientific Reports 10:1.
Crossref
Léo Adenis, Emilie Gontran, Christophe Deroulers, Basile Grammaticos, Marjorie Juchaux, Olivier Seksek & Mathilde Badoual. (2020) Experimental and modeling study of the formation of cell aggregates with differential substrate adhesion. PLOS ONE 15:2, pages e0222371.
Crossref
Isaree PitaktongCecillia LuiJustin LowenthalGunnar MattsonWei-Hung JungYang BaiEnoch YeungChin Siang OngYun ChenSharon GerechtNarutoshi Hibino. (2020) Early Vascular Cells Improve Microvascularization Within 3D Cardiac Spheroids. Tissue Engineering Part C: Methods 26:2, pages 80-90.
Crossref
Vítor M. Gaspar, Pedro Lavrador, João Borges, Mariana B. Oliveira & João F. Mano. (2019) Advanced Bottom‐Up Engineering of Living Architectures. Advanced Materials 32:6, pages 1903975.
Crossref
Leandra Santos Baptista. (2020) Adipose stromal/stem cells in regenerative medicine: Potentials and limitations. World Journal of Stem Cells 12:1, pages 1-7.
Crossref
Charles-Henri Wassmer, Kevin Bellofatto, Lisa Perez, Vanessa Lavallard, David Cottet-Dumoulin, Sanda Ljubicic, Géraldine Parnaud, Domenico Bosco, Ekaterine Berishvili & Fanny Lebreton. (2020) Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study. Cell Transplantation 29, pages 096368972093729.
Crossref
Andrew S. Khalil, Rudolf Jaenisch & David J. Mooney. (2020) Engineered tissues and strategies to overcome challenges in drug development. Advanced Drug Delivery Reviews 158, pages 116-139.
Crossref
Xiaoqin Zhang, Xin Jia & Xiaolong Wang. 2020. Structure and Properties of Additive Manufactured Polymer Components. Structure and Properties of Additive Manufactured Polymer Components 391 408 .
Laura di Blasio, Marianela Vara-Messler & Luca Primo. 2020. Biomaterials for 3D Tumor Modeling. Biomaterials for 3D Tumor Modeling 175 189 .
David Caballero, Rui L. Reis & Subhas C. Kundu. 2020. Biomaterials for 3D Tumor Modeling. Biomaterials for 3D Tumor Modeling 3 41 .
D. Krewski, M. E. Andersen, M. G. Tyshenko, K. Krishnan, T. Hartung, K. Boekelheide, J. F. Wambaugh, D. Jones, M. Whelan, R. Thomas, C. Yauk, T. Barton-Maclaren & I. Cote. (2019) Toxicity testing in the 21st century: progress in the past decade and future perspectives. Archives of Toxicology 94:1, pages 1-58.
Crossref
Samaneh Hosseini, Majid Halvaei, Amin Ebrahimi, Mohammad Amin Shamekhi & Mohamadreza Baghaban Eslaminejad. 2020. Applications of Biomedical Engineering in Dentistry. Applications of Biomedical Engineering in Dentistry 195 221 .
Christabella Adine & João Ferreira. 2020. Organ Tissue Engineering. Organ Tissue Engineering 1 22 .
I. Kulvinskiene, R. Aldonyte, R. Miksiunas, A. Mobasheri & Daiva Bironaite. 2020. Cell Biology and Translational Medicine, Volume 10. Cell Biology and Translational Medicine, Volume 10 43 77 .
Valentin Jossen, Dieter Eibl & Regine Eibl. 2021. Digital Twins. Digital Twins 185 228 .
Sue Anne Chew, Stefania Moscato, Sachin George, Bahareh Azimi & Serena Danti. (2019) Liver Cancer: Current and Future Trends Using Biomaterials. Cancers 11:12, pages 2026.
Crossref
Na-Eun Ryu, Soo-Hong Lee & Hansoo Park. (2019) Spheroid Culture System Methods and Applications for Mesenchymal Stem Cells. Cells 8:12, pages 1620.
Crossref
Alex Wojaczek, Regina-Veronicka Kalaydina, Mohammed Gasmallah, Myron R. Szewczuk & Farhana Zulkernine. (2019) Computer Vision for Detecting and Measuring Multicellular Tumor Shperoids of Prostate Cancer. Computer Vision for Detecting and Measuring Multicellular Tumor Shperoids of Prostate Cancer.
Ernesto Scibona & Massimo Morbidelli. (2019) Expansion processes for cell-based therapies. Biotechnology Advances 37:8, pages 107455.
Crossref
WonJin Kim & GeunHyung Kim. (2019) Collagen/bioceramic-based composite bioink to fabricate a porous 3D hASCs-laden structure for bone tissue regeneration. Biofabrication 12:1, pages 015007.
Crossref
Yoshihisa Matsushita, Barbara Smith, Michael Delannoy, Maria A. Trujillo, Peter Chianchiano, Ross McMillan, Hirohiko Kamiyama, Hong Liang, Elizabeth D. Thompson, Ralph H. Hruban, William Matsui, Laura D. Wood, Nicholas J. Roberts & James R. Eshleman. (2019) Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture. Pancreas 48:9, pages 1225-1231.
Crossref
Sara Žigon-BrancMarica MarkovicJasper Van HoorickSandra Van VlierberghePeter DubruelElise ZerobinStefan BaudisAleksandr Ovsianikov. (2019) Impact of Hydrogel Stiffness on Differentiation of Human Adipose-Derived Stem Cell Microspheroids. Tissue Engineering Part A 25:19-20, pages 1369-1380.
Crossref

Displaying 200 of 368 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.