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Xing Liu, Jianxin Sui, Cui Li, Xudong Peng, Qian Wang, Nan Jiang, Qiang Xu, Luokai Wang, Jing Lin & Guiqiu Zhao. (2022) Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis. International Journal of Nanomedicine 17, pages 537-551.
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Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, William G. Darby, Chris G. Hosking, Lionel Renaud, Matthias Machacek, Peter Lloyd, Arne Skerra & Michael Foley. (2019) Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4. mAbs 11:7, pages 1331-1340.
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Herng C. Leow, Katja Fischer, Yee C. Leow, Katleen Braet, Qin Cheng & James McCarthy. (2019) Cytoplasmic and periplasmic expression of recombinant shark VNAR antibody in Escherichia coli. Preparative Biochemistry & Biotechnology 49:4, pages 315-327.
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Greg Hussack & Jamshid Tanha. (2016) An update on antibody-based immunotherapies for Clostridium difficile infection. Clinical and Experimental Gastroenterology 9, pages 209-224.
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Simon Krah, Christian Schröter, Stefan Zielonka, Martin Empting, Bernhard Valldorf & Harald Kolmar. (2016) Single-domain antibodies for biomedical applications. Immunopharmacology and Immunotoxicology 38:1, pages 21-28.
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Stefan Zielonka, Martin Empting, Julius Grzeschik, Doreen Könning, Caroline J Barelle & Harald Kolmar. (2015) Structural insights and biomedical potential of IgNAR scaffolds from sharks. mAbs 7:1, pages 15-25.
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Articles from other publishers (61)
P. Smyth, L. Ferguson, J. F. Burrows, R. E. Burden, S. R. Tracey, Ú. M. Herron, M. Kovaleva, R. Williams, A. J. Porter, D. B. Longley, C. J. Barelle & C. J. Scott. (2023) Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy. Frontiers in Pharmacology 14.
Crossref
Crossref
Shannon R. Tracey, Peter Smyth, Una M. Herron, James F. Burrows, Andrew J. Porter, Caroline J. Barelle & Christopher J. Scott. (2023)
Development of a cationic polyethyleneimine-poly(lactic-
co
-glycolic acid) nanoparticle system for enhanced intracellular delivery of biologics
. RSC Advances 13:48, pages 33721-33735.
Crossref
Crossref
Hiroyuki Takeda, Tatsuhiko Ozawa, Hiroki Zenke, Yoh Ohnuki, Yuri Umeda, Wei Zhou, Honoka Tomoda, Akihiko Takechi, Kimiyoshi Narita, Takaaki Shimizu, Takuya Miyakawa, Yuji Ito & Tatsuya Sawasaki. (2023) VNAR development through antigen immunization of Japanese topeshark (Hemitriakis japanica). Frontiers in Bioengineering and Biotechnology 11.
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Crossref
Lanyi Qin, Qingyu Ren, Chaoling Lu, Tianci Zhu, Yijun Lu, Shuangxing Chen, Shuna Tong, Xiaofeng Jiang & Zhengbing Lyu. (2023)
Screening and anti‐glioma activity of
Chiloscyllium plagiosum
anti‐human
IL‐13Rα2
single‐domain antibody
. Immunology 170:1, pages 105-119.
Crossref
Crossref
Hui Ting Lim, Boon Hui Kok, Chiuan Yee Leow & Chiuan Herng Leow. (2023) Exploring shark VNAR antibody against infectious diseases using phage display technology. Fish & Shellfish Immunology 140, pages 108986.
Crossref
Crossref
Harald Kolmar, Julius Grzeschik, Doreen Könning, Simon Krah & Stefan Zielonka. 2023. Phage Display. Phage Display
227
243
.
Aaron R.J Hutton, Obinna Ubah, Caroline Barelle & Ryan F. Donnelly. (2022) Enhancing the Transdermal Delivery of ‘Next Generation’ Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study. Journal of Pharmaceutical Sciences 111:12, pages 3362-3376.
Crossref
Crossref
H.T. Lim, B.H. Kok, C.P. Lim, A.B. Abdul Majeed, C.Y. Leow & C.H. Leow. (2022) Single domain antibodies derived from ancient animals as broadly neutralizing agents for SARS-CoV-2 and other coronaviruses. Biomedical Engineering Advances 4, pages 100054.
Crossref
Crossref
Chang Liu, Hong Lin, Limin Cao, Kaiqiang Wang & Jianxin Sui. (2022) Research progress on unique paratope structure, antigen binding modes, and systematic mutagenesis strategies of single-domain antibodies. Frontiers in Immunology 13.
Crossref
Crossref
Fang Zheng, Yucheng Pang, Luyao Li, Yuxing Pang, Jiaxin Zhang, Xinyi Wang & Geert Raes. (2022) Applications of nanobodies in brain diseases. Frontiers in Immunology 13.
Crossref
Crossref
Martin A. Rossotti, Kasandra Bélanger, Kevin A. Henry & Jamshid Tanha. (2021) Immunogenicity and humanization of single‐domain antibodies. The FEBS Journal 289:14, pages 4304-4327.
Crossref
Crossref
Bo Feng, Zhilong Chen, Jing Sun, Tingting Xu, Qian Wang, Haisu Yi, Xuefeng Niu, Jiabin Zhu, Mengzhu Fan, Ruitian Hou, Ying Shao, Sihui Huang, Cuiyun Li, Peiyu Hu, Pingqian Zheng, Ping He, Jia Luo, Qihong Yan, Xiaoli Xiong, Jinsong Liu, Jincun Zhao & Ling Chen. (2022) A Class of Shark‐Derived Single‐Domain Antibodies can Broadly Neutralize SARS‐Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape. Small Methods 6:7.
Crossref
Crossref
Zunera Khalid, Yulei Chen, Du Yu, Misbah Abbas, Ma Huan, Zara Naz, Hylemariam Mihiretie Mengist, Min-jie Cao & Tengchuan Jin. (2022) IgNAR antibody: Structural features, diversity and applications. Fish & Shellfish Immunology 121, pages 467-477.
Crossref
Crossref
Xiaona Wang, Fengcheng Li, Wenqi Qiu, Binbin Xu, Yanlin Li, Xichen Lian, Hongyan Yu, Zhao Zhang, Jianxin Wang, Zhaorong Li, Weiwei Xue & Feng Zhu. (2022) SYNBIP: synthetic binding proteins for research, diagnosis and therapy. Nucleic Acids Research 50:D1, pages D560-D570.
Crossref
Crossref
P. J. Wookey, P. Gupta, D. L. Hare, G. D. Ciccotosto & C. J. Hutchings. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology
1
45
.
Samata S. Pandey, Marina Kovaleva, Caroline J. Barelle & Obinna C. Ubah. 2022. Single-Domain Antibodies. Single-Domain Antibodies
19
33
.
Arghavan Soleimanizadeh, Heiko Dinter & Katharina Schindowski. (2021) Central Nervous System Delivery of Antibodies and Their Single-Domain Antibodies and Variable Fragment Derivatives with Focus on Intranasal Nose to Brain Administration. Antibodies 10:4, pages 47.
Crossref
Crossref
Shannon R. TraceyPeter SmythCaroline J. BarelleChristopher J. Scott. (2021) Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface. Biochemical Society Transactions 49:5, pages 2253-2269.
Crossref
Crossref
Hajime Enatsu, Nako Okamoto, Yoshiki Nomura, Masayoshi Onitsuka, Noriko Yamano-Adachi, Yuichi Koga & Takeshi Omasa. (2021) Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system. Journal of Bioscience and Bioengineering 132:3, pages 302-309.
Crossref
Crossref
Salma Nassor Juma, Xiaoxia Gong, Sujie Hu, Zhengbing Lv, Jianzhong Shao, Lili Liu & Guiqian Chen. (2021) Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical Applications. Cells 10:5, pages 1140.
Crossref
Crossref
Nachiket Shembekar. 2021. Immunodiagnostic Technologies from Laboratory to Point-Of-Care Testing. Immunodiagnostic Technologies from Laboratory to Point-Of-Care Testing
223
245
.
Long Wang, Gengyuan Zhang, Long Qin, Huili Ye, Yan Wang, Bo Long & Zuoyi Jiao. (2020) Anti-EGFR Binding Nanobody Delivery System to Improve the Diagnosis and Treatment of Solid Tumours. Recent Patents on Anti-Cancer Drug Discovery 15:3, pages 200-211.
Crossref
Crossref
Arturo Macarrón Palacios, Julius Grzeschik, Lukas Deweid, Simon Krah, Stefan Zielonka, Thies Rösner, Matthias Peipp, Thomas Valerius & Harald Kolmar. (2020) Specific Targeting of Lymphoma Cells Using Semisynthetic Anti-Idiotype Shark Antibodies. Frontiers in Immunology 11.
Crossref
Crossref
Roger Dodd, Darren J. Schofield, Trevor Wilkinson & Zachary T. Britton. (2020) Generating therapeutic monoclonal antibodies to complex multi-spanning membrane targets: Overcoming the antigen challenge and enabling discovery strategies. Methods 180, pages 111-126.
Crossref
Crossref
Sung In Lim. (2020) Fine-tuning bispecific therapeutics. Pharmacology & Therapeutics 212, pages 107582.
Crossref
Crossref
Wei Shien Cheong, Chiuan Yee Leow, Abu Bakar Abdul Majeed & Chiuan Herng Leow. (2020) Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody. International Journal of Biological Macromolecules 147, pages 369-375.
Crossref
Crossref
Murat Karadag, Merve Arslan, Nazli Eda Kaleli & Sibel Kalyoncu. 2020.
85
114
.
John Steven, Obinna C. Ubah, Magdalena Buschhaus, Marina Kovaleva, Laura Ferguson, Andrew J. Porter & Caroline J. Barelle. 2020. Genotype Phenotype Coupling. Genotype Phenotype Coupling
115
142
.
Doreen Könning, Stefan Zielonka, Anna Kaempffe, Sebastian Jäger, Harald Kolmar & Christian Schröter. 2020. Genotype Phenotype Coupling. Genotype Phenotype Coupling
191
209
.
Magdalena J Buschhaus, Stefan Becker, Andrew J Porter & Caroline J Barelle. (2019) Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents. Protein Engineering, Design and Selection 32:9, pages 385-399.
Crossref
Crossref
Mark L. Chiu, Dennis R. Goulet, Alexey Teplyakov & Gary L. Gilliland. (2019) Antibody Structure and Function: The Basis for Engineering Therapeutics. Antibodies 8:4, pages 55.
Crossref
Crossref
Kathryn L. Pepple, Leslie Wilson, Russell N. Van Gelder, Marina Kovaleva, Obinna C. Ubah, John Steven, Caroline J. Barelle & Andrew Porter. (2019) Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand. Translational Vision Science & Technology 8:5, pages 11.
Crossref
Crossref
Michael F. Criscitiello, Igor Kraev & Sigrun Lange. (2019) Deiminated proteins in extracellular vesicles and plasma of nurse shark (Ginglymostoma cirratum) - Novel insights into shark immunity. Fish & Shellfish Immunology 92, pages 249-255.
Crossref
Crossref
João C. F. Nogueira, Michelle K. Greene, Daniel A. Richards, Alexander O. Furby, John Steven, Andrew Porter, Caroline Barelle, Christopher J. Scott & Vijay Chudasama. (2019)
Oriented attachment of V
NAR
proteins,
via
site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
. Chemical Communications 55:53, pages 7671-7674.
Crossref
Crossref
Olivia Cabanillas-Bernal, Salvador Dueñas, Marta Ayala-Avila, Alexandra Rucavado, Teresa Escalante & Alexei F. Licea-Navarro. (2019) Synthetic libraries of shark vNAR domains with different cysteine numbers within the CDR3. PLOS ONE 14:6, pages e0213394.
Crossref
Crossref
Chris P. Hughes, Neil M.J. O’Flynn, Maureen Gatherer, Michelle E. McClements, Jennifer A. Scott, Robert E. MacLaren, Srinivas Goverdhan, Martin J. Glennie & Andrew J. Lotery. (2019) AAV2/8 Anti-angiogenic Gene Therapy Using Single-Chain Antibodies Inhibits Murine Choroidal Neovascularization. Molecular Therapy - Methods & Clinical Development 13, pages 86-98.
Crossref
Crossref
Hong Zhou, Shengtang Liu, Xiuhua Yin, Zengpeng Li, Zaixing Yang & Ruhong Zhou. (2019) Molecular Origin of the Stability Difference in Four Shark IgNAR Constant Domains. Biophysical Journal 116:10, pages 1907-1917.
Crossref
Crossref
Kasandra Bélanger, Umar Iqbal, Jamshid Tanha, Roger MacKenzie, Maria Moreno & Danica Stanimirovic. (2019) Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases. Antibodies 8:2, pages 27.
Crossref
Crossref
Starlynn C. Clarke, Biao Ma, Nathan D. Trinklein, Ute Schellenberger, Michael J. Osborn, Laure-Hélène Ouisse, Andrew Boudreau, Laura M. Davison, Katherine E. Harris, Harshad S. Ugamraj, Aarti Balasubramani, Kevin H. Dang, Brett Jorgensen, Heather Anne N. Ogana, Duy T. Pham, Payal P. Pratap, Preethi Sankaran, Ignacio Anegon, Wim C. van Schooten, Marianne Brüggemann, Roland Buelow & Shelley Force Aldred. (2019) Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies. Frontiers in Immunology 9.
Crossref
Crossref
Carl Luer & Catherine Walsh. (2018) Potential Human Health Applications from Marine Biomedical Research with Elasmobranch Fishes. Fishes 3:4, pages 47.
Crossref
Crossref
Doreen Könning & Harald Kolmar. (2018) Beyond antibody engineering: directed evolution of alternative binding scaffolds and enzymes using yeast surface display. Microbial Cell Factories 17:1.
Crossref
Crossref
Ronan O’Dwyer, Marina Kovaleva, Jiquan Zhang, John Steven, Emma Cummins, Deborah Luxenberg, Alfredo Darmanin-Sheehan, Miguel F. Carvalho, Matthew Whitters, Kenneth Saunders & Caroline J. Barelle. (2018) Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis. Journal of Immunology Research 2018, pages 1-13.
Crossref
Crossref
Dalia Millán-Gómez, Salvador Dueñas, Patricia L.A. Muñoz, Tanya Camacho-Villegas, Carolina Elosua, Olivia Cabanillas-Bernal, Teresa Escalante, Almudena Perona, David Abia, Florian Drescher, Pierrick G.J. Fournier, Marco A. Ramos, Rosa E. Mares, Jorge Paniagua-Solis, Teresa Mata-Gonzalez, Jorge Gonzalez-Canudas, Robert M. Hoffman, Alexei Licea-Navarro & Noemí Sánchez-Campos. (2018)
In silico-designed
mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization
. Oncotarget 9:46, pages 28016-28029.
Crossref
Crossref
Tanya Camacho-Villegas, María Mata-González, Walter García-Ubbelohd, Linda Núñez-García, Carolina Elosua, Jorge Paniagua-Solis & Alexei Licea-Navarro. (2018) Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF165 Neutralization. Marine Drugs 16:4, pages 113.
Crossref
Crossref
Doreen Könning, Julius Grzeschik, Steffen C. Hinz, Simon Krah, Martin Empting, Harald Kolmar & Stefan Zielonka. (2018) Shark attack: Haiantikörper für Biomedizin und Biotechnologie. BIOspektrum 24:2, pages 142-145.
Crossref
Crossref
Chiuan Herng Leow, Qin Cheng, Katja Fischer & James McCarthy. 2018. Antibody Engineering. Antibody Engineering.
Julius Grzeschik, Doreen Könning, Steffen C. Hinz, Simon Krah, Christian Schröter, Martin Empting, Harald Kolmar & Stefan Zielonka. 2018. Phage Display. Phage Display
147
167
.
Greg Hussack, Toya Nath Baral, Jason Baardsnes, Henk van Faassen, Shalini Raphael, Kevin A. Henry, Jianbing Zhang & C. Roger MacKenzie. (2017) A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display. Frontiers in Immunology 8.
Crossref
Crossref
John Steven, Mischa R. Müller, Miguel F. Carvalho, Obinna C. Ubah, Marina Kovaleva, Gerard Donohoe, Thomas Baddeley, Dawn Cornock, Kenneth Saunders, Andrew J. Porter & Caroline Jane Barelle. (2017) In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development. Frontiers in Immunology 8.
Crossref
Crossref
Chiuan Leow, Katja Fischer, Chiuan Leow, Qin Cheng, Candy Chuah & James McCarthy. (2017) Single Domain Antibodies as New Biomarker Detectors. Diagnostics 7:4, pages 52.
Crossref
Crossref
Marina Kovaleva, Katherine Johnson, John Steven, Caroline J. Barelle & Andrew Porter. (2017) Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis. Frontiers in Immunology 8.
Crossref
Crossref
Doreen Könning, Laura Rhiel, Martin Empting, Julius Grzeschik, Carolin Sellmann, Christian Schröter, Stefan Zielonka, Stephan Dickgießer, Thomas Pirzer, Desislava Yanakieva, Stefan Becker & Harald Kolmar. (2017) Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders. Scientific Reports 7:1.
Crossref
Crossref
Doreen Könning, Stefan Zielonka, Julius Grzeschik, Martin Empting, Bernhard Valldorf, Simon Krah, Christian Schröter, Carolin Sellmann, Björn Hock & Harald Kolmar. (2017) Camelid and shark single domain antibodies: structural features and therapeutic potential. Current Opinion in Structural Biology 45, pages 10-16.
Crossref
Crossref
Julius Grzeschik, Steffen C. Hinz, Doreen Könning, Thomas Pirzer, Stefan Becker, Stefan Zielonka & Harald Kolmar. (2017) A simplified procedure for antibody engineering by yeast surface display: Coupling display levels and target binding by ribosomal skipping. Biotechnology Journal 12:2, pages 1600454.
Crossref
Crossref
Obinna Ubah & Soumya Palliyil. 2017. Recombinant Antibodies for Infectious Diseases. Recombinant Antibodies for Infectious Diseases
99
117
.
Sara Mashoof & Michael Criscitiello. (2016) Fish Immunoglobulins. Biology 5:4, pages 45.
Crossref
Crossref
George P. Anderson, Daniel D. Teichler, Dan Zabetakis, Lisa C. Shriver-Lake, Jinny L. Liu, Stephen G. Lonsdale, Sarah A. Goodchild & Ellen R. Goldman. (2016) Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. PLOS ONE 11:8, pages e0160534.
Crossref
Crossref
Caroline Barelle & Andy Porter. (2015) VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins. Antibodies 4:3, pages 240-258.
Crossref
Crossref
Miguel de los Rios, Michael F Criscitiello & Vaughn V Smider. (2015) Structural and genetic diversity in antibody repertoires from diverse species. Current Opinion in Structural Biology 33, pages 27-41.
Crossref
Crossref
晟 刘. (2015) Research Advance in Single-Domain Antibody. QianRen Biology 02:03, pages 26-38.
Crossref
Crossref
Michaela Gebauer & Arne Skerra. 2015. Biobetters. Biobetters
221
268
.