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Review

RNAi as a gene therapy approach

Pages 575-586 | Published online: 03 Mar 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Malak Rizk & Şükrü Tüzmen. (2017) Update on the clinical utility of an RNA interference-based treatment: focus on Patisiran. Pharmacogenomics and Personalized Medicine 10, pages 267-278.
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Vsevolod V. Gurevich & Eugenia V. Gurevich. (2015) Analyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKs. Critical Reviews in Biochemistry and Molecular Biology 50:5, pages 440-452.
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Dominique Briane, Hocine Slimani, Arezki Tagounits, Regine Naejus, Oualid Haddad, Robert Coudert, Nathalie Charnaux & An Cao. (2012) Inhibition of VEGF expression in A431 and MDA-MB-231 tumour cells by cationic lipid-mediated siRNA delivery. Journal of Drug Targeting 20:4, pages 347-354.
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Shingo Niimi, Mizuho Harashima, Masashi Hyuga & Teruhide Yamaguchi. (2007) Study of hepatocytes using RNA interference. Journal of Organ Dysfunction 3:3, pages 164-182.
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Rosanne M Crooke. (2005) Antisense oligonucleotides as therapeutics for hyperlipidaemias. Expert Opinion on Biological Therapy 5:7, pages 907-917.
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Janet L Douglas. (2004) In search of a small-molecule inhibitor for respiratory syncytial virus. Expert Review of Anti-infective Therapy 2:4, pages 625-639.
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Eric Devroe & Pamela A Silver. (2004) Therapeutic potential of retroviral RNAi vectors. Expert Opinion on Biological Therapy 4:3, pages 319-327.
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Sheyda Ranjbar, Xiao-bo Zhong, José Manautou & Xiuling Lu. (2023) A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics. Advanced Drug Delivery Reviews 201, pages 115052.
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Krishna Yadav, Deependra Singh, Manju Rawat Singh, Sunita Minz, Kantrol Kumar Sahu, Monika Kaurav & Madhulika Pradhan. (2022) Dermal nanomedicine: Uncovering the ability of nucleic acid to alleviate autoimmune and other related skin disorders. Journal of Drug Delivery Science and Technology 73, pages 103437.
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Yixin Yang, Jinsong Zhao, Yunze Li, Xiangyao Li, Xiaowei Chen & Zhiying Feng. (2021) Fragile X mental retardation protein‐regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant. Journal of Neurochemistry 159:3, pages 512-524.
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Nitin Verma, Komal Thapa & Kamal Dua. 2021. Targeting Cellular Signalling Pathways in Lung Diseases. Targeting Cellular Signalling Pathways in Lung Diseases 903 926 .
Yan Wu, Tianqiang Song, Peipei Chen, Xiaohong Jiang, Qiang Wang & Qihan Chen. (2020) Prolonged siRNA expression in mammalian cells using an Epstein–Barr virus-based plasmid expression system. Biochemical and Biophysical Research Communications 529:1, pages 51-56.
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Edwin H. Yau, Robert T. Taggart, Mohammed Zuber, Alexandria J. Trujillo, Zahra S. Fayazi, Mark C. Butler, Lowell G. Sheflin, Jennifer B. Breen, Dian Yu & Jack M. Sullivan. (2019) Systematic Screening, Rational Development, and Initial Optimization of Efficacious RNA Silencing Agents for Human Rod Opsin Therapeutics. Translational Vision Science & Technology 8:6, pages 28.
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Jun Hu & Yuxian Xia. (2016) F 1 -ATP synthase α -subunit: a potential target for RNAi-mediated pest management of Locusta migratoria manilensis . Pest Management Science 72:7, pages 1433-1439.
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Giuliana Di Rocco, Alessandra Verdina, Veronica Gatti, Ilaria Virdia, Gabriele Toietta, Matilde Todaro, Giorgio Stassi & Silvia Soddu. (2015) Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform. Oncotarget 7:2, pages 1675-1686.
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Ramsey N. Majzoub, Chia-Ling Chan, Kai K. Ewert, Bruno F.B. Silva, Keng S. Liang & Cyrus R. Safinya. (2015) Fluorescence microscopy colocalization of lipid–nucleic acid nanoparticles with wildtype and mutant Rab5–GFP: A platform for investigating early endosomal events. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:6, pages 1308-1318.
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Cary G. Pfeffer. 2012. The Business of Healthcare Innovation. The Business of Healthcare Innovation 194 345 .
Sebastián Ezequiel Pérez, Yamila Gándola, Adriana Mónica Carlucci, Lorena González, Daniel Turyn & Carlos Bregni. (2012) Formulation Strategies, Characterization, and In Vitro Evaluation of Lecithin-Based Nanoparticles for siRNA Delivery . Journal of Drug Delivery 2012, pages 1-9.
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Cecília Leal, Nathan F. Bouxsein, Kai K. Ewert & Cyrus R. Safinya. (2010) Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix. Journal of the American Chemical Society 132:47, pages 16841-16847.
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Kai K. Ewert, Alexandra Zidovska, Ayesha Ahmad, Nathan F. Bouxsein, Heather M. Evans, Christopher S. McAllister, Charles E. Samuel & Cyrus R. Safinya. 2010. Nucleic Acid Transfection. Nucleic Acid Transfection 191 226 .
Michael Zinke, Sabine Kendl, Katrin Singethan, Markus Fehrholz, Dajana Reuter, Linda Rennick, Marco J. Herold & Jürgen Schneider-Schaulies. (2009) Clearance of Measles Virus from Persistently Infected Cells by Short Hairpin RNA. Journal of Virology 83:18, pages 9423-9431.
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S. Ruiz, B.D. Schyth, P. Encinas, C. Tafalla, A. Estepa, N. Lorenzen & J.M. Coll. (2009) New tools to study RNA interference to fish viruses: Fish cell lines permanently expressing siRNAs targeting the viral polymerase of viral hemorrhagic septicemia virus. Antiviral Research 82:3, pages 148-156.
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Hua Yue, Dingfei Li, Anjing Fu, Li Ma, Falong Yang & Cheng Tang. (2008) shRNA-triggered RNAi inhibits expression of NDV NP gene in chicken embryo fibroblast. Frontiers of Biology in China 3:4.
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Manzoor M. KhanManzoor M. Khan. 2008. Immunopharmacology. Immunopharmacology 227 252 .
Ai Ling Fu, Xue Bin Yan & Li Sui. (2007) Down-regulation of β1-adrenoceptors gene expression by short interfering RNA impairs the memory retrieval in the basolateral amygdala of rats. Neuroscience Letters 428:2-3, pages 77-81.
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Wei-Jia Kong, Su-Lin Zhang, Xiong Chen, Song Zhang, Yan-Jun Wang, Dan Zhang & Yu Sun. (2007) PC cell-derived growth factor overexpression promotes proliferation and survival of laryngeal carcinoma. Anti-Cancer Drugs 18:1, pages 29-40.
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Thorsten Reuter, Benedikt Weissbrich, Sibylle Schneider-Schaulies & Jürgen Schneider-Schaulies. (2006) RNA Interference with Measles Virus N, P, and L mRNAs Efficiently Prevents and with Matrix Protein mRNA Enhances Viral Transcription. Journal of Virology 80:12, pages 5951-5957.
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Mark A. Crumling & Yehoash Raphael. (2006) Manipulating gene expression in the mature inner ear. Brain Research 1091:1, pages 265-269.
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Wei-Hua Pan & Gary A. Clawson. (2006) Antisense applications for biological control. Journal of Cellular Biochemistry 98:1, pages 14-35.
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Martha Meaney Murray & Michael F. Murray. 2006. The Pediatric and Adolescent Knee. The Pediatric and Adolescent Knee 33 40 .
Yun-Han Lee, Ik-Jae Moon, Bin Hur, Jeong-Hoh Park, Kil-Hwan Han, Seok-Yong Uhm, Yong-Joo Kim, Koo-Jeong Kang, Jong-Wook Park, Young-Bae Seu, Young-Ho Kim & Jong-Gu Park. (2005) Gene knockdown by large circular antisense for high-throughput functional genomics. Nature Biotechnology 23:5, pages 591-599.
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Anna M. Wobus & Kenneth R. Boheler. (2005) Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy. Physiological Reviews 85:2, pages 635-678.
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M Golzio, L Mazzolini, P Moller, M P Rols & J Teissié. (2004) Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery. Gene Therapy 12:3, pages 246-251.
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Lu Xin, Zheng Qichang & Xiong Jun. (2005) Effect of siRNA targeting survivin gene on the biological behavior of hepatocellular carcinoma. Journal of Huazhong University of Science and Technology [Medical Sciences] 25:1, pages 48-50.
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P.L. Rachel Ee, Xiaolong He, Douglas D. Ross & William T. Beck. (2004) Modulation of breast cancer resistance protein ( BCRP / ABCG2 ) gene expression using RNA interference . Molecular Cancer Therapeutics 3:12, pages 1577-1584.
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Dante S. Zarlenga. (2007) Vaccinating against zoonotic parasitic diseases: myth or reality?. Animal Health Research Reviews 5:2, pages 219-222.
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Tracey L.H. Jason, James Koropatnick & Randal W. Berg. (2004) Toxicology of antisense therapeutics. Toxicology and Applied Pharmacology 201:1, pages 66-83.
Crossref
Erwei Song, Deborah Palliser, Judy Lieberman, Patrick Stern & Luk Van Parijs. 2004. Gene Silencing by RNA Interference. Gene Silencing by RNA Interference.
Natasha Caplen. 2004. Gene Silencing by RNA Interference. Gene Silencing by RNA Interference.
Benjamin G Cocks & Thomas P Theriault. (2004) Developments in effective application of small inhibitory RNA (siRNA) technology in mammalian cells. Drug Discovery Today: TARGETS 3:4, pages 165-171.
Crossref
Alessandro Salvi, Bruna Arici, Giuseppina De Petro & Sergio Barlati. (2004) Small interfering RNA urokinase silencing inhibits invasion and migration of human hepatocellular carcinoma cells. Molecular Cancer Therapeutics 3:6, pages 671-678.
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Jan Krönke, Ralf Kittler, Frank Buchholz, Marc P. Windisch, Thomas Pietschmann, Ralf Bartenschlager & Michael Frese. (2004) Alternative Approaches for Efficient Inhibition of Hepatitis C Virus RNA Replication by Small Interfering RNAs. Journal of Virology 78:7, pages 3436-3446.
Crossref
R.L. Page & S. Ambady. (2004) Animal cloning applications in agriculture. IEEE Engineering in Medicine and Biology Magazine 23:2, pages 27-31.
Crossref
Yongjie Yang, Siddharth Kaul, Danhui Zhang, Vellareddy Anantharam & Anumantha G Kanthasamy. (2004) Suppression of caspase-3-dependent proteolytic activation of protein kinase Cδ by small interfering RNA prevents MPP+-induced dopaminergic degeneration. Molecular and Cellular Neuroscience 25:3, pages 406-421.
Crossref
Le Hung & Vijay Kumar. (2004) Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c- myc by small interfering RNAs . FEBS Letters 560:1-3, pages 210-214.
Crossref
Ralf Bartenschlager, Michael Frese & Thomas Pietschmann. 2004. Advances in Virus Research Volume 63. Advances in Virus Research Volume 63 71 180 .

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