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Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 3
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Review

Therapeutic potential of TGF-β inhibition in chronic renal failure

Elena Gagliardini Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy. [email protected]
&
Ariela Benigni Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy. [email protected]
Pages 293-304 | Published online: 19 Feb 2007

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Solange Moll, Matthias Meier, Ivan Formentini, Silvia Pomposiello & Marco Prunotto. (2014) New renal drug development to face chronic renal disease. Expert Opinion on Drug Discovery 9:12, pages 1471-1485.
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Koji Takakura, Atsuo Tahara, Masanao Sanagi, Hiroyuki Itoh & Yuichi Tomura. (2012) Antifibrotic Effects of Pirfenidone in Rat Proximal Tubular Epithelial Cells. Renal Failure 34:10, pages 1309-1316.
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Articles from other publishers (27)

Jonathan S. Chávez-Iñiguez, Jorge L. Poo, Miguel Ibarra-Estrada, Leonel García-Benavides, Guillermo Navarro-Blackaller, Cynthia Cervantes-Sánchez, Eduardo Nungaray-Pacheco, Ramón Medina-González, Juan Armendariz-Borunda & Guillermo García-García. (2021) Effect of Prolonged-Release Pirfenidone on Renal Function in Septic Acute Kidney Injury Patients: A Double-Blind Placebo-Controlled Clinical Trial. International Journal of Nephrology 2021, pages 1-7.
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Yan Zhang, Yuqiao Dai, Archana Raman, Emily Daniel, July Metcalf, Gail Reif, Fernando Pierucci-Alves & Darren P. Wallace. (2020) Overexpression of TGF-β1 induces renal fibrosis and accelerates the decline in kidney function in polycystic kidney disease. American Journal of Physiology-Renal Physiology 319:6, pages F1135-F1148.
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Anupam Agarwal & Karl A. Nath. 2020. Chronic Renal Disease. Chronic Renal Disease 263 278 .
Zhang Sen, Wang Weida, Yan Li, Li Zhaojun, Xue Nina & Chen Xiaoguang. (2019) Nicousamide attenuates renal dysfunction and glomerular injury in remnant kidneys by inhibiting TGF-β1 internalisation and renin activity. European Journal of Pharmacology 845, pages 74-84.
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Mirco Belingheri, Gabriella Moroni & Piergiorgio Messa. (2017) Available and incoming therapies for idiopathic focal and segmental glomerulosclerosis in adults. Journal of Nephrology 31:1, pages 37-45.
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Jing Yuan, Yan Shen, Xia Yang, Ying Xie, Xin Lin, Wen Zeng, Yingting Zhao, Maolu Tian & Yan Zha. (2017) Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models. BMC Nephrology 18:1.
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Wen-Pyng Wu, Yi-Giien Tsai, Tze-Yi Lin, Ming-Ju Wu & Ching-Yuang Lin. (2017) The attenuation of renal fibrosis by histone deacetylase inhibitors is associated with the plasticity of FOXP3+IL-17+ T cells. BMC Nephrology 18:1.
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Daniela Macconi, Ariela Benigni & Giuseppe Remuzzi. 2016. Kidney Development, Disease, Repair and Regeneration. Kidney Development, Disease, Repair and Regeneration 351 366 .
Youakim Saliba, Ralph Karam, Viviane Smayra, Georges Aftimos, Joel Abramowitz, Lutz Birnbaumer & Nassim Farès. (2015) Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis. Journal of the American Society of Nephrology 26:8, pages 1855-1876.
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Anupam Agarwal & Karl A. Nath. 2015. Chronic Renal Disease. Chronic Renal Disease 136 150 .
Sen Zhang, Jingzhi Yang, Hongyan Li, Yan Li, Yue Liu, Dongming Zhang, Furong Zhang, Wanqi Zhou & Xiaoguang Chen. (2012) Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats. European Journal of Pharmacology 692:1-3, pages 78-83.
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Min-Jung Kim, Uk Namgung & Kwon-Eui Hong. (2012) Regenerative Effects of Moxibustion on Skeletal Muscle in Collagen-Induced Arthritic Mice. Journal of Acupuncture and Meridian Studies 5:3, pages 126-135.
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Abolfazl Zarjou & Anupam Agarwal. (2012) Heme Oxygenase-1 as a Target for TGF-β in Kidney Disease. Seminars in Nephrology 32:3, pages 277-286.
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Ayesha Ghayur, Limin Liu, Martin Kolb, Arun Chawla, Shahid Lambe, Anil Kapoor & Peter J. Margetts. (2012) Adenovirus-Mediated Gene Transfer of TGF-β1 to the Renal Glomeruli Leads to Proteinuria. The American Journal of Pathology 180:3, pages 940-951.
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Howard Trachtman, Fernando C. Fervenza, Debbie S. Gipson, Peter Heering, David R.W. Jayne, Harm Peters, Stefano Rota, Giuseppe Remuzzi, L. Christian Rump, Lorenz K. Sellin, Jeremy P.W. Heaton, James B. Streisand, Marjie L. Hard, Steven R. Ledbetter & Flavio Vincenti. (2011) A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney International 79:11, pages 1236-1243.
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Marco Prunotto, Giulio Gabbiani, Silvia Pomposiello, GianMarco Ghiggeri & Solange Moll. (2011) The kidney as a target organ in pharmaceutical research. Drug Discovery Today 16:5-6, pages 244-259.
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Xia Liu, Lei Lü, Bei-bei Tao, Ai-ling Zhou & Yi-chun Zhu. (2011) Amelioration of glomerulosclerosis with all-trans retinoic acid is linked to decreased plasminogen activator inhibitor-1 and α-smooth muscle actin. Acta Pharmacologica Sinica 32:1, pages 70-78.
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Wen-Pyng WuChi-Hao ChangYung-Tsung ChiuCheng-Lung KuMei-Chin Wen, Kuo-Hsiung Shu & Ming-Ju Wu. (2010) A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren. American Journal of Physiology-Renal Physiology 299:5, pages F929-F941.
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Hong‐Wei Chang, Vin‐Cent Wu, Kwan‐Dun Wu, Hong‐Yu Huang, Bor‐Shen Hsieh & Yung‐Ming Chen. (2010) In rat renal fibroblasts, mycophenolic acid inhibits proliferation and production of the chemokine CCL2, stimulated by tumour necrosis factor‐α. British Journal of Pharmacology 160:7, pages 1611-1620.
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Koji Takakuta, Akira Fujimori, Toshihiro Chikanishi, Akira Tanokura, Yoshiyuki Iwatsuki, Masanori Yamamoto, Hidenori Nakajima, Masamichi Okada & Hiroyuki Itoh. (2010) Renoprotective properties of pirfenidone in subtotally nephrectomized rats. European Journal of Pharmacology 629:1-3, pages 118-124.
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Maddalena Marasà & Jeffrey B. Kopp. (2009) Monoclonal antibodies for podocytopathies: rationale and clinical responses. Nature Reviews Nephrology 5:6, pages 337-348.
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S. H. Yang, S. J. Shin, J. E. Oh, J. Z. Jin, N. H. Chung, C. S. Lim, S. Kim & Y. S. Kim. (2008) The protective role of uteroglobin through the modulation of tissue transglutaminase in the experimental crescentic glomerulonephritis. Nephrology Dialysis Transplantation 23:11, pages 3437-3445.
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Christoph Daniel. (2008) Blocking of angiotensin II is more than blocking of transforming growth factor-β. Kidney International 74:5, pages 551-553.
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Zhao Bo Li, Helen D. Kollias & Kathryn R. Wagner. (2008) Myostatin Directly Regulates Skeletal Muscle Fibrosis. Journal of Biological Chemistry 283:28, pages 19371-19378.
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S. Zhu, Y. Liu, L. Wang & Q. H. Meng. (2008) Transforming growth factor- 1 is associated with kidney damage in patients with essential hypertension: renoprotective effect of ACE inhibitor and/or angiotensin II receptor blocker. Nephrology Dialysis Transplantation 23:9, pages 2841-2846.
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Jonghoon Kang, Myung Soog Lee, John A. CoplandIIIIII, Bruce A. Luxon & David G. Gorenstein. (2008) Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-β1 protein. Bioorganic & Medicinal Chemistry Letters 18:6, pages 1835-1839.
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Paul Jennings, Christian KoppelstÄtter, Judith Lechner & Walter Pfaller. 2008. Clinical Nephrotoxins. Clinical Nephrotoxins 223 249 .

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