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Review

Advances in ischemic stroke treatment: neuroprotective and combination therapies

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Pages 97-112 | Published online: 14 Mar 2007

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Hongyin Ma, Zhenmin Jiang, Jiayun Xu, Junqiu Liu & Zhen-Ni Guo. (2021) Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke. Drug Delivery 28:1, pages 357-371.
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Paul A Lapchak. (2011) Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective. Expert Opinion on Investigational Drugs 20:1, pages 13-22.
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Paul A Lapchak. (2008) The many faces of erythropoietin: from erythropoiesis to a rational neuroprotective strategy – correspondence. Expert Opinion on Investigational Drugs 17:10, pages 1615-1616.
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Paul A Lapchak. (2008) Carbamylated erythropoietin to treat neuronal injury: new development strategies. Expert Opinion on Investigational Drugs 17:8, pages 1175-1186.
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Iordanis Gravanis & Stella E Tsirka. (2008) Tissue-type plasminogen activator as a therapeutic target in stroke. Expert Opinion on Therapeutic Targets 12:2, pages 159-170.
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Paul A Lapchak & Dalia M Araujo. (2007) Advances in hemorrhagic stroke therapy: conventional and novel approaches. Expert Opinion on Emerging Drugs 12:3, pages 389-406.
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Jia-Hao Feng, Xiao-Long Hu, Xian-Yu Lv, Yu Hong, Yuan-Hao Zhang, Huan long, Rong Wang, Jing-Jin Wang, Fei Xiong & Hao Wang. (2022) 4-Trifluoromethyl-(E)-cinnamoyl]-L-4-F-phenylalanine acid exerts its effects on the prevention, post-therapeutic and prolongation of the thrombolytic window in ischemia-reperfusion rats through multiple mechanisms of action. Pharmacological Research 178, pages 106182.
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Patrick D. Lyden. (2021) Cerebroprotection for Acute Ischemic Stroke: Looking Ahead. Stroke 52:9, pages 3033-3044.
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Mark B. Plotnikov & Tatiana M. Plotnikova. (2021) Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant. Current Neuropharmacology 19:4, pages 434-448.
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Neha Dhir, Bikash Medhi, Ajay Prakash, Manoj Kumar Goyal, Manish Modi & Sandeep Mohindra. (2020) Pre-clinical to Clinical Translational Failures and Current Status of Clinical Trials in Stroke Therapy: A Brief Review. Current Neuropharmacology 18:7, pages 596-612.
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Anders Bach, Bettina H. Clausen, Lotte K. Kristensen, Maria G. Andersen, Ditte Gry Ellman, Pernille B.L. Hansen, Henrik Hasseldam, Marc Heitz, Dennis Özcelik, Ellie J. Tuck, Maksym V. Kopanitsa, Seth G.N. Grant, Karin Lykke-Hartmann, Flemming F. Johansen, Kate L. Lambertsen & Kristian Strømgaard. (2019) Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor. Neuropharmacology 150, pages 100-111.
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Yi Li, Han-xu Xi, Sha Zhu, Na Yu, Jing Wang, Yan Li, Guo-pei Yu, Xie-min Ma, Jun Zhang & Lue-ping Zhao. (2014) Cost-effectiveness analysis of combined Chinese medicine and Western medicine for ischemic stroke patients. Chinese Journal of Integrative Medicine 20:8, pages 570-584.
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Bowen Yang, Jingpu Shi, Xin Chen, Bing Ma & Hao Sun. (2014) Efficacy and Safety of Therapies for Acute Ischemic Stroke in China: A Network Meta-Analysis of 13289 Patients from 145 Randomized Controlled Trials. PLoS ONE 9:2, pages e88440.
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Yaohui Tang, Yaning Li, Xiaojie Lin, Peng Miao, Yongting Wang & Guo-Yuan Yang. 2014. Cerebral Angiogenesis. Cerebral Angiogenesis 317 329 .
Jie Miao, Lin‐Hui Shen, Yao‐Hui Tang, Yong‐Ting Wang, Mei‐Xin Tao, Kun‐Lin Jin, Yong‐Ju Zhao & Guo‐Yuan Yang. (2013) Overexpression of Adiponectin Improves Neurobehavioral Outcomes After Focal Cerebral Ischemia in Aged Mice. CNS Neuroscience & Therapeutics 19:12, pages 969-977.
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Paul A. Lapchak. (2012) Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules. Translational Stroke Research 4:3, pages 328-342.
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P.D. Schellinger & M. Köhrmann. (2012) Nah-Infrarot-Lasertherapie beim akuten SchlaganfallNear-infrared laser treatment of acute stroke. Der Nervenarzt 83:8, pages 966-974.
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Kiyoshi Kikuchi, Hisaaki Uchikado, Motohiro Morioka, Yoshinaka Murai & Eiichiro Tanaka. (2012) Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke. International Journal of Molecular Sciences 13:6, pages 7739-7761.
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Iliana Sosa Teste, Yuneidys Mengana Tamos, Yamila Rodríguez Cruz, Adriana Muñoz Cernada, Janette Cruz Rodríguez, Nelvis Subirós Martínez, Rosa Maria Coro Antich, Alina González-Quevedo & Julio Cesar García Rodríguez. (2012) Dose Effect Evaluation and Therapeutic Window of the Neuro-EPO Nasal Application for the Treatment of the Focal Ischemia Model in the Mongolian Gerbil. The Scientific World Journal 2012, pages 1-12.
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T. Prakash, D. Kotresha & N. Rama Rao. (2011) Cerebroprotective activity of Wedelia calendulacea on global cerebral ischemia in rats . Acta Biologica Hungarica 62:4, pages 361-375.
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Michel P. Rathbone, Tarek M. Saleh, Barry J. Connell, Ruby Chang, Caixin Su, Brandon Worley, Minji Kim & Shucui Jiang. (2011) Systemic administration of guanosine promotes functional and histological improvement following an ischemic stroke in rats. Brain Research 1407, pages 79-89.
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Paul A. Lapchak, David R. Schubert & Pamela A. Maher. (2011) Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. Journal of Neurochemistry 116:1, pages 122-131.
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Xian-kun Tu, Wei-zhong Yang, Chun-hua Wang, Song-sheng Shi, Yong-liang Zhang, Chun-mei Chen, Yi-kun Yang, Chang-dan Jin & Shuai Wen. (2010) Zileuton Reduces Inflammatory Reaction and Brain Damage Following Permanent Cerebral Ischemia in Rats. Inflammation 33:5, pages 344-352.
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Paul A. Lapchak & Moon Ku Han. (2010) Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: Synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator. Brain Research 1344, pages 217-225.
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Paul A. Lapchak. (2010) Translational Stroke Research Using a Rabbit Embolic Stroke Model: A Correlative Analysis Hypothesis for Novel Therapy Development. Translational Stroke Research 1:2, pages 96-107.
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William M. Armstead, Kumkum Ganguly, J. W. Kiessling, John Riley, Xiao‐Han Chen, Douglas H. Smith, Sherman C. Stein, Abd A. R. Higazi, Douglas B. Cines, Khalil Bdeir, Sergei Zaitsev & Vladimir R. Muzykantov. (2010) Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders. Journal of Neurochemistry 113:2, pages 303-312.
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Paul A. Lapchak. (2010) Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: A combination therapy study with tissue plasminogen activator. Brain Research 1309, pages 136-145.
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Paul A. Lapchak & Luis De Taboada. (2010) Transcranial near infrared laser treatment (NILT) increases cortical adenosine-5?-triphosphate (ATP) content following embolic strokes in rabbits. Brain Research 1306, pages 100-105.
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Pamela Maher. 2009. Micronutrients and Brain Health. Micronutrients and Brain Health.
Sabareesh K. NatarajanKenneth V. SnyderAdnan H. SiddiquiCatalina C. IonitaL. Nelson HopkinsElad I. Levy. (2009) Safety and Effectiveness of Endovascular Therapy After 8 Hours of Acute Ischemic Stroke Onset and Wake-Up Strokes. Stroke 40:10, pages 3269-3274.
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Paul A. Lapchak. (2009) Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model. Brain Research 1294, pages 211-217.
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Xian-kun Tu, Wei-zhong Yang, Song-sheng Shi, Chun-hua Wang & Chun-mei Chen. (2009) Neuroprotective Effect of Baicalin in a Rat Model of Permanent Focal Cerebral Ischemia. Neurochemical Research 34:9, pages 1626-1634.
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Paul A. Lapchak & Justin A. Zivin. (2009) The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: A combination therapy study with tissue plasminogen activator. Experimental Neurology 215:1, pages 95-100.
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W. David Lust, Jennifer Zechel & Svetlana Pundik. 2009. Metabolic Encephalopathy. Metabolic Encephalopathy 41 67 .
Johannes Boltze, Annette Förschler, Björn Nitzsche, Daniela Waldmin, Anke Hoffmann, Christiane M Boltze, Antje Y Dreyer, Axel Goldammer, Anne Reischauer, Wolfgang Hartig, Kathrin D Geiger, Henryk Barthel, Frank Emmrich & Uwe Gille. (2008) Permanent Middle Cerebral Artery Occlusion in Sheep: A Novel Large Animal Model of Focal Cerebral Ischemia. Journal of Cerebral Blood Flow & Metabolism 28:12, pages 1951-1964.
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Paul A. LapchakMoon-Ku HanKarmen F. SalgadoJackson StreeterJustin A. Zivin. (2008) Safety Profile of Transcranial Near-Infrared Laser Therapy Administered in Combination With Thrombolytic Therapy to Embolized Rabbits. Stroke 39:11, pages 3073-3078.
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Paul A. Lapchak, Agnete Kirkeby, Justin A. Zivin & Thomas N. Sager. (2008) Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits. Brain Research 1238, pages 208-214.
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Yewei Sun, Jie Jiang, Zaijun Zhang, Pei Yu, Linda Wang, Changlin Xu, Wei Liu & Yuqiang Wang. (2008) Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke. Bioorganic & Medicinal Chemistry 16:19, pages 8868-8874.
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Alfredo Casasco, Hugo Cuellar, Francisco Gilo, Leopoldo Guimaraens & Jacques Theron. (2007) Vertebrobasilar recanalization after 12 h of onset using balloon expandable stent and thrombolysis. Emergency Radiology 15:4, pages 273-276.
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P.A. Lapchak, P. Maher, D. Schubert & J.A. Zivin. (2007) Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. Neuroscience 150:3, pages 585-591.
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Alan R. Young, Carine Ali, Arnaud Duretête & Denis Vivien. (2007) Neuroprotection and stroke: time for a compromise. Journal of Neurochemistry 103:4, pages 1302-1309.
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Pamela Maher, Karmen F. Salgado, Justin A. Zivin & Paul A. Lapchak. (2007) A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Research 1173, pages 117-125.
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P.A. Lapchak, K.F. Salgado, C.H. Chao & J.A. Zivin. (2007) Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: An extended therapeutic window study using continuous and pulse frequency delivery modes. Neuroscience 148:4, pages 907-914.
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Paul A. Lapchak. (2007) Tumor necrosis factor-α is involved in thrombolytic-induced hemorrhage following embolic strokes in rabbits. Brain Research 1167, pages 123-128.
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