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Review

Emerging therapies for osteoporosis

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Pages 1-43 | Published online: 24 Feb 2005

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JH Tobias, AM Flanagan & AM Scutt. (2002) Novel therapeutic targets in osteoporosis. Expert Opinion on Therapeutic Targets 6:1, pages 41-56.
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Tomi Sawyer, Brendan Boyce, David Dalgarno & John Iuliucci. (2001) Src inhibitors: genomics to therapeutics. Expert Opinion on Investigational Drugs 10:7, pages 1327-1344.
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Laura D Gegnas. (2000) Patent focus on agents for osteoporosis: September 1999 - February 2000. Expert Opinion on Therapeutic Patents 10:6, pages 833-846.
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Chang-Soo Cho, Hye-Seong Jeong, In-Young Kim, Go-Woon Jung, Bon-Hwa Ku, Dong-Chan Park, Seung-Bae Moon, Hyung-Rae Cho, Khawaja Muhammad Imran Bashir, Sae Kwang Ku & Jae-Suk Choi. (2018) Anti-osteoporotic effects of mixed compositions of extracellular polymers isolated from Aureobasidium pullulans and Textoria morbifera in ovariectomized mice. BMC Complementary and Alternative Medicine 18:1.
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Chang-Soo Cho, Hye-Seong Jeong, In-Young Kim, Go-Woon Jung, Bon-Hwa Ku, Dong-Chan Park, Seung-Bae Moon, Hyung-Rae Cho, Sae Kwang Ku & Jae-Suk Choi. (2018) Antiosteoporotic effects of 3:1 (g/g) mixed formulation of exopolymers purified from Aureobasidium pullulans SM-2001 and Dendropanax morbifera leaf extracts in ovariectomized rats . Journal of Food Biochemistry 42:5, pages e12548.
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Jae-Suk ChoiMi-Yeon ParkJong-Dae KimHyung Rae ChoIn Soon ChoiJoo-Wan Kim. (2013) Safety and Efficacy of Polycalcium for Improving Biomarkers of Bone Metabolism: A 4-Week Open-Label Clinical Study. Journal of Medicinal Food 16:3, pages 263-267.
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Jae-Suk Choi, Joo-Wan Kim, Ki-Young Kim, Hyung-Rae Cho, Yu-Mi Ha, Sae-Kwang Ku, Kwang-Keun Cho & In-Soon Choi. (2011) In vitro Activities of Polycalcium, a Mixture of Polycan and Calcium Lactate-Gluconate, on Osteoclasts and Osteoblasts. Journal of Life Science 21:8, pages 1199-1203.
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Youmie Park, Jae Yang Kong & Heeyeong Cho. (2009) A furanquinone from Paulownia tomentosa stem for a new cathepsin K inhibitor . Phytotherapy Research 23:10, pages 1485-1488.
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Sang Yeob Han, Jong Rok Lee, Young Kyu Kwon, Mi Jeong Jo, Sook Jahr Park, Sang Chan Kim, Hyeung Sik Lee & Sae Kwang Ku. (2007) Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations. Journal of Ethnopharmacology 114:3, pages 400-405.
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Vadim D. Romanenko & Valery P. Kukhar. (2006) Fluorinated Phosphonates:  Synthesis and Biomedical Application. Chemical Reviews 106:9, pages 3868-3935.
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Ashvinikumar V. Gavai, Roy J. Vaz, Amarendra B. Mikkilineni, Jacques Y. Roberge, Yalei Liu, R. Michael Lawrence, James R. Corte, Wu Yang, Mark Bednarz, John K. DicksonJr.Jr., Zhengping Ma, Ramakrishna Seethala & Jean H.M. Feyen. (2005) Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists. Bioorganic & Medicinal Chemistry Letters 15:24, pages 5478-5482.
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Gunther Spohn, Katrin Schwarz, Patrik Maurer, Harald Illges, Narendiran Rajasekaran, Yongwon Choi, Gary T. Jennings & Martin F. Bachmann. (2005) Protection against Osteoporosis by Active Immunization with TRANCE/RANKL Displayed on Virus-Like Particles. The Journal of Immunology 175:9, pages 6211-6218.
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David Gunn, Christiana Akuche, Jeremy Baryza, Marie-Louise Blue, Catherine Brennan, Ann-Marie Campbell, Soongyu Choi, James Cook, Patricia Conrad, Brian Dixon, Jacques Dumas, Paul Ehrlich, Todd Gane, Ted Joe, Jeffrey Johnson, Jerold Jordan, Richard Kramss, Peying Liu, Joan Levy, Derek Lowe, Ian McAlexander, Reina Natero, Anikó M. Redman, William Scott, Thomas Seng, Robert Sibley, Ming Wang, Yamin Wang, Jill Wood & Zhonghua Zhang. (2005) 4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR. Bioorganic & Medicinal Chemistry Letters 15:12, pages 3053-3057.
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Jonathan R. Green. (2004) Preclinical Profile of Zoledronic Acid in Prostate Cancer Models. European Urology Supplements 3:5, pages 16-24.
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Orit Segev, Aviva Samach, Alexander Faerman, Hagar Kalinski, Merav Beiman, Anna Gelfand, Hagit Turam, Shlomit Boguslavsky, Anat Moshayov, Helen Gottlieb, Eugeniy Kazanov, Zvi Nevo, Dror Robinson, Rami Skaliter, Paz Einat, Itzhak Binderman & Elena Feinstein. (2004) CMF608—a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. Bone 34:2, pages 246-260.
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Sanjay Sarkhel, Ashoke Sharon, Vishal Trivedi, Prakas R Maulik, Man Mohan Singh, Paloth Venugopalan & Suprabhat Ray. (2003) Structure-Based drug design: synthesis, crystal structure, biological evaluation and docking studies of mono- and bis-benzo[ b ]oxepines as non-steroidal estrogens. Bioorganic & Medicinal Chemistry 11:23, pages 5025-5033.
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T. J. Chambers. 2003. The Macrophage as Therapeutic Target. The Macrophage as Therapeutic Target 353 372 .
Jonathan R. Green & Philippe Clézardin. (2002) Mechanisms of Bisphosphonate Effects on Osteoclasts, Tumor Cell Growth, and Metastasis. American Journal of Clinical Oncology 25, pages S3-S9.
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Fabien Lecaille, Jadwiga Kaleta & Dieter Brömme. (2002) Human and Parasitic Papain-Like Cysteine Proteases:  Their Role in Physiology and Pathology and Recent Developments in Inhibitor Design. Chemical Reviews 102:12, pages 4459-4488.
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Jonathan R. Green. (2002) Bisphosphonates in cancer therapy. Current Opinion in Oncology 14:6, pages 609-615.
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Cho‐Rok Jung, Igor A. Schepetkin, Sang B. Woo, Andrei I. Khlebnikov & Byoung S. Kwon. (2002) Osteoblastic differentiation of mesenchymal stem cells by mumie extract. Drug Development Research 57:3, pages 122-133.
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Roger A. Smith, Jinshan Chen, Mary M. Mader, Ingo Muegge, Ulrike Moehler, Suresh Katti, Diana Marrero, William G. Stirtan, Daniel R. Weaver, Hong Xiao & William Carley. (2002) Solid-Phase synthesis and investigation of benzofurans as selective estrogen receptor modulators. Bioorganic & Medicinal Chemistry Letters 12:20, pages 2875-2878.
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Lukas Scheibler, Dale F. Mierke, Gal Bitan, Michael Rosenblatt & Michael Chorev. (2001) Identification of a Contact Domain between Echistatin and the Integrin α v β 3 by Photoaffinity Cross-Linking . Biochemistry 40:50, pages 15117-15126.
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David L. Soper, Jared B. J. Milbank, Glen E. Mieling, Michelle J. Dirr, Andrew S. Kende, Robin Cooper, Webster S. S. Jee, Wei Yao, Jian Liang Chen, Mark Bodman, Mark W. Lundy, Biswanath De, Mark E. Stella, Frank H. Ebetino, Yili Wang, Mitchell A. deLong & John A. Wos. (2001) Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis. Journal of Medicinal Chemistry 44:24, pages 4157-4169.
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S. Aubrey Stoch, Michael Chorev & Michael Rosenblatt. 2001. Osteoporosis. Osteoporosis 769 818 .
M. Šušva, M. Missbach & J. Green. (2000) Src inhibitors: drugs for the treatment of osteoporosis, cancer or both?. Trends in Pharmacological Sciences 21:12, pages 489-495.
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