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Review

Emerging therapies for osteoporosis

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Pages 1-43 | Published online: 24 Feb 2005

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  • •The report of an orally-active vitronectin receptor antagonist that inhibits bone resorption.
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  • •References [105-107] report the identification and cloning of cathepsin K from human osteoclasts.
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  • •References [105-107] report the identification and cloning of cathepsin K from human osteoclasts.
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  • •References [105-107] report the identification and cloning of cathepsin K from human osteoclasts.
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  • ••References [111,112] links mutations in cathepsin K genethat results in cathepsin K deficiency and osteopetrotic phenotype and validates cathepsin K as a therapeutic target.
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  • ••References [111,112] links mutations in cathepsin K genethat results in cathepsin K deficiency and osteopetrotic phenotype and validates cathepsin K as a therapeutic target.
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  • ••References [113,114] reports the characterisation ofcathepsin k null mice as osteopetrotic and validates cathepsin K as a therapeutic target.
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  • ••References [113,114] reports the characterisation ofcathepsin k null mice as osteopetrotic and validates cathepsin K as a therapeutic target.
  • THOMPSON SK, HALBERT SM, BOSSARD MJ, et al.: Design of potent and selective human cathepsin K inhibitors that span the active site. Proc. Natl. Acad. Sci. USA (1997) 94:14249–14254.
  • •References [115,116] reports the development of inhibitors of cathepsin K and L that inhibit bone resorption in vivo.
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  • •References [115,116] reports the development of inhibitors of cathepsin K and L that inhibit bone resorption in vivo.
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