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Emerging Drugs Volume 5, 2000 - Issue 2
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Review

The development of protein farnesyltransferase and other ras-directed therapeutics for malignant diseases

Eric K Rowinsky Institute for Drug Development, Cancer Therapy and Research Centre, 8122 Datapoint Drive, Suite 700, San Antonio, TX 78229-3272, USA. [email protected]
&
Amita Patnaik Institute for Drug Development, Cancer Therapy and Research Centre, 8122 Datapoint Drive, Suite 700, San Antonio, TX 78229-3272, USA. [email protected]
Pages 161-199 | Published online: 24 Feb 2005

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Devendra S. Puntambekar, Rajani Giridhar & Mange Ram Yadav. (2007) Inhibition of farnesyltransferase: A rational approach to treat cancer?. Journal of Enzyme Inhibition and Medicinal Chemistry 22:2, pages 127-140.
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Articles from other publishers (11)

Patrick Angibaud, Laurence Mevellec, Christophe Meyer, Xavier Bourdrez, Patricia Lezouret, Isabelle Pilatte, Virginie Poncelet, Bruno Roux, Sophie Merillon, David W. End, Jacky Van Dun, Walter Wouters & Marc Venet. (2007) Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra® series. European Journal of Medicinal Chemistry 42:5, pages 702-714.
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Andreas Mitsch, Mirko Altenkämper, Isabel Sattler & Martin Schlitzer. (2005) Non‐Thiol Farnesyltransferase Inhibitors: Utilization of the Far Aryl Binding Site by Arylthienylacryloylaminobenzophenones. Archiv der Pharmazie 338:1, pages 9-17.
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Andreas Mitsch, Pia Wißner, Katrin Silber, Peter Haebel, Isabel Sattler, Gerhard Klebe & Martin Schlitzer. (2004) Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides. Bioorganic & Medicinal Chemistry 12:17, pages 4585-4600.
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Andreas Mitsch, Pia Wißner, Markus Böhm, Katrin Silber, Gerhard Klebe, Isabel Sattler & Martin Schlitzer. (2004) Non‐thiol Farnesyltransferase Inhibitors: Utilization of the Far Aryl Binding Site by 5‐Cinnamoylaminobenzophenones. Archiv der Pharmazie 337:9, pages 493-501.
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Ian M. Bell. (2004) Inhibitors of Farnesyltransferase:  A Rational Approach to Cancer Chemotherapy?. Journal of Medicinal Chemistry 47:8, pages 1869-1878.
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Andreas Mitsch, Markus Böhm, Isabel Sattler & Martin Schlitzer. (2004) Non‐Thiol Farnesyltransferase Inhibitors: Utilization of the Near Aryl Binding Site by 5‐Arylacetylaminobenzophenones. Archiv der Pharmazie 337:4, pages 213-218.
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Patrick Angibaud, Ashis K. Saha, Xavier Bourdrez, David W. End, Eddy Freyne, Patricia Lezouret, Geert Mannens, Laurence Mevellec, Christophe Meyer, Isabelle Pilatte, Virginie Poncelet, Bruno Roux, Gerda Smets, Jacky Van Dun, Marc Venet & Walter Wouters. (2003) 4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the Farnesyltransferase inhibitor ZARNESTRA ™. Bioorganic & Medicinal Chemistry Letters 13:24, pages 4361-4364.
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Patrick Angibaud, Xavier Bourdrez, David W. End, Eddy Freyne, Michel Janicot, Patricia Lezouret, Yannick Ligny, Geert Mannens, Siegrid Damsch, Laurence Mevellec, Christophe Meyer, Philippe Muller, Isabelle Pilatte, Virginie Poncelet, Bruno Roux, Gerda Smets, Jacky Van Dun, Pieter Van Remoortere, Marc Venet & Walter Wouters. (2003) Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors. Bioorganic & Medicinal Chemistry Letters 13:24, pages 4365-4369.
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Patrick Angibaud, Xavier Bourdrez, Ann Devine, David W End, Eddy Freyne, Yannick Ligny, Philippe Muller, Geert Mannens, Isabelle Pilatte, Virginie Poncelet, Stacy Skrzat, Gerda Smets, Jacky Van Dun, Pieter Van Remoortere, Marc Venet & Walter Wouters. (2003) 5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors. Bioorganic & Medicinal Chemistry Letters 13:9, pages 1543-1547.
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Katja Kettler, Jacek Sakowski, Katrin Silber, Isabel Sattler, Gerhard Klebe & Martin Schlitzer. (2003) Non-thiol farnesyltransferase inhibitors: n -(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides. Bioorganic & Medicinal Chemistry 11:7, pages 1521-1530.
Crossref
Andreas Mitsch, Markus Böhm, Pia Wißner, Isabel Sattler & Martin Schlitzer. (2002) Non-Thiol farnesyltransferase inhibitors: utilization of an aryl binding site by 5-arylacryloylaminobenzophenones. Bioorganic & Medicinal Chemistry 10:8, pages 2657-2662.
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