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Expert Opinion on Therapeutic Targets Volume 13, 2009 - Issue 1
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Review

TRP channels as emerging targets for pain therapeutics

Lisa M Broad Eli Lilly and Company, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK +01276 483016; +01276 483525; [email protected]
,
Adrian J Mogg Eli Lilly and Company, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK +01276 483016; +01276 483525; [email protected]
,
Ruth E Beattie Eli Lilly and Company, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK +01276 483016; +01276 483525; [email protected]
,
Ann-Marie Ogden Eli Lilly and Company, Lilly Corporate Center, Lilly Research Laboratories, Indianapolis, IN 46285, USA
,
Maria-Jesus Blanco Eli Lilly and Company, Lilly Corporate Center, Lilly Research Laboratories, Indianapolis, IN 46285, USA
&
David Bleakman Eli Lilly and Company, Lilly Corporate Center, Lilly Research Laboratories, Indianapolis, IN 46285, USA
Pages 69-81 | Published online: 08 Dec 2008

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Laura Vay, Chunjing Gu & Peter A McNaughton. (2010) Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications. Expert Review of Clinical Pharmacology 3:5, pages 687-704.
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Eric A Voight & Michael E Kort. (2010) Transient receptor potential vanilloid-1 antagonists: a survey of recent patent literature. Expert Opinion on Therapeutic Patents 20:9, pages 1107-1122.
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Lisa Hill & Stephan A Schug. (2009) Recent advances in the pharmaceutical management of pain. Expert Review of Clinical Pharmacology 2:5, pages 543-557.
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Articles from other publishers (32)

Arthur Neuberger, Mai Oda, Yury A. Nikolaev, Kirill D. Nadezhdin, Elena O. Gracheva, Sviatoslav N. Bagriantsev & Alexander I. Sobolevsky. (2023) Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 14:1.
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Joel Castro, Jessica Maddern, Chun Yuen Chow, Poanna Tran, Irina Vetter, Glenn F. King & Stuart M. Brierley. (2023) The voltage‐gated sodium channel Na V 1 .7 underlies endometriosis‐associated chronic pelvic pain . Journal of Neurochemistry.
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Sung-Min Hwang, Youn-Yi Jo, Cinder Faith Cohen, Yong-Ho Kim, Temugin Berta & Chul-Kyu Park. (2022) Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development. International Journal of Molecular Sciences 23:10, pages 5772.
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T. Louwies & B. Greenwood-Van Meerveld. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 132 163 .
Joel Castro, Jessica Maddern, Andelain Erickson, Ashlee Caldwell, Luke Grundy, Andrea M. Harrington & Stuart M. Brierley. (2021) Pharmacological modulation of voltage-gated sodium (NaV) channels alters nociception arising from the female reproductive tract. Pain 162:1, pages 227-242.
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Jessica Maddern, Luke Grundy, Joel Castro & Stuart M. Brierley. (2020) Pain in Endometriosis. Frontiers in Cellular Neuroscience 14.
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Mustafa Nazıroğlu, Ahmi Öz & Kenan Yıldızhan. (2020) Selenium and Neurological Diseases: Focus on Peripheral Pain and TRP Channels. Current Neuropharmacology 18:6, pages 501-517.
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Stephan A. Schug. 2020. Mechanisms of Vascular Disease. Mechanisms of Vascular Disease 469 487 .
M.J. Nirenberg, R. Chaouni, T.M. Biller, R.M. Gilbert & C. Paisán-Ruiz. (2018) A novel TRPA1 variant is associated with carbamazepine-responsive cramp-fasciculation syndrome . Clinical Genetics 93:1, pages 164-168.
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Jee Myung Yang, Fengxian Li, Qin Liu, Marco Rüedi, Edward Tak Wei, Michael Lentsman, Hyo Seok Lee, Won Choi, Seong Jin Kim & Kyung Chul Yoon. (2017) A novel TRPM8 agonist relieves dry eye discomfort. BMC Ophthalmology 17:1.
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João Araújo BARROS-NETO, Tascya Morganna de Morais SANTOS, Matheus Lopes CORTES, Rosangela Passos de JESUS, Mariana Carvalho FREITAS & Durval Campos KRAYCHETE. (2017) Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study. Revista de Nutrição 30:5, pages 567-581.
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Amit Joshi, Abhay Joshi, Hiren Patel, Dovenia Ponnoth & Grazia Stagni. (2017) Cutaneous Penetration–Enhancing Effect of Menthol: Calcium Involvement. Journal of Pharmaceutical Sciences 106:7, pages 1923-1932.
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Geunyeol Choi & Sun Wook Hwang. (2016) Modulation of the Activities of Neuronal Ion Channels by Fatty Acid-Derived Pro-Resolvents. Frontiers in Physiology 7.
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Luciano De Petrocellis, Francisco J. Arroyo, Pierangelo Orlando, Aniello Schiano Moriello, Rosa Maria Vitale, Pietro Amodeo, Aránzazu Sánchez, Cesáreo Roncero, Giulia Bianchini, M. Antonia Martín, Pilar López-Alvarado & J. Carlos Menéndez. (2016) Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents. Journal of Medicinal Chemistry 59:12, pages 5661-5683.
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Neelima Khairatkar-Joshi, Daisy M Shah, Indranil Mukhopadhyay, VS Prasadarao Lingam & Abraham Thomas. (2015) TRPC channel modulators and their potential therapeutic applications. Pharmaceutical Patent Analyst 4:3, pages 207-218.
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J.N. Ablin & D. Buskila. (2014) Predicting fibromyalgia, a narrative review: Are we better than fools and children?. European Journal of Pain 18:8, pages 1060-1066.
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Olivera Grubisha, Adrian J Mogg, Jessica L Sorge, Laura-Jayne Ball, Helen Sanger, Cara L A Ruble, Elizabeth A Folly, Daniel Ursu & Lisa M Broad. (2014) Pharmacological profiling of the TRPV3 channel in recombinant and native assays. British Journal of Pharmacology 171:10, pages 2631-2644.
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Sungjae Yoo, Ji Lim & Sun Hwang. (2014) Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes. Molecules 19:4, pages 4708-4744.
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A. M. Harrington, S. M. Brierley, N. J. Isaacs, R. L. Young & L. Ashley Blackshaw. (2013) Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology & Motility, pages n/a-n/a.
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Bin Zhu, Mingde Xia, Xiaoqing Xu, Donald W. Ludovici, Manomi Tennakoon, Mark A. Youngman, Jay M. Matthews, Scott L. Dax, Raymond W. Colburn, Ning Qin, Tasha L. Hutchinson, Mary Lou Lubin, Michael R. Brandt, Dennis J. Stone, Christopher M. Flores & Mark J. Macielag. (2013) Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists. Bioorganic & Medicinal Chemistry Letters 23:7, pages 2234-2237.
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Lesley M. Arnold, Jinbo Fan, I. Jon Russell, Muhammad B. Yunus, Muhammad Asim Khan, Irving Kushner, Jane M. Olson & Sudha K. Iyengar. (2013) The Fibromyalgia Family Study: A Genome‐Wide Linkage Scan Study. Arthritis & Rheumatism 65:4, pages 1122-1128.
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S Bang, S Yoo, TJ Yang, H Cho & SW Hwang. (2012) Nociceptive and pro-inflammatory effects of dimethylallyl pyrophosphate via TRPV4 activation. British Journal of Pharmacology 166:4, pages 1433-1443.
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Sonali S. BharateSandip B. Bharate. (2012) Modulation of Thermoreceptor TRPM8 by Cooling Compounds. ACS Chemical Neuroscience 3:4, pages 248-267.
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Sungjae Yoo & Sun Wook Hwang. 2012. TRP Channels in Drug Discovery. TRP Channels in Drug Discovery 237 256 .
Asia Fernández-Carvajal, Gregorio Fernández-Ballester, Isabel Devesa, José Manuel González-Ros & Antonio Ferrer-Montiel. (2011) New Strategies to Develop Novel Pain Therapies: Addressing Thermoreceptors from Different Points of View. Pharmaceuticals 5:1, pages 16-48.
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Daniel J. Parks, William H. Parsons, Raymond W. Colburn, Sanath K. Meegalla, Shelley K. Ballentine, Carl R. Illig, Ning Qin, Yi Liu, Tasha L. Hutchinson, Mary Lou Lubin, Dennis J. StoneJr.Jr., Judith F. Baker, Craig R. Schneider, Jianya Ma, Bruce P. Damiano, Christopher M. Flores & Mark R. Player. (2010) Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists. Journal of Medicinal Chemistry 54:1, pages 233-247.
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Seung Jun Jung. (2011) The Role of Transient Receptor Potential Channel in Pain. Hanyang Medical Reviews 31:2, pages 116.
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Man-Kyo Chung, Sung Jun Jung & Seog Bae Oh. 2011. Transient Receptor Potential Channels. Transient Receptor Potential Channels 615 636 .
Pamela S. Puttfarcken, Ping Han, Shailen K. Joshi, Torben R. Neelands, Donna M. Gauvin, Scott J. Baker, La Geisha R. Lewis, Bruce R. Bianchi, Joseph P. Mikusa, John R. Koenig, Richard J. Perner, Michael E. Kort, Prisca Honore, Connie R. Faltynek, Philip R. Kym & Regina M. Reilly. (2010) A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model. Pain 150:2, pages 319-326.
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Kun Liu, Manoj Samuel, Melisa Ho, Richard K. Harrison & Jeff W. Paslay. (2010) NPPB structure-specifically activates TRPA1 channels. Biochemical Pharmacology 80:1, pages 113-121.
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P.R. Brumovsky & G.F. Gebhart. (2010) Visceral organ cross-sensitization — An integrated perspective. Autonomic Neuroscience 153:1-2, pages 106-115.
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Joris Vriens, Giovanni Appendino & Bernd Nilius. (2009) Pharmacology of Vanilloid Transient Receptor Potential Cation Channels. Molecular Pharmacology 75:6, pages 1262-1279.
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