Expert Opinion on Therapeutic Targets, Volume 13, Issue 1 (2009)

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Expert Opinion on Therapeutic Targets, Volume 13, Issue 1 (2009)

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Original Research

Article
Serum total homocysteine, folate, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T genotype and subclinical atherosclerosis
Andrie Panayiotou PhD, Andrew Nicolaides MS FRCS PhD (Hon), Maura Griffin MSc DIC PhD, Theodosis Tyllis MD MSc DIC, Niki Georgiou RN, Richard M Martin BM BS PhD, Dawn Bond RGN MA, Chrysa Tziakouri-Shiakalli MD, Charis Fessas MD FACC FESC & Constantinos Deltas PhD
Pages: 1-11
Published online: 19 Nov 2008
AbstractforSerum total homocysteine, folate, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T genotype and subclinical atherosclerosis | Full Text | References | PDF (274.9 KB)
  • 104 Views
  • 11 CrossRef citations
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Perspective

Article
Defining protein interactions that regulate disease progression
Racha Al-Khoury & Benoit Coulombe
Pages: 13-17
Published online: 08 Dec 2008
AbstractforDefining protein interactions that regulate disease progression | Full Text | References | PDF (249.1 KB)
  • 82 Views
  • 4 CrossRef citations
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Reviews

Article
PCSK9 as a therapeutic target of dyslipidemia
Nabil G Seidah PhD
Pages: 19-28
Published online: 21 Nov 2008
AbstractforPCSK9 as a therapeutic target of dyslipidemia | Full Text | References | PDF (674.9 KB)
  • 761 Views
  • 100 CrossRef citations
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Review

Article
Vitamin D and the vasculature: can we teach an old drug new tricks?
José M Valdivielso, Blai Coll & Elvira Fernandez
Pages: 29-38
Published online: 19 Nov 2008
AbstractforVitamin D and the vasculature: can we teach an old drug new tricks? | Full Text | References | PDF (244.3 KB)
  • 127 Views
  • 18 CrossRef citations
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Article
The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury
Melanie van der Heijden MSc PhD, Geerten P van Nieuw Amerongen PhD, Sunita Chedamni, Victor WM van Hinsbergh PhD & AB Johan Groeneveld MD PhD FCCP FCCM
Pages: 39-53
Published online: 08 Dec 2008
AbstractforThe angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury | Full Text | References | PDF (355.8 KB)
  • 679 Views
  • 56 CrossRef citations
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Article
Regulation of the Na+/H+ exchanger in the healthy and diseased myocardium
Larry Fliegel
Pages: 55-68
Published online: 19 Nov 2008
AbstractforRegulation of the Na+/H+ exchanger in the healthy and diseased myocardium | Full Text | References | PDF (306.4 KB)
  • 327 Views
  • 71 CrossRef citations
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Article
TRP channels as emerging targets for pain therapeutics
Lisa M Broad, Adrian J Mogg, Ruth E Beattie, Ann-Marie Ogden, Maria-Jesus Blanco & David Bleakman
Pages: 69-81
Published online: 08 Dec 2008
AbstractforTRP channels as emerging targets for pain therapeutics | Full Text | References | PDF (306 KB)
  • 385 Views
  • 35 CrossRef citations
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Article
Protein kinase A as a biological target in cancer therapy
Silvio Naviglio, Michele Caraglia, Alberto Abbruzzese, Emilio Chiosi, Davide Di Gesto, Monica Marra, Maria Romano, Annunziata Sorrentino, Luca Sorvillo, Annamaria Spina & Gennaro Illiano
Pages: 83-92
Published online: 21 Nov 2008
AbstractforProtein kinase A as a biological target in cancer therapy | Full Text | References | PDF (297.6 KB)
  • 797 Views
  • 66 CrossRef citations
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Article
Melanoma: targeting signaling pathways and RaLP
Luigi Pasini, Margherita Y Turco, Lucilla Luzi, Ewa Aladowicz, Ernesta Fagiani & Luisa Lanfrancone
Pages: 93-104
Published online: 08 Dec 2008
AbstractforMelanoma: targeting signaling pathways and RaLP | Full Text | References | PDF (388.1 KB)
  • 162 Views
  • 7 CrossRef citations
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Article
Trypanosoma cruzi targets for new chemotherapeutic approaches
Maria Nazaré C Soeiro & Solange L de Castro
Pages: 105-121
Published online: 08 Dec 2008
AbstractforTrypanosoma cruzi targets for new chemotherapeutic approaches | Full Text | References | PDF (429.1 KB)
  • 289 Views
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Article
Targeting bone morphogenetic protein antagonists: in vitro and in vivo evidence of their role in bone metabolism
Evaggelos Tsialogiannis MD, Ioannis Polyzois MB ChB MRCS, Quen Oak Tang BSc(Hons), George Pavlou MBBS MRCS, Evgenios Tsiridis MD, Manolis Heliotis MBBS MSc FDS FRCS & Eleftherios Tsiridis MD MSc PhD FRCS
Pages: 123-137
Published online: 08 Dec 2008
AbstractforTargeting bone morphogenetic protein antagonists: in vitro and in vivo evidence of their role in bone metabolism | Full Text | References | PDF (291.7 KB)
  • 331 Views
  • 36 CrossRef citations
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