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Review

New promises for manipulation of kynurenine pathway in cancer and neurological diseases

Pages 247-258 | Published online: 13 Jan 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Praveen Kumar Munipally, Satish G. Agraharm, Vijay Kumar Valavala, Sridhar Gundae & Naga Raju Turlapati. (2011) Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients. Archives of Physiology and Biochemistry 117:5, pages 254-258.
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Joerg C. Schefold, Jan-Philip Zeden, Rene Pschowski, Ben Hammoud, Christina Fotopoulou, Dietrich Hasper, Gerhard Fusch, Stephan Von Haehling, Hans-Dieter Volk, Christian Meisel, Christine Schütt & Petra Reinke. (2010) Treatment with granulocyte–macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. Scandinavian Journal of Infectious Diseases 42:3, pages 164-171.
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Vivek Kumar Sharma, Thakur Gurjeet Singh, Nirbhay Kumar Prabhakar & Ashi Mannan. (2022) Kynurenine Metabolism and Alzheimer’s Disease: The Potential Targets and Approaches. Neurochemical Research 47:6, pages 1459-1476.
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Arghya Ray, Yan Song, Ting Du, Yu-Tzu Tai, Dharminder Chauhan & Kenneth C. Anderson. (2019) Targeting tryptophan catabolic kynurenine pathway enhances antitumor immunity and cytotoxicity in multiple myeloma. Leukemia 34:2, pages 567-577.
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Roberto Pellicciari, Paride Liscio, Nicola Giacchè, Francesca De Franco, Andrea Carotti, Janet Robertson, Lucia Cialabrini, Elena Katsyuba, Nadia Raffaelli & Johan Auwerx. (2018) α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD + ) Biosynthesis . Journal of Medicinal Chemistry 61:3, pages 745-759.
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Masaaki Konishi, Nicole Ebner, Jochen Springer, Joerg C. Schefold, Wolfram Doehner, Thomas Bernd Dschietzig, Stefan D. Anker & Stephan von Haehling. (2017) Impact of Plasma Kynurenine Level on Functional Capacity and Outcome in Heart Failure ― Results From Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF) ―. Circulation Journal 81:1, pages 52-61.
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Guanchen Sun, Alireza Nematollahi, Naveed A. Nadvi, Ann H. Kwan, Cy M. Jeffries & W. Bret Church. (2016) Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set. Protein Expression and Purification 121, pages 41-45.
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Petr Tomek, Brian D. Palmer, Jackie D. Kendall, Jack U. Flanagan & Lai-Ming Ching. (2015) Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon–carbon bond formation at the 2-position of the amine. Biochimica et Biophysica Acta (BBA) - General Subjects 1850:9, pages 1772-1780.
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Hui Zuo, Grethe S. Tell, Stein E. Vollset, Per M. Ueland, Ottar Nygård, Øivind Midttun, Klaus Meyer, Arve Ulvik & Simone J.P.M. Eussen. (2014) Interferon‐γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study. Cancer 120:21, pages 3370-3377.
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Gian Paolo Vallerini, Laura Amori, Claudia Beato, Margarita Tararina, Xiao-Dan Wang, Robert Schwarcz & Gabriele Costantino. (2013) 2-Aminonicotinic Acid 1-Oxides Are Chemically Stable Inhibitors of Quinolinic Acid Synthesis in the Mammalian Brain: A Step toward New Antiexcitotoxic Agents. Journal of Medicinal Chemistry 56:23, pages 9482-9495.
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C. O. Akagbosu, G. C. Evans, D. Gulick, R. F. Suckow & D. J. Bucci. (2010) Exposure to Kynurenic Acid During Adolescence Produces Memory Deficits in Adulthood. Schizophrenia Bulletin 38:4, pages 769-778.
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Yunjiang Feng, Bruce F. Bowden & Vimal Kapoor. (2012) Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata. Bioorganic & Medicinal Chemistry Letters 22:10, pages 3398-3401.
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Jessica R. Adams Wilson, Alessandro Morandi, Timothy D. Girard, Jennifer L. Thompson, Chad S. Boomershine, Ayumi K. Shintani, E. Wesley Ely & Pratik P. Pandharipande. (2012) The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*. Critical Care Medicine 40:3, pages 835-841.
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Francesca M. Notarangelo, Hui-Qiu Wu, Anthony Macherone, David R. Graham & Robert Schwarcz. (2012) Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain. Analytical Biochemistry 421:2, pages 573-581.
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S.B. AdamsJr.Jr., L.A. Setton, E. Kensicki, M.P. Bolognesi, A.P. Toth & D.L. Nettles. (2012) Global metabolic profiling of human osteoarthritic synovium. Osteoarthritis and Cartilage 20:1, pages 64-67.
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Robert D. Oades. (2011) An exploration of the associations of pregnancy and perinatal features with cytokines and tryptophan/kynurenine metabolism in children with attention-deficit hyperactivity disorder (ADHD). ADHD Attention Deficit and Hyperactivity Disorders 3:4, pages 301-318.
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Elisabetta Passera, Barbara Campanini, Franca Rossi, Valentina Casazza, Menico Rizzi, Roberto Pellicciari & Andrea Mozzarelli. (2011) Human kynurenine aminotransferase II – reactivity with substrates and inhibitors. The FEBS Journal 278:11, pages 1882-1900.
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Juliana Croitoru-Lamoury, Francois M. J. Lamoury, Michael Caristo, Kazuo Suzuki, David Walker, Osamu Takikawa, Rosanne Taylor & Bruce J. Brew. (2011) Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO). PLoS ONE 6:2, pages e14698.
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Mark S. Sundrud & Sergei Koralov. 2011. TH17 Cells in Health and Disease. TH17 Cells in Health and Disease 129 155 .
Daniela Krause, Judith Matz, Elif Weidinger, Jenny Wagner, Agnes Wildenauer, Michael Obermeier, Michael Riedel & Norbert Müller. (2009) Association between intracellular infectious agents and Tourette’s syndrome. European Archives of Psychiatry and Clinical Neuroscience 260:4, pages 359-363.
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Qian Han, Tao Cai, Danilo A. Tagle & Jianyong Li. (2009) Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Cellular and Molecular Life Sciences 67:3, pages 353-368.
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Stephen Courtney & Andreas Scheel. 2010. Neurodegenerative Diseases. Neurodegenerative Diseases 149 176 .

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