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Review

Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer

Pages 1287-1298 | Published online: 02 Oct 2007

Keep up to date with the latest research on this topic with citation updates for this article.

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Prashant R Murumkar, Shirshendu DasGupta, Sneha R Chandani, Rajani Giridhar & Mange Ram Yadav. (2010) Novel TACE inhibitors in drug discovery: a review of patented compounds. Expert Opinion on Therapeutic Patents 20:1, pages 31-57.
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Brian W. Booth & Gilbert H. Smith. (2007) Roles of transforming growth factor-α in mammary development and disease. Growth Factors 25:4, pages 227-235.
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Articles from other publishers (19)

Nina Hedemann, Christoph Rogmans, Susanne Sebens, Daniela Wesch, Manuel Reichert, Dirk Schmidt-Arras, Hans-Heinrich Oberg, Ulrich Pecks, Marion van Mackelenbergh, Jörg Weimer, Norbert Arnold, Nicolai Maass & Dirk O. Bauerschlag. (2018) ADAM17 inhibition enhances platinum efficiency in ovarian cancer. Oncotarget 9:22, pages 16043-16058.
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Lisheng Ge & Nikola L. Vujanovic. (2017) Soluble TNF Regulates TACE via AP-2α Transcription Factor in Mouse Dendritic Cells. The Journal of Immunology 198:1, pages 417-427.
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Sung Woo Hong, Wonhee Hur, Jung Eun Choi, Jung-Hee Kim, Daehee Hwang & Seung Kew Yoon. (2016) Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation. Oncotarget 7:17, pages 23482-23497.
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Mohammad Arabpour, Klaas Poelstra, Wijnand Helfrich, Edwin Bremer & Hidde J. Haisma. (2014) Targeted elimination of activated hepatic stellate cells by an anti-epidermal growth factor-receptor single chain fragment variable antibody-tumor necrosis factor-related apoptosis-inducing ligand (scFv425-sTRAIL). The Journal of Gene Medicine 16:9-10, pages 281-290.
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Esther A Peterson, Eirini Pectasides, Shabana Shabbeer, Lisa Wiechmann, Joseph A Sparano & Paraic A Kenny. (2013) Evaluation of serum Amphiregulin levels in breast cancer patients and cancer-free controls. Experimental Hematology & Oncology 2:1.
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Jia WuWei ZhangAiqiang XuLi ZhangTao YanZhuo LiXiaopan WuXilin ZhuJuan MaKe LiHui LiYing Liu. (2013) Association of Epidermal Growth Factor and Epidermal Growth Factor Receptor Polymorphisms with the Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma in the Population of North China. Genetic Testing and Molecular Biomarkers 17:8, pages 595-600.
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Manoranjan Sharma, Jogeswar Mohapatra, Aviseka Acharya, Shrikalp S. Deshpande, Abhijit Chatterjee & Mukul R. Jain. (2013) Blockade of tumor necrosis factor-α converting enzyme (TACE) enhances IL-1β and IFN-γ via caspase-1 activation: A probable cause for loss of efficacy of TACE inhibitors in humans?. European Journal of Pharmacology 701:1-3, pages 106-113.
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Natalie Steck, Kerstin Mueller, Michael Schemann & Dirk Haller. (2013) Republished: Bacterial proteases in IBD and IBS. Postgraduate Medical Journal 89:1047, pages 25-33.
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Bonnie F. Sloane, Karin List, Barbara Fingleton & Lynn Matrisian. 2013. Proteases: Structure and Function. Proteases: Structure and Function 491 550 .
Ping Lin, Xicai Sun, Tian Feng, Haifeng Zou, Ying Jiang, Zijun Liu, Dandan Zhao & Xiaoguang Yu. (2011) ADAM17 regulates prostate cancer cell proliferation through mediating cell cycle progression by EGFR/PI3K/AKT pathway. Molecular and Cellular Biochemistry 359:1-2, pages 235-243.
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Chaoyang Dai, Dansu Li, Janeta Popovici-Muller, Lianyun Zhao, Vinay M. Girijavallabhan, Kristin E. Rosner, Brian J. Lavey, Razia Rizvi, Bandarpalle B. Shankar, Michael K.C. Wong, Zhuyan Guo, Peter Orth, Corey O. Strickland, Jing Sun, Xiaoda Niu, Shiying Chen, Joseph A. Kozlowski, Daniel J. Lundell, John J. Piwinski, Neng-Yang Shih & M. Arshad Siddiqui. (2011) 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors. Bioorganic & Medicinal Chemistry Letters 21:10, pages 3172-3176.
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Rosamaria Lappano & Marcello Maggiolini. (2010) G protein-coupled receptors: novel targets for drug discovery in cancer. Nature Reviews Drug Discovery 10:1, pages 47-60.
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Jennifer L. Gilmore, Ryan M. Gonterman, Keshav Menon, Gwendolen Lorch, David J. RieseIIII, Alex Robling & John Foley. (2009) Reconstitution of Amphiregulin–Epidermal Growth Factor Receptor Signaling in Lung Squamous Cell Carcinomas Activates PTHrP Gene Expression and Contributes to Cancer-Mediated Diseases of the Bone. Molecular Cancer Research 7:10, pages 1714-1728.
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Mark Katakowski, Feng Jiang, XuGuang Zheng, Jorge A. Gutierrez, Alexandra Szalad & Michael Chopp. (2009) Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17. Cancer Science 100:9, pages 1597-1604.
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Carmen Berasain, Maria J. Perugorria, Maria Ujue Latasa, Josefa Castillo, Saioa Goñi, Mónica Santamaría, Jesús Prieto & Matías A. Avila. (2009) The Epidermal Growth Factor Receptor: A Link Between Inflammation and Liver Cancer. Experimental Biology and Medicine 234:7, pages 713-725.
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Shirshendu DasGupta, Prashant R. Murumkar, Rajani Giridhar & Mange Ram Yadav. (2009) Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones as potential TACE inhibitors: Design, synthesis, molecular modeling, and preliminary biological evaluation. Bioorganic & Medicinal Chemistry 17:10, pages 3604-3617.
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Shirshendu DasGupta, Prashant R. Murumkar, Rajani Giridhar & Mange Ram Yadav. (2009) Current perspective of TACE inhibitors: A review. Bioorganic & Medicinal Chemistry 17:2, pages 444-459.
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Hans Peter Sørensen, Jonas Jacobsen, Steen Nielbo, Flemming M. Poulsen & Ulla M. Wewer. (2008) Expression, purification and insights into structure and folding of the ADAM22 pro domain. Protein Expression and Purification 61:2, pages 175-183.
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Dimitris Georgiadis & Athanasios Yiotakis. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: Progress toward a multifarious challenge. Bioorganic & Medicinal Chemistry 16:19, pages 8781-8794.
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