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Expert Opinion on Therapeutic Targets Volume 11, 2007 - Issue 5
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Review

New therapeutic targets in atrophic age-related macular degeneration

Konstantin Petrukhin Associate Professor, Columbia University, Department of Ophthalmology, Eye Institute Annex, Suite 503, 630 West 168th Street, New York, NY 10032, USA. [email protected]
Pages 625-639 | Published online: 27 Apr 2007

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Huiling Li, Sumana R. Chintalapudi & Monica M. Jablonski. (2017) Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development. Expert Opinion on Investigational Drugs 26:10, pages 1103-1114.
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Jean Pierre Hubschman, Shantan Reddy & Steven D Schwartz. (2009) Age-related macular degeneration: experimental and emerging treatments. Clinical Ophthalmology 3, pages 167-174.
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Daniel N. Cortright, Robin Meade, Stephen M. Waters, Bertrand L. Chenard & James E. Krause. (2009) C5a, But Not C3a, Increases VEGF Secretion in ARPE-19 Human Retinal Pigment Epithelial Cells. Current Eye Research 34:1, pages 57-61.
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Theodor Sauer, Mrinali Patel, Chi-Chao Chan & Jingsheng Tuo. (2008) Unfolding the therapeutic potential of chemical chaperones for age-related macular degeneration. Expert Review of Ophthalmology 3:1, pages 29-42.
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Articles from other publishers (34)

Jian Lee Yeong, Emma Loveman, Jill L Colquitt, Pamela Royle, Norman Waugh & Noemi Lois. (2020) Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to age-related macular degeneration. Cochrane Database of Systematic Reviews.
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Christopher L. Cioffi, Parthasarathy Muthuraman, Arun Raja, Andras Varadi, Boglarka Racz & Konstantin Petrukhin. (2020) Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities. Journal of Medicinal Chemistry 63:19, pages 11054-11084.
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Boglarka Racz, Andras Varadi, Paul G. Pearson & Konstantin Petrukhin. (2020) Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey. PLOS ONE 15:1, pages e0228291.
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Konstantin Petrukhin. 2020. Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases. Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases 125 160 .
Céline Borras, Jérémie Canonica, Sylvie Jorieux, Toufik Abache, Mohamed El Sanharawi, Christophe Klein, Kimberley Delaunay, Laurent Jonet, Michèle Salvodelli, Marie-Christine Naud, Yvan Arsenijevic, Andrée Shalabi, Landry Souchaud, Francine Behar-Cohen & Virginie Dinet. (2019) CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex. Scientific Reports 9:1.
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George Inana, Christopher Murat, Weijun An, Xiang Yao, Ian R. Harris & Jing Cao. (2018) RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. Journal of Translational Medicine 16:1.
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Jian Lee Yeong, Emma Loveman, Jill L Colquitt, Pamela Royle, Norman Waugh & Noemi Lois. (2018) Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to age-related macular degeneration. Cochrane Database of Systematic Reviews.
Crossref
Boglarka Racz, Andras Varadi, Jian Kong, Rando Allikmets, Paul G. Pearson, Graham Johnson, Christopher L. Cioffi & Konstantin Petrukhin. (2018) A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle. Journal of Biological Chemistry 293:29, pages 11574-11588.
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Hiromi Murase, Kazuhiro Tsuruma, Yoshiki Kuse, Masamitsu Shimazawa & Hideaki Hara. (2017) Progranulin increases phagocytosis by retinal pigment epithelial cells in culture. Journal of Neuroscience Research 95:12, pages 2500-2510.
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Bongsu Kim, Rania Kusibati, Tyler Heisler-Taylor, Dimosthenis Mantopoulos, Jiaxi Ding, Mohamed H. Abdel-Rahman, Abhay R. Satoskar, Jonathan P. Godbout, Sanjoy K. Bhattacharya & Colleen M. Cebulla. (2017) MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Scientific Reports 7:1.
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Karina E. Guziewicz, Divya Sinha, Néstor M. Gómez, Kathryn Zorych, Emily V. Dutrow, Anuradha Dhingra, Robert F. Mullins, Edwin M. Stone, David M. Gamm, Kathleen Boesze-Battaglia & Gustavo D. Aguirre. (2017) Bestrophinopathy: An RPE-photoreceptor interface disease. Progress in Retinal and Eye Research 58, pages 70-88.
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Jing Cao, Christopher Murat, Weijun An, Xiang Yao, John Lee, Sandra Santulli-Marotto, Ian R. Harris & George Inana. (2016) Human umbilical tissue-derived cells rescue retinal pigment epithelium dysfunction in retinal degeneration. Stem Cells 34:2, pages 367-379.
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Sun-Myung Yoon, Bom-Lee Lee, Yuan-Ri Guo & Se-Young Choung. (2015) Preventive effect of Vaccinium uliginosum L. extract and its fractions on age-related macular degeneration and its action mechanisms. Archives of Pharmacal Research 39:1, pages 21-32.
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Alessandro Iannaccone, Francesco Giorgianni, David D. New, T. J. Hollingsworth, Allison Umfress, Albert H. Alhatem, Indira Neeli, Nataliya I. Lenchik, Barbara J. Jennings, Jorge I. Calzada, Suzanne Satterfield, Dennis Mathews, Rocio I. Diaz, Tamara Harris, Karen C. Johnson, Steve Charles, Stephen B. Kritchevsky, Ivan C. Gerling, Sarka Beranova-Giorgianni & Marko Z. Radic. (2015) Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis. PLOS ONE 10:12, pages e0145323.
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Christopher L. Cioffi, Boglarka Racz, Emily E. Freeman, Michael P. Conlon, Ping Chen, Douglas G. Stafford, Daniel M. C. Schwarz, Lei Zhu, Douglas B. Kitchen, Keith D. Barnes, Nicoleta Dobri, Enrique Michelotti, Charles L. Cywin, William H. Martin, Paul G. Pearson, Graham Johnson & Konstantin Petrukhin. (2015) Bicyclic [3.3.0]-Octahydrocyclopenta[ c ]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease . Journal of Medicinal Chemistry 58:15, pages 5863-5888.
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Monika Kalesinskaitė, Diana Uljanionok & Rasa Liutkevičienė. (2014) Age-related macular degeneration treatment: current view (literature review)Amžinės geltonosios dėmės degeneracijos gydymas: dabartinis požiūris (literatūros apžvalga). Medicinos teorija ir praktika 21:1, pages 43-50.
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Christopher L. Cioffi, Nicoleta Dobri, Emily E. Freeman, Michael P. Conlon, Ping Chen, Douglas G. Stafford, Daniel M. C. Schwarz, Kathy C. Golden, Lei Zhu, Douglas B. Kitchen, Keith D. Barnes, Boglarka Racz, Qiong Qin, Enrique Michelotti, Charles L. Cywin, William H. Martin, Paul G. Pearson, Graham Johnson & Konstantin Petrukhin. (2014) Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease. Journal of Medicinal Chemistry 57:18, pages 7731-7757.
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Ian Catchpole, Volker Germaschewski, Jaimie Hoh Kam, Peter Lundh von Leithner, Susannah Ford, Gerald Gough, Peter Adamson, Philip Overend, Jan Hilpert, Francisco J. López, Yin Shan Eric Ng, Pete Coffey & Glen Jeffery. (2013) Systemic Administration of Abeta mAb Reduces Retinal Deposition of Abeta and Activated Complement C3 in Age-Related Macular Degeneration Mouse Model. PLoS ONE 8:6, pages e65518.
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Qiong QinAnna KnapinskaNicoleta DobriFranck MadouxPeter ChasePeter HodderKonstantin Petrukhin. (2013) In Pursuit of Synthetic Modulators for the Orphan Retina-Specific Nuclear Receptor NR2E3. Journal of Ocular Pharmacology and Therapeutics 29:3, pages 298-309.
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Konstantin Petrukhin. (2013) Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment. Drug Discovery Today: Therapeutic Strategies 10:1, pages e11-e20.
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Alice L. Yu, Kerstin Birke, Johannes Burger & Ulrich Welge-Lussen. (2012) Biological Effects of Cigarette Smoke in Cultured Human Retinal Pigment Epithelial Cells. PLoS ONE 7:11, pages e48501.
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V. Savolainen, K. Juuti-Uusitalo, N. Onnela, H. Vaajasaari, S. Narkilahti, R. Suuronen, H. Skottman & J. Hyttinen. (2011) Impedance Spectroscopy in Monitoring the Maturation of Stem Cell-Derived Retinal Pigment Epithelium. Annals of Biomedical Engineering 39:12, pages 3055-3069.
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Roger A. Sabbadini. (2011) Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. British Journal of Pharmacology 162:6, pages 1225-1238.
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Pradeep S. Prasad, Steven D. Schwartz & Jean-Pierre Hubschman. (2010) Age-related macular degeneration: Current and novel therapies. Maturitas 66:1, pages 46-50.
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Paola Bargagna-Mohan, Riya R. Paranthan, Adel Hamza, Neviana Dimova, Beatrice Trucchi, Cidambi Srinivasan, Gregory I. Elliott, Chang-Guo Zhan, Daniel L. Lau, Haiyan Zhu, Kousuke Kasahara, Masaki Inagaki, Franca Cambi & Royce Mohan. (2010) Withaferin A Targets Intermediate Filaments Glial Fibrillary Acidic Protein and Vimentin in a Model of Retinal Gliosis. Journal of Biological Chemistry 285:10, pages 7657-7669.
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Amir Ghorbanihaghjo, Alireza Javadzadeh, Nadereh Rashtchizadeh, Hassan Argani, Sima Masoodnia & Nariman Nezami. (2010) High-sensitivity C-reactive protein and endothelin-1 in age-related macular degeneration. Journal of Men's Health 7:1, pages 85-91.
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Stuart Richer, William Stiles & Carla Thomas. (2009) Molecular medicine in ophthalmic care. Optometry - Journal of the American Optometric Association 80:12, pages 695-701.
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Kyung Hwa Kang, Greg Lemke & Jin Woo Kim. (2009) The PI3K–PTEN tug-of-war, oxidative stress and retinal degeneration. Trends in Molecular Medicine 15:5, pages 191-198.
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Zhao-Yang Wang, Ke-Ke Zhao, Zong-Ming Song, Li-Jun Shen & Jia Qu. (2009) Erythropoietin as a novel therapeutic agent for atrophic age-related macular degeneration. Medical Hypotheses 72:4, pages 448-450.
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Alice L. Yu, Reinhard L. Lorenz, Christos Haritoglou, Anselm Kampik & Ulrich Welge-Lussen. (2009) Biological effects of native and oxidized low-density lipoproteins in cultured human retinal pigment epithelial cells. Experimental Eye Research 88:3, pages 495-503.
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Brandon J. Lujan, Philip J. Rosenfeld, Giovanni Gregori, Fenghua Wang, Robert W. Knighton, William J. Feuer & Carmen A. Puliafito. (2009) Spectral Domain Optical Coherence Tomographic Imaging of Geographic Atrophy. Ophthalmic Surgery, Lasers and Imaging Retina 40:2, pages 96-101.
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Francesca Mojana, Lingyun Cheng, Dirk-Uwe G. Bartsch, Gabriel A. Silva, Igor Kozak, Nitin Nigam & William R. Freeman. (2008) The Role of Abnormal Vitreomacular Adhesion in Age-related Macular Degeneration: Spectral Optical Coherence Tomography and Surgical Results. American Journal of Ophthalmology 146:2, pages 218-227.e1.
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Jack M. Sullivan, Edwin H. Yau, R. Thomas Taggart, Mark C. Butler & Tiffany A. Kolniak. (2008) Bottlenecks in development of retinal therapeutic post-transcriptional gene silencing agents. Vision Research 48:3, pages 453-469.
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Daniel Ricklin & John D. Lambris. 2008. Current Topics in Complement II. Current Topics in Complement II 262 281 .

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