New therapeutic targets in atrophic age-related macular degeneration

Bibliography

• TASMAN W, ROVNER B: Age-related macular degeneration: treating the whole patient. Arch. Ophthalmol. (2004) 122(4):648-649.
   PubMedGoogle Scholar
• KLEIN ML, MAULDIN WM, STOUMBOS VD: Heredity and age-related macular degeneration. Observations in monozygotic twins. Arch. Ophthalmol. (1994) 112(7):932-937.
   PubMedGoogle Scholar
• MEYERS SM, GREENE T, GUTMAN FA: A twin study of age-related macular degeneration. Am. J. Ophthalmol. (1995) 120(6):757-766.
   PubMed Web of Science ®Google Scholar
• HEIBA IM, ELSTON RC, KLEIN BE, KLEIN R: Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. Genet. Epidemiol. (1994) 11(1):51-67.
   PubMed Web of Science ®Google Scholar
• ALLIKMETS R: Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. Am. J. Hum. Genet. (2000) 67(2):487-491.
   PubMed Web of Science ®Google Scholar
• MARX J: A clearer view of macular degeneration. Science (2006) 311(5768):1704-1705.
   PubMed Web of Science ®Google Scholar
• MITCHELL P, WANG JJ, SMITH W, LEEDER SR: Smoking and the 5-year incidence of age-related maculopathy: the Blue Mountains Eye Study. Arch. Ophthalmol. (2002) 120(10):1357-1363.
   PubMed Web of Science ®Google Scholar
• KLEIN R, KLEIN BE, TOMANY SC, MOSS SE: Ten-year incidence of age-related maculopathy and smoking and drinking: the Beaver Dam Eye Study. Am. J. Epidemiol. (2002) 156(7):589-598.
   PubMed Web of Science ®Google Scholar
• MICHELS S, SCHMIDT-ERFURTH U, ROSENFELD PJ: Promising new treatments for neovascular age-related macular degeneration. Expert Opin. Investig. Drugs (2006) 15(7):779-793.
   PubMedGoogle Scholar
• YEOH J, SIMS J, GUYMER RH: A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin. Pharmacother. (2006) 7(17):2355-2368.
   PubMed Web of Science ®Google Scholar
• DUNAIEF JL, DENTCHEV T, YING GS, MILAM AH: The role of apoptosis in age-related macular degeneration. Arch. Ophthalmol. (2002) 120(11):1435-1442.
   PubMedGoogle Scholar
• ZARBIN MA: Current concepts in the pathogenesis of age-related macular degeneration. Arch. Ophthalmol. (2004) 122(4):598-614.
   PubMed Web of Science ®Google Scholar
• DE JONG PT: Age-related macular degeneration. N. Engl. J. Med. (2006) 355(14):1474-1485.
   PubMed Web of Science ®Google Scholar
• BEATTY S, KOH H, PHIL M, HENSON D, BOULTON M: Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest. Ophthalmol. Vis. Sci. (2001) 42(2):439-446.
   PubMed Web of Science ®Google Scholar
• DONOSO LA, KIM D, FROST A, CALLAHAN A, HAGEMAN G: The role of inflammation in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. (2006) 51(2):137-152.
   PubMed Web of Science ®Google Scholar
• KENNEDY CJ, RAKOCZY PE, CONSTABLE IJ: Lipofuscin of the retinal pigment epithelium: a review. Eye (1995) 9(Pt. 6):763-771.
   PubMed Web of Science ®Google Scholar
• GUIDRY C, MEDEIROS NE, CURCIO CA: Phenotypic variation of retinal pigment epithelium in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. (2002) 43(1):267-273.
   PubMed Web of Science ®Google Scholar
• LOPEZ PF, SIPPY BD, LAMBERT HM, THACH AB, HINTON DR: Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest. Ophthalmol. Vis. Sci. (1996) 37(5):855-868.
   PubMed Web of Science ®Google Scholar
• CURCIO CA, MEDEIROS NE, MILLICAN CL: Photoreceptor loss in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. (1996) 37(7):1236-1249.
   PubMed Web of Science ®Google Scholar
• MADIGAN MC, PENFOLD PL, PROVIS JM, BALIND TK, BILLSON FA: Intermediate filament expression in human retinal macroglia. Histopathologic changes associated with age-related macular degeneration. Retina (1994) 14(1):65-74.
   PubMed Web of Science ®Google Scholar
• AHMED J, BRAUN RD, DUNN R Jr, LINSENMEIER RA: Oxygen distribution in the macaque retina. Invest. Ophthalmol. Vis. Sci. (1993) 34(3):516-521.
   PubMed Web of Science ®Google Scholar
• YU DY, CRINGLE SJ: Outer retinal anoxia during dark adaptation is not a general property of mammalian retinas. Comp. Biochem. Physiol. A Mol. Integr. Physiol. (2002) 132(1):47-52.
   PubMed Web of Science ®Google Scholar
• FLIESLER SJ, ANDERSON RE: Chemistry and metabolism of lipids in the vertebrate retina. Prog. Lipid Res. (1983) 22(2):79-131.
   PubMed Web of Science ®Google Scholar
• SPARROW JR, BOULTON M: RPE lipofuscin and its role in retinal pathobiology. Exp. Eye Res. (2005) 80(5):595-606.
   PubMed Web of Science ®Google Scholar
• GAILLARD ER, ATHERTON SJ, ELDRED G, DILLON J: Photophysical studies on human retinal lipofuscin. Photochem. Photobiol. (1995) 61(5):448-453.
   PubMed Web of Science ®Google Scholar
• ROZANOWSKA M, WESSELS J, BOULTON M et al.: Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media. Free Radic. Biol. Med. (1998) 24(7-8):1107-1112.
   PubMed Web of Science ®Google Scholar
• SPARROW JR, ZHOU J, BEN-SHABAT S, VOLLMER H, ITAGAKI Y, NAKANISHI K: Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE. Invest. Ophthalmol. Vis. Sci. (2002) 43(4):1222-1227.
   PubMed Web of Science ®Google Scholar
• SPARROW JR, VOLLMER-SNARR HR, ZHOU J et al.: A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J. Biol. Chem. (2003) 278(20):18207-18213.
   PubMed Web of Science ®Google Scholar
• TEZEL TH, BORA NS, KAPLAN HJ: Pathogenesis of age-related macular degeneration. Trends Mol. Med. (2004) 10(9):417-420.
   PubMed Web of Science ®Google Scholar
• WANG Z, KELLER LM, DILLON J, GAILLARD ER: Oxidation of A2E results in the formation of highly reactive aldehydes and ketones. Photochem. Photobiol. (2006) 82(5):1251-1257.
   PubMed Web of Science ®Google Scholar
• DILLON J, WANG Z, AVALLE LB, GAILLARD ER: The photochemical oxidation of A2E results in the formation of a 5,8,5',8'-bis-furanoid oxide. Exp. Eye Res. (2004) 79(4):537-542.
   PubMed Web of Science ®Google Scholar
• ZHOU J, JANG YP, KIM SR, SPARROW JR: Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc. Natl. Acad. Sci. USA (2006) 103(44):16182-16187.
   PubMed Web of Science ®Google Scholar
• BEN-SHABAT S, ITAGAKI Y, JOCKUSCH S, SPARROW JR, TURRO NJ, NAKANISHI K: Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew. Chem. Int. Ed. Engl. (2002) 41(5):814-817.
   PubMed Web of Science ®Google Scholar
• SPARROW JR, FISHKIN N, ZHOU J et al.: A2E, a byproduct of the visual cycle. Vision Res. (2003) 43(28):2983-2990.
   PubMed Web of Science ®Google Scholar
• AGE-RELATED EYE DISEASE STUDY RESEARCH GROUP: Randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, β carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch. Ophthalmol. (2001) 119(10):1417-1436.
   PubMed Web of Science ®Google Scholar
• LAME ME, KALGUTKAR AS, LAFONTAINE M: Intravenous pharmacokinetics and metabolism of the reactive oxygen scavenger α-phenyl-N-tert-butyl nitrone (PBN) in the cynomolgus monkey. Drug Metabol. Drug Interact. (2004) 20(1-2):11-24.
   PubMedGoogle Scholar
• TRUDEAU-LAME ME, KALGUTKAR AS, LAFONTAINE M: Pharmacokinetics and metabolism of the reactive oxygen scavenger α-phenyl-N-tert-butylnitrone in the male Sprague-Dawley rat. Drug Metab. Dispos. (2003) 31(2):147-152.
   PubMed Web of Science ®Google Scholar
• PETERSON SL, PURVIS RS, GRIFFITH JW: Comparison of neuroprotective effects induced by α-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-α-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus. Neurotoxicology (2005) 26(6):969-979.
   PubMed Web of Science ®Google Scholar
• FONG JJ, RHONEY DH: NXY-059: review of neuroprotective potential for acute stroke. Ann. Pharmacother. (2006) 40(3):461-471.
   PubMed Web of Science ®Google Scholar
• MAPLES KR, GREEN AR, FLOYD RA: Nitrone-related therapeutics: potential of NXY-059 for the treatment of acute ischaemic stroke. CNS Drugs (2004) 18(15):1071-1084.
   PubMed Web of Science ®Google Scholar
• RANCHON I, LAVAIL MM, KOTAKE Y, ANDERSON RE: Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration. J. Neurosci. (2003) 23(14):6050-6057.
   PubMed Web of Science ®Google Scholar
• RANCHON I, CHEN S, ALVAREZ K, ANDERSON RE: Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage. Invest. Ophthalmol. Vis. Sci. (2001) 42(6):1375-1379.
   PubMed Web of Science ®Google Scholar
• SALVEMINI D, RILEY DP, CUZZOCREA S: SOD mimetics are coming of age. Nat. Rev. Drug Discov. (2002) 1(5):367-374.
   PubMed Web of Science ®Google Scholar
• PONG K: Oxidative stress in neurodegenerative diseases: therapeutic implications for superoxide dismutase mimetics. Expert Opin. Biol. Ther. (2003) 3(1):127-139.
   PubMed Web of Science ®Google Scholar
• BAKER K, MARCUS CB, HUFFMAN K, KRUK H, MALFROY B, DOCTROW SR: Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. (1998) 284(1):215-221.
   PubMed Web of Science ®Google Scholar
• ASTON K, RATH N, NAIK A, SLOMCZYNSKA U, SCHALL OF, RILEY DP: Computer-aided design (CAD) of Mn(II) complexes: superoxide dismutase mimetics with catalytic activity exceeding the native enzyme. Inorg. Chem. (2001) 40(8):1779-1789.
   PubMed Web of Science ®Google Scholar
• LIVERSIDGE J, GRABOWSKI P, RALSTON S, BENJAMIN N, FORRESTER JV: Rat retinal pigment epithelial cells express an inducible form of nitric oxide synthase and produce nitric oxide in response to inflammatory cytokines and activated T cells. Immunology (1994) 83(3):404-409.
   PubMed Web of Science ®Google Scholar
• CHIOU GC: Review: effects of nitric oxide on eye diseases and their treatment. J. Ocul. Pharmacol. Ther. (2001) 17(2):189-198.
   PubMed Web of Science ®Google Scholar
• GOTO R, DOI M, MA N, SEMBA R, UJI Y: Contribution of nitric oxide-producing cells in normal and diabetic rat retina. Jpn. J. Ophthalmol. (2005) 49(5):363-370.
   PubMed Web of Science ®Google Scholar
• GOUREAU O, JEANNY JC, BECQUET F, HARTMANN M, COURTOIS I: Protection against light-induced retinal degeneration by an inhibitor of NO synthase. Neuroreport (1993) 5(3):233-236.
   PubMed Web of Science ®Google Scholar
• KALDI I, DITTMAR M, PIERCE P, ANDERSON RE: L-NAME protects against acute light damage in albino rats, but not against retinal degeneration in P23H and S334ter transgenic rats. Exp. Eye Res. (2003) 76(4):453-461.
   PubMed Web of Science ®Google Scholar
• DONOVAN M, CARMODY RJ, COTTER, T.G: Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent. J. Biol. Chem. (2001) 276(25):23000-23008.
   PubMed Web of Science ®Google Scholar
• NEUFELD AH, KAWAI S, DAS S, VORA S, GACHIE E, CONNOR JR, MANNING PT: Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase. Exp. Eye Res. (2002) 75(5):521-528.
   PubMed Web of Science ®Google Scholar
• NAKA M, NANBU T, KOBAYASHI K et al.: A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cyclic amidine derivative. Biochem. Biophys. Res. Commun. (2000) 270(2):663-667.
   PubMed Web of Science ®Google Scholar
• HAHN P, MILAM AH, DUNAIEF JL: Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. Arch. Ophthalmol. (2003) 121(8):1099-1105.
   PubMedGoogle Scholar
• HERSHKO C, KONIJN AM, LINK G: Iron chelators for thalassaemia. Br. J. Haematol. (1998) 101(3):399-406.
   PubMed Web of Science ®Google Scholar
• NISBET-BROWN E, OLIVIERI NF, GIARDINA PJ et al.: Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet (2003) 361(9369):1597-1602.
   PubMed Web of Science ®Google Scholar
• VANORDEN HE, HAGEMANN TM: Deferasirox–an oral agent for chronic iron overload. Ann. Pharmacother. (2006) 40(6):1110-1117.
   PubMed Web of Science ®Google Scholar
• NEUFELD EJ: Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions. Blood (2006) 107(9):3436-3441.
   PubMed Web of Science ®Google Scholar
• HAGEMAN GS, LUTHERT PJ, VICTOR CHONG NH, JOHNSON LV, ANDERSON DH, MULLINS RF: An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog. Retin. Eye Res. (2001) 20(6):705-732.
   PubMed Web of Science ®Google Scholar
• ANDERSON DH, MULLINS RF, HAGEMAN GS, JOHNSON LV: A role for local inflammation in the formation of drusen in the aging eye. Am. J. Ophthalmol. (2002) 134(3):411-431.
   PubMed Web of Science ®Google Scholar
• CRABB JW, MIYAGI M, GU X et al.: Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc. Natl. Acad. Sci. USA (2002) 99(23):14682-14687.
   PubMed Web of Science ®Google Scholar
• HOLLYFIELD JG, SALOMON RG, CRABB JW: Proteomic approaches to understanding age-related macular degeneration. Adv. Exp. Med. Biol. (2003) 533:83-89.
   PubMed Web of Science ®Google Scholar
• KLEIN RJ, ZEISS C, CHEW EY et al.: Complement factor H polymorphism in age-related macular degeneration. Science (2005) 308(5720):385-389.
   PubMed Web of Science ®Google Scholar
• EDWARDS AO, RITTER R III, ABEL KJ, MANNING A, PANHUYSEN C, FARRER LA: Complement factor H polymorphism and age-related macular degeneration. Science (2005) 308(5720):421-424.
   PubMed Web of Science ®Google Scholar
• HAINES JL, HAUSER MA, SCHMIDT S et al.: Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 308(5720):419-421.
   PubMed Web of Science ®Google Scholar
• HAGEMAN GS, ANDERSON DH, JOHNSON LV et al.: A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc. Natl. Acad. Sci. USA (2005) 102(20):7227-7232.
   PubMed Web of Science ®Google Scholar
• GOLD B, MERRIAM JE, ZERNANT J et al.: Variation in factor B (BF) and complement component 2(C2) genes is associated with age-related macular degeneration. Nat. Genet. (2006) 38(4):458-462.
   PubMed Web of Science ®Google Scholar
• FRANK MM, FRIES LF: The role of complement in inflammation and phagocytosis. Immunol. Today (1991) 12(9):322-326.
   PubMedGoogle Scholar
• ZIPFEL PF, HEINEN S, JOZSI M, SKERKA C: Complement and diseases: defective alternative pathway control results in kidney and eye diseases. Mol. Immunol. (2006) 43(1-2):97-106.
   PubMed Web of Science ®Google Scholar
• PANGBURN MK, PANGBURN KL, KOISTINEN V, MERI S, SHARMA AK: Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement. J. Immunol. (2000) 164(9):4742-4751.
   PubMed Web of Science ®Google Scholar
• BOK D: Evidence for an inflammatory process in age-related macular degeneration gains new support. Proc. Natl. Acad. Sci. USA (2005) 102(20):7053-7054.
   PubMed Web of Science ®Google Scholar
• SIVAPRASAD S, CHONG NV: The complement system and age-related macular degeneration. Eye (2006) 20(8):867-872.
   PubMed Web of Science ®Google Scholar
• HOURCADE DE, MITCHELL LM, OGLESBY TJ: A conserved element in the serine protease domain of complement factor B. J. Biol. Chem. (1998) 273(40):25996-26000.
   PubMed Web of Science ®Google Scholar
• VOLANAKIS JE, NARAYANA SV: Complement factor D, a novel serine protease. Protein Sci. (1996) 5(4):553-564.
   PubMed Web of Science ®Google Scholar
• BORA NS, KALIAPPAN S, JHA P et al.: Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J. Immunol. (2006) 177(3):1872-1878.
   PubMed Web of Science ®Google Scholar
• FUNG M, LOUBSER PG, UNDAR A et al.: Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuits. J. Thorac. Cardiovasc. Surg. (2001) 122(1):113-122.
   PubMed Web of Science ®Google Scholar
• UNDAR A, FRASER CD Jr: Anti-factor D monoclonal antibody, pulsatile flow and cardiotomy suction during cardiopulmonary bypass. Eur. J. Cardiothorac. Surg. (2002) 22(2):330-331.
   PubMed Web of Science ®Google Scholar
• UNDAR A, EICHSTAEDT HC, CLUBB FJ Jr et al.: Novel anti-factor D monoclonal antibody inhibits complement and leukocyte activation in a baboon model of cardiopulmonary bypass. Ann. Thorac. Surg. (2002) 74(2):355-362.
   PubMed Web of Science ®Google Scholar
• BORA PS, SOHN JH, CRUZ JM et al.: Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J. Immunol. (2005) 174(1):491-497.
   PubMed Web of Science ®Google Scholar
• PICKERING MC, WARREN J, ROSE KL et al.: Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc. Natl. Acad. Sci. USA (2006) 103(25):9649-9654.
   PubMed Web of Science ®Google Scholar
• ROTHER RP, MOJCIK CF, MCCROSKERY EW: Inhibition of terminal complement: a novel therapeutic approach for the treatment of systemic lupus erythematosus. Lupus (2004) 13(5):328-334.
   PubMed Web of Science ®Google Scholar
• LI JS, JAGGERS J, ANDERSON PA: The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass. Expert Rev. Cardiovasc. Ther. (2006) 4(5):649-654.
   PubMedGoogle Scholar
• THEROUX P, MARTEL C: Complement activity and pharmacological inhibition in cardiovascular disease. Can. J. Cardiol. (2006) 22(Suppl B):18B-24B
   PubMed Web of Science ®Google Scholar
• MOCCO J, MACK WJ, DUCRUET AF et al.: Preclinical evaluation of the neuroprotective effect of soluble complement receptor type 1 in a nonhuman primate model of reperfused stroke. J. Neurosurg. (2006) 105(4):595-601.
   PubMed Web of Science ®Google Scholar
• MAHAFFEY KW, VAN DE WERF F, SHERNAN SK et al.: Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: a systematic overview. Am. Heart J. (2006) 152(2):291-296.
   PubMed Web of Science ®Google Scholar
• FEENEY-BURNS L, ELDRED GE: The fate of the phagosome: conversion to age pigment and impact in human retinal pigment epithelium. Trans. Ophthalmol. Soc. UK (1983) 103(Pt. 4):416-421.
   PubMedGoogle Scholar
• WING GL, BLANCHARD GC, WEITER JJ: The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. (1978) 17(7):601-607.
   PubMed Web of Science ®Google Scholar
• DELORI C, GOGER DG, DOREY CK: Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest. Ophthalmol. Vis. Sci. (2001) 42:1855-1866.
   PubMed Web of Science ®Google Scholar
• DELORI FC: RPE Lipofuscin in ageing and age-related macular degeneration. In: Retinal Pigment Epithelium and Macular Disease (Documenta Ophthalmologica) (Vol. 62). Coscas G, Piccolino FC (Eds), Kluwer Academic Publishers, Dordrecht, The Netherlands (1995):37-45.
   Google Scholar
• DOREY CK, WU G, EBENSTEIN D, GARSD A, WEITER JJ: Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest. Ophthalmol. Vis. Sci. (1989) 30:1691-1699.
   PubMed Web of Science ®Google Scholar
• FEENEY-BURNS , HILDERBRAND ES, ELDRIDGE S: Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells. Invest. Ophthalmol. Vis. Sci. (1984) 25:195-200.
   PubMed Web of Science ®Google Scholar
• HOLZ FG, BELLMAN C, STAUDT S, SCHUTT F, VOLCKER HE: Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. (2001) 42:1051-1056.
   PubMed Web of Science ®Google Scholar
• HOLZ FG, BELLMANN C, MARGARITIDIS M, SCHUTT F, OTTO TP, VOLCKER HE: Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefes Arch. Clin. Exp. Ophthalmol. (1999) 237:145-152.
   PubMed Web of Science ®Google Scholar
• VON RÜCKMANN A, FITZKE FW, BIRD AC: Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest. Ophthalmol. Vis. Sci. (1997) 38:478-486.
   PubMedGoogle Scholar
• HOLZ FG, BELLMAN C, STAUDT S, SCHUTT F, VOLCKER HE: Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. (2001) 42:1051-1056.
   PubMed Web of Science ®Google Scholar
• KATZ ML, DREA CM, ROBISON WG Jr: Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium. Mech. Ageing Dev. (1986) 35:291-305.
   PubMed Web of Science ®Google Scholar
• KATZ ML, ELDRED GE, ROBISON WG Jr: Lipofuscin autofluorescence: evidence for vitamin A involvement in the retina. Mech. Ageing Dev. (1987) 39:81-90.
   PubMed Web of Science ®Google Scholar
• KATZ ML, REDMOND TM: Effect of Rpe65 knockout on accumulation of lipofuscin fluorophores in the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. (2001) 42:3023-3030.
   PubMed Web of Science ®Google Scholar
• FINNEMANN SC, LEUNG LW, RODRIGUEZ-BOULAN E: The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc. Natl. Acad. Sci. USA (2002) 99(6):3842-3847.
   PubMed Web of Science ®Google Scholar
• SUTER M, REME C, GRIMM C et al.: Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J. Biol Chem. (2000) 275(50):39625-39630.
   PubMed Web of Science ®Google Scholar
• GOLLAPALLI DR, RANDO RR: The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration. Proc. Natl. Acad. Sci. USA (2004) 101(27):10030-10035.
   PubMed Web of Science ®Google Scholar
• RADU RA, MATA NL, NUSINOWITZ S, LIU X, SIEVING PA, TRAVIS GH: Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc. Natl. Acad. Sci. USA (2003) 100(8):4742-4747.
   PubMed Web of Science ®Google Scholar
• MAITI P, KONG J, KIM SR, SPARROW JR, ALLIKMETS R, RANDO RR: Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Biochemistry (2006) 45(3):852-860.
   PubMed Web of Science ®Google Scholar
• JIN M, LI S, MOGHRABI WN, SUN H, TRAVIS GH: Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell (2005) 122(3):449-459.
   PubMed Web of Science ®Google Scholar
• MOISEYEV G, CHEN Y, TAKAHASHI Y, WU BX, MA JX: RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc. Natl. Acad. Sci. USA (2005) 102(35):12413-12418.
   PubMed Web of Science ®Google Scholar
• REDMOND TM, POLIAKOV E, YU S, TSAI JY, LU Z, GENTLEMAN S: Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. Proc. Natl. Acad. Sci. USA (2005) 102(38):13658-13663.
   PubMed Web of Science ®Google Scholar
• RADU RA, HAN Y, BUI TV et al.: Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest. Ophthalmol. Vis. Sci. (2005) 46(12):4393-4401.
   PubMed Web of Science ®Google Scholar
• BERNI R, FORMELLI F: In vitro interaction of fenretinide with plasma retinol-binding protein and its functional consequences. FEBS Lett. (1992) 308(1):43-45.
   PubMed Web of Science ®Google Scholar
• NAIK HR, KALEMKERIAN G, PIENTA KJ: 4-Hydroxyphenylretinamide in the chemoprevention of cancer. Adv. Pharmacol. (1995) 33:315-347.
   PubMedGoogle Scholar
• CURCIO CA: Photoreceptor topography in ageing and age-related maculopathy. Eye (2001) 15(Pt. 3):376-383.
   PubMed Web of Science ®Google Scholar
• CURCIO CA, MILLICAN CL, ALLEN KA, KALINA RE: Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Invest. Ophthalmol. Vis. Sci. (1993) 34(12):3278-3296.
   PubMed Web of Science ®Google Scholar
• JACKSON GR, OWSLEY C, CORDLE EP, FINLEY CD: Aging and scotopic sensitivity. Vision Res. (1998) 38(22):3655-3662.
   PubMed Web of Science ®Google Scholar
• JACKSON GR, OWSLEY C, MCGWIN G Jr: Aging and dark adaptation. Vision Res. (1999) 39(23):3975-3982.
   PubMed Web of Science ®Google Scholar
• OWSLEY C, JACKSON GR, CIDECIYAN AV et al.: Psychophysical evidence for rod vulnerability in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. (2000) 41(1):267-273.
   PubMed Web of Science ®Google Scholar
• SCILLEY K, JACKSON GR, CIDECIYAN AV, MAGUIRE MG, JACOBSON SG, OWSLEY C: Early age-related maculopathy and self-reported visual difficulty in daily life. Ophthalmology (2002) 109(7):1235-1242.
   PubMed Web of Science ®Google Scholar
• CURCIO CA, OWSLEY C, JACKSON GR: Spare the rods, save the cones in aging and age-related maculopathy. Invest. Ophthalmol. Vis. Sci. (2000) 41(8):2015-2018.
   PubMed Web of Science ®Google Scholar
• JACKSON GR, OWSLEY C, CURCIO CA: Photoreceptor degeneration and dysfunction in aging and age-related maculopathy. Ageing Res. Rev. (2002) 1(3):381-396.
   PubMed Web of Science ®Google Scholar
• CIDECIYAN AV, HOOD DC, HUANG Y et al.: Disease sequence from mutant rhodopsin allele to rod and cone photoreceptor degeneration in man. Proc. Natl. Acad. Sci. USA (1998) 95(12):7103-7108.
   PubMed Web of Science ®Google Scholar
• JOHN SK, SMITH JE, AGUIRRE GD, MILAM AH: Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa. Mol. Vis. (2000) 6:204-215.
   PubMed Web of Science ®Google Scholar
• MOHAND-SAID S, HICKS D, LEVEILLARD T, PICAUD S, PORTO F, SAHEL JA: Rod-cone interactions: developmental and clinical significance. Prog. Retin. Eye Res. (2001) 20(4):451-467.
   PubMed Web of Science ®Google Scholar
• MOHAND-SAID S, HICKS D, DREYFUS H, SAHEL JA: Selective transplantation of rods delays cone loss in a retinitis pigmentosa model. Arch. Ophthalmol. (2000) 118(6):807-811.
   PubMedGoogle Scholar
• STREICHERT LC, BIRNBACH CD, REH TA: A diffusible factor from normal retinal cells promotes rod photoreceptor survival in an in vitro model of retinitis pigmentosa. J. Neurobiol. (1999) 39(4):475-490.
   PubMedGoogle Scholar
• FINTZ AC, AUDO I, HICKS D, MOHAND-SAID S, LEVEILLARD T, SAHEL J: Partial characterization of retina-derived cone neuroprotection in two culture models of photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. (2003) 44(2):818-825.
   PubMed Web of Science ®Google Scholar
• LEVEILLARD T, MOHAND-SAID S, LORENTZ O et al.: Identification and characterization of rod-derived cone viability factor. Nat. Genet. (2004) 36(7):755-759.
   PubMed Web of Science ®Google Scholar
• LAVAIL MM, YASUMURA D, MATTHES MT et al.: Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest. Ophthalmol. Vis. Sci. (1998) 39(3):592-602.
   PubMed Web of Science ®Google Scholar
• OKOYE G, ZIMMER J, SUNG J et al.: Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J. Neurosci. (2003) 23(10):4164-4172.
   PubMed Web of Science ®Google Scholar
• STEINBERG RH: Survival factors in retinal degenerations. Curr. Opin. Neurobiol. (1994) 4(4):515-524.
   PubMedGoogle Scholar
• MCGEE SANFTNER LH, ABEL H, HAUSWIRTH WW, FLANNERY JG: Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa. Mol. Ther. (2001) 4(6):622-629.
   PubMed Web of Science ®Google Scholar
• LAVAIL MM, YASUMURA D, MATTHES MT, LAU-VILLACORTA C, UNOKI K, SUNG CH, STEINBERG RH: Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest. Ophthalmol. Vis. Sci. (1998) 39(3):592-602.
   PubMed Web of Science ®Google Scholar
• CAYOUETTE M, GRAVEL C: Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum. Gene Ther. (1997) 8(4):423-430.
   PubMed Web of Science ®Google Scholar
• CAYOUETTE M, BEHN D, SENDTNER M, LACHAPELLE P, GRAVEL C: Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J. Neurosci. (1998) 18(22):9282-9293.
   PubMed Web of Science ®Google Scholar
• LIANG FQ, ALEMAN TS, DEJNEKA NS et al.: Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Mol. Ther. (2001) 4(5):461-472.
   PubMed Web of Science ®Google Scholar
• LIANG FQ, DEJNEKA NS, COHEN DR et al.: AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse. Mol. Ther. (2001) 3(2):241-248.
   PubMed Web of Science ®Google Scholar
• CHONG NH, ALEXANDER RA, WATERS L, BARNETT KC, BIRD AC, LUTHERT PJ: Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration. Invest. Ophthalmol. Vis. Sci. (1999) 40(6):1298-1305.
   PubMed Web of Science ®Google Scholar
• TAO W, WEN R, GODDARD MB et al.: Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. (2002) 43(10):3292-3298.
   PubMed Web of Science ®Google Scholar
• LAVAIL MM, UNOKI K, YASUMURA D, MATTHES MT, YANCOPOULOS GD, STEINBERG RH: Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc. Natl. Acad. Sci. USA (1992) 89(23):11249-11253.
   PubMed Web of Science ®Google Scholar
• TAO W: Application of encapsulated cell technology for retinal degenerative diseases. Expert Opin. Biol. Ther. (2006) 6(7):717-726.
   PubMedGoogle Scholar
• SIEVING PA, CARUSO RC, TAO Wet al.: Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc. Natl. Acad. Sci. USA (2006) 103(10):3896-3901.
   PubMed Web of Science ®Google Scholar
• CAMPOCHIARO PA, NGUYEN QD, SHAH SM et al.: Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial. Hum. Gene Ther. (2006) 17(2):167-176.
   PubMed Web of Science ®Google Scholar
• IMAI D, YONEYA S, GEHLBACH PL, WEI LL, MORI K: Intraocular gene transfer of pigment epithelium-derived factor rescues photoreceptors from light-induced cell death. J. Cell Physiol. (2005) 202(2):570-578.
   PubMed Web of Science ®Google Scholar
• CAYOUETTE M, SMITH SB, BECERRA SP, GRAVEL C: Pigment epithelium-derived factor delays the death of photoreceptors in mouse model of inherited retinal degenerations. Neurobiol. Dis. (1999) 6:523-532.
   PubMed Web of Science ®Google Scholar
• CAO W, TOMBRAN-TINK J, ELIAS R, SEZATE S, MRAZEK D, MCGINNIS JF: In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. Invest. Ophthalmol. Vis. Sci. (2001) 42:1646-1652.
   PubMed Web of Science ®Google Scholar
• MIYAZAKI M, IKEDA Y, YONEMITSU Y et al.: Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats. Hum. Gene Ther. (2003) 10:1503-1511.
   Google Scholar
• MORI K, GEHLBACH P, ANDO A, MCVEY D, WEI L, CAMPOCHIARO PA: Regression of ocular neovascularization by increased expression of pigment epithelium-derived factor. Invest. Ophthalmol. Vis. Sci. (2001) 43:2428-2434.
   Web of Science ®Google Scholar
• MORI K, GEHLBACH P, YAMAMOTO S et al.: AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. (2002) 43:1994-2000.
   PubMed Web of Science ®Google Scholar
• SAISHIN Y, SILVA RL, SAISHIN Y et al.: Periocular gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization in a human-sized eye. Hum. Gene Ther. (2005) 16:473-478.
   PubMed Web of Science ®Google Scholar
• SUGITA Y, BECERRA SP, CHADER GJ, SCHWARTZ JP: Pigment epithelium-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes. J. Neurosci. Res. (1997) 49(6):710-718.
   PubMed Web of Science ®Google Scholar
• WEN R, CHENG T, LI Y, CAO W, STEINBERG RH: α2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. J. Neurosci. (1996) 16:5986-5992.
   PubMed Web of Science ®Google Scholar
• KAPITSKAYA M, CUNNINGHAM ME, LACSON R, KORNIENKO O, BEDNAR B, PETRUKHIN K: Development of the high throughput screening assay for identification of agonists of an orphan nuclear receptor. Assay Drug Dev. Technol. (2006) 4(3):253-262.
   PubMed Web of Science ®Google Scholar
• WOLKENBERG SE, ZHAO Z, KAPITSKAYA M et al.: Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand. Bioorg. Med. Chem. Lett. (2006) 16(19):5001-5004.
   PubMed Web of Science ®Google Scholar
• REME CE, GRIMM C, HAFEZI F, MARTI A, WENZEL A: Apoptotic cell death in retinal degenerations. Prog. Retin. Eye Res. (1998) 17:443-464.
   PubMed Web of Science ®Google Scholar
• MILAM AH, LI ZY, FARISS RN: Histopathology of the human retina in retinitis pigmentosa. Prog. Retin. Eye Res. (1998) 17:175-205.
   PubMed Web of Science ®Google Scholar
• CHANG HY, YANG X: Proteases for cell suicide: functions and regulation of caspases. Microbiol. Mol. Biol. Rev. (2000) 64:821-846.
   PubMed Web of Science ®Google Scholar
• LIU C, LI Y, PENG M, LATIES AM, WEN R: Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration. J. Neurosci. (1999) 19:4778-4785.
   PubMed Web of Science ®Google Scholar
• YAMAZAKI H, OHGURO H, MAEDA T et al.: Preservation of retinal morphology and functions in royal college surgeons rat by nilvadipine, a Ca2+ antagonist. Invest. Ophthalmol. Vis. Sci. (2002) 43:919-926.
   PubMed Web of Science ®Google Scholar
• BODE C, WOLFRUM U: Caspase-3 inhibitor reduces apoptotic photoreceptor cell death during inherited retinal degeneration in tubby mice. Mol. Vis. (2003) 9:144-150.
   PubMed Web of Science ®Google Scholar
• HUGHES EH, SCHLICHTENBREDE FC, MURPHY CC et al.: Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. Exp. Eye Res. (2004) 78(6):1077-1084.
   PubMed Web of Science ®Google Scholar
• SAMARDZIJA M, WENZEL A, THIERSCH M, FRIGG R, REME C, GRIMM C: Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. (2006) 47(12):5181-5190.
   PubMed Web of Science ®Google Scholar
• FARISS RN, LI ZY, MILAM AH: Abnormalities in rod photoreceptors, amacrine cells, and horizontal cells in human retinas with retinitis pigmentosa. Am. J. Ophthalmol. (2000) 129(2):215-223.
   PubMed Web of Science ®Google Scholar
• HARTIG W, GROSCHE J, DISTLER C, GRIMM D, EL-HIFNAWI E, REICHENBACH A: Alterations of Muller (glial) cells in dystrophic retinae of RCS rats. J. Neurocytol. (1995) 24(7):507-517.
   PubMedGoogle Scholar
• DILORETO DA Jr, MARTZEN MR, DEL CERRO C, COLEMAN PD, DEL CERRO M: Muller cell changes precede photoreceptor cell degeneration in the age-related retinal degeneration of the Fischer 344 rat. Brain Res. (1995) 698(1-2):1-14.
   PubMed Web of Science ®Google Scholar
• EKSTROM P, SANYAL S, NARFSTROM K, CHADER GJ, VAN VEEN T: Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. Invest. Ophthalmol. Vis. Sci. (1988) 29(9):1363-1371.
   PubMed Web of Science ®Google Scholar
• GROSCHE J, HARTIG W, REICHENBACH A: Expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and Bcl-2 protooncogene protein by Muller (glial) cells in retinal light damage of rats. Neurosci. Lett. (1995) 185(2):119-122.
   PubMed Web of Science ®Google Scholar
• LEWIS GP, MATSUMOTO B, FISHER SK: Changes in the organization and expression of cytoskeletal proteins during retinal degeneration induced by retinal detachment. Invest. Ophthalmol. Vis. Sci. (1995) 36(12):2404-2416.
   PubMed Web of Science ®Google Scholar
• ZACK DJ: Neurotrophic rescue of photoreceptors: are Muller cells the mediators of survival? Neuron (2000) 26(2):285-286.
   PubMed Web of Science ®Google Scholar
• HARADA T, HARADA C, NAKAYAMA N et al.: Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron (2000) 26(2):533-541.
   PubMed Web of Science ®Google Scholar
• WAHLIN KJ, CAMPOCHIARO PA, ZACK DJ, ADLER R: Neurotrophic factors cause activation of intracellular signaling pathways in Muller cells and other cells of the inner retina, but not photoreceptors. Invest. Ophthalmol. Vis. Sci. (2000) 41(3):927-936.
   PubMed Web of Science ®Google Scholar
• WAHLIN KJ, ADLER R, ZACK DJ, CAMPOCHIARO PA: Neurotrophic signaling in normal and degenerating rodent retinas. Exp. Eye Res. (2001) 73(5):693-701.
   PubMed Web of Science ®Google Scholar
• NEWMAN E, REICHENBACH A: The Muller cell: a functional element of the retina. Trends Neurosci. (1996) 19(8):307-312.
   PubMed Web of Science ®Google Scholar
• JONES KJ, COERS S, STORER PD, TANZER L, KINDERMAN NB: Androgenic regulation of the central glia response following nerve damage. J. Neurobiol. (1999) 40(4):560-573.
   PubMedGoogle Scholar
• GHIRNIKAR RS, YU AC, ENG LF: Astrogliosis in culture: III. Effect of recombinant retrovirus expressing antisense glial fibrillary acidic protein RNA. J. Neurosci. Res. (1994) 38(4):376-385.
   PubMed Web of Science ®Google Scholar
• LEFRANCOIS T, FAGES C, PESCHANSKI M, TARDY M: Neuritic outgrowth associated with astroglial phenotypic changes induced by antisense glial fibrillary acidic protein (GFAP) mRNA in injured neuron-astrocyte cocultures. J. Neurosci. (1997) 17(11):4121-4128.
   PubMed Web of Science ®Google Scholar
• MALEK G, LI CM, GUIDRY C, MEDEIROS NE, CURCIO CA: Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. Am. J. Pathol. (2003) 162(2):413-425.
   PubMed Web of Science ®Google Scholar
• CURCIO CA, PRESLEY JB, MALEK G, MEDEIROS NE, AVERY DV, KRUTH HS: Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy. Exp. Eye Res. (2005) 81(6):731-741.
   PubMed Web of Science ®Google Scholar
• ANDERSON DH, OZAKI S, NEALON M et al.: Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation. Am. J. Ophthalmol. (2001) 131(6):767-781.
   PubMed Web of Science ®Google Scholar
• THAKKINSTIAN A, BOWE S, MCEVOY M, SMITH W, ATTIA J: Association between apolipoprotein E polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis. Am. J. Epidemiol. (2006) 164(9):813-822.
   PubMed Web of Science ®Google Scholar
• MCGWIN G Jr, OWSLEY C, CURCIO CA, CRAIN RJ: The association between statin use and age related maculopathy. Br. J. Ophthalmol. (2003) 87(9):1121-1125.
   PubMed Web of Science ®Google Scholar
• HALL NF, GALE CR, SYDDALL H, PHILLIPS DI, MARTYN CN: Risk of macular degeneration in users of statins: cross sectional study. BMJ (2001) 323(7309):375-376.
   PubMed Web of Science ®Google Scholar
• MCCARTY CA, MUKESH BN, GUYMER RH, BAIRD PN, TAYLOR HR: Cholesterol-lowering medications reduce the risk of age-related maculopathy progression. Med. J. Aust. (2001) 175(6):340.
   PubMed Web of Science ®Google Scholar
• VAN LEEUWEN R, TOMANY SC, WANG JJ et al.: Is medication use associated with the incidence of early age-related maculopathy? Pooled findings from 3 continents. Ophthalmology (2004) 111(6):1169-1175.
   PubMed Web of Science ®Google Scholar
• DASHTI N, MCGWIN G, OWSLEY C, CURCIO CA: Plasma apolipoproteins and risk for age related maculopathy. Br. J. Ophthalmol. (2006) 90(8):1028-1033.
   PubMed Web of Science ®Google Scholar
• JOHNSON LV, LEITNER WP, RIVEST AJ, STAPLES MK, RADEKE MJ, ANDERSON DH: The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc. Natl. Acad. Sci. USA (2002) 99(18):11830-11835.
   PubMed Web of Science ®Google Scholar
• DENTCHEV T, MILAM AH, LEE VM, TROJANOWSKI JQ, DUNAIEF JL: Amyloid-β is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol. Vis. (2003) 9:184-190.
   PubMed Web of Science ®Google Scholar
• ANDERSON DH, TALAGA KC, RIVEST AJ, BARRON E, HAGEMAN GS, JOHNSON LV: Characterization of β amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp. Eye Res. (2004) 78(2):243-256.
   PubMed Web of Science ®Google Scholar
• YOSHIDA T, OHNO-MATSUI K, ICHINOSE S et al.: The potential role of amyloid β in the pathogenesis of age-related macular degeneration. J. Clin. Invest. (2005) 115(10):2793-2800.
   PubMed Web of Science ®Google Scholar
• LOMBARDO JA, STERN EA, MCLELLAN ME et al.: Amyloid-β antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. J. Neurosci. (2003) 23(34):10879-83.
   PubMed Web of Science ®Google Scholar
• MORGAN D: Immunotherapy for Alzheimer's disease. J. Alzheimers Dis. (2006) 9(3 Suppl):425-432.
   PubMed Web of Science ®Google Scholar
• VASILEVKO V, CRIBBS DH: Novel approaches for immunotherapeutic intervention in Alzheimer's disease. Neurochem. Int. (2006) 49(2):113-126.
   PubMed Web of Science ®Google Scholar
• WEISZ JM, HUMAYUN MS, DE JUAN E Jr et al.: Allogenic fetal retinal pigment epithelial cell transplant in a patient with geographic atrophy. Retina (1999) 19(6):540-545.
   PubMed Web of Science ®Google Scholar
• ALGVERE PV, BERGLIN L, GOURAS P, SHENG Y, KOPP ED: Transplantation of RPE in age-related macular degeneration: observations in disciform lesions and dry RPE atrophy. Graefes Arch. Clin. Exp. Ophthalmol. (1997) 235(3):149-158.
   PubMed Web of Science ®Google Scholar
• ALGVERE PV, GOURAS P, DAFGARD KOPP E: Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD. Eur. J. Ophthalmol. (1999) 9(3):217-230.
   PubMed Web of Science ®Google Scholar
• ALGVERE PV, BERGLIN L, GOURAS P, SHENG Y: Transplantation of fetal retinal pigment epithelium in age-related macular degeneration with subfoveal neovascularization. Graefes Arch. Clin. Exp. Ophthalmol. (1994) 232(12):707-716.
   PubMed Web of Science ®Google Scholar
• DAS T, DEL CERRO M, JALALI S et al.: The transplantation of human fetal neuroretinal cells in advanced retinitis pigmentosa patients: results of a long-term safety study. Exp. Neurol. (1999) 157(1):58-68.
   PubMed Web of Science ®Google Scholar
• BERGER AS, TEZEL TH, DEL PRIORE LV, KAPLAN HJ: Photoreceptor transplantation in retinitis pigmentosa: short-term follow-up. Ophthalmology (2003) 10(2):383-391.
   Google Scholar
• RADTKE ND, ARAMANT RB, SEILER MJ, PETRY HM, PIDWELL D: Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa. Arch. Ophthalmol. (2004) 122(8):1159-1165.
   PubMedGoogle Scholar
• KLIMANSKAYA I, HIPP J, REZAI KA, WEST M, ATALA A, LANZA R: Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning Stem Cells (2004) 6(3):217-245.
   PubMedGoogle Scholar
• TROPEPE V, COLES BL, CHIASSON BJ, HORSFORD DJ, ELIA AJ, MCINNES RR, VAN DER KOOY D: Retinal stem cells in the adult mammalian eye. Science (2000) 287(5460):2032-2036.
   PubMed Web of Science ®Google Scholar
• COLES BL, ANGENIEUX B, INOUE T et al.: Facile isolation and the characterization of human retinal stem cells. Proc. Natl. Acad. Sci. USA (2004) 101(44):15772-15777.
   PubMed Web of Science ®Google Scholar
• MAYER EJ, CARTER DA, REN Y et al.: Neural progenitor cells from postmortem adult human retina. Br. J. Ophthalmol. (2005) 89(1):102-106.
   PubMed Web of Science ®Google Scholar
• QUIGLEY HA, IGLESIA DS: Stem cells to replace the optic nerve. Eye (2004) 18(11):1085-1088.
   PubMed Web of Science ®Google Scholar
• OTANI A, DORRELL MI, KINDER K et al.: Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. J. Clin. Invest. (2004) 114(6):765-774.
   PubMed Web of Science ®Google Scholar
• CABALLERO S, SENGUPTA N, CRAFOORD S et al.: The many possible roles of stem cells in age-related macular degeneration. Graefes Arch. Clin. Exp. Ophthalmol. (2004) 242(1):85-90.
   PubMed Web of Science ®Google Scholar
• TOMITA M, YAMADA H, ADACHI Y et al.: Choroidal neovascularization is provided by bone marrow cells. Stem Cells (2004) 22(1):21-26.
   PubMed Web of Science ®Google Scholar
• MOOSMANN B, BEHL C: Antioxidants as treatment for neurodegenerative disorders. Expert Opin. Investig. Drugs (2002) 11(10):1407-1435.
   PubMed Web of Science ®Google Scholar
• GU X, MEER SG, MIYAGI M et al.: Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J. Biol. Chem. (2003) 278(43):42027-42035.
   PubMed Web of Science ®Google Scholar
• RAKOCZY PE, ZHANG D, ROBERTSON T et al.: Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model. Am. J. Pathol. (2002) 161(4):1515-1524.
   PubMed Web of Science ®Google Scholar
• ZHANG D, BRANKOV M, MAKHIJA MT et al.: Correlation between inactive cathepsin D expression and retinal changes in mcd2/mcd2 transgenic mice. Invest. Ophthalmol. Vis. Sci. (2005) 46(9):3031-3038.
   PubMed Web of Science ®Google Scholar
• KATZ ML, RICE LM, GAO CL et al.: Reversible accumulation of lipofuscin-like inclusions in the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. (1999) 40(1):175-181.
   PubMed Web of Science ®Google Scholar
• KATZ ML, GAO CL: Vitamin A incorporation into lipofuscin-like inclusions in the retinal pigment epithelium. Mech. Ageing Dev. (1995) 84(1):29-38.
   PubMed Web of Science ®Google Scholar
• ROMERO-BORJA F, VENKATESWARAN K, ROORDA A, HEBERT T: Optical slicing of human retinal tissue in vivo with the adaptive optics scanning laser ophthalmoscope. Appl. Opt. (2005) 44(19):4032-4040.
   PubMed Web of Science ®Google Scholar