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Review

Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery

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Pages 695-705 | Published online: 27 Apr 2007

Keep up to date with the latest research on this topic with citation updates for this article.

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Bianca M. Liederer, Jonathan Cheong, Kang-Jye Chou, Peter S. Dragovich, Hoa Le, Xiaorong Liang, Justin Ly, Sophie Mukadam, Jason Oeh, Deepak Sampath, Leslie Wang & Susan Wong. (2019) Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor. Xenobiotica 49:9, pages 1063-1077.
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Keivan Sadrerafi, Emilia O Mason & Mark W Lee$suffix/text()$suffix/text(). (2018) Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors. Drug Design, Development and Therapy 12, pages 987-995.
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Hang Chen, Shiyu Wang, Haiyuan Zhang, Edouard C. Nice & Canhua Huang. (2016) Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities. Expert Review of Anticancer Therapy 16:8, pages 827-838.
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Hassina Massudi, Ross Grant, Gilles J Guillemin & Nady Braidy. (2012) NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns. Redox Report 17:1, pages 28-46.
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Mark Watson, Anne Roulston, Laurent Bélec, Xavier Billot, Richard Marcellus, Dominique Bédard, Cynthia Bernier, Stéphane Branchaud, Helen Chan, Kenza Dairi, Karine Gilbert, Daniel Goulet, Michel-Olivier Gratton, Henady Isakau, Anne Jang, Abdelkrim Khadir, Elizabeth Koch, Manon Lavoie, Michael Lawless, Mai Nguyen, Denis Paquette, Émilie Turcotte, Alvin Berger, Matthew Mitchell, Gordon C. Shore & Pierre Beauparlant. (2009) The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors. Molecular and Cellular Biology 29:21, pages 5872-5888.
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