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The potential for phospholipase D as a new therapeutic target

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Pages 707-716 | Published online: 27 Apr 2007

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Chunyu Zeng, Van Anthony M. Villar, Peiying Yu, Lin Zhou & Pedro A. Jose. (2009) Reactive Oxygen Species and Dopamine Receptor Function in Essential Hypertension. Clinical and Experimental Hypertension 31:2, pages 156-178.
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P. Binu, M. Abhilash, R. Harikumaran Nair & Mathews V. Varghese. 2023. Phospholipases in Physiology and Pathology. Phospholipases in Physiology and Pathology 309 320 .
Simita Das, P.H. Krushnamurthy, G. Dhananjaya & Nilkamal Mahanta. 2023. Phospholipases in Physiology and Pathology. Phospholipases in Physiology and Pathology 253 267 .
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Oludoyin Adeseun Adigun, Muhammad Nadeem, Thu Huong Pham, Linda Elizabeth Jewell, Mumtaz Cheema & Raymond Thomas. (2020) Recent advances in bio‐chemical, molecular and physiological aspects of membrane lipid derivatives in plant pathology. Plant, Cell & Environment 44:1, pages 1-16.
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Hyun Jung Yoo, Won Chan Hwang & Do Sik Min. (2020) Targeting of Phospholipase D1 Ameliorates Collagen-Induced Arthritis via Modulation of Treg and Th17 Cell Imbalance and Suppression of Osteoclastogenesis. International Journal of Molecular Sciences 21:9, pages 3230.
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M.I. McDermott, Y. Wang, M.J.O. Wakelam & V.A. Bankaitis. (2020) Mammalian phospholipase D: Function, and therapeutics. Progress in Lipid Research 78, pages 101018.
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Mengshan Tan, Jieqiong Li, Fangchen Ma, Xing Zhang, Qingfei Zhao & Xipeng Cao. (2019) PLD3 Rare Variants Identified in Late-Onset Alzheimer’s Disease Affect Amyloid-β Levels in Cellular Model. Frontiers in Neuroscience 13.
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Noel-Marie Plonski, Bianca Bissoni, Madara Hetti Arachchilage, Karl Romstedt, Edgar E. Kooijman & Helen Piontkivska. (2018) Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs. Gene 656, pages 95-105.
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Hae-In Song & Mee-Sup Yoon. (2016) PLD1 regulates adipogenic differentiation through mTOR - IRS-1 phosphorylation at serine 636/639. Scientific Reports 6:1.
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Jin-Won Park. (2015) Phase Asymmetry Effect on Vesicle Fusion Induced by Phospholipase D. Korean Chemical Engineering Research 53:6, pages 672-676.
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Do Sik Min. (2014) The Functional Role of Phospholipase D Isozymes in Apoptosis. Journal of Life Science 24:12, pages 1378-1382.
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Francesca Fiory, Luca Parrillo, Gregory Alexander Raciti, Federica Zatterale, Cecilia Nigro, Paola Mirra, Roberta Falco, Luca Ulianich, Bruno Di Jeso, Pietro Formisano, Claudia Miele & Francesco Beguinot. (2014) PED/PEA-15 Inhibits Hydrogen Peroxide-Induced Apoptosis in Ins-1E Pancreatic Beta-Cells via PLD-1. PLoS ONE 9:12, pages e113655.
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Yalin Yang, Jie Xiong, Zhigang Zhou, Fengmin Huo, Wei Miao, Chao Ran, Yuchun Liu, Jinyong Zhang, Jinmei Feng, Meng Wang, Min Wang, Lei Wang & Bin Yao. (2014) The Genome of the Myxosporean Thelohanellus kitauei Shows Adaptations to Nutrient Acquisition within Its Fish Host. Genome Biology and Evolution 6:12, pages 3182-3198.
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Sarah A. Scott, Thomas P. Mathews, Pavlina T. Ivanova, Craig W. Lindsley & H. Alex Brown. (2014) Chemical modulation of glycerolipid signaling and metabolic pathways. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841:8, pages 1060-1084.
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Kerstin Göbel, Michael K. Schuhmann, Susann Pankratz, David Stegner, Alexander M. Herrmann, Attila Braun, Johanna Breuer, Stefan Bittner, Tobias Ruck, Heinz Wiendl, Christoph Kleinschnitz, Bernhard Nieswandt & Sven G. Meuth. (2014) Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. European Journal of Immunology 44:8, pages 2295-2305.
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Xiaodong Jia, Fangyan Chen, Weihua Pan, Rentao Yu, Shuguang Tian, Gaige Han, Haiqin Fang, Shuo Wang, Jingya Zhao, Xianping Li, Dongyu Zheng, Sha Tao, Wanqing Liao, Xuelin Han & Li Han. (2014) Gliotoxin promotes Aspergillus fumigatus internalization into type II human pneumocyte A549 cells by inducing host phospholipase D activation. Microbes and Infection 16:6, pages 491-501.
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Y H Jang, K Y Choi & D S Min. (2013) Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy. Cell Death & Differentiation 21:4, pages 533-546.
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Ute Burkhardt, Bartosch Wojcik, Martina Zimmermann & Jochen Klein. (2014) Phospholipase D is a target for inhibition of astroglial proliferation by ethanol. Neuropharmacology 79, pages 1-9.
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Yong Ryoul Yang, Hyun-Jun Jang, Sung Ho Ryu & Pann-Ghill Suh. 2014. Phospholipases in Health and Disease. Phospholipases in Health and Disease 3 38 .
Mi Hee Park, Dong Woo Kang, Yunjin Jung, Kang-Yell Choi & Do Sik Min. (2013) Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NFκB transactivation. Biochemical and Biophysical Research Communications 442:1-2, pages 1-7.
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Gil Sun Lee & Jin-Won Park. (2013) Effect of Vesicle Curvature on Phospholipase D Reaction-Induced-Rupture. Bulletin of the Korean Chemical Society 34:11, pages 3223-3226.
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Ju Cheol Son, Dong Woo Kang, Kwang Mo Yang, Kang-Yell Choi, Tae Gen Son & Do Sik Min. (2013) Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells. Experimental & Molecular Medicine 45:8, pages e38-e38.
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D W Kang, W C Hwang, M H Park, G-H Ko, W-S Ha, K-S Kim, Y-C Lee, K-Y Choi & D S Min. (2012) Rebamipide abolishes Helicobacter pylori CagA-induced phospholipase D1 expression via inhibition of NFκB and suppresses invasion of gastric cancer cells. Oncogene 32:30, pages 3531-3542.
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Sarah A. Scott, Yun Xiang, Thomas P. Mathews, Hyekyung P. Cho, David S. Myers, Michelle D. Armstrong, Keri A. Tallman, Matthew C. O'Reilly, Craig W. Lindsley & H. Alex Brown. (2013) Regulation of Phospholipase D Activity and Phosphatidic Acid Production after Purinergic (P2Y6) Receptor Stimulation. Journal of Biological Chemistry 288:28, pages 20477-20487.
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Sheereen Majd, Erik C. Yusko, Jerry Yang, David Sept & Michael Mayer. (2013) A Model for the Interfacial Kinetics of Phospholipase D Activity on Long-Chain Lipids. Biophysical Journal 105:1, pages 146-153.
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Jin-Won Park. (2013) RETRACTED ARTICLE: Correlation Between Composition of the Outer Layer and Phase Asymmetry for Vesicles Ruptured by Phospholipase D. The Journal of Membrane Biology 246:5, pages 399-405.
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Frank Chen, Ayantika Ghosh & Benjamin L. Shneider. (2013) Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1. Journal of Lipid Research 54:2, pages 379-385.
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Jin-Won Park. (2012) RETRACTED ARTICLE:Effect of Mixed-Phospholipid Layer on Phospholipase D Reaction-induced Vesicle Rupture. The Journal of Membrane Biology 245:11, pages 691-696.
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Jin-Won Park. (2012) Phase effect of mixed-phospholipid layer on phospholipase D reaction-induced-vesicle rupture. Colloids and Surfaces B: Biointerfaces 97, pages 207-210.
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Margitta Elvers, Magnus Grenegård, Hanieh Khoshjabinzadeh, Patrick Münzer, Oliver Borst, Huasong Tian, Gilbert Di Paolo, Florian Lang, Meinrad Gawaz, Tomas L. Lindahl & Knut Fälker. (2012) A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity. Cellular Signalling 24:9, pages 1743-1752.
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Chunfa Huang, Leslie A. Bruggeman, Lindsey M. Hydo & R. Tyler Miller. (2012) Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. Experimental Cell Research 318:10, pages 1075-1085.
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X. Peng & M. A. Frohman. (2011) Mammalian phospholipase D physiological and pathological roles. Acta Physiologica 204:2, pages 219-226.
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Young Hoon Jang & Do Sik Min. (2012) Intermolecular association between caspase-mediated cleavage fragments of phospholipase D1 protects against apoptosis. The International Journal of Biochemistry & Cell Biology 44:2, pages 358-365.
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Qun Gao & Michael A. Frohman. (2012) Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis. BMB Reports 45:1, pages 7-13.
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Xianping Li, Meihua Gao, Xuelin Han, Sha Tao, Dongyu Zheng, Ying Cheng, Rentao Yu, Gaige Han, Martina Schmidt & Li Han. (2012) Disruption of the Phospholipase D Gene Attenuates the Virulence of Aspergillus fumigatus. Infection and Immunity 80:1, pages 429-440.
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Jin-Won Park. (2011) Effect of Phospholipid Bilayer Phase Asymmetry on Phospholipase D Reaction-Induced Vesicle Rupture. The Journal of Membrane Biology 244:2, pages 55-59.
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M. Wallert, A. McCoy, J. Voog, D. Rastedt, J. Taves-Patterson, N. Korpi-Steiner, J. Canine, T. Ngyuen, C. Nguyen & J. Provost. (2011) α1-Adrenergic receptor-induced cytoskeletal organization and cell motility in CCL39 fibroblasts requires phospholipase D1. Journal of Cellular Biochemistry 112:10, pages 3025-3034.
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Xuelin Han, Rentao Yu, Lei Ji, Dongyu Zhen, Sha Tao, Shuai Li, Yansong Sun, Liuyu Huang, Zhe Feng, Xianping Li, Gaige Han, Martina Schmidt & Li Han. (2011) InlB-mediated Listeria monocytogenes internalization requires a balanced phospholipase D activity maintained through phospho-cofilin. Molecular Microbiology 81:4, pages 860-880.
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Jin-Won Park. (2011) Curvature effect on nanometer-scale surface properties of phospholipid layers. Colloids and Surfaces B: Biointerfaces 86:1, pages 166-168.
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Xuelin Han, Rentao Yu, Dongyu Zhen, Sha Tao, Martina Schmidt & Li Han. (2011) β-1,3-Glucan-Induced Host Phospholipase D Activation Is Involved in Aspergillus fumigatus Internalization into Type II Human Pneumocyte A549 Cells. PLoS ONE 6:7, pages e21468.
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Laura J. Norton, Qifeng Zhang, Khalid M. Saqib, Heinrich Schrewe, Karol Macura, Karen E. Anderson, Craig W. Lindsley, H. Alex Brown, Simon A. Rudge & Michael J. O. Wakelam. (2011) PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fcγ-receptor-stimulated ROS production in neutrophils. Journal of Cell Science 124:12, pages 1973-1983.
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Iris Camehl, Corinna Drzewiecki, Jyothilakshmi Vadassery, Bationa Shahollari, Irena Sherameti, Celine Forzani, Teun Munnik, Heribert Hirt & Ralf Oelmüller. (2011) The OXI1 Kinase Pathway Mediates Piriformospora indica-Induced Growth Promotion in Arabidopsis. PLoS Pathogens 7:5, pages e1002051.
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Dong Woo Kang, Mi Hee Park, Young Jun Lee, Hyung Sik Kim, Craig W. Lindsley, H. Alex Brown & Do Sik Min. (2011) Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote invasion of breast cancer cells. International Journal of Cancer 128:4, pages 805-816.
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Swaminathan Sethu & Alirio J. Melendez. (2010) New developments on the TNFα-mediated signalling pathways. Bioscience Reports 31:1, pages 63-76.
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Per Magne Ueland. (2010) Choline and betaine in health and disease. Journal of Inherited Metabolic Disease 34:1, pages 3-15.
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Dong Woo Kang, Kang-Yell Choi & Do Sik Min. (2011) Phospholipase D Meets Wnt Signaling: A New Target for Cancer Therapy. Cancer Research 71:2, pages 293-297.
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Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, Junming Yue, Yunhui Cheng, Huazhang Guo, Alyssa Bolen, Chunxiang Zhang, Louisa Balazs, Fabio Re, Guangwei Du, Michael A. Frohman, Daniel L. Baker, Abby L. Parrill, Ayako Uchiyama, Tetsuyuki Kobayashi, Kimiko Murakami-Murofushi & Gabor Tigyi. (2010) Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid. Molecular Cell 39:3, pages 421-432.
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Dong Woo Kang, Soung-Hoon Lee, Jeong Whan Yoon, Won-Sang Park, Kang-Yell Choi & Do Sik Min. (2010) Phospholipase D1 Drives a Positive Feedback Loop to Reinforce the Wnt/β-Catenin/TCF Signaling Axis. Cancer Research 70:10, pages 4233-4242.
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Hao Yin, Yu Gui, Guangwei Du, Michael A. Frohman & Xi-Long Zheng. (2010) Dependence of Phospholipase D1 Multi-monoubiquitination on Its Enzymatic Activity and Palmitoylation. Journal of Biological Chemistry 285:18, pages 13580-13588.
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Margitta ElversDavid StegnerIna HagedornChristoph KleinschnitzAttila BraunMarijke E. J. KuijpersMichael BoeslQin ChenJohan W. M. HeemskerkGuido StollMichael A. FrohmanBernhard Nieswandt. (2010) Impaired α IIb β 3 Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1 . Science Signaling 3:103.
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Sheereen Majd, Erik C. Yusko, Alexander D. MacBriar, Jerry Yang & Michael Mayer. (2009) Gramicidin Pores Report the Activity of Membrane-Active Enzymes. Journal of the American Chemical Society 131:44, pages 16119-16126.
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Wenjuan Su, Qin Chen & Michael A Frohman. (2009) Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis. Future Oncology 5:9, pages 1477-1486.
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Irene Litosch, Rajeshree Pujari & Shawn J. Lee. (2009) Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-β1. Cellular Signalling 21:9, pages 1379-1384.
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Yueqiang Zhang & Guangwei Du. (2009) Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1791:9, pages 850-855.
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Huiyan Huang & Michael A. Frohman. (2009) Lipid signaling on the mitochondrial surface. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1791:9, pages 839-844.
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Maoyin Li, Yueyun Hong & Xuemin Wang. (2009) Phospholipase D- and phosphatidic acid-mediated signaling in plants. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1791:9, pages 927-935.
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Yueyun Hong, Shivakumar P. Devaiah, Sung Chul Bahn, Bharath N. Thamasandra, Maoyin Li, Ruth Welti & Xuemin Wang. (2009) Phospholipase Dε and phosphatidic acid enhance Arabidopsis nitrogen signaling and growth. The Plant Journal 58:3, pages 376-387.
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Wenjuan Su, Oladapo Yeku, Srinivas Olepu, Alyssa Genna, Jae-Sook Park, Hongmei Ren, Guangwei Du, Michael H. Gelb, Andrew J. Morris & Michael A. Frohman. (2009) 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis. Molecular Pharmacology 75:3, pages 437-446.
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Guangwei Du & Michael A. Frohman. (2009) A Lipid-signaled Myosin Phosphatase Surge Disperses Cortical Contractile Force Early in Cell Spreading. Molecular Biology of the Cell 20:1, pages 200-208.
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Young Hoon Jang, Bong-Hyun Ahn, Seung Namkoong, Young Myeong Kim, Jae-Kwang Jin, Yong-Sun Kim & Do Sik Min. (2008) Differential regulation of apoptosis by caspase-mediated cleavage of phospholipase D isozymes. Cellular Signalling 20:12, pages 2198-2207.
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Jennifer Taves, Danielle Rastedt, Jenny Canine, Dave Mork, Mark A. Wallert & Joseph J. Provost. (2008) Sodium hydrogen exchanger and phospholipase D are required for α1-adrenergic receptor stimulation of metalloproteinase-9 and cellular invasion in CCL39 fibroblasts. Archives of Biochemistry and Biophysics 477:1, pages 60-66.
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Indrapal N. Singh & Edward D. Hall. (2008) Multifaceted roles of sphingosine-1-phosphate: How does this bioactive sphingolipid fit with acute neurological injury?. Journal of Neuroscience Research 86:7, pages 1419-1433.
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Laura Fantuzzi, Francesca Spadaro, Cristina Purificato, Serena Cecchetti, Franca Podo, Filippo Belardelli, Sandra Gessani & Carlo Ramoni. (2008) Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB–driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages. Blood 111:7, pages 3355-3363.
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