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Review

Therapeutic potential of drugs to modulate DNA repair in cancer

Pages 783-799 | Published online: 15 May 2007

Keep up to date with the latest research on this topic with citation updates for this article.

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Ho-Jae Lee, Jong-Min Park, Young Min Han, Hong Kwon Gil, Jinhyung Kim, Ji Young Chang, Migyeong Jeong, Eun-Jin Go & Ki Baik Hahm. (2016) The role of chronic inflammation in the development of gastrointestinal cancers: reviewing cancer prevention with natural anti-inflammatory intervention. Expert Review of Gastroenterology & Hepatology 10:1, pages 129-139.
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David M. Weingeist, Jing Ge, David K. Wood, James T. Mutamba, Qiuying Huang, Elizabeth A. Rowland, Michael B. Yaffe, Scott Floyd & Bevin P. Engelward. (2013) Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle 12:6, pages 907-915.
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LawrenceR. Phillips, KimberlyD. Hill & Eva Majerova. (2008) Liquid Chromatographic Determination of NSC 737664 (ABT-888: An Inhibitor of Poly(ADP-ribose) Polymerase (PARP)) in Plasma and Urine in a Phase 0 Clinical Trial. Journal of Liquid Chromatography & Related Technologies 32:2, pages 261-272.
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Kai-Keen Shiu, David SP Tan & Jorge S Reis-Filho. (2008) Development of therapeutic approaches to ‘triple negative’ phenotype breast cancer. Expert Opinion on Therapeutic Targets 12:9, pages 1123-1137.
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Articles from other publishers (21)

Yuqing Wang, Jie Huang, Qiong Wu, Jingjing Zhang, Zhiyuan Ma, Shenglin Ma & Shirong Zhang. (2021) Downregulation of breast cancer resistance protein by long-term fractionated radiotherapy sensitizes lung adenocarcinoma to SN-38. Investigational New Drugs 39:2, pages 458-468.
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César López-Camarillo, Dolores G. Rincón, Erika Ruiz-García, Horacio Astudillo-de la Vega & Laurence A. Marchat. (2019) DNA Repair Proteins as Therapeutic Targets in Ovarian Cancer. Current Protein & Peptide Science 20:4, pages 316-323.
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M. D’Arcangelo, Y. Drew & R. Plummer. 2016. DNA Repair in Cancer Therapy. DNA Repair in Cancer Therapy 115 134 .
Ira Skvortsova, Paul Debbage, Vinod Kumar & Sergej Skvortsov. (2015) Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling. Seminars in Cancer Biology 35, pages 39-44.
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Sergej Skvortsov, Paul Debbage, Peter Lukas & Ira Skvortsova. (2015) Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways. Seminars in Cancer Biology 31, pages 36-42.
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Carmen Avendaño & J. Carlos Menéndez. 2015. Medicinal Chemistry of Anticancer Drugs. Medicinal Chemistry of Anticancer Drugs 655 700 .
Ruth Plummer & Yvette Drew. 2015. PARP Inhibitors for Cancer Therapy. PARP Inhibitors for Cancer Therapy 475 486 .
Vincent Murray, Jon K. Chen & Anne M. Galea. (2014) Enhanced DNA repair of bleomycin-induced 3?-phosphoglycolate termini at the transcription start sites of actively transcribed genes in human cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 769, pages 93-99.
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Jin Zhang, Dongmei Yin & Hongxia Li. (2014) hMSH2 expression is associated with paclitaxel resistance in ovarian carcinoma, and inhibition of hMSH2 expression in�vitro restores paclitaxel sensitivity. Oncology Reports.
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Wenqi Wu, Hanliang Zhu, Yeping Liang, Zhenzhen Kong, Xiaolu Duan, Shujue Li, Zhijian Zhao, Dong Yang & Guohua Zeng. (2014) Expression of PARP-1 and its active polymer PAR in prostate cancer and benign prostatic hyperplasia in Chinese patients. International Urology and Nephrology 46:7, pages 1345-1349.
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R. Plummer. (2014) Poly(ADP-ribose)polymerase (PARP) Inhibitors: From Bench to?Bedside. Clinical Oncology 26:5, pages 250-256.
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William Jacot, Simon Thezenas, Romain Senal, Cathy Viglianti, Anne-Claire Laberenne, Evelyne Lopez-Crapez, Fr?d?ric Bibeau, Jean-Pierre Bleuse, Gilles Romieu & Pierre-Jean Lamy. (2013) BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer. BMC Cancer 13:1.
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Giuseppe Giaccone & Jean-Charles SoriaPeter Stephens & Ruth Plummer. 2013. Targeted Therapies in Oncology, Second Edition. Targeted Therapies in Oncology, Second Edition 423 444 .
Nicola J. Curtin, Asima Mukhopadhyay, Yvette Drew & Ruth Plummer. 2012. DNA Repair in Cancer Therapy. DNA Repair in Cancer Therapy 55 73 .
Haseeb Ahmad Khan & Abdullah Saleh Alhomida. (2011) A review of the logistic role of l-carnitine in the management of radiation toxicity and radiotherapy side effects. Journal of Applied Toxicology 31:8, pages 707-713.
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R A Daniel, A L Rozanska, E A Mulligan, Y Drew, H D Thomas, D J Castelbuono, Z Hostomsky, E R Plummer, D A Tweddle, A V Boddy, S C Clifford & N J Curtin. (2010) Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. British Journal of Cancer 103:10, pages 1588-1596.
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Xuesong Liu, Edward K. Han, Mark Anderson, Yan Shi, Dimitri Semizarov, Gang Wang, Thomas McGonigal, Lisa Roberts, Loren Lasko, Joann Palma, Gui-dong Zhu, Thomas Penning, Saul Rosenberg, Vincent L. Giranda, Yan Luo, Joel Leverson, Eric F. Johnson & Alexander R. Shoemaker. (2009) Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways. Molecular Cancer Research 7:10, pages 1686-1692.
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Stephen P. Jackson. (2009) The DNA-damage response: new molecular insights and new approaches to cancer therapy. Biochemical Society Transactions 37:3, pages 483-494.
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Ira Skvortsova, Sergej Skvortsov, Taras Stasyk, Uma Raju, Bela-Andre Popper, Bernhard Schiestl, Elisabeth von Guggenberg, Andreas Neher, Guenther K. Bonn, Lukas A. Huber & Peter Lukas. (2008) Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells. PROTEOMICS 8:21, pages 4521-4533.
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Xuesong Liu, Joann Palma, Robert Kinders, Yan Shi, Cherrie Donawho, Paul A Ellis, Luis E Rodriguez, Milagros Colon-Lopez, Mary Saltarelli, David LeBlond, C Thomas Lin, David J. Frost, Yan Luo & Vincent L. Giranda. (2008) An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors. Analytical Biochemistry 381:2, pages 240-247.
Crossref
Carmen Avenda?o & J. Carlos Men?ndez. 2008. Medicinal Chemistry of Anticancer Drugs. Medicinal Chemistry of Anticancer Drugs 387 416 .

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