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Expert Opinion on Therapeutic Targets Volume 14, 2010 - Issue 11
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TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy

Jian-Liang Chou National Chung Cheng University, Department of Life Science, Room 452, 168 University Road, Min-Hsiung, Chia-Yi, 621, Taiwan, ROC +886 5 2720411 ext 66510; +886 5 2722871; [email protected]; National Chung Cheng University, Institute of Molecular Biology, Min-Hsiung, Chia-Yi, Taiwan, ROC
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Lin-Yu Chen National Chung Cheng University, Department of Life Science, Room 452, 168 University Road, Min-Hsiung, Chia-Yi, 621, Taiwan, ROC +886 5 2720411 ext 66510; +886 5 2722871; [email protected]; National Chung Cheng University, Institute of Molecular Biology, Min-Hsiung, Chia-Yi, Taiwan, ROC
,
Hung-Cheng Lai National Defense Medical Center, Tri-Service General Hospital, Department of Obstetrics and Gynecology, Taipei, Taiwan, ROC
&
Michael WY Chan National Chung Cheng University, Department of Life Science, Room 452, 168 University Road, Min-Hsiung, Chia-Yi, 621, Taiwan, ROC +886 5 2720411 ext 66510; +886 5 2722871; [email protected]; Human Epigenomics Center, National Chung Cheng University, Min-Hsiung, Chia-Yi, Taiwan, ROC
Pages 1213-1223 | Published online: 06 Oct 2010

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Mamadou Keita, Magdalena Bachvarova, Chantale Morin, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Alexandra Sebastianelli, Xuan Bich Trinh & Dimcho Bachvarov. (2013) The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion. Cell Cycle 12:6, pages 972-986.
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Kun-Tu Yeh, Tze-Ho Chen, Hui-Wen Yang, Jian-Liang Chou, Lin-Yu Chen, Chia-Ming Yeh, Yu-Hsin Chen, Ru-Inn Lin, Her-Young Su, Gary C.-W. Chen, Daniel E. Deatherage, Yi-Wen Huang, Pearlly S. Yan, Huey-Jen Lin, Kenneth P. Nephew, Tim H.-M. Huang, Hung-Cheng Lai & Michael W.Y. Chan. (2011) Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer. Epigenetics 6:6, pages 727-739.
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Xin Li, Xuzhu Gao, Jia Yuan, Fancheng Wang, Xiaolin Xu, Chenglong Wang, Huiqiang Liu, Wencai Guan, Jihong Zhang & Guoxiong Xu. (2022) The miR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGF-β signal pathway. Frontiers in Endocrinology 13.
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Ching-Chung ChiangGuan-Ling LinShu-Yi YangChi-Wen TuWen-Long HuangChun-Feng WeiFeng-Chi WangPin-Ju LinWan-Hong HuangYu-Ming ChuangYu-Ting LeeChia-Chou YehMichael ChanYu-Chen Hsu. (2022) PCDHB15 as a potential tumor suppressor and epigenetic biomarker for breast cancer. Oncology Letters 23:4.
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Chang Liu, Lu Zhang, Yang Liu, Qingqing Zhao, Yu Pan & Yifan Zhang. (2021) Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis. Frontiers in Oncology 11.
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Donata Ponikwicka-Tyszko, Marcin Chrusciel, Kamila Pulawska, Piotr Bernaczyk, Maria Sztachelska, Peilan Guo, Xiangdong Li, Jorma Toppari, Ilpo T. Huhtaniemi, Slawomir Wołczyński & Nafis A. Rahman. (2020) Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice. Cancers 12:11, pages 3263.
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Guannan Zhao, Qinghui Wang, Zhongzhi Wu, Xinchun Tian, Huan Yan, Baojin Wang, Peixin Dong, Hidemichi Watari, Lawrence M. Pfeffer, Yuqi Guo, Wei Li & Junming Yue. (2019) Ovarian Primary and Metastatic Tumors Suppressed by Survivin Knockout or a Novel Survivin Inhibitor. Molecular Cancer Therapeutics 18:12, pages 2233-2245.
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Donata Ponikwicka-Tyszko, Marcin Chrusciel, Joanna Stelmaszewska, Piotr Bernaczyk, Paulina Chrusciel, Maria Sztachelska, Mika Scheinin, Mariusz Bidzinski, Jacek Szamatowicz, Ilpo T. Huhtaniemi, Slawomir Wolczynski & Nafis A. Rahman. (2019) Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression. EBioMedicine 47, pages 170-183.
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Martyna Pakuła, Paweł Uruski, Arkadiusz Niklas, Aldona Woźniak, Dariusz Szpurek, Andrzej Tykarski, Justyna Mikuła-Pietrasik & Krzysztof Książek. (2019) A Unique Pattern of Mesothelial-Mesenchymal Transition Induced in the Normal Peritoneal Mesothelium by High-Grade Serous Ovarian Cancer. Cancers 11:5, pages 662.
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Paolo Martini, Monica Chiogna, Enrica Calura & Chiara Romualdi. (2019) MOSClip: multi-omic and survival pathway analysis for the identification of survival associated gene and modules. Nucleic Acids Research.
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Xiaoling Tian, Wencai Guan, Lingyun Zhang, Wenwen Sun, Daibing Zhou, Qunbo Lin, Weimin Ren, Lubna Nadeem & Guoxiong Xu. (2018) Physical interaction of STAT1 isoforms with TGF-β receptors leads to functional crosstalk between two signaling pathways in epithelial ovarian cancer. Journal of Experimental & Clinical Cancer Research 37:1.
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Lingyun Zhang, Daibing Zhou, Wencai Guan, Weimin Ren, Wenwen Sun, Jimin Shi, Qunbo Lin, Jinguo Zhang, Tiankui Qiao, Yulong Ye, Yun Wu, Yaning Zhang, Xulei Zuo, Kristin L Connor & Guoxiong Xu. (2017) Pyridoxine 5′-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer. Cell Death & Disease 8:12.
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Guannan Zhao, Qinghui Wang, Qingqing Gu, Wenan Qiang, Jian-Jun Wei, Peixin Dong, Hidemichi Watari, Wei Li & Junming Yue. (2017) Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 editing inhibits epithelial to mesenchymal transition in ovarian cancer cells. Oncotarget 8:55, pages 94666-94680.
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Neriya Gutgold, Ben Davidson, Liora Jacobs Catane, Arild Holth, Ellen Hellesylt, Claes G. Tropé, Anne Dørum & Reuven Reich. (2017) TGFβ splicing and canonical pathway activation in high-grade serous carcinoma. Virchows Archiv 470:6, pages 665-678.
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Jianfang Zhao, Christian Klausen, Siyuan Xiong, Jung-Chien Cheng, Hsun-Ming Chang & Peter C.K. Leung. (2016) Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation. Cellular Signalling 28:11, pages 1615-1622.
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Chung-Min Yeh, Liang-Yu Chang, Shu-Hui Lin, Jian-Liang Chou, Hsiao-Yen Hsieh, Li-Han Zeng, Sheng-Yu Chuang, Hsiao-Wen Wang, Claudia Dittner, Cheng-Yu Lin, Jora M. J. Lin, Yao-Ting Huang, Enders K. W. Ng, Alfred S. L. Cheng, Shu-Fen Wu, Jiayuh Lin, Kun-Tu Yeh & Michael W. Y. Chan. (2016) Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer. Scientific Reports 6:1.
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Premalatha ShathasivamAlexandra KollaraMaurice J. Ringuette, Carl Virtanen, Jeffrey L. WranaTheodore J. Brown. (2015) Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling . Proceedings of the National Academy of Sciences 112:23.
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