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Targeting the p53 signaling pathway in cancer therapy – the promises, challenges and perils

, PhD
Pages 67-83 | Published online: 12 Jan 2012

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Wan-Atirah Azemin, Nadiawati Alias, Abdul Manaf Ali & Mohd Shahir Shamsir. (2023) In silico analysis prediction of HepTH1-5 as a potential therapeutic agent by targeting tumour suppressor protein networks. Journal of Biomolecular Structure and Dynamics 41:4, pages 1141-1167.
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Weihua Wang, ZhanJiang Han, Dongqi Guo & Yanju Xiang. (2021) Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais. OncoTargets and Therapy 14, pages 1401-1416.
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Peigang Liu, Jinbao Pu, Junhui Zhang, Zhilu Chen, Kemin Wei & Lian’gen Shi. (2019) Bioinformatic analysis of miR-4792 regulates Radix Tetrastigma hemsleyani flavone to inhibit proliferation, invasion, and induce apoptosis of A549 cells. OncoTargets and Therapy 12, pages 1401-1412.
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Noor Atatreh, Mohammad A Ghattas, Sanaa K Bardaweel, Sara Al Rawashdeh & Mohammad Al Sorkhy. (2018) Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening. Drug Design, Development and Therapy 12, pages 3741-3752.
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Wamidh H Talib, Sonia A Al-hadid, Mai B Wild Ali, Intisar Hadi AL-Yasari & Mohammed R Abd Ali. (2018) Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action. Breast Cancer: Targets and Therapy 10, pages 207-217.
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Qiaowei Fan & Bingrong Liu. (2018) Comprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer. OncoTargets and Therapy 11, pages 2453-2466.
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Zhongwu Hu, Daorong Hou, Xiaowei Wang, Zhenbing You & Xiufeng Cao. (2018) TSPAN12 is overexpressed in NSCLC via p53 inhibition and promotes NSCLC cell growth in vitro and in vivo. OncoTargets and Therapy 11, pages 1095-1103.
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Benjamin R. E. Harris, Defeng Wang, Ye Zhang, Marina Ferrari, Aniekan Okon, Margot P. Cleary, Carston R. Wagner & Da-Qing Yang. (2018) Induction of the p53 Tumor Suppressor in Cancer Cells through Inhibition of Cap-Dependent Translation. Molecular and Cellular Biology 38:10.
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Anshika N Singh & Neeti Sharma. (2017) Identification of key pathways and genes with aberrant methylation in prostate cancer using bioinformatics analysis. OncoTargets and Therapy 10, pages 4925-4933.
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Esra Gov, Medi Kori & Kazim Yalcin Arga. (2017) RNA-based ovarian cancer research from ‘a gene to systems biomedicine’ perspective. Systems Biology in Reproductive Medicine 63:4, pages 219-238.
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Li Song, Zhuo-Yu Li, Wei-Ping Liu & Mei-Rong Zhao. (2015) Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy . Cancer Biology & Therapy 16:1, pages 1-7.
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Guang-xia Chen, Shu Zhang, Xiao-hua He, Shi-yu Liu, Chao Ma & Xiao-Ping Zou. (2014) Clinical utility of recombinant adenoviral human p53 gene therapy: current perspectives. OncoTargets and Therapy 7, pages 1901-1909.
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Varun V Prabhu, Joshua E Allen, Bo Hong, Shengliang Zhang, Hairong Cheng & Wafik S El-Deiry. (2012) Therapeutic targeting of the p53 pathway in cancer stem cells. Expert Opinion on Therapeutic Targets 16:12, pages 1161-1174.
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