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DISC1 as a therapeutic target for mental illnesses

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Pages 1151-1160 | Published online: 06 Nov 2012

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Akira Sawa, Koko Ishizuka & Nicholas Katsanis. (2016) The potential of DISC1 protein as a therapeutic target for mental illness. Expert Opinion on Therapeutic Targets 20:6, pages 641-643.
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Articles from other publishers (31)

Muneaki Watanabe, Tung Mei Khu, Grant Warren, Juyoung Shin, Charles E. StewartJrJr & Julien Roche. (2023) Evidence of DISC1 as an arsenic binding protein and implications regarding its role as a translational activator. Frontiers in Molecular Biosciences 10.
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Abhishek Cukkemane, Nina Becker, Mara Zielinski, Benedikt Frieg, Nils-Alexander Lakomek, Henrike Heise, Gunnar F. Schröder, Dieter Willbold & Oliver H. Weiergräber. (2021) Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses. Translational Psychiatry 11:1.
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Brian R. Barnett, Sue Y. Yi, McKenzie J. Poetzel, Keith Dodd, Nicholas A. Stowe & John-Paul J. Yu. (2021) Mapping Sex-Specific Neurodevelopmental Alterations in Neurite Density and Morphology in a Rat Genetic Model of Psychiatric Illness. eneuro 8:2, pages ENEURO.0426-20.2020.
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Stephanie L. Saundh, Debasis Patnaik, Steve Gagné, Joshua A. Bishop, Sean Lipsit, Samat Amat, Narsimha Pujari, Anand Krishnan Nambisan, Robert Bigsby, Mary Murphy, Li-Huei Tsai, Stephen J. Haggarty & Adelaine Kwun-Wai Leung. (2020) Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein. ACS Chemical Neuroscience 11:24, pages 4128-4138.
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M. M. Gevorgyan, S. Ya. Zhanaeva, E. L. Alperina, T. V. Lipina & G. V. Idova. (2020) The composition of peripheral immunocompetent cell subpopulations and cytokine content in the brain structures of mutant Disc1-Q31L mice. Vavilov Journal of Genetics and Breeding 24:7, pages 770-776.
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Brian R. Barnett, Cameron P. Casey, Maribel Torres-Velázquez, Paul A. Rowley & John-Paul J. Yu. (2020) Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study. Magnetic Resonance Imaging 70, pages 36-42.
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Razia Sultana & Charles C. Lee. (2020) Expression of Behavioral Phenotypes in Genetic and Environmental Mouse Models of Schizophrenia. Frontiers in Behavioral Neuroscience 14.
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Takatoshi Hikida, Makiko Morita, Mahomi Kuroiwa, Tom Macpherson, Takahide Shuto, Naoki Sotogaku, Minae Niwa, Akira Sawa & Akinori Nishi. (2020) Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neuroscience Research 151, pages 38-45.
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Andrea de Bartolomeis, Camilla Avagliano, Licia Vellucci, Luigi D’Ambrosio, Mirko Manchia, Giordano D’Urso, Elisabetta Filomena Buonaguro & Felice Iasevoli. (2019) Translating preclinical findings in clinically relevant new antipsychotic targets: focus on the glutamatergic postsynaptic density. Implications for treatment resistant schizophrenia. Neuroscience & Biobehavioral Reviews 107, pages 795-827.
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Tom Macpherson & Takatoshi Hikida. (2019) Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders. Psychiatry and Clinical Neurosciences 73:6, pages 289-301.
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Brian R. Barnett, Maribel Torres-Velázquez, Sue Y. Yi, Paul A. Rowley, Emily A. Sawin, C. Dustin Rubinstein, Kathleen Krentz, Jacqueline M. Anderson, Vaishali P. Bakshi & John-Paul J. Yu. (2019) Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat. Translational Psychiatry 9:1.
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Yu-Ting Weng, Ting Chien, I-I Kuan & Yijuang Chern. (2018) The TRAX, DISC1, and GSK3 complex in mental disorders and therapeutic interventions. Journal of Biomedical Science 25:1.
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Larisa Ryskalin, Fiona Limanaqi, Alessandro Frati, Carla Busceti & Francesco Fornai. (2018) mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders. International Journal of Molecular Sciences 19:8, pages 2226.
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N. I. Dubrovina, M. V. Khrapova & T. V. Lipina. (2018) Characteristics of the Formation of Memories Relating to Fear in Mice with Depression- and Schizophrenia-Like Phenotypes: Effects of Gender and Age. Neuroscience and Behavioral Physiology 48:4, pages 488-495.
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Himani Pandey, Katia Bourahmoune, Takato Honda, Ken Honjo, Kazuki Kurita, Tomohito Sato, Akira Sawa & Katsuo Furukubo-Tokunaga. (2017) Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses. npj Schizophrenia 3:1.
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M Fujita, E M Richards, M J Niciu, D F Ionescu, S S Zoghbi, J Hong, S Telu, C S Hines, V W Pike, C A Zarate & R B Innis. (2016) cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor. Molecular Psychiatry 22:5, pages 754-759.
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T Dahoun, S V Trossbach, N J Brandon, C Korth & O D Howes. (2017) The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review. Translational Psychiatry 7:1, pages e1015-e1015.
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K Furukubo-Tokunaga, K Kurita, K Honjo, H Pandey, T Ando, K Takayama, Y Arai, H Mochizuki, M Ando, A Kamiya & A Sawa. (2016) DISC1 causes associative memory and neurodevelopmental defects in fruit flies. Molecular Psychiatry 21:9, pages 1232-1243.
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Bang-Shun He, Ling-Yun Zhang, Yu-Qin Pan, Kang Lin, Li-Li Zhang, Hui-Ling Sun, Tian-Yi Gao, Tai-Qin Su, Shu-Kui Wang & Cheng-Bin Zhu. (2016) Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population. Gene 590:2, pages 293-297.
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Huiyuan Li, Farid Rahimi & Gal Bitan. (2016) Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity. ACS Chemical Neuroscience 7:7, pages 845-856.
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T. Tomoda, A. Sumitomo, H. Jaaro-Peled & A. Sawa. (2016) Utility and validity of DISC1 mouse models in biological psychiatry. Neuroscience 321, pages 99-107.
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D Tropea, I Molinos, E Petit, S Bellini, I Nagakura, C O'Tuathaigh, L Schorova, K J Mitchell, J Waddington, M Sur, M Gill & A P Corvin. (2016) Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro. Translational Psychiatry 6:1, pages e712-e712.
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Aline Monin, Margot Fournier, Philipp S. Baumann, Michel Cuénod & Kim Q. Do. 2016. Modeling the Psychopathological Dimensions of Schizophrenia - From Molecules to Behavior. Modeling the Psychopathological Dimensions of Schizophrenia - From Molecules to Behavior 481 500 .
Colm M. O’Tuathaigh & John L. Waddington. (2015) Closing the translational gap between mutant mouse models and the clinical reality of psychotic illness. Neuroscience & Biobehavioral Reviews 58, pages 19-35.
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Sandeep Kumar Barodia, Sang Ki Park, Koko Ishizuka, Akira Sawa & Atsushi Kamiya. (2015) Half-life of DISC1 protein and its pathological significance under hypoxia stress. Neuroscience Research 97, pages 1-6.
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D Schubert, G J M Martens & S M Kolk. (2014) Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders. Molecular Psychiatry 20:7, pages 795-809.
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John L. Waddington & Colm M. P. O’Tuathaigh. 2015. Drug Discovery for Schizophrenia. Drug Discovery for Schizophrenia 89 114 .
Omar Šerý, Jan Lochman, Jana Povová, Vladimír Janout, Jiří Plesník & Vladimir J Balcar. (2015) Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia. Behavioral and Brain Functions 11:1, pages 10.
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Lynda El-Hassar, Arthur A. Simen, Alvaro Duque, Kiran D. Patel, Leonard K. Kaczmarek, Amy F.T. Arnsten & Mark F. Yeckel. (2014) Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. Biological Psychiatry 76:6, pages 476-485.
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Catherine L. Winchester, Judith A. Pratt & Brian J. Morris. (2014) Risk genes for schizophrenia: Translational opportunities for drug discovery. Pharmacology & Therapeutics 143:1, pages 34-50.
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Tsuyoshi Nakai, Taku Nagai, Rui Wang, Shinnosuke Yamada, Keisuke Kuroda, Kozo Kaibuchi & Kiyofumi Yamada. (2014) Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene. Neurochemistry International 74, pages 74-83.
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