DISC1 as a therapeutic target for mental illnesses

Bibliography

• Kim Y, Zerwas S, Trace SE, Sullivan PF. Schizophrenia genetics: where next? Schizophr Bull 2011;37:456-63
   PubMedGoogle Scholar
• Porteous DJ, Millar JK, Brandon NJ, Sawa A. DISC1 at 10: connecting psychiatric genetics and neuroscience. Trends Mol Med 2011;17:699-706
   PubMed Web of Science ®Google Scholar
• Brandon NJ, Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 2011;12:707-22
   PubMed Web of Science ®Google Scholar
• Mathieson I, Munafo MR, Flint J. Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. Mol Psychiatry 2012;17:634-41
   PubMed Web of Science ®Google Scholar
• O'Donovan MC, Craddock N, Norton N, Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 2008;40:1053-5
   PubMed Web of Science ®Google Scholar
• Purcell SM, Wray NR, Stone JL, Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009;460:748-52
   PubMed Web of Science ®Google Scholar
• Shi J, Levinson DF, Duan J, Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009;460:753-7
   PubMed Web of Science ®Google Scholar
• Stefansson H, Ophoff RA, Steinberg S, Common variants conferring risk of schizophrenia. Nature 2009;460:744-7
   PubMed Web of Science ®Google Scholar
• Blackwood DH, Muir WJ. Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia. Neurotox Res 2004;6:35-41
   PubMedGoogle Scholar
• Callicott JH, Straub RE, Pezawas L, Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci USA 2005;102:8627-32
   PubMed Web of Science ®Google Scholar
• Cannon TD, Hennah W, van Erp TG, Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry 2005;62:1205-13
   PubMed Web of Science ®Google Scholar
• Hashimoto R, Numakawa T, Ohnishi T, Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet 2006;15:3024-33
   PubMed Web of Science ®Google Scholar
• Hennah W, Tuulio-Henriksson A, Paunio T, A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia. Mol Psychiatry 2005;10:1097-103
   PubMedGoogle Scholar
• Thomson PA, Harris SE, Starr JM, Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett 2005;389:41-5
   PubMedGoogle Scholar
• Di Giorgio A, Blasi G, Sambataro F, Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding. Eur J Neurosci 2008;28:2129-36
   PubMed Web of Science ®Google Scholar
• Prata DP, Mechelli A, Fu CH, Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function. Mol Psychiatry 2008;13:915-17. 09
   PubMed Web of Science ®Google Scholar
• Szeszko PR, Hodgkinson CA, Robinson DG, DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia. Biol Psychol 2008;79:103-10
   PubMedGoogle Scholar
• Takahashi T, Suzuki M, Tsunoda M, The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. Psychiatry Res 2009;172:128-35
   PubMedGoogle Scholar
• Carless MA, Glahn DC, Johnson MP, Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Mol Psychiatry 2011;16:1096-104
   PubMed Web of Science ®Google Scholar
• Mata I, Perez-Iglesias R, Roiz-Santianez R, Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia. Neuroimage 2010;53:1016-22
   PubMed Web of Science ®Google Scholar
• Raznahan A, Lee Y, Long R, Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents. Mol Psychiatry 2011;16:917-26
   PubMedGoogle Scholar
• Macgregor S, Visscher PM, Knott SA, A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42. Mol Psychiatry 2004;9:1083-90
   PubMedGoogle Scholar
• Song W, Li W, Noltner K, Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder. Neurosci Lett 2010;486:136-40
   PubMedGoogle Scholar
• Schosser A, Gaysina D, Cohen-Woods S, Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. Mol Psychiatry 2010;15:844-9
   PubMed Web of Science ®Google Scholar
• Harris SE, Hennah W, Thomson PA, Variation in DISC1 is associated with anxiety, depression and emotional stability in elderly women. Mol Psychiatry 2010;15:232-4
   PubMed Web of Science ®Google Scholar
• Hodgkinson CA, Goldman D, Jaeger J, Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet 2004;75:862-72
   PubMed Web of Science ®Google Scholar
• Hamshere ML, Bennett P, Williams N, Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Arch Gen Psychiatry 2005;62:1081-8
   PubMed Web of Science ®Google Scholar
• Kilpinen H, Ylisaukko-Oja T, Hennah W, Association of DISC1 with autism and Asperger syndrome. Mol Psychiatry 2008;13:187-96
   PubMed Web of Science ®Google Scholar
• Fukuda S, Hashimoto R, Ohi K, A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome. Life Sci 2010;86:722-5
   PubMedGoogle Scholar
• Osbun N, Li J, O'Driscoll MC, Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene. Am J Med Genet A 2011;155A:1865-76
   PubMedGoogle Scholar
• Jaaro-Peled H, Hayashi-Takagi A, Seshadri S, Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci 2009;32:485-95
   PubMed Web of Science ®Google Scholar
• Ishizuka K, Paek M, Kamiya A, Sawa A. A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biol Psychiatry 2006;59:1189-97
   PubMed Web of Science ®Google Scholar
• Sawamura N, Ando T, Maruyama Y, Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Mol Psychiatry 2008;13:1138-48. 069
   PubMed Web of Science ®Google Scholar
• Sawamura N, Sawamura-Yamamoto T, Ozeki Y, A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc Natl Acad Sci USA 2005;102:1187-92
   PubMed Web of Science ®Google Scholar
• Ozeki Y, Tomoda T, Kleiderlein J, Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci USA 2003;100:289-94
   PubMed Web of Science ®Google Scholar
• James R, Adams RR, Christie S, Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol Cell Neurosci 2004;26:112-22
   PubMedGoogle Scholar
• Morris JA, Kandpal G, Ma L, Austin CP. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet 2003;12:1591-608
   PubMed Web of Science ®Google Scholar
• Kamiya A, Kubo K, Tomoda T, A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol 2005;7:1167-78
   PubMed Web of Science ®Google Scholar
• Maher BJ, LoTurco JJ. Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses. PLoS One 2012;7:e34053
   PubMedGoogle Scholar
• Atkin TA, Brandon NJ, Kittler JT. Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport. Hum Mol Genet 2012;21:2017-28
   PubMed Web of Science ®Google Scholar
• Leliveld SR, Bader V, Hendriks P, Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. J Neurosci 2008;28:3839-45
   PubMedGoogle Scholar
• Ishizuka K, Kamiya A, Oh EC, DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature 2011;473:92-6
   PubMedGoogle Scholar
• Camargo LM, Collura V, Rain JC, Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry 2007;12:74-86
   PubMed Web of Science ®Google Scholar
• Chubb JE, Bradshaw NJ, Soares DC, The DISC locus in psychiatric illness. Mol Psychiatry 2008;13:36-64
   PubMed Web of Science ®Google Scholar
• Millar JK, Pickard BS, Mackie S, DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 2005;310:1187-91
   PubMed Web of Science ®Google Scholar
• Bauman AL, Goehring AS, Scott JD. Orchestration of synaptic plasticity through AKAP signaling complexes. Neuropharmacology 2004;46:299-310
   PubMedGoogle Scholar
• Arnsten AF, Paspalas CD, Gamo NJ, Dynamic network connectivity: a new form of neuroplasticity. Trends Cogn Sci 2010;14:365-75
   PubMed Web of Science ®Google Scholar
• Gamo NJ, Arnsten AF. Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders. Behav Neurosci 2011;125:282-96
   PubMed Web of Science ®Google Scholar
• Wilensky AE, Schafe GE, LeDoux JE. The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning. J Neurosci 2000;20:7059-66
   PubMedGoogle Scholar
• Hopkins WF, Johnston D. Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus. J Neurophysiol 1988;59:667-87
   PubMed Web of Science ®Google Scholar
• Runyan JD, Dash PK. Inhibition of hippocampal protein synthesis following recall disrupts expression of episodic-like memory in trace conditioning. Hippocampus 2005;15:333-9
   PubMedGoogle Scholar
• Seamans JK, Floresco SB, Phillips AG. D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat. J Neurosci 1998;18:1613-21
   PubMed Web of Science ®Google Scholar
• Murdoch H, Mackie S, Collins DM, Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels. J Neurosci 2007;27:9513-24
   PubMed Web of Science ®Google Scholar
• Mao Y, Ge X, Frank CL, Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3ß/ß-catenin signaling. Cell 2009;136:1017-31
   PubMed Web of Science ®Google Scholar
• Wang Q, Charych EI, Pulito VL, The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol Psychiatry 2011;16:1006-23
   PubMed Web of Science ®Google Scholar
• Matigian N, Windus L, Smith H, Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway. Mol Psychiatry 2007;12:815-25
   PubMed Web of Science ®Google Scholar
• Potkin SG, Turner JA, Guffanti G, A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull 2009;35:96-108
   PubMed Web of Science ®Google Scholar
• Garey LJ, Ong WY, Patel TS, Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J Neurol Neurosurg Psychiatry 1998;65:446-53
   PubMed Web of Science ®Google Scholar
• Selemon LD, Goldman-Rakic PS. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biol Psychiatry 1999;45:17-25
   PubMed Web of Science ®Google Scholar
• Ramsey AJ, Milenkovic M, Oliveira AF, Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proc Natl Acad Sci USA 2011;108:5795-800
   PubMedGoogle Scholar
• Cahill ME, Xie Z, Day M, Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proc Natl Acad Sci USA 2009;106:13058-63
   PubMed Web of Science ®Google Scholar
• Hayashi-Takagi A, Takaki M, Graziane N, Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci 2010;13:327-32
   PubMed Web of Science ®Google Scholar
• Glantz LA, Lewis DA. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry 2000;57:65-73
   PubMed Web of Science ®Google Scholar
• Black JE, Kodish IM, Grossman AW, Pathology of layer V pyramidal neurons in the prefrontal cortex of patients with schizophrenia. Am J Psychiatry 2004;161:742-4
   PubMedGoogle Scholar
• Kirkpatrick B, Xu L, Cascella N, DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. J Comp Neurol 2006;497:436-50
   PubMed Web of Science ®Google Scholar
• Hendricks JC, Williams JA, Panckeri K, A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat Neurosci 2001;4:1108-15
   PubMedGoogle Scholar
• Millar JK, James R, Christie S, Porteous DJ. Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria. Mol Cell Neurosci 2005;30:477-84
   PubMed Web of Science ®Google Scholar
• Monti JM, Monti D. Sleep disturbance in schizophrenia. Int Rev Psychiatry 2005;17:247-53
   PubMed Web of Science ®Google Scholar
• Kamiya A, Tomoda T, Chang J, DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Hum Mol Genet 2006;15:3313-23
   PubMed Web of Science ®Google Scholar
• Duan X, Chang JH, Ge S, Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell 2007;130:1146-58
   PubMed Web of Science ®Google Scholar
• Millar JK, Wilson-Annan JC, Anderson S, Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000;9:1415-23
   PubMed Web of Science ®Google Scholar
• Hayashi MA, Portaro FC, Bastos MF, Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. Proc Natl Acad Sci USA 2005;102:3828-33
   PubMed Web of Science ®Google Scholar
• Camargo AC, Caldo H, Emson PC. Degradation of neurotensin by rabbit brain endo-peptidase A and endo-peptidase B (proline-endopeptidase). Biochem Biophys Res Commun 1983;116:1151-9
   PubMed Web of Science ®Google Scholar
• Camargo AC, Oliveira EB, Toffoletto O, Brain endo-oligopeptidase A, a putative enkephaline converting enzyme. J Neurochem 1987;48:1258-63
   PubMed Web of Science ®Google Scholar
• Camargo AC, Shapanka R, Greene LJ. Preparation, assay, and partial characterization of a neutral endopeptidase from rabbit brain. Biochemistry 1973;12:1838-44
   PubMed Web of Science ®Google Scholar
• Hayashi MA, Guerreiro JR, Charych E, Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth. Mol Cell Neurosci 2010;44:353-61
   PubMed Web of Science ®Google Scholar
• Wang Q, Jaaro-Peled H, Sawa A, Brandon NJ. How has DISC1 enabled drug discovery? Mol Cell Neurosci 2008;37:187-95
   PubMedGoogle Scholar
• Kang E, Burdick KE, Kim JY, Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron 2011;72:559-71
   PubMed Web of Science ®Google Scholar
• Sawa A, Snyder SH. Genetics. Two genes link two distinct psychoses. Science 2005;310:1128-9
   PubMedGoogle Scholar
• Niwa M, Kamiya A, Murai R, Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron 2010;65:480-9
   PubMed Web of Science ®Google Scholar
• Savege MJ, Gingrich DE. Advances in the development of kinase inhibitor therapeutics for Altzheimer's disease. Drug Dev Res 2009;70:125-44
   Google Scholar
• Barnett DGS, Bibb JA. The role of Cdk5 in cognition and neuropsychiatric and neurological pathology. Brain Re Bull 2011;85:9-13
   PubMedGoogle Scholar
• Marder SR, Roth B, Sullivan PF, Advancing drug discovery for schizophrenia. Ann N Y Acad Sci 2011;1236:30-43
   PubMedGoogle Scholar
• Compton CH, Gubb J, Nieman R, Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study. Lancet 2001;358:265-70
   PubMed Web of Science ®Google Scholar
• Hebenstreit GF, Fellerer K, Fichte K, Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine. Pharmacopsychiatry 1989;22:156-60
   PubMed Web of Science ®Google Scholar
• Krause W, Kuhne G. Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences. Xenobiotica 1988;18:561-71
   PubMed Web of Science ®Google Scholar
• Robichaud A, Stamatiou PB, Jin SL, Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest 2002;110:1045-52
   PubMed Web of Science ®Google Scholar
• Manning CD, Burman M, Christensen SB, Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B. Br J Pharmacol 1999;128:1393-8
   PubMed Web of Science ®Google Scholar
• Eldar-Finkelman H, Martinez A. GSK-3 Inhibitors: preclinical and Clinical Focus on CNS. Front Mol Neurosci 2011;4:32
   PubMed Web of Science ®Google Scholar
• Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 1996;93:8455-9
   PubMed Web of Science ®Google Scholar
• Penzes P, Johnson RC, Alam MR, An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction. J Biol Chem 2000;275:6395-403
   PubMedGoogle Scholar
• Deacon SW, Beeser A, Fukui JA, An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol 2008;15:322-31
   PubMedGoogle Scholar
• Misaghian N, Ligresti G, Steelman LS, Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Leukemia 2009;23:25-42
   PubMed Web of Science ®Google Scholar
• Hikida T, Jaaro-Peled H, Seshadri S, Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci USA 2007;104:14501-6
   PubMed Web of Science ®Google Scholar
• Clapcote SJ, Lipina TV, Millar JK, Behavioral phenotypes of Disc1 missense mutations in mice. Neuron 2007;54:387-402
   PubMed Web of Science ®Google Scholar
• Li W, Zhou Y, Jentsch JD, Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci USA 2007;104:18280-5
   PubMed Web of Science ®Google Scholar
• Pletnikov MV, Ayhan Y, Nikolskaia O, Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry 2008;13:173-86. 15
   PubMedGoogle Scholar
• Shen S, Lang B, Nakamoto C, Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci 2008;28:10893-904
   PubMedGoogle Scholar
• Koike H, Arguello PA, Kvajo M, Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci USA 2006;103:3693-7
   PubMed Web of Science ®Google Scholar
• Kuroda K, Yamada S, Tanaka M, Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 2011;20:4666-83
   PubMed Web of Science ®Google Scholar
• Kvajo M, McKellar H, Arguello PA, A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci USA 2008;105:7076-81
   PubMedGoogle Scholar
• Abazyan B, Nomura J, Kannan G, Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology. Biol Psychiatry 2010;68:1172-81
   PubMed Web of Science ®Google Scholar
• Pollak DD, Rey CE, Monje FJ. Rodent models in depression research: classical strategies and new directions. Ann Med 2010;42:252-64
   PubMed Web of Science ®Google Scholar
• St Clair D, Blackwood D, Muir W, Association within a family of a balanced autosomal translocation with major mental illness. Lancet 1990;336:13-16
   PubMed Web of Science ®Google Scholar
• Blackwood DH, Fordyce A, Walker MT, Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 2001;69:428-33
   PubMed Web of Science ®Google Scholar
• Lee FH, Fadel MP, Preston-Maher K, Disc1 point mutations in mice affect development of the cerebral cortex. J Neurosci 2011;31:3197-206
   PubMedGoogle Scholar
• Kvajo M, McKellar H, Drew LJ, Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice. Proc Natl Acad Sci USA 2011;108:E1349-58
   PubMedGoogle Scholar
• Jentsch JD, Roth RH. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1999;20:201-25
   PubMed Web of Science ®Google Scholar
• Mouri A, Noda Y, Enomoto T, Nabeshima T. Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment. Neurochem Int 2007;51:173-84
   PubMed Web of Science ®Google Scholar
• Lewis DA, Levitt P. Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 2002;25:409-32
   PubMed Web of Science ®Google Scholar
• Rapoport JL, Addington AM, Frangou S, Psych MR. The neurodevelopmental model of schizophrenia: update 2005. Mol Psychiatry 2005;10:434-49
   PubMed Web of Science ®Google Scholar
• Schurov IL, Handford EJ, Brandon NJ, Whiting PJ. Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Mol Psychiatry 2004;9:1100-10
   PubMed Web of Science ®Google Scholar
• Ibi D, Nagai T, Koike H, Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behav Brain Res 2010;206:32-7
   PubMedGoogle Scholar