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gp130: a promising drug target for cancer therapy

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Pages 1303-1328 | Published online: 07 Oct 2013

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Rui Sun, Yating Wang & Hassan Abolhassani. (2023) Cellular mechanisms and clinical applications for phenocopies of inborn errors of immunity: infectious susceptibility due to cytokine autoantibodies. Expert Review of Clinical Immunology 19:7, pages 771-784.
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Yuwen Cao, Yu Tian, Yueqin Liu & Zhaoliang Su. (2022) Reg3β: A Potential Therapeutic Target for Tissue Injury and Inflammation-Associated Disorders. International Reviews of Immunology 41:2, pages 160-170.
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Articles from other publishers (51)

Alankar Roy, Ishani Paul, Shreya Luharuka & Sujay Ray. (2023) An in-silico scaffold- hopping approach to design novel inhibitors against gp130: A potential therapeutic application in cancer and Covid-19. Molecular Diversity.
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Siyuan Tan, Haodong Tang, Yang Wang, Peng Xie, Haifeng Li, Zheng Zhang & Jiahua Zhou. (2023) Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development. Heliyon 9:9, pages e19296.
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Yonghyun Lee, Jongyoon Shinn, Cheng Xu, Hannah E. Dobson, Nouri Neamati & James J. Moon. (2023) Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy. Nature Communications 14:1.
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Xiaojuan Yang, Lu Xu, Li Yang & Shaohong Xu. (2023) Research progress of STAT3-based dual inhibitors for cancer therapy. Bioorganic & Medicinal Chemistry 91, pages 117382.
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Yaxian Wang, Xipeng Sun, Quanjun Yang & Cheng Guo. (2023) Cucurbitacin IIb attenuates cancer cachexia induced skeletal muscle atrophy by regulating the IL ‐6/ STAT3 / FoxO signaling pathway . Phytotherapy Research 37:8, pages 3380-3393.
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Ziyu Ji, Jianlin Shen, Yujian Lan, Qian Yi & Huan Liu. (2023) Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies. MedComm 4:4.
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Jiayu Bao, Peng Zhang, Binge Wu, Jingyi Wang, Siyuan Li, Ao Li & Ying Jie. (2023) Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis. Investigative Opthalmology & Visual Science 64:4, pages 5.
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Yanesko Fernandes Bella, Carlos Rocha Oliveira, José Roberto Mateus-Silva, Maysa Alves Rodrigues Brandao-Rangel, Anamei Silva-Reis, Juliana de Melo Batista Santos, Regiane Albertini, Rodrigo Alvaro Brandao Lopes-Martins, Luis Vicente Franco de Oliveira & Rodolfo P. Vieira. (2023) A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling. Biomedicine & Pharmacotherapy 159, pages 114263.
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Ioannis Pozios, Nina A. Hering, Emily Guenzler, Marco Arndt, Sefer Elezkurtaj, Thomas Knösel, Christiane J. Bruns, Georgios A. Margonis, Katharina Beyer & Hendrik Seeliger. (2022) Gp130 is expressed in pancreatic cancer and can be targeted by the small inhibitor molecule SC144. Journal of Cancer Research and Clinical Oncology 149:1, pages 271-280.
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Yuwaraj Kadariya, Eleonora Sementino, Ujjawal Shrestha, Greg Gorman, Jonathan M White, Eric A Ross, Margie L Clapper, Nouri Neamati, Mark Steven Miller & Joseph R Testa. (2022) Inflammation as a chemoprevention target in asbestos-induced malignant mesothelioma. Carcinogenesis 43:12, pages 1137-1148.
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Sujay Ray & Shreya Luharuka. (2022) Targeting the gp130_D5 domain through pharmacophore modelling and structure-based virtual screening using natural plant products: A detailed molecular dynamics study for development of novel anti-cancer therapeutics. Journal of Molecular Graphics and Modelling 117, pages 108290.
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Md. Hafiz Uddin, Md. Najeeb Al-Hallak, Philip A. Philip, Herbert Chen, Bassel El-Rayes & Asfar S. Azmi. (2022) Aberrant transcription factors in the cancers of the pancreas. Seminars in Cancer Biology 86, pages 28-45.
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Jiangyan Xu, Jinrong Zhang, Qi-Fen Mao, Jian Wu & Yuan Wang. (2022) The Interaction Between Autophagy and JAK/STAT3 Signaling Pathway in Tumors. Frontiers in Genetics 13.
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Douglas L. Mann. (2022) Targeting Inflammation in Pulmonary Artery Hypertension: Is It Time to Forget About the Lungs?. Circulation: Heart Failure 15:1.
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Hua Yu Ling, Zhong Yang, Pan Jun Wang, Yu Sun, Song Guang Ju, Jun Li & Jin Xiang Fu. (2022) Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway. Chemico-Biological Interactions 352, pages 109779.
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Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang & Xueran Chen. (2021) Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Stem Cell Research & Therapy 12:1.
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Sarah Peisl, Claudia Mellenthin, Lucie Vignot, Carmen Gonelle-Gispert, Leo Bühler & Bernhard Egger. (2021) Therapeutic targeting of STAT3 pathways in pancreatic adenocarcinoma: A systematic review of clinical and preclinical literature. PLOS ONE 16:6, pages e0252397.
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Huan Liu, Wenlong Lin, Zhiyong Liu, Yinjing Song, Hao Cheng, Huazhang An & Xiaojian Wang. (2021) E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by promoting GP130 degradation. EMBO reports 22:5.
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Rosa K. Kortekaas, Janette K. Burgess, Roël van Orsoy, David Lamb, Megan Webster & Reinoud Gosens. (2021) Therapeutic Targeting of IL-11 for Chronic Lung Disease. Trends in Pharmacological Sciences 42:5, pages 354-366.
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Narges Rostami, Afshin Nikkhoo, Yalda Khazaei‐poul, Shohreh Farhadi, Melika Sadat Haeri, Sadaf Moghadaszadeh Ardebili, Nasimeh Aghaei Vanda, Fatemeh Atyabi, Afshin Namdar, Masoumeh Baghaei, Navideh Haghnavaz, Tohid Kazemi, Mehdi Yousefi, Ghasem Ghalamfarsa, Gholamabas Sabz & Farhad Jadidi‐Niaragh. (2020) Coinhibition of S1PR1 and GP130 by siRNA‐loaded alginate‐conjugated trimethyl chitosan nanoparticles robustly blocks development of cancer cells. Journal of Cellular Physiology 235:12, pages 9702-9717.
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Sebastiano Andò, Giuseppina Daniela Naimo, Luca Gelsomino, Stefania Catalano & Loredana Mauro. (2020) Novel insights into adiponectin action in breast cancer: Evidence of its mechanistic effects mediated by ERα expression. Obesity Reviews 21:5.
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Xuanhao Li, Shanshan He, Ye Tian, Robert M. Weiss & Darryl T. Martin. (2019) Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth. Cellular Signalling 63, pages 109381.
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Fangming Liu, Haizhen Jin, Jinhong Shen, Dan Wu, Ye Tian & Chao Huang. (2019) Gp130 degradation induced by epirubicin contributes to chemotherapy efficacy. Biochemical and Biophysical Research Communications 519:3, pages 572-578.
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Payal Tiwari, Ariane Blank, Chang Cui, Kelly Q. Schoenfelt, Guolin Zhou, Yanfei Xu, Galina Khramtsova, Funmi Olopade, Ajay M. Shah, Seema A. Khan, Marsha Rich Rosner & Lev Becker. (2019) Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. Journal of Experimental Medicine 216:6, pages 1345-1358.
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Xiang Chen, Jilai Tian, Gloria H. Su & Jiayuh Lin. (2019) Blocking IL-6/GP130 Signaling Inhibits Cell Viability/Proliferation, Glycolysis, and Colony Forming Activity in Human Pancreatic Cancer Cells. Current Cancer Drug Targets 19:5, pages 417-427.
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Ali Masjedi, Vida Hashemi, Mohammad Hojjat-Farsangi, Ghasem Ghalamfarsa, Gholamreza Azizi, Mehdi Yousefi & Farhad Jadidi-Niaragh. (2018) The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer. Biomedicine & Pharmacotherapy 108, pages 1415-1424.
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Kriti Ray, Beata Ujvari, Venkata Ramana & John Donald. (2018) Cross-talk between EGFR and IL-6 drives oncogenic signaling and offers therapeutic opportunities in cancer. Cytokine & Growth Factor Reviews 41, pages 18-27.
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Sunyoung Ham, Luize G. Lima, Edna Pei Zhi Chai, Alexandra Muller, Richard J. Lobb, Sophie Krumeich, Shu Wen Wen, Adrian P. Wiegmans & Andreas Möller. (2018) Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling. Frontiers in Immunology 9.
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Weihua Zhu, Yazhou Wang, Dafang Zhang, Xin Yu & Xisheng Leng. (2018) MiR-7-5p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma. Biochemical and Biophysical Research Communications 497:4, pages 963-970.
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Jean-Marc Cavaillon & Mervyn SingerToshio Tanaka, Masashi Narazaki & Tadamistu Kishimoto. 2017. Inflammation - From Molecular and Cellular Mechanisms to the Clinic. Inflammation - From Molecular and Cellular Mechanisms to the Clinic 573 586 .
Xiang Chen, Jia Wei, Chenglong Li, Christopher Pierson, Jonathan Finlay & Jiayuh Lin. (2017) Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells. International Journal of Oncology.
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Hui Xiao, Hemant Kumar Bid, Xiang Chen, Xiaojuan Wu, Jia Wei, Yang Bian, Chengguang Zhao, Huameng Li, Chenglong Li & Jiayuh Lin. (2017) Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy. PLOS ONE 12:7, pages e0180297.
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Yanyan Yuan, Yang Xi, Jiayi Chen, Pan Zhu, Jinyu Kang, Zuquan Zou, Fuyan Wang & Shizhong Bu. (2017) STAT3 stimulates adipogenic stem cell proliferation and cooperates with HMGA2 during the early stage of differentiation to promote adipogenesis. Biochemical and Biophysical Research Communications 482:4, pages 1360-1366.
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