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Protease-activated receptor 2 signalling pathways: a role in pain processing

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Feryel Soualmia & Chahrazade El Amri. (2018) Serine protease inhibitors to treat inflammation: a patent review (2011-2016). Expert Opinion on Therapeutic Patents 28:2, pages 93-110.
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Yanju Bao, Yebo Gao, Liping Yang, Xiangying Kong, Jing Yu, Wei Hou & Baojin Hua. (2015) The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence. Channels 9:5, pages 235-243.
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Baojin Hua, Yebo Gao, Xiangying Kong, Liping Yang, Wei Hou & Yanju Bao. (2015) New insights of nociceptor sensitization in bone cancer pain. Expert Opinion on Therapeutic Targets 19:2, pages 227-243.
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Articles from other publishers (27)

Moeno Kume, Ayesha Ahmad, Kathryn A. DeFea, Josef Vagner, Gregory Dussor, Scott Boitano & Theodore J. Price. (2023) Protease-Activated Receptor 2 (PAR2) Expressed in Sensory Neurons Contributes to Signs of Pain and Neuropathy in Paclitaxel Treated Mice. The Journal of Pain 24:11, pages 1980-1993.
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Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu & Min Chen. (2023) Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis. Frontiers in Pharmacology 14.
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Moeno Kume, Ayesha Ahmad, Stephanie Shiers, Michael D. Burton, Kathryn A. DeFea, Josef Vagner, Gregory Dussor, Scott Boitano & Theodore J. Price. (2023) C781, a β-Arrestin Biased Antagonist at Protease-Activated Receptor-2 (PAR2), Displays in vivo Efficacy Against Protease-Induced Pain in Mice. The Journal of Pain 24:4, pages 605-616.
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Jeong-Mi Kim, Eun-Mi Noh, Yong-Ouk You, Min Seuk Kim & Young-Rae Lee. (2022) Downregulation of Matriptase Inhibits Porphyromonas gingivalis Lipopolysaccharide-Induced Matrix Metalloproteinase-1 and Proinflammatory Cytokines by Suppressing the TLR4/NF-κB Signaling Pathways in Human Gingival Fibroblasts. BioMed Research International 2022, pages 1-11.
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Jeong-Mi Kim, Jinny Park, Eun-Mi Noh, Hyun-Kyung Song, Sang Kang, Sung Jung, Jong-Suk Kim, Hyun Youn & Young-Rae Lee. (2021) Downregulation of matriptase suppresses the PAR‑2/PLCγ2/PKC‑mediated invasion and migration abilities of MCF‑7 breast cancer cells. Oncology Reports 46:6.
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Yani Liu, Zongtao Liu & KeWei Wang. (2021) The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?. Acta Pharmaceutica Sinica B 11:6, pages 1412-1433.
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Moe Soeda, Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata, Tatsuya Ichinohe, Ken-ichi Fukuda & Kazutaka Ikeda. (2021) Cold pain sensitivity is associated with single-nucleotide polymorphisms of PAR2 / F2RL1 and TRPM8 . Molecular Pain 17, pages 174480692110020.
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Ophélie Pierre, Maxime Fouchard, Paul Buscaglia, Nelig Le Goux, Raphaël Leschiera, Olivier Mignen, Joachim W. Fluhr, Laurent Misery & Raphaële Le Garrec. (2020) Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling. Cells 9:12, pages 2704.
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Charlotte Avet, Claudio Sturino, Sébastien Grastilleur, Christian Le Gouill, Meriem Semache, Florence Gross, Louis Gendron, Youssef Bennani, Joseph A. Mancini, Camil E. Sayegh & Michel Bouvier. (2020) The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects. Communications Biology 3:1.
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Doaa I. Mohamed, Eman Khairy, Sara A. Khedr, Eman K. Habib, Wael M. Elayat & Omnyah A. El-kharashi. (2020) N-acetylcysteine (NAC) alleviates the peripheral neuropathy associated with liver cirrhosis via modulation of neural MEG3/PAR2/ NF-ҡB axis. Neurochemistry International 132, pages 104602.
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Mason Henehan & Anna De Benedetto. (2019) Update on protease‐activated receptor 2 in cutaneous barrier, differentiation, tumorigenesis and pigmentation, and its role in related dermatologic diseases. Experimental Dermatology 28:8, pages 877-885.
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Lijun Du, Yanqin Long, John J. Kim, Binrui Chen, Yubin Zhu & Ning Dai. (2018) Protease Activated Receptor-2 Induces Immune Activation and Visceral Hypersensitivity in Post-infectious Irritable Bowel Syndrome Mice. Digestive Diseases and Sciences 64:3, pages 729-739.
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Maho Tsubota, Tomoka Ozaki, Yuko Hayashi, Yasumasa Okawa, Ayaka Fujimura, Fumiko Sekiguchi, Hiroyuki Nishikawa & Atsufumi Kawabata. (2018) Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca 2+ channels. Journal of Pharmacological Sciences 136:1, pages 46-49.
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Kent H. Nouri, Uzondu Osuagwu, Jessica Boyette-Davis, Matthias Ringkamp, Srinivasa N. Raja & Patrick M. Dougherty. 2018. Essentials of Pain Medicine. Essentials of Pain Medicine 11 20.e2 .
Meng Zhang, Cun‑Xiang Gao, Yan‑Ping Wang, Ke‑Tao Ma, Li Li, Jiang‑Wen Yin, Zhi‑Gang Dai, Sheng Wang & Jun‑Qiang Si. (2017) The association between the expression of PAR2 and TMEM16A and neuropathic pain. Molecular Medicine Reports.
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David A. Hart. (2017) Targeting Mast Cells as a Viable Therapeutic Option in Endometriosis. EMJ Reproductive Health, pages 76-83.
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Efrat Shavit-Stein, Avital Artan-Furman, Ekaterina Feingold, Marina Ben Shimon, Zeev Itzekson-Hayosh, Joab Chapman, Andreas Vlachos & Nicola Maggio. (2017) Protease Activated Receptor 2 (PAR2) Induces Long-Term Depression in the Hippocampus through Transient Receptor Potential Vanilloid 4 (TRPV4). Frontiers in Molecular Neuroscience 10.
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Sonja Stahn, Lisa Thelen, Ina‐Maria Albrecht, Jens Bitzer, Thomas Henkel & Nicole Elisabeth Teusch. (2016) Teleocidin A2 inhibits human proteinase‐activated receptor 2 signaling in tumor cells. Pharmacology Research & Perspectives 4:4.
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P. MROZKOVA, J. PALECEK & D. SPICAROVA. (2016) The Role of Protease-Activated Receptor Type 2 in Nociceptive Signaling and Pain. Physiological Research, pages 357-367.
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Florian Guenther & Matthias F. Melzig. (2015) Protease-activated receptors and their biological role—focused on skin inflammation. Journal of Pharmacy and Pharmacology 67:12, pages 1623-1633.
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YANJU BAO, GAIMEI WANG, YEBO GAO, MAOBO DU, LIPING YANG, XIANGYING KONG, HONGGANG ZHENG, WEI HOU & BAOJIN HUA. (2015) Topical treatment with Xiaozheng Zhitong Paste alleviates bone cancer pain by inhibiting proteinase-activated receptor 2 signaling pathway. Oncology Reports 34:3, pages 1449-1459.
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Scott Boitano, Justin Hoffman, Andrea N Flynn, Marina N Asiedu, Dipti V Tillu, Zhenyu Zhang, Cara L Sherwood, Candy M Rivas, Kathryn A DeFea, Josef Vagner & Theodore J Price. (2015) The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo . British Journal of Pharmacology 172:18, pages 4535-4545.
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Yanju Bao, Yebo Gao, Wei Hou, Liping Yang, Xiangying Kong, Honggang Zheng, Conghuang Li & Baojin Hua. (2015) Engagement of signaling pathways of protease-activated receptor 2 and ?-opioid receptor in bone cancer pain and morphine tolerance. International Journal of Cancer 137:6, pages 1475-1483.
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Yanju Bao, Wei Hou, Liping Yang, Rui Liu, Yebo Gao, Xiangying Kong, Zhan Shi, Weidong Li, Honggang Zheng, Shulong Jiang & Baojin Hua. (2014) Increased Expression of Protease-Activated Receptor 2 and 4 Within Dorsal Root Ganglia in a Rat Model of Bone Cancer Pain. Journal of Molecular Neuroscience 55:3, pages 706-714.
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Yanju Bao, Wei Hou, Liping Yang, Xiangying Kong, Maobo Du, Honggang Zheng, Yebo Gao & Baojin Hua. (2015) Protease-Activated Receptor 2 Antagonist Potentiates Analgesic Effects of Systemic Morphine in a Rat Model of Bone Cancer Pain. Regional Anesthesia and Pain Medicine 40:2, pages 158-165.
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Rink-Jan Lohman, Rosemary S. Harrison, Gloria Ruiz-G?mez, Huy N. Hoang, Nicholas E. Shepherd, Shiao Chow, Timothy A. Hill, Praveen K. Madala & David P. Fairlie. 2015. Nociceptin Opioid. Nociceptin Opioid 1 55 .
Yanju Bao, Wei Hou, Rui Liu, Yebo Gao, Xiangying Kong, Liping Yang, Zhan Shi, Weidong Li, Honggang Zheng, Shulong Jiang, Conghuang Li, Yinggang Qin & Baojin Hua. (2014) PAR2-Mediated Upregulation of BDNF Contributes to Central Sensitization in Bone Cancer Pain. Molecular Pain 10, pages 1744-8069-10-28.
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