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Targeting FLT3 to treat leukemia

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Jun Li, Dan Liao, Fujue Wang, Zhongwang Wang, Yueshan Li, Yu Xiong & Ting Niu. (2022) RIPK1 inhibition enhances the therapeutic efficacy of chidamide in FLT3-ITD positive AML, both in vitro and in vivo. Leukemia & Lymphoma 63:5, pages 1167-1179.
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Marie-Anne Hospital, Alexa S Green, Thiago T Maciel, Ivan C Moura, Anskar Y Leung, Didier Bouscary & Jerome Tamburini. (2017) FLT3 inhibitors: clinical potential in acute myeloid leukemia. OncoTargets and Therapy 10, pages 607-615.
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Tor Henrik Tvedt, Ina Nepstad & Øystein Bruserud. (2017) Antileukemic effects of midostaurin in acute myeloid leukemia – the possible importance of multikinase inhibition in leukemic as well as nonleukemic stromal cells. Expert Opinion on Investigational Drugs 26:3, pages 343-355.
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Catherine J. Lee, Parveen Shiraz & Lori Muffly. (2017) Pharmacologic maintenance strategies following allogeneic hematopoietic cell transplantation for acute myeloid leukemia. Leukemia & Lymphoma 58:3, pages 516-527.
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Sara Mongiorgi, Carlo Finelli, Yong Ryoul Yang, Cristina Clissa, James A. McCubrey, Anna Maria Billi, Lucia Manzoli, Pann-Ghill Suh, Lucio Cocco & Matilde Y. Follo. (2016) Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes. Expert Opinion on Therapeutic Targets 20:6, pages 677-687.
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Articles from other publishers (51)

Hamidreza Zalpoor, Maryam Bakhtiyari, Abdullatif Akbari, Fatemeh Aziziyan, Hooriyeh Shapourian, Mahsa Liaghat, Zahra Zare-Badie, Sheida Yahyazadeh, Vahideh Tarhriz & Mazdak Ganjalikhani-Hakemi. (2022) Potential role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights. Cell Communication and Signaling 20:1.
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Fangli Chen, Emilia Licarete, Xue Wu, Daniela Petrusca, Callista Maguire, Max Jacobsen, Austyn Colter, George E. Sandusky, Magdalena Czader, Maegan L. Capitano, James P. Ropa, H. Scott Boswell, Fabrizio Carta, Claudiu T. Supuran, Brian Parkin, Melissa L. Fishel & Heiko Konig. (2021) Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions. Journal of Cellular and Molecular Medicine 25:24, pages 11039-11052.
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Bartholomew J. Eisfelder, Caner Saygin, Joseph Wynne, Margaret W. Colton, Mariafausta Fischietti, Elspeth M. Beauchamp, Jason X. Cheng, Olatoyosi Odenike, Gail Roboz, Houda Alachkar & Wendy Stock. (2021) OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia. Blood Cancer Journal 11:3.
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Hanane Djamai, Jeannig Berrou, Mélanie Dupont, Anna Kaci, Jan Erik Ehlert, Holger Weber, André Baruchel, Fabrice Paublant, Renaud Prudent, Claude Gardin, Hervé Dombret & Thorsten Braun. (2021) Synergy of FLT3 inhibitors and the small molecule inhibitor of LIM kinase1/2 CEL_Amide in FLT3-ITD mutated Acute Myeloblastic Leukemia (AML) cells. Leukemia Research 100, pages 106490.
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Nur Şebnem ERSÖZ & Aysun ADAN. (2020) Cytotoxic Effects of Resveratrol and Its Combinations with Ceramide Metabolism Inhibitors on FLT3 Positive Acute Myeloid LeukemiaResveratrol ve Seramid Metabolizması Enzim İnhibitörleri İle Kombinasyonlarının FLT3 Pozitif Akut Miyeloid Lösemideki Sitotoksik Etkileri. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 13:3, pages 1205-1216.
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Xiaoli Hu, Jiayi Cai, Jianyi Zhu, Wenjing Lang, Jihua Zhong, Hua Zhong & Fangyuan Chen. (2020) Arsenic trioxide potentiates Gilteritinib-induced apoptosis in FLT3-ITD positive leukemic cells via IRE1a-JNK-mediated endoplasmic reticulum stress. Cancer Cell International 20:1.
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Eirik Solum, Trond Vidar Hansen, Reidun Aesoy & Lars Herfindal. (2020) New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry 28:10, pages 115461.
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Mengyuan Lyu, Hongyan Liao, Xiao Shuai, Yongmei Jin, Jun Su & Qin Zheng. (2020) The prognosis predictive value of FMS-like tyrosine kinase 3-internal tandem duplications mutant allelic ratio (FLT3-ITD MR) in patients with acute myeloid leukemia detected by GeneScan. Gene 726, pages 144195.
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Heather R. Dorman, David Close, Bentley M. Wingert, Carlos J. Camacho, Paul A. Johnston & Thomas E. Smithgall. (2019) Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck. Frontiers in Chemistry 7.
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Nessar Ahmad Azrakhsh, Patrycja Mensah-glanowska, Kristoffer Sand & Astrid Olsnes Kittang. (2019) Targeting Immune Signaling Pathways in Clonal Hematopoiesis. Current Medicinal Chemistry 26:28, pages 5262-5277.
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Ralf Buettner, Le Xuan Truong Nguyen, Bijender Kumar, Corey Morales, Chao Liu, Lisa S. Chen, Tea Pemovska, Timothy W. Synold, Joycelynne Palmer, Ryan Thompson, Ling Li, Dinh Hoa Hoang, Bin Zhang, Lucy Ghoda, Claudia Kowolik, Mika Kontro, Calum Leitch, Krister Wennerberg, Xiaochun Yu, Ching‐Cheng Chen, David Horne, Varsha Gandhi, Vinod Pullarkat, Guido Marcucci & Steven T. Rosen. (2019) 8‐chloro‐adenosine activity in FLT3‐ITD acute myeloid leukemia. Journal of Cellular Physiology 234:9, pages 16295-16303.
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Xin Tang, Jesse DrotarKeji Li, Cullen D. Clairmont, Anna Sophie BrummAustin J. Sullins, Hao WuXiaoxiao Shawn LiuJinhua WangNathanael S. GrayMriganka Sur & Rudolf Jaenisch. (2019) Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice . Science Translational Medicine 11:503.
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Catherine J. Lee, Bipin N. Savani, Mohamad Mohty, Norbert C. Gorin, Myriam Labopin, Annalisa Ruggeri, Christoph Schmid, Frédéric Baron, Jordi Esteve, Sebastian Giebel, Fabio Ciceri & Arnon Nagler. (2018) Post-remission strategies for the prevention of relapse following allogeneic hematopoietic cell transplantation for high-risk acute myeloid leukemia: expert review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Bone Marrow Transplantation 54:4, pages 519-530.
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Tapan Mahendra Kadia, Hagop M. Kantarjian & Marina Konopleva. (2019) Myeloid cell leukemia-1 dependence in acute myeloid leukemia: a novel approach to patient therapy. Oncotarget 10:12, pages 1250-1265.
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Dilana Staudt, Heather Murray, Tabitha McLachlan, Frank Alvaro, Anoop Enjeti, Nicole Verrills & Matthew Dun. (2018) Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: The Path to Least Resistance. International Journal of Molecular Sciences 19:10, pages 3198.
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Rui Wang, Ying Li, Ping Gong, Janice Gabrilove, Samuel Waxman & Yongkui Jing. (2018) Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute Myeloid Leukemia Cells. Molecular Cancer Therapeutics 17:9, pages 1871-1880.
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Eman Z. Kandeel, Ghada El Sayed, Nahla Elsharkawy, Dalia Negm Eldin, Hanan R. Nassar, Dalia Ibrahiem, Randa Amin, Marwa Hanafi, Mohamed Khalil & Azza Kamel. (2018) Impact of FLT3 Receptor (CD135) Detection by Flow Cytometry on Clinical Outcome of Adult Acute Myeloid Leukemia Patients. Clinical Lymphoma Myeloma and Leukemia 18:8, pages 541-547.
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Fu Li, May Kung Sutherland, Changpu Yu, Roland B. Walter, Lori Westendorf, John Valliere-Douglass, Lucy Pan, Ashley Cronkite, Django Sussman, Kerry Klussman, Michelle Ulrich, Martha E. Anderson, Ivan J. Stone, Weiping Zeng, Mechthild Jonas, Timothy S. Lewis, Maitrayee Goswami, Sa A. Wang, Peter D. Senter, Che-Leung Law, Eric J. Feldman & Dennis R. Benjamin. (2018) Characterization of SGN-CD123A, A Potent CD123-Directed Antibody–Drug Conjugate for Acute Myeloid Leukemia. Molecular Cancer Therapeutics 17:2, pages 554-564.
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Jennifer N. Moloney, Ashok Kumar Jayavelu, Joanna Stanicka, Sarah L. Roche, Rebecca L. O’Brien, Sebastian Scholl, Frank-D. Böhmer & Thomas G. Cotter. (2017) Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML. Oncotarget 8:62, pages 105440-105457.
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Hubert Hackl, Ksenia Astanina & Rotraud Wieser. (2017) Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia. Journal of Hematology & Oncology 10:1.
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J. Kyle Bruner, Hayley S. Ma, Li Li, Alice Can Ran Qin, Michelle A. Rudek, Richard J. Jones, Mark J. Levis, Keith W. Pratz, Christine A. Pratilas & Donald Small. (2017) Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase–Driven Leukemias and Other Malignancies. Cancer Research 77:20, pages 5554-5563.
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H-Q Ju, G Zhan, A Huang, Y Sun, S Wen, J Yang, W-h Lu, R-h Xu, J Li, Y Li, G Garcia-Manero, P Huang & Y Hu. (2017) ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition. Leukemia 31:10, pages 2143-2150.
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Alfred Chung, Yanli Hou, Robert S. Ohgami, Ann Von Gehr, Dianna G. Fisk, Krishna M. Roskin, Xu Li, Linda Gojenola, Charles D. Bangs, Daniel A. Arber, Andrew Z. Fire, Athena M. Cherry, James L. Zehnder, Jason Gotlib & Jason D. Merker. (2017) A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia. Cancer Genetics 216-217, pages 10-15.
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Masamichi Mori, Naoki Kaneko, Yoko Ueno, Masaki Yamada, Ruriko Tanaka, Rika Saito, Itsuro Shimada, Kenichi Mori & Sadao Kuromitsu. (2017) Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia. Investigational New Drugs 35:5, pages 556-565.
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Mrinal M Patnaik. (2017) Midostaurin for the treatment of acute myeloid leukemia. Future Oncology 13:21, pages 1853-1871.
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Panpan Hou, Chao Wu, Yuchen Wang, Rui Qi, Dheeraj Bhavanasi, Zhixiang Zuo, Cedric Dos Santos, Shuliang Chen, Yu Chen, Hong Zheng, Hong Wang, Alexander Perl, Deyin Guo & Jian Huang. (2017) A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Cancer Research 77:16, pages 4402-4413.
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Sarah Etheridge. (2017) Patients in Focus: What’s Relevant for Chronic Myeloid Leukaemia and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukaemia?. EMJ Hematology, pages 53-61.
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Mark C. Weir, Sabine Hellwig, Li Tan, Yao Liu, Nathanael S. Gray & Thomas E. Smithgall. (2017) Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth. PLOS ONE 12:7, pages e0181178.
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Jonathan Metts, Heath L. Bradley, Zhengqi Wang, Neil P. Shah, Reuben Kapur, Jack L. Arbiser & Kevin D. Bunting. (2017) Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells. Scientific Reports 7:1.
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Xiaochu Ma, Jie Zhou, Changhao Wang, Brandon Carter-Cooper, Fan Yang, Elizabeth Larocque, Jonathan Fine, Genichiro Tsuji, Gaurav Chopra, Rena G. Lapidus & Herman O. Sintim. (2017) Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach. ACS Medicinal Chemistry Letters 8:5, pages 492-497.
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Emily-Marie Latuske, Hauke Stamm, Marianne Klokow, Gabi Vohwinkel, Jana Muschhammer, Carsten Bokemeyer, Manfred Jücker, Maxim Kebenko, Walter Fiedler & Jasmin Wellbrock. (2017) Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia. Oncotarget 8:17, pages 29187-29201.
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A Staffas, L S Arabanian, S Y Wei, A Jansson, S Ståhlman, P Johansson, L Fogelstrand, J Cammenga, F Kuchenbauer & L Palmqvist. (2016) Upregulation of Flt3 is a passive event in Hoxa9/Meis1-induced acute myeloid leukemia in mice. Oncogene 36:11, pages 1516-1524.
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Maximilian Fleischmann, Ulf Schnetzke, Karin G. Schrenk, Volker Schmidt, Herbert G. Sayer, Inken Hilgendorf, Andreas Hochhaus & Sebastian Scholl. (2016) Outcome of FLT3-ITD-positive acute myeloid leukemia: impact of allogeneic stem cell transplantation and tyrosine kinase inhibitor treatment. Journal of Cancer Research and Clinical Oncology 143:2, pages 337-345.
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Claudia M. Kowolik, Min Lin, Jun Xie, Larry E. Overman & David A. Horne. (2016) NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia . Oncotarget 7:52, pages 86186-86197.
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Sabine Kayser & Mark J Levis. (2016) Are FLT3 inhibitors likely to improve FLT3 -mutated acute myeloid leukemia in the foreseeable future? . International Journal of Hematologic Oncology 5:4, pages 123-126.
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Phillip M. Garfin & Eric J. Feldman. (2016) Antibody-Based Treatment of Acute Myeloid Leukemia. Current Hematologic Malignancy Reports 11:6, pages 545-552.
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Marianne Jarfelt, Niels H. Andersen & Henrik Hasle. (2016) Is it possible to cure childhood acute myeloid leukaemia without significant cardiotoxicity?. British Journal of Haematology 175:4, pages 577-587.
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I De Kouchkovsky & M Abdul-Hay. (2016) ‘Acute myeloid leukemia: a comprehensive review and 2016 update’. Blood Cancer Journal 6:7, pages e441-e441.
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Amin Huang, Huai-Qiang Ju, Kaiyan Liu, Guilian Zhan, Daolu Liu, Shijun Wen, Guillermo Garcia-Manero, Peng Huang & Yumin Hu. (2016) Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation. Cancer Letters 377:2, pages 149-157.
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