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Triple-negative breast cancer: investigating potential molecular therapeutic target

, MD, , MD, , MD (Full Professor of Medical Oncology) , , MD PhD, , MD & , MD PhD

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Ernestina Marianna De Francesco, Francesca Cirillo, Veronica Vella, Antonino Belfiore, Marcello Maggiolini & Rosamaria Lappano. (2022) Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress. Expert Opinion on Therapeutic Targets 26:6, pages 513-535.
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Peipei Liu, Wenhui Li, Yuanyuan Hu & Youhong Jiang. (2018) Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer. OncoTargets and Therapy 11, pages 5485-5498.
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Yang Gao, Qing Ma, Yan-Bin Ma, Liang Ding, Xiao-Long Xu, De-Fei Wei, Lei Wei & Jing-Wei Zhang. (2018) Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastructural Pathology 42:1, pages 49-54.
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Nelson Rangel, Victoria E Villegas & Milena Rondón-Lagos. (2017) Profiling of gene expression regulated by 17β-estradiol and tamoxifen in estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines. Breast Cancer: Targets and Therapy 9, pages 537-550.
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Giuliana De Gregoriis, Juliene Antonio Ramos, Priscila Valverde Fernandes, Giselle Maria Vignal, Rafael Canfield Brianese, Dirce Maria Carraro, Alvaro N. Monteiro, Claudio José Struchiner, Guilherme Suarez-Kurtz, Rosane Vianna-Jorge & Marcelo Alex de Carvalho. (2017) DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis. Cancer Biology & Therapy 18:6, pages 439-449.
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Zimiao Luo, Linwei Lu, Weixia Xu, Nana Meng, Sunyi Wu, Jianfen Zhou, Qianzhu Xu, Cao Xie, Yu Liu & Weiyue Lu. (2022) In vivo self-assembled drug nanocrystals for metastatic breast cancer all-stage targeted therapy. Journal of Controlled Release 346, pages 32-42.
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Xiao Luo & Hui Wang. (2021) LINC00514 upregulates CCDC71L to promote cell proliferation, migration and invasion in triple‐negative breast cancer by sponging miR-6504-5p and miR-3139. Cancer Cell International 21:1.
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Domenico Ribatti, Tiziana Annese & Roberto Tamma. (2021) Controversial role of mast cells in breast cancer tumor progression and angiogenesis. Clinical Breast Cancer 21:6, pages 486-491.
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Giacomo Barchiesi, Michela Roberto, Monica Verrico, Patrizia Vici, Silverio Tomao & Federica Tomao. (2021) Emerging Role of PARP Inhibitors in Metastatic Triple Negative Breast Cancer. Current Scenario and Future Perspectives. Frontiers in Oncology 11.
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Ha Thi Thu Do & Jungsook Cho. (2020) Involvement of the ERK/HIF-1α/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells. International Journal of Molecular Sciences 22:1, pages 89.
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Chu Tang, Yang Du, Qian Liang, Zhen Cheng & Jie Tian. (2019) A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy . Journal of Materials Chemistry B 7:22, pages 3528-3536.
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Chu Tang, Yang Du, Qian Liang, Zhen Cheng & Jie Tian. (2018) Development of a Novel Ferrocenyl Histone Deacetylase Inhibitor for Triple-Negative Breast Cancer Therapy. Organometallics 37:14, pages 2368-2375.
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Sepideh Parvizpour, Jafar Razmara, Mohammad M. Pourseif & Yadollah Omidi. (2018) In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens. BioImpacts 9:1, pages 45-56.
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Elke J. A. H. van Beek, Jonathan M. Hernandez, Debra A. Goldman, Jeremy L. Davis, Kaitlin McLaughlin, R. Taylor Ripley, Teresa S. Kim, Laura H. Tang, Jaclyn F. Hechtman, Jian Zheng, Marinela Capanu, Nikolaus Schultz, David M. Hyman, Marc Ladanyi, Michael F. Berger, David B. Solit, Yelena Y. Janjigian & Vivian E. Strong. (2018) Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer. Annals of Surgical Oncology 25:7, pages 2027-2033.
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Jun-Xia Zhang, Jiao-Mei Guo, Ting-Ting Zhang, Hong-Jun Lin, Nai-Song Qi, Zhen-Guo Li, Ji-Chun Zhou & Zhen-Zhong Zhang. (2018) Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7 Breast Cancer. Molecules 23:6, pages 1288.
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Yuki InoueMasamitsu ShimazawaShinsuke NakamuraShinsuke TakataYuhei HashimotoHiroshi IzawaTomomi MasudaKazuhiro TsurumaTomohisa SakaueHironao NakayamaShigeki HigashiyamaHideaki Hara. (2018) Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization. Arteriosclerosis, Thrombosis, and Vascular Biology 38:1, pages 174-185.
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Jiali Wu, Zeyu Shuang, Jianfu Zhao, Hailin Tang, Peng Liu, Lijuan Zhang, Xiaoming Xie & Xiangsheng Xiao. (2018) Linc00152 promotes tumorigenesis by regulating DNMTs in triple-negative breast cancer. Biomedicine & Pharmacotherapy 97, pages 1275-1281.
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Katharina Gohr, Alexandra Hamacher, Laura H. Engelke & Matthias U. Kassack. (2017) Inhibition of PI3K/Akt/mTOR overcomes cisplatin resistance in the triple negative breast cancer cell line HCC38. BMC Cancer 17:1.
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Jordan M. Reese, Elizabeth S. Bruinsma, David G. Monroe, Vivian Negron, Vera J. Suman, James N. Ingle, Matthew P. Goetz & John R. Hawse. (2017) ERβ inhibits cyclin dependent kinases 1 and 7 in triple negative breast cancer. Oncotarget 8:57, pages 96506-96521.
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Litao Liu, Wenlan Liu, Lili Wang, Ting Zhu, Jianhua Zhong & Ni Xie. (2017) Hypoxia‑inducible factor 1 mediates intermittent hypoxia‑induced migration of human breast cancer MDA‑MB‑231 cells. Oncology Letters.
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Anca Maria Cimpean, Roberto Tamma, Simona Ruggieri, Beatrice Nico, Alina Toma & Domenico Ribatti. (2017) Mast cells in breast cancer angiogenesis. Critical Reviews in Oncology/Hematology 115, pages 23-26.
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Lingshuang Lü, Xuhua Mao, Peiyi Shi, Biyu He, Kun Xu, Simin Zhang & Jianming Wang. (2017) MicroRNAs in the prognosis of triple-negative breast cancer. Medicine 96:22, pages e7085.
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Hongyan Jia, Cristina I. Truica, Bin Wang, Yanhong Wang, Xingcong Ren, Harold A. Harvey, Jianxun Song & Jin-Ming Yang. (2017) Immunotherapy for triple-negative breast cancer: Existing challenges and exciting prospects. Drug Resistance Updates 32, pages 1-15.
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Lee Yueh Jia, Muthu K. Shanmugam, Gautam Sethi & Anupam Bishayee. (2016) Potential role of targeted therapies in the treatment of triple-negative breast cancer. Anti-Cancer Drugs 27:3, pages 147-155.
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Nataly Shtraizent, Hiroshi Matsui, Alla Polotskaia & Jill Bargonetti. (2015) Hot Spot Mutation in TP53 (R248Q) Causes Oncogenic Gain-of-Function Phenotypes in a Breast Cancer Cell Line Derived from an African American patient. International Journal of Environmental Research and Public Health 13:1, pages 22.
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Taotao Ling, My Tran, Miguel A. González, Lekh Nath Gautam, Michele Connelly, Rachael K. Wood, Iram Fatima, Gustavo Miranda-Carboni & Fatima Rivas. (2015) (+)-Dehydroabietylamine derivatives target triple-negative breast cancer. European Journal of Medicinal Chemistry 102, pages 9-13.
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