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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 8
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Review

Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes

Lara BelliniUniversité PARIS-DIDEROT (7), Unité Biologie Fonctionnelle et Adaptative – UMR CNRS 8251, Équipe Régulation de la glycémie par le système nerveux central (REGLYS), 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 PARIS Cedex 13, France+01 57 27 77 97; +01 57 27 77 96; [email protected]
,
Mélanie CampanaUniversité PARIS-DIDEROT (7), Unité Biologie Fonctionnelle et Adaptative – UMR CNRS 8251, Équipe Régulation de la glycémie par le système nerveux central (REGLYS), 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 PARIS Cedex 13, France+01 57 27 77 97; +01 57 27 77 96; [email protected]
,
Rana MahfouzINSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France;Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France;Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France
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Aurélie CarlierINSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France;Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France;Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France
,
Julien VéretUniversité PARIS-DIDEROT (7), Unité Biologie Fonctionnelle et Adaptative – UMR CNRS 8251, Équipe Régulation de la glycémie par le système nerveux central (REGLYS), 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 PARIS Cedex 13, France+01 57 27 77 97; +01 57 27 77 96; [email protected]
,
Christophe MagnanUniversité PARIS-DIDEROT (7), Unité Biologie Fonctionnelle et Adaptative – UMR CNRS 8251, Équipe Régulation de la glycémie par le système nerveux central (REGLYS), 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 PARIS Cedex 13, France+01 57 27 77 97; +01 57 27 77 96; [email protected]
,
Eric HajduchINSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France;Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France;Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France
&
Hervé Le StunffUniversité PARIS-DIDEROT (7), Unité Biologie Fonctionnelle et Adaptative – UMR CNRS 8251, Équipe Régulation de la glycémie par le système nerveux central (REGLYS), 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 PARIS Cedex 13, France+01 57 27 77 97; +01 57 27 77 96; [email protected]
 show all
Pages 1037-1050 | Published online: 26 Mar 2015

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Xuefeng Bai, Jiangxin Ma, Xiaohong Wu, Lingling Qiu, Rongfu Huang, Haibin Zhang, Huibin Huang & Xiaoyu Chen. (2023) Impact of Visceral Obesity on Structural and Functional Alterations of Gut Microbiota in Polycystic Ovary Syndrome (PCOS): A Pilot Study Using Metagenomic Analysis. Diabetes, Metabolic Syndrome and Obesity 16, pages 1-14.
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Xiaoxu Wang, Yuming Wang, Jie Xu & Changhu Xue. (2021) Sphingolipids in food and their critical roles in human health. Critical Reviews in Food Science and Nutrition 61:3, pages 462-491.
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Articles from other publishers (38)

Sarah Ali-Berrada, Jeanne Guitton, Sophie Tan-Chen, Anna Gyulkhandanyan, Eric Hajduch & Hervé Le Stunff. (2023) Circulating Sphingolipids and Glucose Homeostasis: An Update. International Journal of Molecular Sciences 24:16, pages 12720.
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Hao Jiang, Tianyu Huang, Yanbo Yu, Charles Zhou, Lin Qiu, Hien Ngoc Mai, Robert J. Gropler, Robyn S. Klein & Zhude Tu. (2023) Characterization of a S1PR2 specific 11C-labeled radiotracer in streptozotocin-induced diabetic murine model. Nuclear Medicine and Biology 122-123, pages 108370.
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Cécile L. Bandet, Sophie Tan-Chen, Sarah Ali-Berrada, Mélanie Campana, Maxime Poirier, Agnieszka Blachnio-Zabielska, Jean-Paul Pais-de-Barros, Claude Rouch, Pascal Ferré, Fabienne Foufelle, Hervé Le Stunff & Eric Hajduch. (2023) Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway. Journal of Biological Chemistry 299:6, pages 104815.
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Guanqiong Na, Jing Zhang, Dian Lv, Ping Chen, Xinyue Song, Fenfen Cai, Sicong Zheng, Wenting Wan & Yujuan Shan. (2023) Germinated Brown rice enhanced n-3 PUFA metabolism in type 2 diabetes patients: A randomized controlled trial. Clinical Nutrition 42:4, pages 579-589.
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Hengwei Yu, Sayed Haidar Abbas Raza, Yueting Pan, Gong Cheng, Chugang Mei & Linsen Zan. (2023) Integrative Analysis of Blood Transcriptomics and Metabolomics Reveals Molecular Regulation of Backfat Thickness in Qinchuan Cattle. Animals 13:6, pages 1060.
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Fang Yang & Guoxun Chen. (2022) The nutritional functions of dietary sphingomyelin and its applications in food. Frontiers in Nutrition 9.
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Li Chen, Rui Xu, Joshua D. McDonald, Richard S. Bruno, Fouad Choueiry & Jiangjiang Zhu. (2022) Dairy Milk Casein and Whey Proteins Differentially Alter the Postprandial Lipidome in Persons with Prediabetes: A Comparative Lipidomics Study. Journal of Agricultural and Food Chemistry 70:33, pages 10209-10220.
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Christophe Magnan & Hervé Le Stunff. (2021) Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders. Molecular Metabolism 53, pages 101298.
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Kelly Meneyrol, Ánxela Estévez-Salguero, Ismael González-García, Jeanne Guitton, Mohammed Taouis, Yacir Benomar, Christophe Magnan, Miguel López & Hervé Le Stunff. (2021) Ovarian insufficiency impairs glucose-stimulated insulin secretion through activation of hypothalamic de novo ceramide synthesis. Metabolism 123, pages 154846.
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Lei Yan, Pei Han, Jin Man, Yongmei Tian, Fudi Wang & Jia Wang. (2021) Discovery of lipid profiles of type 2 diabetes associated with hyperlipidemia using untargeted UPLC Q-TOF/MS-based lipidomics approach. Clinica Chimica Acta 520, pages 53-62.
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Andressa Reginato, Alana Carolina Costa Veras, Mayara da Nóbrega Baqueiro, Carolina Panzarin, Beatriz Piatezzi Siqueira, Marciane Milanski, Patrícia Cristina Lisboa & Adriana Souza Torsoni. (2021) The Role of Fatty Acids in Ceramide Pathways and Their Influence on Hypothalamic Regulation of Energy Balance: A Systematic Review. International Journal of Molecular Sciences 22:10, pages 5357.
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Floriane Lachkar, Pascal Ferré, Fabienne Foufelle & Alexandra Papaioannou. (2021) Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases. American Journal of Physiology-Endocrinology and Metabolism 320:1, pages E122-E130.
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Jeanne Guitton, Cécile L. Bandet, Mohamed L. Mariko, Sophie Tan-Chen, Olivier Bourron, Yacir Benomar, Eric Hajduch & Hervé Le Stunff. (2020) Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes. Cells 9:7, pages 1682.
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Tiziana Filardi, Giuseppina Catanzaro, Stefania Mardente, Alessandra Zicari, Carmela Santangelo, Andrea Lenzi, Susanna Morano & Elisabetta Ferretti. (2020) Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications. International Journal of Molecular Sciences 21:11, pages 4020.
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Mélanie Le Barz, Marie Michèle Boulet, Catherine Calzada, David Cheillan & Marie-Caroline Michalski. (2020) Alterations of endogenous sphingolipid metabolism in cardiometabolic diseases: Towards novel therapeutic approaches. Biochimie 169, pages 133-143.
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Agnieszka Dobrzyn, Justyna Janikiewicz, Zuzanna Tracz-Gaszewska, Anna Filip, Aneta M. Dobosz, Ewelina Krogulec & Pawel Dobrzyn. 2020. Lipid Signaling and Metabolism. Lipid Signaling and Metabolism 385 411 .
Zijian Fang, Susan Pyne & Nigel J. Pyne. (2019) WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction. Progress in Lipid Research, pages 100991.
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Hervé Le Stunff, Julien Véret, Nadim Kassis, Jessica Denom, Kelly Meneyrol, Jean-Louis Paul, Céline Cruciani-Guglielmacci, Christophe Magnan & Nathalie Janel. (2019) Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration. Frontiers in Neurology 10.
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Huamei Wei, Jianchu Wang, Wenchuan Li, Rihai Ma, Zuoming Xu, Zongjiang Luo, Yuan Lu, Xiaoyu Zhang, Xidai Long, Jian Pu & Qianli Tang. (2018) The underlying pathophysiology association between the Type 2‐diabetic and hepatocellular carcinoma. Journal of Cellular Physiology 234:7, pages 10835-10841.
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Li Ying, Trevor Stanley Tippetts & Bhagirath Chaurasia. (2019) Ceramide dependent lipotoxicity in metabolic diseases. Nutrition and Healthy Aging 5:1, pages 1-12.
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Zijian Fang, Susan Pyne & Nigel J. Pyne. (2019) Ceramide and sphingosine 1-phosphate in adipose dysfunction. Progress in Lipid Research 74, pages 145-159.
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Sunil Kumar Sahu, Yusuf A. Hannun & Nan Yao. (2019) Emergence of membrane sphingolipids as a potential therapeutic target. Biochimie 158, pages 257-264.
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Louise K Metcalfe, Greg C Smith & Nigel Turner. (2019) Defining lipid mediators of insulin resistance: controversies and challenges. Journal of Molecular Endocrinology 62:1, pages R65-R82.
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Adrian Chabowski & Jan Górski. 2019. Muscle and Exercise Physiology. Muscle and Exercise Physiology 271 284 .
Lara Bellini, Mélanie Campana, Claude Rouch, Marta Chacinska, Marco Bugliani, Kelly Meneyrol, Isabelle Hainault, Véronique Lenoir, Jessica Denom, Julien Véret, Nadim Kassis, Bernard Thorens, Mark Ibberson, Piero Marchetti, Agnieszka Blachnio-Zabielska, Céline Cruciani-Guglielmacci, Carina Prip-Buus, Christophe Magnan & Hervé Le Stunff. (2018) Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets. Diabetologia 61:8, pages 1780-1793.
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Sabine Daemen, Nynke van Polanen & Matthijs K. C. Hesselink. (2018) The effect of diet and exercise on lipid droplet dynamics in human muscle tissue. Journal of Experimental Biology 221:Suppl_1.
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Yuan Zhou, Lihui Men, Zifeng Pi, Mengying Wei, Fengrui Song, Chunfang Zhao & Zhiqiang Liu. (2018) Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique . Journal of Agricultural and Food Chemistry 66:6, pages 1591-1599.
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Axelle Le Marec, Selvee Sungeelee, Amina Zeghouani, Laurine Gonzalez & Hervé Le Stunff. (2018) Rôle du métabolisme des céramides adipocytaires dans le brunissement du tissu adipeux blanc. médecine/sciences 34:2, pages 132-135.
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Mélanie Campana, Lara Bellini, Claude Rouch, Latif Rachdi, Nicolas Coant, Noémie Butin, Cécile L. Bandet, Erwann Philippe, Kelly Meneyrol, Nadim Kassis, Julien Dairou, Eric Hajduch, Benoit Colsch, Christophe Magnan & Hervé Le Stunff. (2018) Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Molecular Metabolism 8, pages 23-36.
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Stephan Werth, Helge Müller-Fielitz & Walter Raasch. (2017) Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. Journal of Endocrinology 235:3, pages 251-265.
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Magdalene K. Montgomery, Simon H. J. Brown, Todd W. Mitchell, Adelle C. F. Coster, Gregory J. Cooney & Nigel Turner. (2017) Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains. Scientific Reports 7:1.
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Céline Cruciani-Guglielmacci, Lara Bellini, Jessica Denom, Masaya Oshima, Neïké Fernandez, Priscilla Normandie-Levi, Xavier P. Berney, Nadim Kassis, Claude Rouch, Julien Dairou, Tracy Gorman, David M. Smith, Anna Marley, Robin Liechti, Dmitry Kuznetsov, Leonore Wigger, Frédéric Burdet, Anne-Laure Lefèvre, Isabelle Wehrle, Ingo Uphues, Tobias Hildebrandt, Werner Rust, Catherine Bernard, Alain Ktorza, Guy A. Rutter, Raphael Scharfmann, Ioannis Xenarios, Hervé Le Stunff, Bernard Thorens, Christophe Magnan & Mark Ibberson. (2017) Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion. Molecular Metabolism 6:4, pages 340-351.
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Michael M. Mendelson, Riccardo E. Marioni, Roby Joehanes, Chunyu Liu, Åsa K. Hedman, Stella Aslibekyan, Ellen W. Demerath, Weihua Guan, Degui Zhi, Chen Yao, Tianxiao Huan, Christine Willinger, Brian Chen, Paul Courchesne, Michael Multhaup, Marguerite R. Irvin, Ariella Cohain, Eric E. Schadt, Megan L. Grove, Jan Bressler, Kari North, Johan Sundström, Stefan Gustafsson, Sonia Shah, Allan F. McRae, Sarah E. Harris, Jude Gibson, Paul Redmond, Janie Corley, Lee Murphy, John M. Starr, Erica Kleinbrink, Leonard Lipovich, Peter M. Visscher, Naomi R. Wray, Ronald M. Krauss, Daniele Fallin, Andrew Feinberg, Devin M. Absher, Myriam Fornage, James S. Pankow, Lars Lind, Caroline Fox, Erik Ingelsson, Donna K. Arnett, Eric Boerwinkle, Liming Liang, Daniel Levy & Ian J. Deary. (2017) Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach. PLOS Medicine 14:1, pages e1002215.
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