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Targeting the unfolded protein response for disease intervention

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Natalia Salvadores & Felipe A. Court. (2020) The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?. Expert Opinion on Therapeutic Targets 24:7, pages 679-693.
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Arin N. Graner, Justin E. Hellwinkel, Alex M. Lencioni, Helen J. Madsen, Tessa A. Harland, Paul Marchando, Ger J. Nguyen, Mary Wang, Laura M. Russell, Lynne T. Bemis, Thomas J. Anchordoquy & Michael W. Graner. (2017) HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line*. International Journal of Hyperthermia 33:3, pages 303-317.
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Srividhya Iyer & Douglas J. Adams. (2023) Bone and the Unfolded Protein Response: In Sickness and in Health. Calcified Tissue International 113:1, pages 96-109.
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Amin Izadpanah, Kurtis Willingham, Bysani Chandrasekar, Eckhard U. Alt & Reza Izadpanah. (2023) Unfolded protein response and angiogenesis in malignancies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:2, pages 188839.
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Berenice Franco-Juárez, Cristina Coronel-Cruz, Beatriz Hernández-Ochoa, Saúl Gómez-Manzo, Noemi Cárdenas-Rodríguez, Roberto Arreguin-Espinosa, Cindy Bandala, Luis Miguel Canseco-Ávila & Daniel Ortega-Cuellar. (2022) TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator. Cells 11:19, pages 3153.
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Chenxuan Zhao, Yong Liao, Abdul Rahaman & Vijay Kumar. (2022) Towards Understanding the Relationship Between ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis. Frontiers in Aging Neuroscience 14.
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Raymond A Sobel, Megan Albertelli, Julian R Hinojoza, Mary Jane Eaton, Kevin V Grimes & Edward Rubenstein. (2022) Azetidine-2-Carboxylic Acid-Induced Oligodendrogliopathy: Relevance to the Pathogenesis of Multiple Sclerosis. Journal of Neuropathology & Experimental Neurology 81:6, pages 414-433.
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Lichun Qiao, Xuan Liu, Yujie He, Jiaheng Zhang, Hao Huang, Wenming Bian, Mumba Mulutula Chilufya, Yan Zhao & Jing Han. (2021) Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis. International Journal of Molecular Sciences 22:21, pages 11932.
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Ivo Ricardo de Seabra Rodrigues Dias, Hang Hong Lo, Kaixi Zhang, Betty Yuen Kwan Law, Ali Adnan Nasim, Sookja Kim Chung, Vincent Kam Wai Wong & Liang Liu. (2021) Potential therapeutic compounds from traditional Chinese medicine targeting endoplasmic reticulum stress to alleviate rheumatoid arthritis. Pharmacological Research 170, pages 105696.
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Shailendra Pratap Singh, Salomon Amar, Pinky Gehlot, Sanjib K. Patra, Navjot Kanwar & Abhinav Kanwal. (2021) Mitochondrial Modulations, Autophagy Pathways Shifts in Viral Infections: Consequences of COVID-19. International Journal of Molecular Sciences 22:15, pages 8180.
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Gautam Sule, Basel H. Abuaita, Paul A. Steffes, Andrew T. Fernandes, Shanea K. Estes, Craig Dobry, Deepika Pandian, Johann E. Gudjonsson, J. Michelle Kahlenberg, Mary X. O’Riordan & Jason S. Knight. (2021) Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus. Journal of Clinical Investigation 131:7.
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Xingyuan Zhang, Fang Zhang, Changxi Zhang & Jie Li. (2021) miRNA- 125b Signaling Ameliorates Liver Injury Against Obstructive Jaundice-Induced Excessive Fibrosis in Experimental Rats. Yonsei Medical Journal 62:5, pages 453.
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Ramsay E. Beveridge, Heidi Ackerly Wallweber, Avi Ashkenazi, Maureen Beresini, Kevin R. Clark, Paul Gibbons, Elise Ghiro, Susan Kaufman, Alexandre Larivée, Melissa Leblanc, Jean-Philippe Leclerc, Alexandre Lemire, Cuong Ly, Joachim Rudolph, Jacob B. Schwarz, Sanjay Srivastava, Weiru Wang, Liang Zhao & Marie-Gabrielle Braun. (2020) Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity. ACS Medicinal Chemistry Letters 11:12, pages 2389-2396.
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Sylwia Bartoszewska & James F. Collawn. (2020) Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia. Cellular & Molecular Biology Letters 25:1.
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Tina Bagratuni, Dimitrios Patseas, Nefeli Mavrianou-Koutsoukou, Christine Ivy Liacos, Aimilia D. Sklirou, Pantelis Rousakis, Maria Gavriatopoulou, Evangelos Terpos, Ourania E. Tsitsilonis, Ioannis P. Trougakos, Efstathios Kastritis & Meletios A. Dimopoulos. (2020) Characterization of a PERK Kinase Inhibitor with Anti-Myeloma Activity. Cancers 12:10, pages 2864.
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Mandi Gandelman, Warunee Dansithong, Karla P. Figueroa, Sharan Paul, Daniel R. Scoles & Stefan M. Pulst. (2020) Staufen 1 amplifies proapoptotic activation of the unfolded protein response. Cell Death & Differentiation 27:10, pages 2942-2951.
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Shireen R. Lamandé & John F. Bateman. (2019) Genetic Disorders of the Extracellular Matrix. The Anatomical Record 303:6, pages 1527-1542.
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Shreya Bhattacharya, Puja Ghosh, Debasmita Banerjee, Arundhati Banerjee & Sujay Ray. (2020) In Silico Drug Target Discovery Through Proteome Mining from M. tuberculosis: An Insight into Antivirulent Therapy. Combinatorial Chemistry & High Throughput Screening 23:3, pages 253-268.
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Christopher C. Glembotski, Adrian Arrieta, Erik A. Blackwood & Winston T. Stauffer. (2020) ATF6 as a Nodal Regulator of Proteostasis in the Heart. Frontiers in Physiology 11.
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Chinaemere Igwebuike, Julia Yaglom, Leah Huiting, Hui Feng, Joshua D. Campbell, Zhiyong Wang, Andrea Havasi, David Pimentel, Michael Y. Sherman & Steven C. Borkan. (2020) Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity. Cell Death & Disease 11:4.
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Hiroshi Maekawa & Reiko Inagi. (2019) Pathophysiological Role of Organelle Stress/Crosstalk in AKI-to-CKD Transition. Seminars in Nephrology 39:6, pages 581-588.
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Hui-Di Zhang, Jian-Ni Huang, Yun-Zi Liu, Hong Ren, Jing-Yuan Xie & Nan Chen. (2019) Endoplasmic reticulum stress and proteasome pathway involvement in human podocyte injury with a truncated COL4A3 mutation. Chinese Medical Journal 132:15, pages 1823-1832.
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Sarah R. Chadwick & Patrick Lajoie. (2019) Endoplasmic Reticulum Stress Coping Mechanisms and Lifespan Regulation in Health and Diseases. Frontiers in Cell and Developmental Biology 7.
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Paloma Gómez-Fernández, Andoni Urtasun, Ianire Astobiza, Jorge Mena, Iraide Alloza & Koen Vandenbroeck. (2019) Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1). International Journal of Molecular Sciences 20:10, pages 2440.
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Yu Shao, Emily Wichern, Paul J. Childress, Michele Adaway, Jagannath Misra, Angela Klunk, David B. Burr, Ronald C. Wek, Amber L. Mosley, Yunlong Liu, Alexander G. Robling, Nickolay Brustovetsky, James Hamilton, Kylie Jacobs, Deepak Vashishth, Keith R. Stayrook, Matthew R. Allen, Joseph M. Wallace & Joseph P. Bidwell. (2019) Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality . American Journal of Physiology-Endocrinology and Metabolism 316:5, pages E749-E772.
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Qian-Qian Chen, Cheng Zhang, Ming-Qiang Qin, Jian Li, Hua Wang, De-Xiang Xu & Jian-Qing Wang. (2018) Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice. Frontiers in Pharmacology 9.
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Ying-Hsien Huang, Ya-Ling Yang & Feng-Sheng Wang. (2018) The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis. International Journal of Molecular Sciences 19:7, pages 1889.
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Matías González-Quiroz, Hery Urra, Celia María Limia & Claudio Hetz. (2018) Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases. Seminars in Cancer Biology 50, pages 42-52.
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Daiqiang Liu, Yaqun Zhou, Yawen Peng, Peng Su, Zheng Li, Qiaoqiao Xu, Ye Tu, Xuebi Tian, Hui Yang, Zhen Wu, Wei Mei & Feng Gao. (2018) Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance. Frontiers in Molecular Neuroscience 11.
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Ying-Hsien Huang, Ya-Ling Yang, Fu-Chen Huang, Mao-Meng Tiao, Yen-Cheng Lin, Ming-Horng Tsai & Feng-Sheng Wang. (2017) MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. Experimental Biology and Medicine 243:1, pages 13-21.
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Kyle G. Rodino, Lauren VieBrock, Sean M. Evans, Hong Ge, Allen L. Richards & Jason A. Carlyon. (2018) Orientia tsutsugamushi Modulates Endoplasmic Reticulum-Associated Degradation To Benefit Its Growth. Infection and Immunity 86:1.
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Alice C-H Chen, Lucy Burr & Michael A McGuckin. (2018) Oxidative and endoplasmic reticulum stress in respiratory disease. Clinical & Translational Immunology 7:6, pages e1019.
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Bryce G. Johnson, Lan T. Dang, Graham Marsh, Allie M. Roach, Zebulon G. Levine, Anthony Monti, Deepak Reyon, Lionel Feigenbaum & Jeremy S. Duffield. (2017) Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis. Journal of Clinical Investigation 127:11, pages 3954-3969.
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Dexiang Liu, Zunji Ke & Jia Luo. (2016) Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy. Molecular Neurobiology 54:7, pages 5440-5448.
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Min-Kyung Kang, Sin-Hye Park, Yun-Ho Kim, Eun-Jung Lee, Lucia Dwi Antika, Dong Yeon Kim, Yean-Jung Choi & Young-Hee Kang. (2017) Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-eIF2α-ATF-CHOP pathway in diabetic mice. Acta Pharmacologica Sinica 38:8, pages 1129-1140.
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Elzbieta Kania, Gemma Roest, Tim Vervliet, Jan B. Parys & Geert Bultynck. (2017) IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer. Frontiers in Oncology 7.
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Jianjun Li, Delin Wang, Junnan Liu, Yunlang Qin, Liangliang Huang, Qiangfeng Zeng, Maolin Xiao, Jie Hu, Qixin Yang, Jiang He, Li Mai, Ying Li & Wujiang Liu. (2017) Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress. Acta Biochimica et Biophysica Sinica 49:3, pages 254-261.
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Zhengmao Li, Fenzan Wu, Xie Zhang, Yi Chai, Daqing Chen, Yuetao Yang, Kebin Xu, Jiayu Yin, Rui Li, Hongxue Shi, Zhouguang Wang, Xiaokun Li, Jian Xiao & Hongyu Zhang. (2017) Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway. International Journal of Molecular Sciences 18:2, pages 315.
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Hiroshi Maekawa & Reiko Inagi. (2017) Stress Signal Network between Hypoxia and ER Stress in Chronic Kidney Disease. Frontiers in Physiology 8.
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Khaled A. Shaaban, Meredith A. Saunders, Yinan Zhang, Tuan Tran, Sherif I. Elshahawi, Larissa V. Ponomareva, Xiachang Wang, Jianjun Zhang, Gregory C. Copley, Manjula Sunkara, Madan K. Kharel, Andrew J. Morris, James C. Hower, Matthew S. Tremblay, Mark A. Prendergast & Jon S. Thorson. (2016) Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6 . Journal of Natural Products 80:1, pages 2-11.
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Jurgen Heymann, Cheryl A Winkler, Maarten Hoek, Katalin Susztak & Jeffrey B Kopp. (2017) Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte. Nephrology Dialysis Transplantation 32:suppl_1, pages i65-i70.
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Jason Gavin, Fran Quilty, Ferenc Majer, Georgina Gilsenan, Anne Marie Byrne, Aideen Long, Gabor Radics & John F. Gilmer. (2016) A fluorescent analogue of tauroursodeoxycholic acid reduces ER stress and is cytoprotective. Bioorganic & Medicinal Chemistry Letters 26:21, pages 5369-5372.
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A. Cimellaro, M. Perticone, T.V. Fiorentino, A. Sciacqua & M.L. Hribal. (2016) Role of endoplasmic reticulum stress in endothelial dysfunction. Nutrition, Metabolism and Cardiovascular Diseases 26:10, pages 863-871.
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Claudio Hetz & Smita Saxena. (2016) PREFACE: Divergent roles of ER stress in neurodegeneration and brain disorders. Brain Research 1648, pages 527-529.
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Soo-Kyoung Choi, Mihwa Lim, Seon-Hee Byeon & Young-Ho Lee. (2016) Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats. Scientific Reports 6:1.
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Bai Yu, Zhao Wenjun, Yin Changsheng, Fang Yuntao, Ma Jing, Li Ben, Qian Hai, Xing Guangwei, Wang Suhua, Li Fang, Michael Aschner & Lu Rongzhu. (2016) Preconditioning of endoplasmic reticulum stress protects against acrylonitrile-induced cytotoxicity in primary rat astrocytes: The role of autophagy. NeuroToxicology 55, pages 112-121.
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